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PA VARIATION PREVALENCE AND 2-HOUR REPEATABILITY DURING FRACTIONAL FLOW RESERVE ASSESSMENT
398 JACC April 5, 2016 Volume 67, Issue 13
ACC.i2 Interventional Cardiology PD/PA VARIATION PREVALENCE AND 2-HOUR REPEATABILITY DURING FRACTIONAL FLOW RESERVE ASSESSMENT Poster Contributions Poster Area, South Hall A1 Monday, April 04, 2016, 9:45 a.m.-10:30 a.m. Session Title: Hemodynamics and Miscellaneous Abstract Category: 1. ACC.i2 Interventional Cardiology: ACS/AMI/Hemodynamics and Pharmacology Presentation Number: 1254-169 Authors: Dimitrios Alexopoulos, Periklis Davlouros, Grigorios Tsigkas, Nikolaos Koutsogiannis, Athanasios Moulias, Stelios Armilagos, Paraskevi Salata, Marianna Leopoulou, Ioanna Xanthopoulou, Patras University Hospital, Patras, Greece
Background: Variation of coronary/aortic (Pd/Pa) pressure during adenosine infusion has been recently emphasized. We aimed to assess Pd/Pa variation prevalence and repeatability during fractional flow reserve (FFR) assessment.
Methods: We retrospectively analyzed data from 76 patients subjected to FFR assessment twice (2-hour interval between measurements) with 3-min 140 μg/kg/min central adenosine infusion (ClinicalTrials.gov NCT02108808). As steady state hyperemia (SSH) was defined the interval between 15sec post Pd/Pa deep (visually assessed) and the end of adenosine infusion. Variation in Pd/Pa was defined as ≥ 0.05 difference of max Pd/Pa minus min Pd/Pa (ΔPd/Pa) during SSH. Results: Frequency of Pd/Pa variation did not differ between period 1 and 2: 71.1% vs 72.4%, p>0.99. Out of 54 patients with variation in period 1, 83.3% had variation in period 2 too, while 59.2% of them had variation in both periods. Among those with variation at period 1, mean ΔPd/Pa during SSH did not differ between period 1 and 2: 0.09±0.04 vs 0.08±0.05, p=0.5, while min Pd/Pa observed during the SSH correlated well between periods (Figure 1A). Bland-Altman analysis revealed a mean difference between ΔPd/Pa measurements of 0.004±0.04 with -0.08 to 0.09 95% CI limits of agreement (Figure 1B). Conclusions: Variation in Pd/Pa observed during standard adenosine infusion is common and fairly repeatable over a 2-hour period. Among patients with variation, the minimum Pd/Pa value observed during SSH is highly reproducible.
ACC.i2 Interventional Cardiology PD/PA VARIATION PREVALENCE AND 2-HOUR REPEATABILITY DURING FRACTIONAL FLOW RESERVE ASSESSMENT Poster Contributions Poster Area, South Hall A1 Monday, April 04, 2016, 9:45 a.m.-10:30 a.m. Session Title: Hemodynamics and Miscellaneous Abstract Category: 1. ACC.i2 Interventional Cardiology: ACS/AMI/Hemodynamics and Pharmacology Presentation Number: 1254-169 Authors: Dimitrios Alexopoulos, Periklis Davlouros, Grigorios Tsigkas, Nikolaos Koutsogiannis, Athanasios Moulias, Stelios Armilagos, Paraskevi Salata, Marianna Leopoulou, Ioanna Xanthopoulou, Patras University Hospital, Patras, Greece
Background: Variation of coronary/aortic (Pd/Pa) pressure during adenosine infusion has been recently emphasized. We aimed to assess Pd/Pa variation prevalence and repeatability during fractional flow reserve (FFR) assessment.
Methods: We retrospectively analyzed data from 76 patients subjected to FFR assessment twice (2-hour interval between measurements) with 3-min 140 μg/kg/min central adenosine infusion (ClinicalTrials.gov NCT02108808). As steady state hyperemia (SSH) was defined the interval between 15sec post Pd/Pa deep (visually assessed) and the end of adenosine infusion. Variation in Pd/Pa was defined as ≥ 0.05 difference of max Pd/Pa minus min Pd/Pa (ΔPd/Pa) during SSH. Results: Frequency of Pd/Pa variation did not differ between period 1 and 2: 71.1% vs 72.4%, p>0.99. Out of 54 patients with variation in period 1, 83.3% had variation in period 2 too, while 59.2% of them had variation in both periods. Among those with variation at period 1, mean ΔPd/Pa during SSH did not differ between period 1 and 2: 0.09±0.04 vs 0.08±0.05, p=0.5, while min Pd/Pa observed during the SSH correlated well between periods (Figure 1A). Bland-Altman analysis revealed a mean difference between ΔPd/Pa measurements of 0.004±0.04 with -0.08 to 0.09 95% CI limits of agreement (Figure 1B). Conclusions: Variation in Pd/Pa observed during standard adenosine infusion is common and fairly repeatable over a 2-hour period. Among patients with variation, the minimum Pd/Pa value observed during SSH is highly reproducible.