Pharmacokinetics and End Organ Effect of PDE5 Inhibitors in the Fetal Lamb Model of Congenital Diaphragmatic Hernia

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ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS

8.17. Is Thyroidectomy in Patients With Hashimoto’s Thyroiditis More Risky? C. M. McManus, J. Luo, R. Sippel, H. Chen; University of Wisconsin, Madison, WI 8.18. The Natural Flavinoid, Chrysin, in the Treatment of Medullary Thyroid Cancer. B. Zarebczan, M. Kunnimalaiyaan, H. Chen; University of Wisconsin, Madison, WI

8.19. Evidence of a Stabilizing Mutation of-Catenin Encoded by CTNNB1 Exon 3 in a Large Series of Sporadic Parathyroid Adenomas. L. F. Starker,1,2 A. Fonseca,1 G. Akerstrom,2 P. Bjorklund,2 G. Westin,2 T. Carling1; 1Yale University School of Medicine, New Haven, CT; 2Uppsala University Department of Surgical Sciences, Uppsala, Uppsala 8.20. Down-Regulation of Notch1 Expression in Papillary Thyroid Carcinoma Correlates With Advanced Age and Tumor Aggressiveness. X. Yu, H. Chen, R. S. Sippel; University of Wisconsin School of Medicine and Public Health, Madison, WI

PEDIATRICS AND DEVELOPMENTAL BIOLOGY 1: MECHANISMS & MODELS 9.1. Inhibition of Focal Adhesion Kinase (FAK) Leads to Decreased Cell Survival in Malignant Renal Rhabdoid Tumor Cells. M. Megison, L. Gillory, J. E. Stewart, H. Nabers, E. A. Beierle; University of Alabama - Birmingham, Birmingham, AL 9.2. Genetically Engineered Herpes Simplex Virus Expressing IL-12 Suppresses Murine Neuroblastoma Tumor Growth. L. A. Gillory,1 M. C. Haas,2 G. K. Friedman,2 M. L. Megison,1 J. E. Stewart,1 J. N. Parker,4 J. M. Markert,3 G. Y. Gillespie,6 E. A. Beierle5; 1University of Alabama Birmingham, Birmingham, AL; 2Department of Pediatrics, Children’s Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL; 3Division of Neurosurgery, Children’s Hospital of Alabama and University of Alabama at Birmingham, Birmingham, AL; 4Department of Pediatrics, Children’s Hospital of Alabama and University of Alabama at Birmingham, Birmingham, AL; 5Department of Surgery, Division of Pediatric Surgery, University of Alabama at Birmingham, Birmingham, AL; 6Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL

9.3. Notch1 Signaling in Neuroblastoma. J. F. Burke,1,2 Q. Khan,1 S. Kunnimalaiyaan,1 M. Roy,1 M. Kunnimalaiyaan1; 1 Endocrine Surgery Research Laboratory, Department of Surgery, University of Wisconsin–Madison, Madison, WI; 2 Department of General Surgery, University of Wisconsin–Madison, Madison, WI

9.4. Single Lgr5+ Intestinal Stem Cells Co-Cultured With Intestinal Subepithelial Myofibroblasts (ISEMF) Differentiate into Absorptive and Secretory Cell Lineages Without Exogenous Growth Factors. E. R. Barthel, X. Hou, J. A. Matthews, A. L. Speer, F. G. Sala, T. C. Grikscheit; Children’s Hospital Los Angeles, Los Angeles, CA

9.5. Withdrawn

9.6. Formation of Intestinal Atresias in the Fgfr2IIIb-/- Mouse Model is not Associated with Defects in Notochord Development or Alterations in SHH Expression. A. L. Reeder, R. A. Botham, M. Franco, K. Zaremba, P. F. Nichol; University of Wisconsin School of Medicine and Public Health, Madison, WI

9.7. Selective Laser Photocoagulation Manipulates Blood Flow Dynamics in Microcirculation. G. S. Lee,1 R. M. Webber,5 M. Lin,1 D. C. Simpson,1 B. C. Gibney,1 N. Filipovic,2,4 A. Tsuda,2 M. A. Konerding,3 S. J. Mentzer1; 1 Brigham & Women’s Hospital, Boston, MA; 2Harvard School of Public Health, Boston, MA; 3Johannes Gutenberg University - Mainz, Mainz, Germany; 4University of Kragujevac, Kragujevac, Kragujevac; 5Harvard Medical School, Boston, MA

9.8. Reduction of Bioavailable Vascular Endothelial Growth Factor (VEGF) Alters Terminal Differentiation of the Absorptive and Secretory Lineages in Neonatal Mouse Intestine. S. M. Norgaard,2 J. A. Matthews,1 X. Hou,1 F. G. Sala,1 A. L. Speer,1 E. R. Barthel,1 T. C. Grikscheit1; 1Childrens Hospital Los Angeles, Los Angeles, CA; 2University of Southern California Keck School of Medicine, Los Angeles, CA

9.9. Pharmacokinetics and End Organ Effect of PDE5 Inhibitors in the Fetal Lamb Model of Congenital Diaphragmatic Hernia. E. H. Shue,1,2 S. Schecter,1,2 W. Ferrier,2 D. N. Miniati1,2; 1University of California - San Francisco, San Francisco, CA; 2University of California Davis Medical Center, Sacramento, CA

9.10. Human Cholangiocyte Susceptibility to Infection With Rotavirus - Parallels to the Murine Model of Biliary Atresia. A. C. Coots,1 B. M. Donnelly,1 S. K. Mohanty,1 M. McNeal,1 K. Sestak,2 G. M. Tiao1; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; 2Tulane National Primate Research Center, Covington, LA

9.11. A Multi-scale Agent-based Model of Necrotizing Enterocolitis Integrating Oxidative Stress, Inflammation, and Microvascular Thrombosis. M. Kim, S. Christley, J. Alverdy, D. Liu, G. An; University of Chicago, Chicago, IL

9.12. Site-specific Impaired Mucosal Immunity in the Murine Neural Crest-Specific Deletion of Endothelin ReceptorB Model of Hirschsprung’s Disease. A. Gosain, A. Heneghan, J. Pierre, A. Gosain; University of Wisconsin School of Medicine and Public Health - Department of Surgery, Madison, WI 9.13. Diverse Early Intestinal Microbiota as a Contributing Factor in Necrotizing Enterocolitis. M. L. Williams, H. O. Humes, A. J. Fried, B. B. Bell, S. Castle, A. Grishin, H. R. Ford; Childrens Hospital Los Angeles, Los Angeles, CA