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Pharmacokinetics and Metabolism in Drug Design
European Journal of Medicinal Chemistry 38 (2003) 788 www.elsevier.com/locate/ejmech
Book Review Pharmacokinetics and Metabolism in Drug Design By Dennis A. Smith, Han van de Waterbeemd, Don K. Walker (Methods and Principles in Medicinal Chemistry, volume 13) Wiley-VCH, Weinheim, 2001. 150 pp.; ?50 The authors discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic products. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs.
Contents: Physicochemistry Pharmacokinetics Absorption Distribution Clearance Renal Clearance Metabolic (Hepatic) Clearance Toxicity Inter-Species Scaling High(er) Throughput ADME Studies An index is provided.
´ ditions scientifiques et me´dicales Elsevier SAS. All rights reserved. 0223-5234/03/$ - see front matter # 2003 E doi:10.1016/S0223-5234(03)00124-7
Book Review Pharmacokinetics and Metabolism in Drug Design By Dennis A. Smith, Han van de Waterbeemd, Don K. Walker (Methods and Principles in Medicinal Chemistry, volume 13) Wiley-VCH, Weinheim, 2001. 150 pp.; ?50 The authors discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic products. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs.
Contents: Physicochemistry Pharmacokinetics Absorption Distribution Clearance Renal Clearance Metabolic (Hepatic) Clearance Toxicity Inter-Species Scaling High(er) Throughput ADME Studies An index is provided.
´ ditions scientifiques et me´dicales Elsevier SAS. All rights reserved. 0223-5234/03/$ - see front matter # 2003 E doi:10.1016/S0223-5234(03)00124-7