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Pharmacological reduction of insulin release decreases hyperphagia and body weight gain in growing obese Zucker rats
223
ABSTRACTS
The Ontogeny
of Salt Appetite
LESHEM and ILIT YEHUDA.
Aroused
Psychology
by Depletion
Department,
in the Rat. MICAH
Haifa University,
Israel 31999.
The neonatal rat will ingest salt in response to activation of the brain’s renin/angiotensin system (Leshem & Epstein, 1988 a, b, Developmental Psychobiology, 21). However, while this suggests that the brain system mediating the appetite may be functional at this early age, it is not known whether the peripheral components of the response are equally developed. We examined this by depleting pups of sodium using the natriuretic-diuretic, furosamide. Preweanlings of all ages increased their intake of 3% NaCl in response to the treatment, but analysis of the behavior suggests that it is not a specific response to sodium depletion. Thus in the suckling rat sodium depletion does not activate an integrated homeostatic response. The reasons for this, and the age at which the response emerges, will be discussed.
CSF Concentrations
of CCK-8
and Food Intake
P. SODERSTEN. Departments of Pharmacology Stockholm and Huddinge, Sweden.
in Rats. A. LINDEN and
and Psychiatry,
Karolinska
Institute,
CCK-8 decreased in the CSF of male rats after 48 h of food deprivation and was restored after 1 hr of eating. CCK-8 increased in CSF 10 min after 5 pg CCK-8 i.p. and this was prevented by i.p. doses of CCK A receptor antagonists which prevented the inhibitory effect of CCK-8 on food intake. Lactating rats overeat and food deprivation markedly decreased CCK-8 in CSF and plasma, 1 h after eating increased CSF, but not plasma CCK-8 in lactating rats. Changes in CSF CCK-8, which are independent of changes in plasma CCK-8 suggest a role of central CCK-8 in food intake.
Feeding
Pattern
of
Liver-transplanted
Rats.
ACHAGIOTIS, D. HOUSSIN and J. LOUIS-SYLVESTRE. place Jussieu, 75252 Paris Cedex 05, France.
A. MICHEL, C. Universitb PierreetMarie
LARUECurie, 4
A 10 day continuous recording of food intake was performed in rats 15 and 50 days after orthotopic transplantation of the liver. As compared to control rats, it was shown that early after transplantation, total and night-time intakes decreased while day-time intake increased; at night meal size decreased. Seven weeks after surgery there was no sign of reinnervation, total food intake larger than in control rats. In absence of hepatic afferences and efferences, hunger and satiety signals are operating, the only enduring effects seem to be a change in the day-night intake ratio and the absence of large meals.
Pharmacological and Body Weight
Reduction of Insulin Release Decreases Hyperphagia Gain in Growing Obese Zucker Rats. C. A. MAGGIO and
J. R. VASSELLI. Obesity NY 10025, U.S.A.
Research Center, St. Luke’s_Roosevelt
Hospital,
New
York,
Nine-week old male obese and lean Zucker rats were fed a chow-like diet containing 0.015 or 0.030% (HD) diazoxide (Schering), an inhibitor of glucose-stimulated insulin release, or diet alone (CON), for 12 weeks. In the HD condition, the hyperphagia usually seen in growing obese rats was eliminated. Compared to CON, HD significantly reduced cumulative food intake and body weight gain in both genotypes (p
ABSTRACTS
The Ontogeny
of Salt Appetite
LESHEM and ILIT YEHUDA.
Aroused
Psychology
by Depletion
Department,
in the Rat. MICAH
Haifa University,
Israel 31999.
The neonatal rat will ingest salt in response to activation of the brain’s renin/angiotensin system (Leshem & Epstein, 1988 a, b, Developmental Psychobiology, 21). However, while this suggests that the brain system mediating the appetite may be functional at this early age, it is not known whether the peripheral components of the response are equally developed. We examined this by depleting pups of sodium using the natriuretic-diuretic, furosamide. Preweanlings of all ages increased their intake of 3% NaCl in response to the treatment, but analysis of the behavior suggests that it is not a specific response to sodium depletion. Thus in the suckling rat sodium depletion does not activate an integrated homeostatic response. The reasons for this, and the age at which the response emerges, will be discussed.
CSF Concentrations
of CCK-8
and Food Intake
P. SODERSTEN. Departments of Pharmacology Stockholm and Huddinge, Sweden.
in Rats. A. LINDEN and
and Psychiatry,
Karolinska
Institute,
CCK-8 decreased in the CSF of male rats after 48 h of food deprivation and was restored after 1 hr of eating. CCK-8 increased in CSF 10 min after 5 pg CCK-8 i.p. and this was prevented by i.p. doses of CCK A receptor antagonists which prevented the inhibitory effect of CCK-8 on food intake. Lactating rats overeat and food deprivation markedly decreased CCK-8 in CSF and plasma, 1 h after eating increased CSF, but not plasma CCK-8 in lactating rats. Changes in CSF CCK-8, which are independent of changes in plasma CCK-8 suggest a role of central CCK-8 in food intake.
Feeding
Pattern
of
Liver-transplanted
Rats.
ACHAGIOTIS, D. HOUSSIN and J. LOUIS-SYLVESTRE. place Jussieu, 75252 Paris Cedex 05, France.
A. MICHEL, C. Universitb PierreetMarie
LARUECurie, 4
A 10 day continuous recording of food intake was performed in rats 15 and 50 days after orthotopic transplantation of the liver. As compared to control rats, it was shown that early after transplantation, total and night-time intakes decreased while day-time intake increased; at night meal size decreased. Seven weeks after surgery there was no sign of reinnervation, total food intake larger than in control rats. In absence of hepatic afferences and efferences, hunger and satiety signals are operating, the only enduring effects seem to be a change in the day-night intake ratio and the absence of large meals.
Pharmacological and Body Weight
Reduction of Insulin Release Decreases Hyperphagia Gain in Growing Obese Zucker Rats. C. A. MAGGIO and
J. R. VASSELLI. Obesity NY 10025, U.S.A.
Research Center, St. Luke’s_Roosevelt
Hospital,
New
York,
Nine-week old male obese and lean Zucker rats were fed a chow-like diet containing 0.015 or 0.030% (HD) diazoxide (Schering), an inhibitor of glucose-stimulated insulin release, or diet alone (CON), for 12 weeks. In the HD condition, the hyperphagia usually seen in growing obese rats was eliminated. Compared to CON, HD significantly reduced cumulative food intake and body weight gain in both genotypes (p