- Email: [email protected]
Phenotypic Differences in Three Families With Hereditary Gingival Fibromatosis
ORAL AND MAXILLOFACIAL PATHOLOGY e130 Abstracts AO-49 - OSTEOSARCOMAS: CLINICOPATHOLOGICAL CHARACTERISTICS OF FIVE CASES WITH EMPHASIS ON DIAGNOSTIC FEATURES. ÁGUIDA MARIA MENEZES AGUIAR MIRANDA, FÁBIO RAMÔA PIRES, JULIANA DE NORONHA SANTOS NETTO, SIMONE MACEDO AMARAL. UNIVERSIDADE ESTÁCIO DE SÁ E UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO. Osteosarcomas are aggressive malignancies that can affect gnathic bones. Successful management depends on early diagnosis and adequate treatment. The aim of this report is to show clinicopathological and diagnostic features from five gnathic osteosarcomas. Three maxillary (woman, 63; woman, 49; man, 37) and two mandibular (woman, 49; man, 45) osteosarcomas were included. In all five cases there was swelling of the affected area; three were painful. All cases demonstrated ill-defined radiological images, and three had irregular widening of the periodontal ligament. Histological diagnosis revealed chondroblastic osteosarcoma in three cases and osteoblastic osteosarcoma in two. Adequate interpretation of clinical signs and symptoms and correct diagnosis are essential for the prompt treatment of gnathic osteosarcomas.
AO-50 - PAPILLARY THYROID CARCINOMA AND PARATHYROID ADENOMA IN PATIENT WITH ORAL LESIONS OF BROWN TUMOR OF HYPERPARATHYROIDISM: A MULTIDISCIPLINARY APPROACH. THAÍS BORGUEZAN NUNES, SHEYLA BATISTA BOLOGNA, TATHYANE HARUMI NAKAJIMA TESHIMA, ANDRÉA LUSVARGHI WITZEL, MARCELLO MENTA SIMONSEN NICO, SILVIA VANESSA LOURENÇO. DEPARTMENT OF STOMATOLOGY, SCHOOL OF DENTISTRY, USP AND CLINICS HOSPITAL, SCHOOL OF MEDICINE, USP. The brown tumor of hyperparathyroidism is a metabolic disorder that affects the skeleton but is rarely found in the mandible. Woman, 37, came to the CDO-FOUSP complaining of oral pain. Examination showed swelling in the neck and bleeding intraoral lesions. The patient had cachexia and was referred to HCFMUSP for investigation and management. Incisional biopsy of the oral lesion was performed, with histopathological results supporting a diagnosis of central giant cell lesion. Blood tests showed high levels of parathyroid hormone (PTH). Computed tomography revealed the presence of lytic lesions in bones and a solid-cystic lesion near the thyroid, which was surgically removed. In this case, the evaluation of the oral lesions allowed clinicians to diagnose brown tumor of hyperparathyroidism, parathyroid adenoma, and papillary thyroid carcinoma. Surgical removal of the cause and normalization of the patient’s metabolism are fundamental to achieving regression of the oral lesions.
AO-51 - PAROTID LARGE CELL ANAPLASTIC LYMPHOMA ALK NEGATIVE: CASE REPORT. ANDRE LEONARDO DE CASTRO COSTA, MARCUS ANTONIO DE MELLO BORBA, RYUICHI HOSHI, EDVAN DE QUEIROZ CRUSOE, EDUARDO MOREIRA DE QUEIROGA, CARLOS EDUARDO BACCHI. ESCOLA BAHIANA DE MEDICINA E SAUDE PUBLICA/ HOSPITAL PORTUGUES. Lymphoma of the salivary gland accounts for 5% of cases of extranodal lymphoma and 10% of malignant salivary gland tumors. Most primary salivary gland lymphomas are B marginal zone lymphomas arising on a background of sialadenitis associated with autoimmune disorders such as Sjogren’s syndrome. Primary T cell lymphoma of the salivary gland is rare. A previously healthy teenage girl had a case of right parotid progressive
OOOO February 2014 swelling. After an inconclusive fine needle aspiration (FNA) biopsy and rapid growth of the lesion involving the skin, she was underwent a superficial parotidectomy. Final histology results revealed large cell anaplastic lymphoma ALK negative. After this, computed tomography positron electron tomography (CTPET) scan showed no other site of disease and the patient was staged as IE. She underwent successive chemotherapy, radiotherapy, and bone marrow transplantation. After 2 years of follow up she still alive with no evidence of disease.
AO-52 - PERINEURAL SPREAD OF HEAD AND NECK CANCER RESULTING IN ORBITAL APEX SYNDROME: REPORT OF FOUR CASES. ANA CAROLINA PRADO RIBEIRO, ADRIELE FERREIRA GOUVÊA, MARCO AURELIO PETRONI MONTEZUMA, ALAN ROGER SANTOS-SILVA, ICARO CARVALHO, CRISTIANE MARIA ALMEIDA, THAÍS BIANCA BRANDÃO. INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO (ICESP). Perineural invasion is an uncommon type of tumor dissemination that occurs when malignant cells gain access to the perineural space and spread along the nerves to distant locations. This, in turn, may result in orbital apex syndrome (OAS). Although rare, OAS typically damages the oculomotor nerve (III), trochlear nerve (IV), abducens nerve (VI), and trigeminal nerve (V) in association with optic nerve dysfunction. The authors report four cases of OAS diagnosed in patients undergoing treatment for squamous cell carcinoma of the nasopharynx (2), larynx (1) and tongue (1). Ptosis and diplopia were detected, leading to the diagnosis of OAS. Clinicopathological data, tomographic and magnetic resonance image findings, and follow-up information of all patients is discussed. Early diagnosis is crucial for patients with OAS because this disorder carries a poor prognosis. This case series highlights the importance of multidisciplinary teams in cancer treatment.
AO-53 - PHENOTYPIC DIFFERENCES IN THREE FAMILIES WITH HEREDITARY GINGIVAL FIBROMATOSIS. SABINA PENA BORGES PÊGO, LÍVIA MÁRIS RIBEIRO PARANAÍBA, MÁRIO RODRIGUES DE MELO FILHO, RICARDO DELLA COLETTA, SIBELE NASCIMENTO AQUINO, LUCAS RODRIGUES ALVES, HERCÍLIO MARTELLI JÚNIOR. UNIVERSIDADE ESTADUAL DE MONTES CLAROSeUNIMONTES.
Hereditary gingival fibromatosis (HGF) is a rare genetic condition (1:750.000). Its expression may vary from mild to severe. Clinically, there is slow and continuous gingival overgrowth that may lead to partial or full coverage dental clinic crowns. This study presents clinical, radiographic, and histological comparisons between members of three distinct families. Two conditions are observed: individuals who have an exuberant growth with partial coverage of dental crowns and individuals who have only discreet growth. Radiographically, there are no changes, and the transmission pattern is autosomal dominant in three families. Histologically, the epithelium has long, slender ridges that protrude into the underlying connective tissue, which is characterized by dense, thick collagen fiber bundles. Because HGF may present a variety of clinical aspects, it is important to associate all aspectsdclinical, radiographic, and histologicaldso that tenuous HGF cases do not remain undiagnosed. Acknowledgement: FAPEMIG.
AO-54 - PHOTODYNAMIC THERAPY: A NEW APPROACH FOR ACTINIC CHEILITIS? KARLA BIANCA FERNANDES DA COSTA FONTES, REBECA DE SOUZA
AO-50 - PAPILLARY THYROID CARCINOMA AND PARATHYROID ADENOMA IN PATIENT WITH ORAL LESIONS OF BROWN TUMOR OF HYPERPARATHYROIDISM: A MULTIDISCIPLINARY APPROACH. THAÍS BORGUEZAN NUNES, SHEYLA BATISTA BOLOGNA, TATHYANE HARUMI NAKAJIMA TESHIMA, ANDRÉA LUSVARGHI WITZEL, MARCELLO MENTA SIMONSEN NICO, SILVIA VANESSA LOURENÇO. DEPARTMENT OF STOMATOLOGY, SCHOOL OF DENTISTRY, USP AND CLINICS HOSPITAL, SCHOOL OF MEDICINE, USP. The brown tumor of hyperparathyroidism is a metabolic disorder that affects the skeleton but is rarely found in the mandible. Woman, 37, came to the CDO-FOUSP complaining of oral pain. Examination showed swelling in the neck and bleeding intraoral lesions. The patient had cachexia and was referred to HCFMUSP for investigation and management. Incisional biopsy of the oral lesion was performed, with histopathological results supporting a diagnosis of central giant cell lesion. Blood tests showed high levels of parathyroid hormone (PTH). Computed tomography revealed the presence of lytic lesions in bones and a solid-cystic lesion near the thyroid, which was surgically removed. In this case, the evaluation of the oral lesions allowed clinicians to diagnose brown tumor of hyperparathyroidism, parathyroid adenoma, and papillary thyroid carcinoma. Surgical removal of the cause and normalization of the patient’s metabolism are fundamental to achieving regression of the oral lesions.
AO-51 - PAROTID LARGE CELL ANAPLASTIC LYMPHOMA ALK NEGATIVE: CASE REPORT. ANDRE LEONARDO DE CASTRO COSTA, MARCUS ANTONIO DE MELLO BORBA, RYUICHI HOSHI, EDVAN DE QUEIROZ CRUSOE, EDUARDO MOREIRA DE QUEIROGA, CARLOS EDUARDO BACCHI. ESCOLA BAHIANA DE MEDICINA E SAUDE PUBLICA/ HOSPITAL PORTUGUES. Lymphoma of the salivary gland accounts for 5% of cases of extranodal lymphoma and 10% of malignant salivary gland tumors. Most primary salivary gland lymphomas are B marginal zone lymphomas arising on a background of sialadenitis associated with autoimmune disorders such as Sjogren’s syndrome. Primary T cell lymphoma of the salivary gland is rare. A previously healthy teenage girl had a case of right parotid progressive
OOOO February 2014 swelling. After an inconclusive fine needle aspiration (FNA) biopsy and rapid growth of the lesion involving the skin, she was underwent a superficial parotidectomy. Final histology results revealed large cell anaplastic lymphoma ALK negative. After this, computed tomography positron electron tomography (CTPET) scan showed no other site of disease and the patient was staged as IE. She underwent successive chemotherapy, radiotherapy, and bone marrow transplantation. After 2 years of follow up she still alive with no evidence of disease.
AO-52 - PERINEURAL SPREAD OF HEAD AND NECK CANCER RESULTING IN ORBITAL APEX SYNDROME: REPORT OF FOUR CASES. ANA CAROLINA PRADO RIBEIRO, ADRIELE FERREIRA GOUVÊA, MARCO AURELIO PETRONI MONTEZUMA, ALAN ROGER SANTOS-SILVA, ICARO CARVALHO, CRISTIANE MARIA ALMEIDA, THAÍS BIANCA BRANDÃO. INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO (ICESP). Perineural invasion is an uncommon type of tumor dissemination that occurs when malignant cells gain access to the perineural space and spread along the nerves to distant locations. This, in turn, may result in orbital apex syndrome (OAS). Although rare, OAS typically damages the oculomotor nerve (III), trochlear nerve (IV), abducens nerve (VI), and trigeminal nerve (V) in association with optic nerve dysfunction. The authors report four cases of OAS diagnosed in patients undergoing treatment for squamous cell carcinoma of the nasopharynx (2), larynx (1) and tongue (1). Ptosis and diplopia were detected, leading to the diagnosis of OAS. Clinicopathological data, tomographic and magnetic resonance image findings, and follow-up information of all patients is discussed. Early diagnosis is crucial for patients with OAS because this disorder carries a poor prognosis. This case series highlights the importance of multidisciplinary teams in cancer treatment.
AO-53 - PHENOTYPIC DIFFERENCES IN THREE FAMILIES WITH HEREDITARY GINGIVAL FIBROMATOSIS. SABINA PENA BORGES PÊGO, LÍVIA MÁRIS RIBEIRO PARANAÍBA, MÁRIO RODRIGUES DE MELO FILHO, RICARDO DELLA COLETTA, SIBELE NASCIMENTO AQUINO, LUCAS RODRIGUES ALVES, HERCÍLIO MARTELLI JÚNIOR. UNIVERSIDADE ESTADUAL DE MONTES CLAROSeUNIMONTES.
Hereditary gingival fibromatosis (HGF) is a rare genetic condition (1:750.000). Its expression may vary from mild to severe. Clinically, there is slow and continuous gingival overgrowth that may lead to partial or full coverage dental clinic crowns. This study presents clinical, radiographic, and histological comparisons between members of three distinct families. Two conditions are observed: individuals who have an exuberant growth with partial coverage of dental crowns and individuals who have only discreet growth. Radiographically, there are no changes, and the transmission pattern is autosomal dominant in three families. Histologically, the epithelium has long, slender ridges that protrude into the underlying connective tissue, which is characterized by dense, thick collagen fiber bundles. Because HGF may present a variety of clinical aspects, it is important to associate all aspectsdclinical, radiographic, and histologicaldso that tenuous HGF cases do not remain undiagnosed. Acknowledgement: FAPEMIG.
AO-54 - PHOTODYNAMIC THERAPY: A NEW APPROACH FOR ACTINIC CHEILITIS? KARLA BIANCA FERNANDES DA COSTA FONTES, REBECA DE SOUZA