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Phenotypic predictors of increased urinary 11-dehydrothromboxane B2 levels in patients treated with aspirin
Abstracts
females. Overall incidence was 1.38/100.000/year, the incidence for males 1.73/100.000 and for females 1.00/100.000. The most common diagnoses after autopsy were: premature ischemic heart disease (26%), structurally normal heart (17%), hypertrophic cardiomyopathy (14%), arrhythmia related death (14%), myocarditis (7%) and dilated cardiomyopathy (5%). All deaths due to ischemic heart disease occurred in individuals older than 25 years. The age distribution is shown in Fig. 1. Conclusions: The incidence of SCD in Iceland is similar or slightly higher than in neighbouring Sweden, the only other country where SCD has been studied on a nation-wide basis. The causes of death are also similar. The mechanism of death in the absence of structural heart disease is uncertain, an arrhythmic death due to ion channel diseases or subclinical myocardial disease may be suspected.
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levels in relation to cardiovascular risk factors that may affect resistance to aspirin. Methods: We studied 247 patients referred to scheduled percutaneous coronary intervention with drug eluting stents and pretreated with aspirin 100 mg daily. Urinary TXB2 was measured by a commercially available enzyme immunoassay (Cayman Chemical). Logarithmically transformed urinary 11-TXB2/creatinine ratio (log-TXB2/Cr) was used in all analyses. Results: Age correlated positively with log-TXB2/Cr (R = 0.175, p = 0.006). In the fourth age quartile log-TXB2/Cr levels were 44.6% higher compared with the first age quartile (p = 0.013, back-transformed values 69.18 ng/mmol vs 100 ng/ mmol, respectively). Diabetics (n = 41) had about 41.3% higher log-TXB2/Cr compared with non-diabetics (n = 191): back-transformed values 107.15 and 75.86 ng/mmol, respectively (p = 0.012). In backward multiple regression analysis, log-TXB2/Cr was significantly positively associated with age (β = 0.149, p = 0.020) and diabetes (β = 0.217, p = 0.001), and inversely associated with body mass index (β = −0.183, p = 0.007). Conclusions: Age, diabetes and lower BMI are potential phenotypic factors of aspirin resistance when judged by urinary 11-dehydrothromboxane B2 levels. doi:10.1016/j.ijcard.2007.03.086
P72 Sex hormones and serum lipids in middle-aged men
doi:10.1016/j.ijcard.2007.03.085
P71 Phenotypic predictors of increased urinary 11-dehydrothromboxane B2 levels in patients treated with aspirin Gustavs Latkovskis, Paula Stradina Clinical University Hospital, Riga, Latvia, Marina Berzina, Paula Stradina Clinical University Hospital, Riga, Latvia, Milana Zabunova, Paula Stradina Clinical University Hospital, Riga, Latvia, Dace Juhnevica, Paula Stradina Clinical University Hospital, Riga, Latvia, Maija Dambrova, Latvian Institute of Organic Synthesis, Riga, Latvia, Edgars Liepins, Latvian Institute of Organic Synthesis, Riga, Latvia, Normunds Licis, Latvian Biomedical Research and Study Centre, Riga, Latvia, Andrejs Erglis, Paula Stradina Clinical University Hospital, Riga, Latvia Introduction: Inhibition of thromboxane A2 by aspirin can be estimated by urinary levels of a metabolite 11-dehydrothromboxane B2 (TXB2). Our objective was to compare TXB2
Juuso Mäkinen, University of Turku, Turku, Finland, Antti Perheentupa, University of Turku, Turku, Finland, Kerttu Irjala, University of Turku, Turku, Finland, Pasi Pöllänen, University of Turku, Turku, Finland, Juha Mäkinen, University of Turku, Turku, Finland, Ilpo Huhtaniemi, Imperial College London, London, United Kingdom, Olli Raitakari, University of Turku, Turku, Finland Objectives: We examined the association between sex hormones and serum lipids in middle-aged men. Background: The role of sex hormones in the development of atherosclerosis in men is controversial. Methods: We studied 74 from 40- to 69-year old men in the city of Turku, Finland. These men underwent measurements of testosterone, luteinizing hormone, sex hormone binding globulin, estradiol, dehydroepiandrosterone sulphate, hemoglobin, hematocrit, leukocytes and serum triglycerides, total-, LDL- and HDLcholesterol. Results: Testosterone correlated directly with HDL-cholesterol (r = 0.31, p = 0.0079) and inversely with serum triglycerides (r = − 0.25, p = 0.003) and body mass index (r = − 0.55, p b 0.0001). In multivariate analyses adjusted for measured hormones, age, body mass index, smoking, alcohol consumption, diabetes, pulmonary and cardiovascular diseases, the determinants for serum triglycerides were T (β = − 0.23, p = 0.031) and estradiol (β = 0.02, p = 0.036). The multivariate correlates of HDL-cholesterol
females. Overall incidence was 1.38/100.000/year, the incidence for males 1.73/100.000 and for females 1.00/100.000. The most common diagnoses after autopsy were: premature ischemic heart disease (26%), structurally normal heart (17%), hypertrophic cardiomyopathy (14%), arrhythmia related death (14%), myocarditis (7%) and dilated cardiomyopathy (5%). All deaths due to ischemic heart disease occurred in individuals older than 25 years. The age distribution is shown in Fig. 1. Conclusions: The incidence of SCD in Iceland is similar or slightly higher than in neighbouring Sweden, the only other country where SCD has been studied on a nation-wide basis. The causes of death are also similar. The mechanism of death in the absence of structural heart disease is uncertain, an arrhythmic death due to ion channel diseases or subclinical myocardial disease may be suspected.
S35
levels in relation to cardiovascular risk factors that may affect resistance to aspirin. Methods: We studied 247 patients referred to scheduled percutaneous coronary intervention with drug eluting stents and pretreated with aspirin 100 mg daily. Urinary TXB2 was measured by a commercially available enzyme immunoassay (Cayman Chemical). Logarithmically transformed urinary 11-TXB2/creatinine ratio (log-TXB2/Cr) was used in all analyses. Results: Age correlated positively with log-TXB2/Cr (R = 0.175, p = 0.006). In the fourth age quartile log-TXB2/Cr levels were 44.6% higher compared with the first age quartile (p = 0.013, back-transformed values 69.18 ng/mmol vs 100 ng/ mmol, respectively). Diabetics (n = 41) had about 41.3% higher log-TXB2/Cr compared with non-diabetics (n = 191): back-transformed values 107.15 and 75.86 ng/mmol, respectively (p = 0.012). In backward multiple regression analysis, log-TXB2/Cr was significantly positively associated with age (β = 0.149, p = 0.020) and diabetes (β = 0.217, p = 0.001), and inversely associated with body mass index (β = −0.183, p = 0.007). Conclusions: Age, diabetes and lower BMI are potential phenotypic factors of aspirin resistance when judged by urinary 11-dehydrothromboxane B2 levels. doi:10.1016/j.ijcard.2007.03.086
P72 Sex hormones and serum lipids in middle-aged men
doi:10.1016/j.ijcard.2007.03.085
P71 Phenotypic predictors of increased urinary 11-dehydrothromboxane B2 levels in patients treated with aspirin Gustavs Latkovskis, Paula Stradina Clinical University Hospital, Riga, Latvia, Marina Berzina, Paula Stradina Clinical University Hospital, Riga, Latvia, Milana Zabunova, Paula Stradina Clinical University Hospital, Riga, Latvia, Dace Juhnevica, Paula Stradina Clinical University Hospital, Riga, Latvia, Maija Dambrova, Latvian Institute of Organic Synthesis, Riga, Latvia, Edgars Liepins, Latvian Institute of Organic Synthesis, Riga, Latvia, Normunds Licis, Latvian Biomedical Research and Study Centre, Riga, Latvia, Andrejs Erglis, Paula Stradina Clinical University Hospital, Riga, Latvia Introduction: Inhibition of thromboxane A2 by aspirin can be estimated by urinary levels of a metabolite 11-dehydrothromboxane B2 (TXB2). Our objective was to compare TXB2
Juuso Mäkinen, University of Turku, Turku, Finland, Antti Perheentupa, University of Turku, Turku, Finland, Kerttu Irjala, University of Turku, Turku, Finland, Pasi Pöllänen, University of Turku, Turku, Finland, Juha Mäkinen, University of Turku, Turku, Finland, Ilpo Huhtaniemi, Imperial College London, London, United Kingdom, Olli Raitakari, University of Turku, Turku, Finland Objectives: We examined the association between sex hormones and serum lipids in middle-aged men. Background: The role of sex hormones in the development of atherosclerosis in men is controversial. Methods: We studied 74 from 40- to 69-year old men in the city of Turku, Finland. These men underwent measurements of testosterone, luteinizing hormone, sex hormone binding globulin, estradiol, dehydroepiandrosterone sulphate, hemoglobin, hematocrit, leukocytes and serum triglycerides, total-, LDL- and HDLcholesterol. Results: Testosterone correlated directly with HDL-cholesterol (r = 0.31, p = 0.0079) and inversely with serum triglycerides (r = − 0.25, p = 0.003) and body mass index (r = − 0.55, p b 0.0001). In multivariate analyses adjusted for measured hormones, age, body mass index, smoking, alcohol consumption, diabetes, pulmonary and cardiovascular diseases, the determinants for serum triglycerides were T (β = − 0.23, p = 0.031) and estradiol (β = 0.02, p = 0.036). The multivariate correlates of HDL-cholesterol