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Plasminogen activators: from cloning to therapy (Serono Symp Publ vol 77)
132 with a number of metabolic and other abnormalities which may predispose to atherosclerosis. This book reviews the evidence linking diabetes and atherosclerosis. describes the metabolic aecotnpaniments of diabetes and indicates how these may be related to the pathogenesis of atherosclerosis. The experimental evidence linking diabetes and atherosclerosis is also reviewed.
Neurotransmitters and drugs. ZL Kruk. J Pycock, Chapman and Hall, London, 199 I. An understanding of the manner in which therapeutically used drugs modify the nervous system requires knowledge of the functions, dist~bution and control of neurotransmitters. This well established textbook provides a concise and systematic introduction to the main neurotransmitter substances in the body, their association with clinical states. and the interaction of therapeutically used drugs within these systems. Each chapter is devoted to a specific neurot~nsmitter substance, and examines iheir synthesis, storage, &ease. receptor interaction and inactivating mechanisms, together with important drugs known to selectively interact with these various mechanisms. The treatment of relevant disorders, such as Parkinson’s disease and schizophrenia, as well as side-effects, are discussed. This third edition reflects recent advances in the field and incorporates up-to-date references. In particular new material on the structure and function of receptors and on amino acids has been incorporated. Nevertheless, the book retains its compact and didactic style and, il covering all pharmacological aspects of neurotransmission in both the peripheral and central nervous systems, wiII continue to provide students of medicine, pharmacology, pharmacy and postgraduate psychiatry with an excellent reference source.
The new biology of steroid hormones (Serono Symp Pub1 ~0174). RB Hochberg, F Naftolin. Raven Press, New York, 1991.
This volume presents extensive studies of newly discovered mechanisms of steroid hormone action that modulate the effects of these hormones independently of, or in addition to, classical steroid hormone receptor mechanisms. A major focus of the book is the way in which the metabolism of the steroid molecule can modulate the hormonal signal. Important studies describe the metabolic pathways that transform steroid hormocrs into carcinogens and the effects of diet on estrogeaic potential and cancer. Other contributors present new findings on the functions of steroid hormone binding proteins, the role of growth factors in estrogen action, the intraovarian action of estrogens, the c&-to-ceil interactions involved in estrogen action, and the actions of steroids in the 3Gn. Plasminogen activators: from cloning to therapy (Serono Symp PubI ~0177). I?.Abbate, T Barni, A rsafriri. Raven Tress, New York, 199 I. This volume presents new findings on the structure and biological functions of plasminogen activators and the clinical sipaificance of these enzymes in endocrinology, reproduction, dermatology, cardiology and oncology. The book includes studies on the characterization of the 2 types of plasminogen activator. the function of the urokinase receptor, the hormonal regulation of plasminogen activator gene expression, and the role of plasminogen activators in male reproductive function, ovulation and embryo implantation. Noted experts examine the relationship of plasminogen activators to breast cancer, leukemia, in~ammation, epithelial biology and ~brinolysis and assess the current status of coronary thrombolysis with human recombinant tissuetype plasminogen activator.
Errata In the article: Cystic fibrosis: production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a ~brob~astic phenotype by ML Labat et al (~ju~e~ & ~har~~co~~~rap~ 45(9)387-4~1) figure 10 was published by error and does not correspond to anything in the text. In the article: Analysis of purine nucleotides in lymphocytes from healthy subjects and AIDS patiems by A Tabucchi et nl (Biorned & Pharmacothcrupy 46(1)25-29) Names of authors: E Marinello and not F’ MarinelIo. Additional author E Consolmagno.
Neurotransmitters and drugs. ZL Kruk. J Pycock, Chapman and Hall, London, 199 I. An understanding of the manner in which therapeutically used drugs modify the nervous system requires knowledge of the functions, dist~bution and control of neurotransmitters. This well established textbook provides a concise and systematic introduction to the main neurotransmitter substances in the body, their association with clinical states. and the interaction of therapeutically used drugs within these systems. Each chapter is devoted to a specific neurot~nsmitter substance, and examines iheir synthesis, storage, &ease. receptor interaction and inactivating mechanisms, together with important drugs known to selectively interact with these various mechanisms. The treatment of relevant disorders, such as Parkinson’s disease and schizophrenia, as well as side-effects, are discussed. This third edition reflects recent advances in the field and incorporates up-to-date references. In particular new material on the structure and function of receptors and on amino acids has been incorporated. Nevertheless, the book retains its compact and didactic style and, il covering all pharmacological aspects of neurotransmission in both the peripheral and central nervous systems, wiII continue to provide students of medicine, pharmacology, pharmacy and postgraduate psychiatry with an excellent reference source.
The new biology of steroid hormones (Serono Symp Pub1 ~0174). RB Hochberg, F Naftolin. Raven Press, New York, 1991.
This volume presents extensive studies of newly discovered mechanisms of steroid hormone action that modulate the effects of these hormones independently of, or in addition to, classical steroid hormone receptor mechanisms. A major focus of the book is the way in which the metabolism of the steroid molecule can modulate the hormonal signal. Important studies describe the metabolic pathways that transform steroid hormocrs into carcinogens and the effects of diet on estrogeaic potential and cancer. Other contributors present new findings on the functions of steroid hormone binding proteins, the role of growth factors in estrogen action, the intraovarian action of estrogens, the c&-to-ceil interactions involved in estrogen action, and the actions of steroids in the 3Gn. Plasminogen activators: from cloning to therapy (Serono Symp PubI ~0177). I?.Abbate, T Barni, A rsafriri. Raven Tress, New York, 199 I. This volume presents new findings on the structure and biological functions of plasminogen activators and the clinical sipaificance of these enzymes in endocrinology, reproduction, dermatology, cardiology and oncology. The book includes studies on the characterization of the 2 types of plasminogen activator. the function of the urokinase receptor, the hormonal regulation of plasminogen activator gene expression, and the role of plasminogen activators in male reproductive function, ovulation and embryo implantation. Noted experts examine the relationship of plasminogen activators to breast cancer, leukemia, in~ammation, epithelial biology and ~brinolysis and assess the current status of coronary thrombolysis with human recombinant tissuetype plasminogen activator.
Errata In the article: Cystic fibrosis: production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a ~brob~astic phenotype by ML Labat et al (~ju~e~ & ~har~~co~~~rap~ 45(9)387-4~1) figure 10 was published by error and does not correspond to anything in the text. In the article: Analysis of purine nucleotides in lymphocytes from healthy subjects and AIDS patiems by A Tabucchi et nl (Biorned & Pharmacothcrupy 46(1)25-29) Names of authors: E Marinello and not F’ MarinelIo. Additional author E Consolmagno.