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POLYMORPHOUS LOW-GRADE ADENOCARCINOMA OF THE LOWER LIP
ORAL AND MAXILLOFACIAL PATHOLOGY e48 Abstracts development of cancer, serving as important clinical signs identifying patients at high risk of developing malignancies. Our goal is to present the case of a female patient, 53 years old, with a main complaint of “infection in the mouth and burning sensation in the tongue.” Medical history showed a thyroidectomy, removal of inear hamartoma, and liver nodule. On extraoral examination a sessile nodule was seen in the ear and on intraoral examination it was noted multiple coloring papules similar to the mucosa. Incisional biopsy was performed and histopathologic examination proved compatible with inflammatory fibrous hyperplasia. The final diagnosis was CS associated with oral candidiasis. The patient was treated with nystatin to control the infection and has been under observation for 2 years without complaints or deteriorations in the frame.
OP6 - POLYMORPHOUS LOW-GRADE ADENOCARCINOMA OF THE LOWER LIP. TIAGO NOVAES PINHEIRO, CLAUDIA ANDREA GARCIA CORRÊA SIMÕES, ANTONIO JORGE ARAÚJO VASCONCELOS II, MARCO TÚLLIO BRAZÃO-SILVA. Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that frequently occurs in the minor salivary glands of palate and oral cavity. We present a case of lower lip swelling with ulceroproliferative growth in a 48-year-old male with more than 20 years’ history of development. Fine needle aspiration cytology smears suggested salivary gland neoplasia. A wide incisional biopsy was performed and histopathologic examination diagnosed PLGA. The patient was referred to an oncology center and has been under follow-up for the last 6 months. The differential diagnosis of PLGA with pleomorphic adenoma, adenoid cystic carcinoma, mammary analogue secretory carcinoma, mucoepidermoid carcinoma, epithelial myoepithelial carcinoma, and papillary cystadenocarcinoma is discussed, as well as the significance of different histochemical techniques for microscopic diagnosis.
OP7 - EIGHT-YEAR FOLLOW-UP OF CENTRAL GIANT CELL LESION TREATED WITH CORTICOSTEROID: CASE REPORT. JULIANA BORGES, TILA FORTUNA COSTA, SILVIA REIS, ANTÔNIO MÁRCIO TEIXEIRA MARCHIONNI, BRIANA MONTEIRO, ALENA PEIXOTO MEDRADO. Herein we report on a case of a pediatric patient with central giant-cell granuloma of the jaw that was successfully treated with intralesional corticosteroid injections as the sole therapy. We also discuss if there is an ideal waiting period between nonoperative treatment and the need of surgical intervention. An 8-year-old boy with a central giant cell lesion on the right side of the mandible was treated with intralesional corticosteroids injections. After an 8-year follow-up, the patient’s bone architecture was near normal. Panoramic radiography showed areas of new bone formation, without recurrence or side effects of the medication. Is there an ideal waiting period between nonoperative treatment and the need for surgical intervention? It is estimated that a monitoring period of 6 to 8 years is necessary to determine the success of such treatment.
OP8 - SURGICAL CILIATED CYST: A CASE REPORT. JOSÉ ALCIDES ALMEIDA DE ARRUDA, SAULO QUEIROZ DE ARAUJO, THIAGO COELHO GOMES DA SILVA, BELMIRO CAVALCANTI DO EGITO VASCONCELOS, MARCIA MARIA FONSECA DA SILVEIRA, ANA PAULA VERAS SOBRAL.
OOOO August 2017 Surgical ciliated cyst is often described as a postoperative maxillary cyst or paranasal cyst. Characterized by an aggressive injury, it is commonly described in patients who underwent radical surgery on the maxillary sinus region, such as orthognathic or Caldwell-Luc procedures. Herein we report a case of a 47-year-old patient complaining of spontaneous pain and swelling in the anterior maxilla, presenting a history of a 9-month-old surgery in the posterior maxilla intended to remove an odontogenic cystic lesion. CT scan showed a low-density lesion in the left maxillary sinus region. Biopsy and histopathologic examination established the diagnosis of surgical ciliated cyst. The patient is under a 2-year non-symptomatic follow-up.
OP9 - A NEW HETEROZYGOUS MUTATION IN FGFR2 GENE CAUSING PFEIFFER SYNDROME. RENATO ASSIS MACHADO, SHIRLENE BARBOSA PIMENTEL FERREIRA, MARCOS JOSÉ BURLE AGUIAR, DANIELLA REIS B. MARTELLI, RICARDO DELLA COLETTA, HERCÍLIO MARTELLIJÚNIOR. Pfeiffer syndrome (PS) (MIM: #101600) is a rare autosomal dominant disorder classically characterized by coronal craniosynostosis, brachycephaly, midfacial hypoplasia, broad and deviated thumbs, and big toes and fingers. PS occurs in approximately 1:100,000 live births. Clinical manifestations and molecular genetic are used to confirm the diagnosis of the disease. Heterozygous mutations in the fibroblast growth factor receptor types 1 and 2 gene (FGFR1 and FGFR2) can cause PS. Herein we report on a female patient and her mother, both affected with PS of similar severity, carrying a previously undescribed heterozygous missense mutation characterized by c.868T>G, encoding Trp289Gly, in the FGFR2 gene. Classical phenotypes related to PS were exhibited by both PS patients. Intraoral examination revealed malocclusion, dental midline deviation, high arched palate, and excessive interdental spacing. Thus, our approach led to the identification of a new target mutation in FGFR2 gene that contributes to the pathophysiology of PS.
OP10 - ORAL METASTATIC BREAST ADENOCARCINOMA IN A MALE PATIENT. NATHALIA DE ALMEIDA FREIRE, NATHALIE HENRIQUES DA SILVA CANEDO, MICHELLE AGOSTINI, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH. Oral metastatic tumors are uncommon, with the breast, prostate, lung, and kidney being the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date only 4 cases of metastatic breast adenocarcinoma to the oral cavity have been reported in the literature. An 88-year-old male patient with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling of unknown evolution. Intraoral examination revealed a 2-cm reddish pedunculated nodule covered by smooth surface in the left retromolar region. The patient was submitted to incisional biopsy and microscopic evaluation revealed invasive tumor islands compounded by malignant epithelial cells, sometimes exhibiting ductal arrangement, which were positive for estrogen receptor and GCDFP-15. The final diagnosis was oral metastatic breast adenocarcinoma. Clinicians should be aware of aggressive behavior and oral metastasis of breast adenocarcinomas in male patients.
OP6 - POLYMORPHOUS LOW-GRADE ADENOCARCINOMA OF THE LOWER LIP. TIAGO NOVAES PINHEIRO, CLAUDIA ANDREA GARCIA CORRÊA SIMÕES, ANTONIO JORGE ARAÚJO VASCONCELOS II, MARCO TÚLLIO BRAZÃO-SILVA. Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that frequently occurs in the minor salivary glands of palate and oral cavity. We present a case of lower lip swelling with ulceroproliferative growth in a 48-year-old male with more than 20 years’ history of development. Fine needle aspiration cytology smears suggested salivary gland neoplasia. A wide incisional biopsy was performed and histopathologic examination diagnosed PLGA. The patient was referred to an oncology center and has been under follow-up for the last 6 months. The differential diagnosis of PLGA with pleomorphic adenoma, adenoid cystic carcinoma, mammary analogue secretory carcinoma, mucoepidermoid carcinoma, epithelial myoepithelial carcinoma, and papillary cystadenocarcinoma is discussed, as well as the significance of different histochemical techniques for microscopic diagnosis.
OP7 - EIGHT-YEAR FOLLOW-UP OF CENTRAL GIANT CELL LESION TREATED WITH CORTICOSTEROID: CASE REPORT. JULIANA BORGES, TILA FORTUNA COSTA, SILVIA REIS, ANTÔNIO MÁRCIO TEIXEIRA MARCHIONNI, BRIANA MONTEIRO, ALENA PEIXOTO MEDRADO. Herein we report on a case of a pediatric patient with central giant-cell granuloma of the jaw that was successfully treated with intralesional corticosteroid injections as the sole therapy. We also discuss if there is an ideal waiting period between nonoperative treatment and the need of surgical intervention. An 8-year-old boy with a central giant cell lesion on the right side of the mandible was treated with intralesional corticosteroids injections. After an 8-year follow-up, the patient’s bone architecture was near normal. Panoramic radiography showed areas of new bone formation, without recurrence or side effects of the medication. Is there an ideal waiting period between nonoperative treatment and the need for surgical intervention? It is estimated that a monitoring period of 6 to 8 years is necessary to determine the success of such treatment.
OP8 - SURGICAL CILIATED CYST: A CASE REPORT. JOSÉ ALCIDES ALMEIDA DE ARRUDA, SAULO QUEIROZ DE ARAUJO, THIAGO COELHO GOMES DA SILVA, BELMIRO CAVALCANTI DO EGITO VASCONCELOS, MARCIA MARIA FONSECA DA SILVEIRA, ANA PAULA VERAS SOBRAL.
OOOO August 2017 Surgical ciliated cyst is often described as a postoperative maxillary cyst or paranasal cyst. Characterized by an aggressive injury, it is commonly described in patients who underwent radical surgery on the maxillary sinus region, such as orthognathic or Caldwell-Luc procedures. Herein we report a case of a 47-year-old patient complaining of spontaneous pain and swelling in the anterior maxilla, presenting a history of a 9-month-old surgery in the posterior maxilla intended to remove an odontogenic cystic lesion. CT scan showed a low-density lesion in the left maxillary sinus region. Biopsy and histopathologic examination established the diagnosis of surgical ciliated cyst. The patient is under a 2-year non-symptomatic follow-up.
OP9 - A NEW HETEROZYGOUS MUTATION IN FGFR2 GENE CAUSING PFEIFFER SYNDROME. RENATO ASSIS MACHADO, SHIRLENE BARBOSA PIMENTEL FERREIRA, MARCOS JOSÉ BURLE AGUIAR, DANIELLA REIS B. MARTELLI, RICARDO DELLA COLETTA, HERCÍLIO MARTELLIJÚNIOR. Pfeiffer syndrome (PS) (MIM: #101600) is a rare autosomal dominant disorder classically characterized by coronal craniosynostosis, brachycephaly, midfacial hypoplasia, broad and deviated thumbs, and big toes and fingers. PS occurs in approximately 1:100,000 live births. Clinical manifestations and molecular genetic are used to confirm the diagnosis of the disease. Heterozygous mutations in the fibroblast growth factor receptor types 1 and 2 gene (FGFR1 and FGFR2) can cause PS. Herein we report on a female patient and her mother, both affected with PS of similar severity, carrying a previously undescribed heterozygous missense mutation characterized by c.868T>G, encoding Trp289Gly, in the FGFR2 gene. Classical phenotypes related to PS were exhibited by both PS patients. Intraoral examination revealed malocclusion, dental midline deviation, high arched palate, and excessive interdental spacing. Thus, our approach led to the identification of a new target mutation in FGFR2 gene that contributes to the pathophysiology of PS.
OP10 - ORAL METASTATIC BREAST ADENOCARCINOMA IN A MALE PATIENT. NATHALIA DE ALMEIDA FREIRE, NATHALIE HENRIQUES DA SILVA CANEDO, MICHELLE AGOSTINI, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH. Oral metastatic tumors are uncommon, with the breast, prostate, lung, and kidney being the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date only 4 cases of metastatic breast adenocarcinoma to the oral cavity have been reported in the literature. An 88-year-old male patient with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling of unknown evolution. Intraoral examination revealed a 2-cm reddish pedunculated nodule covered by smooth surface in the left retromolar region. The patient was submitted to incisional biopsy and microscopic evaluation revealed invasive tumor islands compounded by malignant epithelial cells, sometimes exhibiting ductal arrangement, which were positive for estrogen receptor and GCDFP-15. The final diagnosis was oral metastatic breast adenocarcinoma. Clinicians should be aware of aggressive behavior and oral metastasis of breast adenocarcinomas in male patients.