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Possible association between arterial stiffness and high SENSITIVE C reaction protein in natural populations of she minority in Fujian province in China
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Abstracts / Journal of the American Society of Hypertension 10(4S) (2016) e19–e38
Figure 1.
time and 24hr heart rate (HR), and dipping degree with a peak in winter. Furthermore, for monthly variation, daytime, night-time and 24hr DBP, and daytime, night-time and 24hr HR, and dipping degree also showed similar findings of those in seasonal variation. On subgroup analysis by age, young age group (65 years, n¼1804) were more likely to have higher levels of daytime (p<0.0001), night-time (p<0.0001) and 24hr DBP (p<0.0001), and daytime (p<0.0001) and 24hr HR (p<0.0001), and higher values of dipping degree (p65 years, n¼502). Interestingly, significant seasonal variation in daytime, night-time and 24hr DBP with a peak in autumn, and dipping degree with a peak in winter were only observed in young age group. Compared with women (n¼1034), men had higher levels of daytime systolic BP (SBP) (p¼0.001) and DBP (p<0.0001), night-time DBP (p¼0.003), 24hr DBP (p<0.0001), and higher value of dipping degree (p¼0.014). Only men demonstrated significant seasonal variation in night-time SBP, DBP and dipping degree with a winter peak, and monthly variation in daytime, night-time and 24hr DBP and dipping degree. Conclusions: Seasonal and monthly variation in 24hr ambulatory BP, especially for DBP, HR and dipping degree were found in men with young age. These findings may be helpful to predict seasonal adverse cardiovascular events as well as BP control status, and also provide individualized management for hypertension according to age and gender. Keywords: ambulatory blood pressure monitoring; blood pressure variability; seasonal variability
ARTERIAL STRUCTURE AND COMPLIANCE P-29 Possible association between arterial stiffness and high SENSITIVE C reaction protein in natural populations of she minority in Fujian province in China Huan Liu,1 Hongyu Wang,1 Yongqiang Hong,2 Jinbo Liu,1 Hongwei Zhao,1 Yingyan Zhou.1 1Peking University Shougang Hospital, Beijing, China; 2 The AffiIiated Mindong Hospital of Fujian Medical University, Fujian, China Objective: Arterial stiffness is the independent predicting factor of the vascular related disease, and carotid femoral pulse wave velocity (CFPWV), cardio-ankle vascular index (CAVI), ankle brachial index (ABI) reflect the degree of arterial stiffness. High sensitive C reaction protein (hs-CRP) is one of the risk factors for vascular disease and can be used for the risk prediction of future cardiovascular events. In the current study, we evaluated the possible association between arterial stiffness and hs-CRP in natural populations of She nationality in Fujian province in China. Method: Two hundred and forty one subjects (male 96, female 145; age: 46.94 12.08 years) from natural populations of She minority in Fujian province in China were enrolled into our study.CF-PWV and ABI were measured by Compliar SP(r). The VS-1000 was used to measure
CAVI. Laboratory examinations included total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) and hs-CRP. Results: There were no statistical significance between left CAVI and right CAVI, however, left ABI (L-ABI) and right ABI(R-ABI) were significantly different, thus we choose right CAVI, left ABI and right ABI for data analysis respectively. Hs-CRP were positively correlated with age, waist hip rate(WHR), systolic blood pressure(SBP), diastolic blood pressure(DBP), pulse pressure(PP), TG, TC, LDL-C, CF-PWV and CAVI (r¼0.211, 0.160, 0.243, 0.164, 0.218, 0.127, 0.210, 0.285, 0.203, 0.275, all p<0.05). Hs-CRP were negatively correlated with L-ABI (r¼-0.207,p<0.05); and had negative correlation tendency with R-ABI (r¼-0.123,P¼0.056). Multivariate linear regression analysis (selected factors including age, WHR, SBP, DBP, PP, FPG, TC, TG, HDL-C, LDL-C, hs-CRP; CF-PWV, CAVI, L-ABI, R-ABI as the dependent variable respectively) showed that hs-CRP was an independent influencing factor of CF-PWV, L-ABI and R-ABI respectively. Age, SBP, DBP, FPG and hs-CRP were independent influencing factors of CFPWV. Age, PP and TG were independent influencing factors of CAVI. Age, PP, hs-CRP were independent influencing factors of both L-ABI and R-ABI. Conclusion: High sensitive C reaction protein was an independent related factor of arterial stiffness, which indicated that inflammatory markers may be involved in the progress of arterial stiffness. Keywords: She minority; Arterial stiffness; High sensitive C reaction protein
BLOOD PRESSURE MEASUREMENT/MONITORING P-30 Association between initial and final blood pressure levels in chronic kidney disease patients with intradialytic hypertension Rita de Ca´ssia M Mattos,1 Sebasti~ao R. Ferreira Filho,1 Helton P. Lemes,2 Bruno P. Alves.2 1Federal University of Uberl^andia, Uberl^andia, Brazil; 2Nefroclınica of Uberl^andia Research Unit, Uberl^andia, Brazil The objective of the study was to determine the association between systolic blood pressure (SBP) values at the start and end of a hemodialysis (HD) session in intradialytic hypertension (IDH) patients. This study evaluated the systolic blood pressure patterns in 154 chronic kidney disease patients; among these patients, 18 were identified as having intradialytic hypertension. After patient selection, four consecutive hemodialysis sessions were prospectively evaluated for each patient, totaling 72 sessions. SBP, diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), and heart rate (HR) were measured at 30, 60, 90, 120, 150, 180, 210, and 240 minutes. PP was calculated using the formula PP¼ SBP - DBP. The results for each pressure represent the arithmetic mean of the 72 sessions analyzed at the previously specified times. A linear relationship was revealed between the systolic blood pressure levels measured after 30 minutes and those obtained after 240 minutes of HD (r¼0.742, p¼0.001). This association became stronger at 90 minutes (r¼0.937; p <0.001), indicating that for intradialytic hypertension patients, systolic blood pressure values at the start of HD were correlated to systolic blood pressure values at the end of the session. We conclude for intradialytic hypertension patients, values obtained at the end of HD are correlated with the initial values. This information could facilitate planning and earlier treatment. Keywords: intradialytic hypertension; hemodialysis; chronic kidney failure; arterial blood pressure
Abstracts / Journal of the American Society of Hypertension 10(4S) (2016) e19–e38
Figure 1.
time and 24hr heart rate (HR), and dipping degree with a peak in winter. Furthermore, for monthly variation, daytime, night-time and 24hr DBP, and daytime, night-time and 24hr HR, and dipping degree also showed similar findings of those in seasonal variation. On subgroup analysis by age, young age group (65 years, n¼1804) were more likely to have higher levels of daytime (p<0.0001), night-time (p<0.0001) and 24hr DBP (p<0.0001), and daytime (p<0.0001) and 24hr HR (p<0.0001), and higher values of dipping degree (p65 years, n¼502). Interestingly, significant seasonal variation in daytime, night-time and 24hr DBP with a peak in autumn, and dipping degree with a peak in winter were only observed in young age group. Compared with women (n¼1034), men had higher levels of daytime systolic BP (SBP) (p¼0.001) and DBP (p<0.0001), night-time DBP (p¼0.003), 24hr DBP (p<0.0001), and higher value of dipping degree (p¼0.014). Only men demonstrated significant seasonal variation in night-time SBP, DBP and dipping degree with a winter peak, and monthly variation in daytime, night-time and 24hr DBP and dipping degree. Conclusions: Seasonal and monthly variation in 24hr ambulatory BP, especially for DBP, HR and dipping degree were found in men with young age. These findings may be helpful to predict seasonal adverse cardiovascular events as well as BP control status, and also provide individualized management for hypertension according to age and gender. Keywords: ambulatory blood pressure monitoring; blood pressure variability; seasonal variability
ARTERIAL STRUCTURE AND COMPLIANCE P-29 Possible association between arterial stiffness and high SENSITIVE C reaction protein in natural populations of she minority in Fujian province in China Huan Liu,1 Hongyu Wang,1 Yongqiang Hong,2 Jinbo Liu,1 Hongwei Zhao,1 Yingyan Zhou.1 1Peking University Shougang Hospital, Beijing, China; 2 The AffiIiated Mindong Hospital of Fujian Medical University, Fujian, China Objective: Arterial stiffness is the independent predicting factor of the vascular related disease, and carotid femoral pulse wave velocity (CFPWV), cardio-ankle vascular index (CAVI), ankle brachial index (ABI) reflect the degree of arterial stiffness. High sensitive C reaction protein (hs-CRP) is one of the risk factors for vascular disease and can be used for the risk prediction of future cardiovascular events. In the current study, we evaluated the possible association between arterial stiffness and hs-CRP in natural populations of She nationality in Fujian province in China. Method: Two hundred and forty one subjects (male 96, female 145; age: 46.94 12.08 years) from natural populations of She minority in Fujian province in China were enrolled into our study.CF-PWV and ABI were measured by Compliar SP(r). The VS-1000 was used to measure
CAVI. Laboratory examinations included total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) and hs-CRP. Results: There were no statistical significance between left CAVI and right CAVI, however, left ABI (L-ABI) and right ABI(R-ABI) were significantly different, thus we choose right CAVI, left ABI and right ABI for data analysis respectively. Hs-CRP were positively correlated with age, waist hip rate(WHR), systolic blood pressure(SBP), diastolic blood pressure(DBP), pulse pressure(PP), TG, TC, LDL-C, CF-PWV and CAVI (r¼0.211, 0.160, 0.243, 0.164, 0.218, 0.127, 0.210, 0.285, 0.203, 0.275, all p<0.05). Hs-CRP were negatively correlated with L-ABI (r¼-0.207,p<0.05); and had negative correlation tendency with R-ABI (r¼-0.123,P¼0.056). Multivariate linear regression analysis (selected factors including age, WHR, SBP, DBP, PP, FPG, TC, TG, HDL-C, LDL-C, hs-CRP; CF-PWV, CAVI, L-ABI, R-ABI as the dependent variable respectively) showed that hs-CRP was an independent influencing factor of CF-PWV, L-ABI and R-ABI respectively. Age, SBP, DBP, FPG and hs-CRP were independent influencing factors of CFPWV. Age, PP and TG were independent influencing factors of CAVI. Age, PP, hs-CRP were independent influencing factors of both L-ABI and R-ABI. Conclusion: High sensitive C reaction protein was an independent related factor of arterial stiffness, which indicated that inflammatory markers may be involved in the progress of arterial stiffness. Keywords: She minority; Arterial stiffness; High sensitive C reaction protein
BLOOD PRESSURE MEASUREMENT/MONITORING P-30 Association between initial and final blood pressure levels in chronic kidney disease patients with intradialytic hypertension Rita de Ca´ssia M Mattos,1 Sebasti~ao R. Ferreira Filho,1 Helton P. Lemes,2 Bruno P. Alves.2 1Federal University of Uberl^andia, Uberl^andia, Brazil; 2Nefroclınica of Uberl^andia Research Unit, Uberl^andia, Brazil The objective of the study was to determine the association between systolic blood pressure (SBP) values at the start and end of a hemodialysis (HD) session in intradialytic hypertension (IDH) patients. This study evaluated the systolic blood pressure patterns in 154 chronic kidney disease patients; among these patients, 18 were identified as having intradialytic hypertension. After patient selection, four consecutive hemodialysis sessions were prospectively evaluated for each patient, totaling 72 sessions. SBP, diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), and heart rate (HR) were measured at 30, 60, 90, 120, 150, 180, 210, and 240 minutes. PP was calculated using the formula PP¼ SBP - DBP. The results for each pressure represent the arithmetic mean of the 72 sessions analyzed at the previously specified times. A linear relationship was revealed between the systolic blood pressure levels measured after 30 minutes and those obtained after 240 minutes of HD (r¼0.742, p¼0.001). This association became stronger at 90 minutes (r¼0.937; p <0.001), indicating that for intradialytic hypertension patients, systolic blood pressure values at the start of HD were correlated to systolic blood pressure values at the end of the session. We conclude for intradialytic hypertension patients, values obtained at the end of HD are correlated with the initial values. This information could facilitate planning and earlier treatment. Keywords: intradialytic hypertension; hemodialysis; chronic kidney failure; arterial blood pressure