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Poster 280: Pamidronate in the Treatment of Diffuse Sclerosing Osteomyelitis of the Mandible
Scientific Poster Session ber of glucose metabolic cells. These data represent one profile of the “healing capacity” of oral mucosa. References Terashi H, et al. J Dermatol Sci, 24: 14-24, 2000 Vorbrodt AW, et al. Acta Neuropathol 102: 278-284, 2001 Johann ACBR, et al. Oral Desease 13: 51-55, 2007
He received administration of pamidronate (30mg/body) after recurrence of spontaneous pain and swelling. The symptoms are still in remission 13 months after pamidronate injection. Results: n/a Conclusion: n/a References
POSTER 280 Pamidronate in the Treatment of Diffuse Sclerosing Osteomyelitis of the Mandible Yoichi Ohiro, DDS, PhD, Oral and Maxillofacial Surgery, Department of Oral Pathobiological Science, Graduated School of Dental Medicine, Hokkaido University, Kita-13, Nishi-7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan (Mabuchi A; Takashi N; Tei K; Totsuka Y) Statement of the Problem: Pamidronate has a pronounced effect on bone metabolism and has been expected its potential as therapeutic agent against diffuse sclerosing osteomyelitis (DSO) which etiology remains poorly understood. Materials and Methods: We report our clinical experience with intravenous administration of pamidronate in DSO of the mandible. Method of Data Analysis: Case 1) A 51-year-old female was referred to our hospital for repeating spontaneous pain and diffuse swelling in the right mandible. The first premolar in the right mandible had been extracted before the presentation. At initial examination, she suffered from swelling and continuous pain. Radiographs, CT scan and MRI presented mixed region of diffuse sclerosis and osteolytic lesion in mandibular bone. Laboratory data showed no abnormalities in the number of leukocytes and C-reactive protein. Regardless of the treatments with antibiotics, hyperbaric oxygen therapy and surgical decortication, spontaneous pain and diffuse swelling occurred at intervals. We decided to administer pamidronate (30mg/body). Repeated diffuse swelling and spontaneous pain disappeared for four months. Recurrence of the symptoms was presented, so she received the second injection of same amount of pamidronate. After the last administration of pamidronate, no symptoms were observed for 10 months. Case 2) A 33-year-old male was referred to our hospital for repeating spontaneous pain and diffuse swelling in the right mandibular. The first molar in the right mandibular had been extracted before the presentation. No swelling and pain were observed at initial examination, because of the frequency of the symptoms in this case was twice a year. Diagnostic imaging presented diffuse sclerosis in the right mandibular. After treatment with antibiotics, hyperbaric oxygen therapy and surgical decortication, the symptoms disappeared for 10 months. AAOMS • 2007
Montonen M, Kalso E, Pylkkaren L, Lindstrorm BM, Lindqvist C. Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandible. Int J Oral Maxillofac Surg. 30:313-7, 2001 Soubrier M, Dubost JJ, Ristori JM, Sauvezie B, Bussiere JL.Pamidronate in the treatment of diffuse sclerosing osteomyelitis of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92:637-40, 2001
POSTER 281 Response of the Oral Mucosa Sutured With 2 Different Materials Raul A. Garcia-Arocha, DMD, Postgrado de Cirugia Bucal, Facultad de Odontologia, Universidad Central de Venezuela, Ciudad Universitaria, Caracas, Venezuela (Garcı´a-Arocha R; Ceden ˜ o J; Del Valle S) Statement of the Problem: The suture materials for intraoral wound closure, present special characteristics because the mouth is a wet environment, with rich bacterial flora, trauma, and constant changes of temperature and ph. Clinical and histopathological tissue response of the oral mucosa sutured with nonabsorbable silk and absorbable polyglactin 910 of rapid absorption (r.a.) was compared. Materials and Methods: The model designed was carried out selecting twenty patients who required odontectomies of impacted third mandibular molars, from the Oral Surgery Graduate Program Clinic of the School of Dental Medicine at Universidad Central de Venezuela. Black silk 3-0 and polyglactin 910 r.a. 3-0 were placed at random in each side after the surgery. Method of Data Analysis: The reaction of the oral mucosa to the suture of all twenty patients was evaluated at 72 hours and at 8 days post surgery during suture removal when microscopic samples of the perisutural mucosa for the histopathology study were taken. Results: Silk presented a more severe response with inflammatory changes with neutrophils and eosinophils, abundant vascularization and rare fibrous connective dense tissue when compared with polyglactin 910 r.a. Polyglactin 910 r.a. clinically showed more generalized eritema. Statistically the clinical and histopathological results did not show significant differences of wound healing. Conclusion: Although histopathological differences were observed between silk and polyglactin 910 r.a, no clinical benefits were encountered indicating that both 43.e157
He received administration of pamidronate (30mg/body) after recurrence of spontaneous pain and swelling. The symptoms are still in remission 13 months after pamidronate injection. Results: n/a Conclusion: n/a References
POSTER 280 Pamidronate in the Treatment of Diffuse Sclerosing Osteomyelitis of the Mandible Yoichi Ohiro, DDS, PhD, Oral and Maxillofacial Surgery, Department of Oral Pathobiological Science, Graduated School of Dental Medicine, Hokkaido University, Kita-13, Nishi-7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan (Mabuchi A; Takashi N; Tei K; Totsuka Y) Statement of the Problem: Pamidronate has a pronounced effect on bone metabolism and has been expected its potential as therapeutic agent against diffuse sclerosing osteomyelitis (DSO) which etiology remains poorly understood. Materials and Methods: We report our clinical experience with intravenous administration of pamidronate in DSO of the mandible. Method of Data Analysis: Case 1) A 51-year-old female was referred to our hospital for repeating spontaneous pain and diffuse swelling in the right mandible. The first premolar in the right mandible had been extracted before the presentation. At initial examination, she suffered from swelling and continuous pain. Radiographs, CT scan and MRI presented mixed region of diffuse sclerosis and osteolytic lesion in mandibular bone. Laboratory data showed no abnormalities in the number of leukocytes and C-reactive protein. Regardless of the treatments with antibiotics, hyperbaric oxygen therapy and surgical decortication, spontaneous pain and diffuse swelling occurred at intervals. We decided to administer pamidronate (30mg/body). Repeated diffuse swelling and spontaneous pain disappeared for four months. Recurrence of the symptoms was presented, so she received the second injection of same amount of pamidronate. After the last administration of pamidronate, no symptoms were observed for 10 months. Case 2) A 33-year-old male was referred to our hospital for repeating spontaneous pain and diffuse swelling in the right mandibular. The first molar in the right mandibular had been extracted before the presentation. No swelling and pain were observed at initial examination, because of the frequency of the symptoms in this case was twice a year. Diagnostic imaging presented diffuse sclerosis in the right mandibular. After treatment with antibiotics, hyperbaric oxygen therapy and surgical decortication, the symptoms disappeared for 10 months. AAOMS • 2007
Montonen M, Kalso E, Pylkkaren L, Lindstrorm BM, Lindqvist C. Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandible. Int J Oral Maxillofac Surg. 30:313-7, 2001 Soubrier M, Dubost JJ, Ristori JM, Sauvezie B, Bussiere JL.Pamidronate in the treatment of diffuse sclerosing osteomyelitis of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92:637-40, 2001
POSTER 281 Response of the Oral Mucosa Sutured With 2 Different Materials Raul A. Garcia-Arocha, DMD, Postgrado de Cirugia Bucal, Facultad de Odontologia, Universidad Central de Venezuela, Ciudad Universitaria, Caracas, Venezuela (Garcı´a-Arocha R; Ceden ˜ o J; Del Valle S) Statement of the Problem: The suture materials for intraoral wound closure, present special characteristics because the mouth is a wet environment, with rich bacterial flora, trauma, and constant changes of temperature and ph. Clinical and histopathological tissue response of the oral mucosa sutured with nonabsorbable silk and absorbable polyglactin 910 of rapid absorption (r.a.) was compared. Materials and Methods: The model designed was carried out selecting twenty patients who required odontectomies of impacted third mandibular molars, from the Oral Surgery Graduate Program Clinic of the School of Dental Medicine at Universidad Central de Venezuela. Black silk 3-0 and polyglactin 910 r.a. 3-0 were placed at random in each side after the surgery. Method of Data Analysis: The reaction of the oral mucosa to the suture of all twenty patients was evaluated at 72 hours and at 8 days post surgery during suture removal when microscopic samples of the perisutural mucosa for the histopathology study were taken. Results: Silk presented a more severe response with inflammatory changes with neutrophils and eosinophils, abundant vascularization and rare fibrous connective dense tissue when compared with polyglactin 910 r.a. Polyglactin 910 r.a. clinically showed more generalized eritema. Statistically the clinical and histopathological results did not show significant differences of wound healing. Conclusion: Although histopathological differences were observed between silk and polyglactin 910 r.a, no clinical benefits were encountered indicating that both 43.e157