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Postoperative radiotherapy after pneumectomy for lung cancers impact of modern treatment facilities
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354 Does preoperativeRF capacitivehyperthermiacombinedwith radiotherapyincreasesurvivalrate in advancedlung cancer?
I;.Shindo M.D., J. NakajinaM.D., T. MiyairiM.D., T. OhtsukaM.D., A. Akanuma M.D.*, Y. Sasaki* A. Furuse M.D., K. KarasawaM.D.*, Departmentof ThoracicSurgery,Departmentof Radiology*, Universityof Tokyo, JAPAN. Surgicaltherapy for advancedlung cancer has not achieved satisfactorysurvivalrate, eve" thoughwith using extended mediastinallymph nodes dissectiontechnique.Radiationalone has proved to be effectivefor squamouscell carcinoma.Hyperthermia has cytosidaland cytostaticeffectsforcancercells with combinationof irradiationfor them. This "a"er will "resent clinicalresultsof preoperativeuse of hypekthermia&nhi"ed with irradiationfor advancedprimary lung cancer. Twelve patientsconsistedof 11 males and a femalewith a" averageage of 57 year old. The clinicalstages of them were class IIIAor IUB. Histologicaldiagnosisshowed 6 squamouscell carcinoma, 5 adenocarcinoma and a" anaplasticcarcinoma.The radiofrequent wave heatingapparatus,ThermotronRF-E with newly developed overlayboluses was used twiced a week with combinedirradiation5 time a week, for 45 to 60 minutes soon after the irradiation.Total heating times "as 8 with 40 Gy irradiationas one course of preoperativetherapy.Effectiverate (CR + PR) was 83% (10/12). Relativecurativeoperationwas performedand all patientssurvived early postoperativestage. Pathologicalexams.ofsurgicalspecimens revealedcytosidaleffect without dependinghistologicaltypes. ._ Five year ~survivalrate was 0.571. In conclusion,preoperativehypertherinia combinedwith irradiation will be a promisingadjuvanttherapy for advancedlung cancer to improveoperabilityand curabilitywithouthistologicaltypes.
POSTOPERATIVE RADIOTHERAPY FOR LOCALLY ADVANCED LUNG CANCERS : IMPORTANCE OF MEDIASTINAL INVOLVEMENTON TREATMENTOUTCOME P.PHLIPS,P.deFRANCQUEN,P.ROCMANS,P.VANHOUTTE Institut Jules Bordet,Hospital Erasme, Brussels Belgium From 1970 til 1985, 216 consecutive pts with a complete resection of a T3NlN2 tumors received a course of postop.rt : 56 Gy was delivered to the mediastinum in 5.5 weeks . This series includes 43 T3N0, 67 Nl and 106 N2 with a 5 Y. survival rate of respectively 17X,26% and 16% . The extent of mediastinal involvement is one of the most significant : prognostic factor minimal disease defined as one mediastinal node involved yields a 5 Y. survival rate of 27% compared to 6% for two or more positive nodes (p
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POSTOPERATIVERADIOTHERAPY AFTER PNEUMECTOMY FOR LUNG CANCERS IMPACT OF MODERN TREATMENT FACILITIES P.PHLIPS, P.ROCMANS, P.VANDERHOEFT, P.VAN HOUTTE INSTITUT JULES BORDET, HOSPITAL ERASME BRUSSELS, BELGIUM
High Dose Rate Endobronchial Brechytherapy using the MicroSelectron
In our prior randomized trial, postoperative rt NaS associated with a poor survival after a pneumectomy, the technique used was advocated to explain this difference . So,we reviewed our experience over the last years to see the impact of modern treatment facilities . From 1970-85, 490 consecutive patients were see* : 160 had a pneumectomy and a complete resection of TlT2NO tumors (57 pts) or T3NlN2 (103 pts) . For the group of NO tumor, the rt delivered a dose of 60 Gy in 6 weeks with a three fields technique and a Co60 unit. 5y survival rate was 4% compared to 34% for the control group treated only with surgery Ip
C. Grafton, S. Lam, N. Voas, I?. Fairey, K. Goddard, K. Yuen BC Cancer Agency, Vancouver, BC, Canada Endobronchlal mdiothempy ualng the MicroSelectron can deliver a high dose to a small volume of lung in the proximal airways. We have treated 105 patients wlth pellfative endobronchial brachythempy delivering 30 cGy et O.Scm from the source axls in a single fraction. 01 these, 10% of petients had metastatic lesions from non-lung primaries, the remainder had fncumble cercinoma of the bronchus. Approxlmetely 50% of cases had felled previous pellfetive mdlotherapy, 5% failed prevloua mdicel mdiotherepy, and the remalnder were treated with brachytherapy as lnttkl palliative treatment elther alone or with externel radlothempy. Symptoms of cough, dyapnee, sputum production, and hemoptysia have been pelllated in 59%, 579b, 4896, ?? nd 38% of petlenta respectively. One patient suffered ulcemtlon to the cartilage ring and three, preaentlng wlth hemoptyala, heve died of massive hemoptysla In the poattreatment per&f. Endobronchlal brachythempy Is a sefe procedure and achieves effective pellbtlon for petlenta wlth lung tumora. Close follow up of patients treeted for hemoptyaia continues.
354 Does preoperativeRF capacitivehyperthermiacombinedwith radiotherapyincreasesurvivalrate in advancedlung cancer?
I;.Shindo M.D., J. NakajinaM.D., T. MiyairiM.D., T. OhtsukaM.D., A. Akanuma M.D.*, Y. Sasaki* A. Furuse M.D., K. KarasawaM.D.*, Departmentof ThoracicSurgery,Departmentof Radiology*, Universityof Tokyo, JAPAN. Surgicaltherapy for advancedlung cancer has not achieved satisfactorysurvivalrate, eve" thoughwith using extended mediastinallymph nodes dissectiontechnique.Radiationalone has proved to be effectivefor squamouscell carcinoma.Hyperthermia has cytosidaland cytostaticeffectsforcancercells with combinationof irradiationfor them. This "a"er will "resent clinicalresultsof preoperativeuse of hypekthermia&nhi"ed with irradiationfor advancedprimary lung cancer. Twelve patientsconsistedof 11 males and a femalewith a" averageage of 57 year old. The clinicalstages of them were class IIIAor IUB. Histologicaldiagnosisshowed 6 squamouscell carcinoma, 5 adenocarcinoma and a" anaplasticcarcinoma.The radiofrequent wave heatingapparatus,ThermotronRF-E with newly developed overlayboluses was used twiced a week with combinedirradiation5 time a week, for 45 to 60 minutes soon after the irradiation.Total heating times "as 8 with 40 Gy irradiationas one course of preoperativetherapy.Effectiverate (CR + PR) was 83% (10/12). Relativecurativeoperationwas performedand all patientssurvived early postoperativestage. Pathologicalexams.ofsurgicalspecimens revealedcytosidaleffect without dependinghistologicaltypes. ._ Five year ~survivalrate was 0.571. In conclusion,preoperativehypertherinia combinedwith irradiation will be a promisingadjuvanttherapy for advancedlung cancer to improveoperabilityand curabilitywithouthistologicaltypes.
POSTOPERATIVE RADIOTHERAPY FOR LOCALLY ADVANCED LUNG CANCERS : IMPORTANCE OF MEDIASTINAL INVOLVEMENTON TREATMENTOUTCOME P.PHLIPS,P.deFRANCQUEN,P.ROCMANS,P.VANHOUTTE Institut Jules Bordet,Hospital Erasme, Brussels Belgium From 1970 til 1985, 216 consecutive pts with a complete resection of a T3NlN2 tumors received a course of postop.rt : 56 Gy was delivered to the mediastinum in 5.5 weeks . This series includes 43 T3N0, 67 Nl and 106 N2 with a 5 Y. survival rate of respectively 17X,26% and 16% . The extent of mediastinal involvement is one of the most significant : prognostic factor minimal disease defined as one mediastinal node involved yields a 5 Y. survival rate of 27% compared to 6% for two or more positive nodes (p
355
356
POSTOPERATIVERADIOTHERAPY AFTER PNEUMECTOMY FOR LUNG CANCERS IMPACT OF MODERN TREATMENT FACILITIES P.PHLIPS, P.ROCMANS, P.VANDERHOEFT, P.VAN HOUTTE INSTITUT JULES BORDET, HOSPITAL ERASME BRUSSELS, BELGIUM
High Dose Rate Endobronchial Brechytherapy using the MicroSelectron
In our prior randomized trial, postoperative rt NaS associated with a poor survival after a pneumectomy, the technique used was advocated to explain this difference . So,we reviewed our experience over the last years to see the impact of modern treatment facilities . From 1970-85, 490 consecutive patients were see* : 160 had a pneumectomy and a complete resection of TlT2NO tumors (57 pts) or T3NlN2 (103 pts) . For the group of NO tumor, the rt delivered a dose of 60 Gy in 6 weeks with a three fields technique and a Co60 unit. 5y survival rate was 4% compared to 34% for the control group treated only with surgery Ip
C. Grafton, S. Lam, N. Voas, I?. Fairey, K. Goddard, K. Yuen BC Cancer Agency, Vancouver, BC, Canada Endobronchlal mdiothempy ualng the MicroSelectron can deliver a high dose to a small volume of lung in the proximal airways. We have treated 105 patients wlth pellfative endobronchial brachythempy delivering 30 cGy et O.Scm from the source axls in a single fraction. 01 these, 10% of petients had metastatic lesions from non-lung primaries, the remainder had fncumble cercinoma of the bronchus. Approxlmetely 50% of cases had felled previous pellfetive mdlotherapy, 5% failed prevloua mdicel mdiotherepy, and the remalnder were treated with brachytherapy as lnttkl palliative treatment elther alone or with externel radlothempy. Symptoms of cough, dyapnee, sputum production, and hemoptysia have been pelllated in 59%, 579b, 4896, ?? nd 38% of petlenta respectively. One patient suffered ulcemtlon to the cartilage ring and three, preaentlng wlth hemoptyala, heve died of massive hemoptysla In the poattreatment per&f. Endobronchlal brachythempy Is a sefe procedure and achieves effective pellbtlon for petlenta wlth lung tumora. Close follow up of patients treeted for hemoptyaia continues.