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Postresuscitation disease
343 efficient, technical highly professional attitude. An all-round textbook which can unreservedly be recommended to the neurosurgeon, the neurologist and to the pediatric neurologist, who wants to orient themselves well and quickly when confronted by a diagnostic or therapeutic dilemma in this field. The lay-out is according to the proverbially high standard of the publishing house, with clear letter-type, excellent illustrations and quality-paper. The price of the book will keep it out of the resident's reach. G.W. BRUYN
Postresuscitation Disease, by V.A. Negovsky, A.M. Gurvitch and E. S. Zolotokrylina, translated from the Russian by V.N. Bespalyi, xvi + 392 pages, illustrated, Elsevier Science Publishers, Amsterdam, New York, Oxford, 1983, US$ 112.75, Dfl 265.00. This monograph is the synopsis of work carried out in the Moscow Research Laboratory of General Reanimatology over a span of 25 years. It is based on clinical and animal-experimental work. The central theme of this book holds that the main problem of resuscitation therapy is not only caused by lesions that arise during the stages of dying and of clinical death, but also, when resuscitation is attempted, by lesions, either caused or aggravated by the very process of restoration, if that process is not carried out properly. During the periods of dying and clinical death only part of the irreversible lesions develop both in the brain, but also in organs and systems such as the lungs, heart, liver, kidneys and endothelium, which are of vital importance for resuscitation to be successful. The systemic and pathophysiological changes becoming operant during resuscitation make many of the irreversible lesions truly irreversible (release and recirculation of endogenous toxic substances from tissue hypoxia, coagulation disturbances, free radicals, electrolyte disequilibrium). This dynamic complex of factors together is called resuscitation pathology or postresuscitation disease. This disease as a new nosological entity has only one etiology: the combination of extreme circulatory hypoxia with restorative medical intervention effecting resumption of some circulation of sufficiently oxygenated blood to develop the resuscitation lesions. Most of the work has been published in the Russian language and, as a consequence, is largely or wholly unknown to the neurologists and neurosurgeons in the Western world. The concept of resuscitation disease as set out in this monograph is bolstered by a bibliography of well over 1,000 mainly Russian references. The monograph is built up of 5 parts (Pathology of internal organs and systems; Pathology of the CNS; Treatment and progress during the postresuscitation period; Conclusion; and Appendices) and deals with a wealth of data in 5 chapters (pre- and postresuscitation pathology of internal organs, pre- and postresuscitation pathology of the CNS, restoration of tissue perfusion, respiration, acid-base balance, etc.). Each chapter closes with a summing up of clinical and pathophysiological data. Even, if the translator has not succeeded in writing the Queen's or even just "normal" English, the Publishing House has rendered Western Science a unique service by opening this door of an unfamiliar activity to the western clinical and scientific workers in neurology. G.W. BRUYN
Postresuscitation Disease, by V.A. Negovsky, A.M. Gurvitch and E. S. Zolotokrylina, translated from the Russian by V.N. Bespalyi, xvi + 392 pages, illustrated, Elsevier Science Publishers, Amsterdam, New York, Oxford, 1983, US$ 112.75, Dfl 265.00. This monograph is the synopsis of work carried out in the Moscow Research Laboratory of General Reanimatology over a span of 25 years. It is based on clinical and animal-experimental work. The central theme of this book holds that the main problem of resuscitation therapy is not only caused by lesions that arise during the stages of dying and of clinical death, but also, when resuscitation is attempted, by lesions, either caused or aggravated by the very process of restoration, if that process is not carried out properly. During the periods of dying and clinical death only part of the irreversible lesions develop both in the brain, but also in organs and systems such as the lungs, heart, liver, kidneys and endothelium, which are of vital importance for resuscitation to be successful. The systemic and pathophysiological changes becoming operant during resuscitation make many of the irreversible lesions truly irreversible (release and recirculation of endogenous toxic substances from tissue hypoxia, coagulation disturbances, free radicals, electrolyte disequilibrium). This dynamic complex of factors together is called resuscitation pathology or postresuscitation disease. This disease as a new nosological entity has only one etiology: the combination of extreme circulatory hypoxia with restorative medical intervention effecting resumption of some circulation of sufficiently oxygenated blood to develop the resuscitation lesions. Most of the work has been published in the Russian language and, as a consequence, is largely or wholly unknown to the neurologists and neurosurgeons in the Western world. The concept of resuscitation disease as set out in this monograph is bolstered by a bibliography of well over 1,000 mainly Russian references. The monograph is built up of 5 parts (Pathology of internal organs and systems; Pathology of the CNS; Treatment and progress during the postresuscitation period; Conclusion; and Appendices) and deals with a wealth of data in 5 chapters (pre- and postresuscitation pathology of internal organs, pre- and postresuscitation pathology of the CNS, restoration of tissue perfusion, respiration, acid-base balance, etc.). Each chapter closes with a summing up of clinical and pathophysiological data. Even, if the translator has not succeeded in writing the Queen's or even just "normal" English, the Publishing House has rendered Western Science a unique service by opening this door of an unfamiliar activity to the western clinical and scientific workers in neurology. G.W. BRUYN