ORAL AND MAXILLOFACIAL PATHOLOGY e74 Abstracts PP - EXACERBATION OF OVARIECTOMY-INDUCED BONE LOSS BY PERIODONTAL DISEASE IN MICE. ANA LIA ANBINDER, RENATA MENDONÇA MORAES, GABRIELA DE MORAIS GOUVÊA LIMA, RODNEI DENNIS ROSSONI, FELIPE EDUARDO DE OLIVEIRA, YUN MA, FLORENT ELEFTERIOU. INSTITUTE OF SCIENCE AND TECHNOLOGY- SÃO JOSÉ DOS CAMPOS-UNIV. ESTADUAL PAULISTA-UNESP, SÃO JOSÉ DOS CAMPOS, SP, BRAZIL/ CENTER FOR BONE BIOLOGY, VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN, USA. Osteoporosis is a known risk factor for periodontal disease (PD); however, the effects of PD on systemic bone remodeling are not well established. The aim of this study was to evaluate the effects of PD on systemic bone loss in mice. Forty female mice (BALB/c) were divided into four groups: PD+OVX group, comprising mice with induced PD and ovariectomy; PD group, comprising mice with induced PD and sham surgery; OVX group, comprising mice with ovariectomy without PD; and control group, comprising mice with sham surgery only. PD was induced by the insertion of a ligature around the mandibular first molars and Porphyromonas gingivalis infection. The animals were sacrificed 51 days after ovariectomy or sham surgery, when blood was collected to quantify serum levels (ELISA) of tumor necrosis factor (TNF)-a, interleukin (IL)-4, IL-6, and IL-17. Mandibles and femurs were removed and analyzed by microtomography. Following statistical analysis, the PD+OVX group showed lower femoral and mandibular bone volume fraction (BV/ TV) compared with the other groups. The PD+OVX and PD groups showed significantly higher levels of TNF-a compared with the OVX and control groups and higher levels of IL-17 and IL-6 compared with the control group. These findings suggested that PD is not an isolated risk factor for systemic bone loss, although it can exacerbate bone loss induced by ovariectomy.
PP - ODONTOGENIC MYXOMA OF THE MAXILLA: A CASE REPORT. SHAJADI CARLOS PARDO KABA, MARCELO MARTINSON RUIZ, FERNANDO KENDI HORIKAWA, BRUNO HENRIQUE DE OLIVEIRA, CELSO AUGUSTO LEMOS. SCHOOL OF DENTISTRY, UNIVERSITY OF SAO PAULO, ORAL AND MAXILLOFACIAL SURGERY DEPARTMENT, UNIVERSITY HOSPITAL, UNIVERSITY OF SAO PAULO. Odontogenic myxoma is defined as a non-metastatic benign neoplasm of dental ectomesenchyme. It is characterized as an asymptomatic lesion with local invasion causing destruction of adjacent structures and displacement of teeth. In gnathic bones, its relative distribution shows predominance in the mandibular posterior portion (28% of cases). It is the second most frequent odontogenic lesion, with an incidence of 0.07 new cases per million people a year. Due to its benign characteristic (non-metastatic), treatment options vary from less invasive procedures, curettage in cases of small lesions, to resection in cases of larger tumors. In view of the non-encapsulated characteristic of this lesion, along with various surgical treatments, odontogenic myxoma has a recurrence rate of 25%, thus requiring periodic evaluation for at least five years. This poster presents the case study of a 33-year-old female patient with a 4-month history of progressive facial swelling diagnosed as myxoma of the maxilla with gross invasion of the maxillary sinus. She was submitted to a left partial maxillectomy through Weber-Ferguson approach and adaptation of a titanium mesh to maintain facial contour. The
OOOO February 2017 patient has remained in follow-up for 3 years with no signs of recurrence.
PP - INTRAOSSEOUS MANDIBULAR LIPOMA: A DIAGNOSTIC CHALLENGE. LIGIA BULOTO SCHMITD, FABIANA DE FREITAS BOMBARDA NUNES, AGNES ASSAO, CLEVERSON TEIXEIRA SOARES, DENISE TOSTES OLIVEIRA. FAESA SCHOOL OF DENTISTRY, VITÓRIA, ES, BRAZIL/ DEPARTMENT OF STOMATOLOGY, PATHOLOGY DIVISION, BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO, BAURU, SP, BRAZIL. A 20-year-old white female presented at FAESA Dental School, with the chief complain of a painless swelling at the right mandible. The lesion was present since she was 12 years old and progressed in the last 2 years. Her medical history was unremarkable. Intraoral examination evidenced a firm, round swelling at the right inferior premolar region, with slight teeth displacement. Occlusal radiography and computed tomography showed low radiopacity and evident cortical expansion at both buccal and lingual aspects of the mandible. An incisional biopsy was performed and the specimen analyzed at the Pathology Service of the Bauru School of Dentistry. Histopathological analysis revealed extensive areas of mature, S-100 positive adipose tissue, interspersed with trabecular viable bone without capsular tissue. Based on clinical, radiographic and microscopic findings, the final diagnosis was of intraosseous lipoma. The patient was submitted to surgical removal of the lesion, preserving the teeth, and is being monitored regularly. Although extremely rare in the jaws, the histopathological analysis is of utmost importance in differential diagnosis of intraosseous lipoma and similar pathologies of the jaws.
PP - PLUNGING RANULA ASSOCIATED WITH THE SUBMANDIBULAR GLAND: A SURGICAL TREATMENT REPORT. SHAJADI CARLOS PARDO KABA, MARCELO MARTINSON RUIZ, FERNANDO KENDI HORIKAWA, BRUNO HENRIQUE DE OLIVEIRA, CELSO AUGUSTO LEMOS. SCHOOL OF DENTISTRY, UNIVERSITY OF SAO PAULO; ORAL AND MAXILLOFACIAL SURGERY DEPARTMENT, UNIVERSITY HOSPITAL, UNIVERSITY OF SAO PAULO.
Ranulas are retention cysts found in the floor of mouth resulting from extravasation of saliva, usually from the sublingual gland. Three varieties of ranula are described: superficial or oral, cervical or plunging, and mixed. The oral or sublingual ranula is the most frequent. By definition, a plunging ranula is located below the mylohyoid muscle, producing a swelling in the upper part of the neck, originating from a defect in the duct of the sublingual gland. The most effective treatment method for plunging ranulas remains controversial. In this poster we present the case study of a 19-year-old male patient that had presented cervical swelling with infectious characteristics for one month. After CT scan and aspiration of the content of the swelling with the presence of mucin, the diagnosis of plunging ranula was confirmed. The CT scan showed an intimate relationship between the capsule and the ipsilateral submandibular gland. The patient underwent surgical procedure for the removal of the pseudocapsule and the submandibular gland on the same side. The pseudocapsule presented an infiltrative pattern with dissection of important structures of the deep neck. The patient had an uneventful postoperative period and a good outcome.