PP059-SUN RELATION BETWEEN NUTRITION AND ORAL FUNCTION IN ELDERLY JAPANESE WITH ALZHEIMER'S DISEASE

Geriatrics I within one year after hospital admission. Patients with a malignancy or vascular disease were more likely to die early after discharge. It could be debated if extra nutritional support should be offered as a standard in patients with these diagnoses. Disclosure of Interest: None Declared.

PP059-SUN RELATION BETWEEN NUTRITION AND ORAL FUNCTION IN ELDERLY JAPANESE WITH ALZHEIMER’S DISEASE E. Sato1 , H. Hirano2 , Y. Watanabe3 , A. Edahiro2 , Y. Ohara4 , S. Morishita3 , A. Katakura1 , G. Yamane1 , T. Suzuki3 . 1 Oral Medicine and Oral and Maxillofacial Surgery, Tokyo Dental Colledge, Chiba, 2 Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, 3 National Center for Geriatrics and Gerontology, Aichi, 4 Graduate School, Section of Behavioral Dentistry, Tokyo Medical and Dental University, Tokyo, Japan Rationale: Elderly patients with dementia have been reported to develop malnutrition with increasing severity of dementia. We investigated the hypothesis that this form of malnutrition is caused by oral dysfunction. Methods: Subjects were 153 elderly (over 65 years) patients with Alzheimer’s disease (AD) who had been admitted to hospital or nursing home. We obtained data on oral function (with or without teeth and occlusion, lip closure, tongue movement, capable of rinsing and brushing teeth in daily life) based on assessment by specialist researchers and nutritional status (MNA-SF) based on interviews with care provider. The severity of Dementia was classified into mild (CDR1), moderate (CDR2), severe (CDR3) by the Clinical Dementia Rating (CDR). Statistical analyses for the relationship between severity of dementia and nutritional status were carried out using SPSS Ver. 19. The Bonferroni test was used for the comparison with MNA-SF between CDR. Student’s ttest was used for the comparison with MNA-SF between oral function. Logistic regression analysis carried out to identify factor with a significant correlated with MNA-SF. Results: Mean(±SD) MNA-SF scores were CDR1 (9.4±2.3), CDR2 (8.9±1.9), CDR3 (6.4±2.2), and significantly different between CDR1 and CDR3 (P < 0.01), CDR2 and CDR3 (P < 0.01). Groups of patients have disability with occlusion (P < 0.01), tongue (P < 0.01) and rinsing (P < 0.01) were found to be significantly lower MNA-SF score than not disability groups. The factor significantly correlated with MNA-SF was tongue function (OR = 13.6, CI = 2.6 70.2). Conclusion: Malnutrition is correlated with oral functions in elderly patients with Alzheimer disease. The present study suggests that in order to provide support oral intake among elderly patients with dementia, it is necessary to not only assess nutritional status, but to make a comprehensive assessment that also considers the effects of dementia progression on oral function. Disclosure of Interest: None Declared.

49 PP060-SUN COST-EFFECTIVENESS OF NUTRITIONAL INTERVENTION IN HIP FRACTURE PATIENTS: A MULTI-CENTRE RANDOMISED CONTROLLED TRIAL (RCT) C. Wyers1 , P.L. Reijven2 , S.M. Evers3 , P.C. Willems4 , I.C. Heyligers5 , A.D. Verburg6 , S. van Helden7 , P.C. Dagnelie1 . 1 Epidemiology, Maastricht University, 2 Dietetics, Maastricht University Medical Centre, 3 Health Services Research, Maastricht University, 4 Orthopaedic Surgery, Maastricht University Medical Centre, Maastricht, 5 Atrium Medical Centre, Heerlen, 6 Orthopaedic Surgery, Orbis Medical Centre, Sittard, 7 Trauma Surgery, Maastricht University Medical Centre, Maastricht, Netherlands Rationale: Previous research on the effect of nutritional intervention on clinical outcome in hip fracture patients yielded contradictory results. Cost-effectiveness of nutritional intervention in hip fracture patients remains unknown. Our aim was to evaluate cost-effectiveness of nutritional intervention in elderly subjects after hip fracture from a societal perspective. Methods: Design: Multi-centre RCT. Patients in the intervention group received nutritional intervention comprising intensive dietetic counselling (10 face-to-face contacts and/or telephone calls) and oral nutritional supplementation for 3 months. Patients in the control group received usual dietetic care. Costs, weight and quality of life were measured at baseline, and 3 and 6 months postoperatively. Incremental cost-effectiveness ratios (ICERs) were calculated for weight at 3 months and QALYs at 6 months postoperatively. Results: Of 152 patients enrolled, 73 were allocated to the intervention group and 79 to the control group. Mean costs of the nutritional intervention was 613 Euro. Total costs and subcategories of costs were not significantly different between both groups. Based on bootstrapping of ICERs, the nutritional intervention was likely to be costeffective for weight as outcome over the 3-month intervention period, regardless of nutritional status at baseline. In contrast, with QALYs as outcome, the probability for the nutritional intervention being cost-effective was relatively low, except in subjects aged below 75 years. Conclusion: Intensive nutritional intervention in elderly hip fracture patients is likely to be cost-effective for weight, but not for QALYs. Future cost-effectiveness studies should incorporate outcome measures appropriate for elderly patients, such as functional limitations and other relevant outcomes for elderly. Disclosure of Interest: None Declared.

PP061-SUN PREOPERATIVE FASTING PROTECTS AGED CORPULENT MICE AGAINST RENAL ISCHEMIA/REPERFUSION INJURY F. Jongbloed1 , J.N.M. IJzermans1 , S. van den Engel1 , e2 , R.W.F. de Bruin1 . H. van Steeg2 , M.E.T. Doll´ 1 Department of Surgery, Erasmus MC, Rotterdam, 2 Laboratory of Health Protection Research, National Institute of Public Health and the Environment, Bilthoven, Netherlands Rationale: Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal