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Progesterone receptor ligands
New Patents
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trifluralin in agriculturally significant substances such as plant materials, soil and water or to otherwise test for trifluralin contamination of water, food and air.
4780420 PROGESTERONE RECEPTOR LIGANDS Richard Hochberg, William Rosner, Hoyte assigned to Yale University
Robert
Radiodinated and non-radiodinated 16 alphaiodoand 17 alpha-(2-iodovinyl)- 19nortestosterones are prepared and are used in progesterone receptor assays.
4781912 CATIONIC COMPLEX OF TECHNETIUM-99M. Giuseppe D Zanelli, Frank Brady, Niranjan Patel, Aviji Lahiri, Harrow, United Kingdom assigned to Mallinckrodt Inc The invention relates to a cationic complex of technetium-99m with (a) at least one bidendate ligand X having the formula See Patent for Tabular Presentation PS where each Z is phosphorus or arsenic, Q is a (CH2)n linking group where n is 2 to 8 or a 1,Zphenylene linking group, each of RI, R2, R3 and R4 is hydrogen, Cl to C.5 alkyl or phenyl; and (b) at least one monodentate isonitrile ligand Y. The invention also relates to a radiopharmaceutical composition comprising said complex, to a kit for preparing said composition, and to the use of said composition for a radiodiagnostic examination.
4782233 MULTIFIELD COLLIMATOR SYSTEM AND METHOD AND RADIONUCLIDE EMISSION TOMOGRAPHY CAMERA USING SAME Sebastian Genna, Andrew P Smith assigned to Digital Scintigraphics Inc A multifield collimator system and radionuclide emission tomography camera using same which include at least two collimator segments whose
fields of view in combination define at least two tomographic field of view boundaries. At least one of the boundaries encompasses the region to be imaged of an object. The fields of view may overlap at least in part to produce enhanced imaging sensitivity in the portion of overlap. The tomography camera detects radionuclide emissions from the region to collect at least one collimated image through each segment and combines the collimated images to produce a final image of the region exhibiting enhanced sensitivity in the portion of overlap. A multifield method of collimation is also disclosed.
4782840 METHOD FOR LOCATING, DIFFERENTIATING, AND REMOVING NEOPLASMS Edward W Martin, Marlin 0 Thurston assigned to Neoprobe Corporation The present invention is addressed to a method for the improved localization, differentiation, and removal of neoplastic tissue in animals. In particular, one aspect of the present invention involves a surgical procedure wherein an animal suspected of containing neoplastic tissue is surgically accessed and the tissue therein examined visually and by palpation for evidence of neoplastic tissue. The improved methodology commences with the administering to the animal of an effective amount of a labelled antibody specific for neoplastic tissue and labelled with a radioactive isotope exhibiting specific photon emissions of energy levels. Next, and importantly, the surgial procedure is delayed for a time interval following said administering for permitting the labelled antibody to preferentially concentrate in any neoplastic tissue present in the animal so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in said animal. Thereafter, an operative field of the animal is surgically accessed and tissue within the operative field to be examined for neoplastic tissue has the background photon emission count determined. Once the background photon emission account for tissue within the operative field has been determined, a handheld probe is manually positioned within the operative field adjacent tissue suspected of being neoplastic. The probe is configured for fascile hand positioning and maneuvering within the operative field of the animal. The probe is characterized by having a collimatable radiation detector having a selective photon entrance and having an output deriving
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trifluralin in agriculturally significant substances such as plant materials, soil and water or to otherwise test for trifluralin contamination of water, food and air.
4780420 PROGESTERONE RECEPTOR LIGANDS Richard Hochberg, William Rosner, Hoyte assigned to Yale University
Robert
Radiodinated and non-radiodinated 16 alphaiodoand 17 alpha-(2-iodovinyl)- 19nortestosterones are prepared and are used in progesterone receptor assays.
4781912 CATIONIC COMPLEX OF TECHNETIUM-99M. Giuseppe D Zanelli, Frank Brady, Niranjan Patel, Aviji Lahiri, Harrow, United Kingdom assigned to Mallinckrodt Inc The invention relates to a cationic complex of technetium-99m with (a) at least one bidendate ligand X having the formula See Patent for Tabular Presentation PS where each Z is phosphorus or arsenic, Q is a (CH2)n linking group where n is 2 to 8 or a 1,Zphenylene linking group, each of RI, R2, R3 and R4 is hydrogen, Cl to C.5 alkyl or phenyl; and (b) at least one monodentate isonitrile ligand Y. The invention also relates to a radiopharmaceutical composition comprising said complex, to a kit for preparing said composition, and to the use of said composition for a radiodiagnostic examination.
4782233 MULTIFIELD COLLIMATOR SYSTEM AND METHOD AND RADIONUCLIDE EMISSION TOMOGRAPHY CAMERA USING SAME Sebastian Genna, Andrew P Smith assigned to Digital Scintigraphics Inc A multifield collimator system and radionuclide emission tomography camera using same which include at least two collimator segments whose
fields of view in combination define at least two tomographic field of view boundaries. At least one of the boundaries encompasses the region to be imaged of an object. The fields of view may overlap at least in part to produce enhanced imaging sensitivity in the portion of overlap. The tomography camera detects radionuclide emissions from the region to collect at least one collimated image through each segment and combines the collimated images to produce a final image of the region exhibiting enhanced sensitivity in the portion of overlap. A multifield method of collimation is also disclosed.
4782840 METHOD FOR LOCATING, DIFFERENTIATING, AND REMOVING NEOPLASMS Edward W Martin, Marlin 0 Thurston assigned to Neoprobe Corporation The present invention is addressed to a method for the improved localization, differentiation, and removal of neoplastic tissue in animals. In particular, one aspect of the present invention involves a surgical procedure wherein an animal suspected of containing neoplastic tissue is surgically accessed and the tissue therein examined visually and by palpation for evidence of neoplastic tissue. The improved methodology commences with the administering to the animal of an effective amount of a labelled antibody specific for neoplastic tissue and labelled with a radioactive isotope exhibiting specific photon emissions of energy levels. Next, and importantly, the surgial procedure is delayed for a time interval following said administering for permitting the labelled antibody to preferentially concentrate in any neoplastic tissue present in the animal so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in said animal. Thereafter, an operative field of the animal is surgically accessed and tissue within the operative field to be examined for neoplastic tissue has the background photon emission count determined. Once the background photon emission account for tissue within the operative field has been determined, a handheld probe is manually positioned within the operative field adjacent tissue suspected of being neoplastic. The probe is configured for fascile hand positioning and maneuvering within the operative field of the animal. The probe is characterized by having a collimatable radiation detector having a selective photon entrance and having an output deriving