- Email: [email protected]
Project title metabolism and PO2 in ischemic and hypoxic brain
conditions to improve the validity and increase power; (2) determine why empirical and nominal error rates sometimes differ for continuous rating format and to investigate procedures for reducing this difference in a broad range of experimental conditions to improve validity and increase power; (3) evaluate the validity of theDBM multireader methodology in estimating confidence intervals for various effect-size differences; (4) develop and evaluate procedures for estimating the minimum reader and case sample sizes needed to detect a clinically meaningful difference with a fair degree of power and a small probability of a Type 1 error; and (5)incorporate covariates into the DBM multireader methodology, and evaluate the validity of this extension. These aims will be addressed by both Monte Carlo simulations and theoretical analysis. Thesaurus Terms: computer assisted diagnosis, data collec-
tion methodology/evaluation, diagnosis design/evaluation, diagnosis quality/standard, imaging/visualization, radiodiagnosis computer program/software, computer simulation bioimaging! biomedical imaging, human data, statisticsfoiometry
Institution: Fiscal Year: Department: Project Start: Project End: ICD: IRG:
University of Iowa Iowa City, IA 52242 1999 Radiology 05-JAN-94 30-APR-01 National Cancer Institute ZRG7
)ROJECT TITLE
METABOLISM AND PO2 IN ISCHEMIC AND HYPOXIC BRAIN Grant Number: PI Name:
5R01CA6731-03 Dunn, Jeffery F.
Abstract: DESCRIPTION: The investigator proposes a model
and means for studying hypoxia/ischemia protective interventions. Oxygen levels, phosphate metabolites and cerebral blood flow will be studied in experiments that are as parallel as the measurements allow. The problems in making the different measurements at the same time were handled well in the introduction to the revised application. This is a revised application proposing the use of NMR and EPR to probe metabolic parameters related to ischemic and hypoxic brain. Thesaurus Terms: brain metabolism, cerebral ischemia/hypoxia, oxygen consumption, oxygen tension cerebral circulation, oxygen, oxygen transport, phosphate, respiratory oxygenation electron spin resonance spectroscopy, laboratory rat, nuclear magnetic resonance spectroscopy, oximetry, ultrasound blood flow measurement
Institution:
Dartmouth College Hanover, NH 03755
Fiscal Year: Department: Project Start: Project End: ICD: IRG:
1999 Diagnostic Radiology 01-JUL-97 30-JUN-00 National Cancer Institute BBCB
)ROJECT TITLE
DISPLAYS FOR FULL BREAST DIGITAL MAMMOGRAPHY Grant Number: PI Name:
5R01CA76564-02 Dwyer, Samuel J.
Abstract: DESCRWFION (Adapted from Applicant's Ab-
stract): Full breast digital mammography (FBDM) has begun to fulfill its promise as a better way to perform diagnostic and screening mammography. Digital mammography permits computer image manipulation, compnter-aided diagnosis, and electronic image transfer. These are the successes, but today there is a need for a display modality that is compatible with digital mammograms. There are two possibilities: laser-printed film and the interactive grayscale workstation. Each is a compromise, compared to original FBDM data. The laser-printed film does not permit a full range of computer enhancements, while the grayscale workstation does not present enough images, nor enough spatial resolution. Each choice has serious economic implications. There are many scientific tasks on the road to finding an optimum way to use the displays in mammographic interpretation. The objective of this research is to find a good set of parameters for putting the image in front of the mammographer, to test the diagnostic accuracy of the chosen parameters, comparing the two modalities, to create a model that will enable us to see how the choices of display modality affect examination throughput and, therefore, cost. The applicants proposed to collect 40 normal and 40 abnormal full breast digital FBDM examinations, create protocols for the laser-film printer and the grayscale monitor, and test the protocols with the FBDM examinations. They proposed to develop a model, which includes diagnostic accuracy, throughput and cost, and use the data collected with the marmnographic examination interpretation to refine the model. They would then collect 100 normal and 100 abnormal examinations to test the chosen protocols for the display modalities for their diagnostic accuracy and their throughput rates. Thesaurus Terms: biomedical equipment development,
computer assisted diagnosis, diagnosis design/evaluation, digital imaging, image enhancement, information display, mammography bioimaging/biomedical imaging, human tissue
Institution:
University of Virginia Charlottesville Charlottesville, VA 22903
213
tion methodology/evaluation, diagnosis design/evaluation, diagnosis quality/standard, imaging/visualization, radiodiagnosis computer program/software, computer simulation bioimaging! biomedical imaging, human data, statisticsfoiometry
Institution: Fiscal Year: Department: Project Start: Project End: ICD: IRG:
University of Iowa Iowa City, IA 52242 1999 Radiology 05-JAN-94 30-APR-01 National Cancer Institute ZRG7
)ROJECT TITLE
METABOLISM AND PO2 IN ISCHEMIC AND HYPOXIC BRAIN Grant Number: PI Name:
5R01CA6731-03 Dunn, Jeffery F.
Abstract: DESCRIPTION: The investigator proposes a model
and means for studying hypoxia/ischemia protective interventions. Oxygen levels, phosphate metabolites and cerebral blood flow will be studied in experiments that are as parallel as the measurements allow. The problems in making the different measurements at the same time were handled well in the introduction to the revised application. This is a revised application proposing the use of NMR and EPR to probe metabolic parameters related to ischemic and hypoxic brain. Thesaurus Terms: brain metabolism, cerebral ischemia/hypoxia, oxygen consumption, oxygen tension cerebral circulation, oxygen, oxygen transport, phosphate, respiratory oxygenation electron spin resonance spectroscopy, laboratory rat, nuclear magnetic resonance spectroscopy, oximetry, ultrasound blood flow measurement
Institution:
Dartmouth College Hanover, NH 03755
Fiscal Year: Department: Project Start: Project End: ICD: IRG:
1999 Diagnostic Radiology 01-JUL-97 30-JUN-00 National Cancer Institute BBCB
)ROJECT TITLE
DISPLAYS FOR FULL BREAST DIGITAL MAMMOGRAPHY Grant Number: PI Name:
5R01CA76564-02 Dwyer, Samuel J.
Abstract: DESCRWFION (Adapted from Applicant's Ab-
stract): Full breast digital mammography (FBDM) has begun to fulfill its promise as a better way to perform diagnostic and screening mammography. Digital mammography permits computer image manipulation, compnter-aided diagnosis, and electronic image transfer. These are the successes, but today there is a need for a display modality that is compatible with digital mammograms. There are two possibilities: laser-printed film and the interactive grayscale workstation. Each is a compromise, compared to original FBDM data. The laser-printed film does not permit a full range of computer enhancements, while the grayscale workstation does not present enough images, nor enough spatial resolution. Each choice has serious economic implications. There are many scientific tasks on the road to finding an optimum way to use the displays in mammographic interpretation. The objective of this research is to find a good set of parameters for putting the image in front of the mammographer, to test the diagnostic accuracy of the chosen parameters, comparing the two modalities, to create a model that will enable us to see how the choices of display modality affect examination throughput and, therefore, cost. The applicants proposed to collect 40 normal and 40 abnormal full breast digital FBDM examinations, create protocols for the laser-film printer and the grayscale monitor, and test the protocols with the FBDM examinations. They proposed to develop a model, which includes diagnostic accuracy, throughput and cost, and use the data collected with the marmnographic examination interpretation to refine the model. They would then collect 100 normal and 100 abnormal examinations to test the chosen protocols for the display modalities for their diagnostic accuracy and their throughput rates. Thesaurus Terms: biomedical equipment development,
computer assisted diagnosis, diagnosis design/evaluation, digital imaging, image enhancement, information display, mammography bioimaging/biomedical imaging, human tissue
Institution:
University of Virginia Charlottesville Charlottesville, VA 22903
213