Prostatic Acid Phosphatase in Serum and Bone Marrow in Patients With Prostatic Carcinoma

413 P. I-L of lvlinneVeterans Administration MedHILL AND

it(W!OlC)f{Y

and

Amer. J. Roentgen., 141: 351-354

1983

Computerized tomography ,(CT) was r-1,nn>rl to conventional noninvasive diagnostic methods in the detection of extracapsular tumor in 30 patients with histologically prostatic carcinoma. AH patients underwent conventional diagnostic tests, consisting of chest radiograph, serum acid phosphatase, radionuclide bone scans with correlative film skeletal surveys and excretory urograms. CT detected extracapsular tumor in 14 per cent of the patients with negative conventional diagnostic studies and confirmed the presence of tumor spread in 43 per cent with positive conventional studies. The sensitivity in detecting extracapsular tumor spread was conventional studies to 59 per increased from 41 per cent cent when CT was added. However, conventional studies were able to detect histologically proved tumor in 32 per cent of the patients with negative CT findings. This study shows that addition of CT to the conventional methods reduces understagwhen the conventional studies are negative, while it confirms the presence of and localizes tumor spread when the conventional studies are nn,,,tmo The use of CT for staging of prostatic cancer does not replace the conventional noninvasive methods but can complement especially in µac,s,Hc.c,Without advanced metastatic disease. P. T. A.. 2 figures, 2 tables, 23 references Prostatic Acid Phosphata§e in Serum and Bone Marrow in Patients With P:rostatic Carcinoma 0. KAALHUS AND A. ENGESET, lii?m,atolciJ!;y

Brit. J. UroL, 55: 306-311

Department of Bioand Lymphology, The

1983

The aim of this was to determine the clinical cance of radioimmunological detection of vw·r. 0 «> 1i"' acid phatase in serum and bone marrow of n,atum1·." the prostate. Of 61 with cent had elevated levels of serum acid ,_,uv01e,uue,,~v determined serun1 acid 38 per cent of th;c; same determined r&··

detetmined serum acid onos1on.a-u1se 'N!IB elevatsd in 12, whereas bone marrow acid phosphatase and enzymatically determined serum pr,:ist.ati,c tase wern increased only in approximately half of the patients. In a control grnup the upper reference limit of bone marrow acid phosphatase determined by :radioimmunoassay was increased significantly above that obtained by serum analyses. The authors believe that these findings indicate that nonprostatic acid phosphatases (possibly from bone marrow cells) cross-react with prostatic acid phosphatase in an unpredictable manner, even when a specific radioimmunoassay is used. They conclude that in patients with metastatic carcinoma of the prostate, the results of bone marrow acid phosphatase determinations analyzed by radioimmunoassay seem to lack diagnostic and/or prognostic information additional to that obtain-

able E. n W. 3

3 tables, 18 references

of T:ram;cutaneom, A§piration illJ! the Definitive Am,em,ment of Nodal involvement i:n Prostatic Ca:rcinoma F. Prncwu, Pathology, S. Chiara rH,,;;µiiai,

L. LUCIANI AND

of

and

Brit, J, Urol., 55: 321-325 (June) 1983 While acknowledging the complications of pelvic lymphadenectomy and the fact that it is the most accurate procedure to assess the stage of prostatic cancer and to define those patients who may require extended irradiation, hormonal manipulation or chemotherapy, the authors believe that transcutaneous fluofine needle aspiration biopsy of pelvic lymph nodes is an innocuous and highly reliable technique to determine nodal metastasis. They believe that the procedure enhances and extends the usefulness of lymphangiography in predicting nodal involvement. On the basis of results obtained in 24 patients with carcinoma of the prostate, the authors suggest transcutaneous fluoroscopyguided fine needle """"'sn.11 biopsy as a satisfactory alternative to pelvic lyrnpha.ctenect
w. 3

2 tables, 23 references

Do Pro,;;tatic Biopsies 12 Nfondts OJ!' It.fore After External bTadiation fo:r Adem:;can::im:,ma, Stage HI, Pn:;dict Lm1g-Te:rm Survival

Between 1970 and !t6 ,,a,a,,,w,0 with clinical stage IH or C disease vve:re treated 1Nith external bearrr id,ho c,cnu conof 6,500 to 7,000 &. cobalt source, Ofthese 7

for tumor were considered with those who had positive n,rm"''"""' for ,.m:>.u1~w:,rn~.v The authors used survival as the end point in the study, since tumor for clinical recurrence. were unable to assess the Of all biopsies performed 24 to 36 months after completion of irradiation 19 per cent were positive for tumor. This rate decreased to 15 per cent at 42 to 73 months after the completion of irradiation, These data were compared to the 66 per cent positive biopsies performed only 3 to 6 months after irradiation therapy. Survival curves through 10 years were identical for patients with positive or negative biopsies ~2 years after the completion of treatment. The authors believe that positive prostatic biopsies within 2 to 3 years after completion of radiotherapy represent cells that