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Quantitative EEG in subjects with mild cognitive impairment carriers and no carriers of allele σ4 of apolipoprotein E
Abstracts of the 5th Latin American Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S143–S177
P01.29 Quantitative EEG in subjects with mild cognitive impairment carriers and no carriers of allele ε4 of apolipoprotein E R. Rodríguez-Valdés, V. Manrique, A. Amador, L.G. García, Y. Fernández, L. López Canovas, A.M. Riverón, B. León Cuban Neurosciences Center, Cubanacán, Playa, Havana, Cuba Purpose: The mild cognitive impairment (MCI) is considered as a prodromic stage of Alzheimer’s disease. In the preset study we evaluate the sensitive of quantitative EEG to detect functional changes in subjects with MCI. Methods: We evaluate 41 subjects with diagnosed of MCI. The results of quantitative analysis broad band spectral parameter and narrow band were comparing with normative base of data. The group of subjects was divided in carriers and not carriers of allele ε4 of Apolipoprotein E (ApoE). For compare the groups we used a student’s t test and analysis of variance. Results: The subject’s carriers of ApoE ε4 have a significant increase of energy in left temporal region in theta-alpha frequencies. The analysis of variance showed that subjects with a few years of education and carriers of ε4 showed a significant increase of energy in theta-alpha frequencies in left temporal region. Conclusions: The subjects with MCI and carriers of allele ε4 and a few years of education have early alteration in the spectral. Could be interesting investigate if different subtypes of MCI have a same spectral alteration. Relevance: The results of spectral EEG analysis in MCI can be affected by different biological and not biological variables.
P01.30 Postsurgical cognitive changes in temporal lobe epilepsy and their relationship with EEG changes D. Cibils, J.C. Alcántara, A. Silveira, J. Ardanaz, A. Barros, L. Cristino Epilepsy Surgery Program, Neurological Institute, Hospital de Clinicas, Montevideo, Uruguay Objective: To study post-surgical cognitive changes related to pre-surgical cognitive evaluation and it relationships with new EEG findings. Methods: We studied 15 patients with intractable temporal lobe epilepsy that were admitted for study into the Epilepsy Surgery Program of the Hospital de Clinicas. 4/15 were operated of their right temporal lobes and 11/15 on their left one. Neuropsychological evaluation included verbal and visual memory and executive function tests. The EEGs were obtained during awake plus activation with hyperpnea and sleep. We performed two EEG by patient with a twelve months interval, the first one 8 months after surgery. Results: 5 of 15 patients showed a post-surgery cognitive evaluation equal or better than previously. 10 presented low performance only in memory tests. Unchanged cognitive tests or mild improvement were observed in 2/4 patients with right temporal lobe surgery and 3/11 with left temporal surgery EEG evaluation in 5 patients without cognitive deficit showed that 3 presented only interictal epileptogenic activity. Of 10 patients with cognitive deficits, 9 presented focal EEG slowing and 6 interictal epileptogenic activity also. In the follow up only 1/5 patient without cognitive deficit and 5/10 patients with cognitive deficit had seizures. Conclusions: Two thirds, (10/15) of surgical treated temporal lobe epilepsy patients showed new memory deficits. Additional memory impairment was only found associated with new focal EEG slowing. Post-surgical seizures were most common in patients with new cognitive deficits.
P01.31 Quantitative cerebral activity of infants with a history of neonatal ischemic-hypoxic encephalopathy L.M. Cordero-Guzmán, G. Romero-Esquiliano Neurophysiology Department, Instituto Nacional de Pediatría, Mexico City, Mexico Quantitative analysis of cerebral electric activity (CEA) renders valuable information on the organization of cerebral rhythms in the early stages of life. The purpose of this paper is to describe the CEA with respect to frequency as well as of absolute and relative power of nine cortical areas of infants with a history of ischemic hypoxic encephalopathy (IHE) during their first
S165
year of life and its influence on neurologic development at two years of age. Methods. Two-minute simples of sleeping CEA were analyzed in 17 infants, one to twelve months of age who had a history of IHE. Absolute and relative power average values were obtained from nine areas: right and left frontal (RF, LF), anterior, central and posterior sagital (AS, CS, PS), right and left temporal (RT, LT), right and left occipital (RO, LO). This information was also analyzed with respect to gender, encephalopathy, neurological syndrome and with the presence of sequelae at two years of age. Results. There was an association with: A) Disautonomic and hypertonic syndrome which included 1. Delta relative power in the temporal, central and occipital areas. 2. Alfa relative power in the temporal areas. 3. Beta2 absolute power in the frontal and central areas. 4. Beta2 relative power in the frontal, central, left temporal and occipital areas. B) Neuroconduct and development sequelae with Beta2 absolute power in the left temporal and the occipital areas. C) Severe and moderate degree sequelae with Beta2 frequency in the right frontal area (p<0.01). Conclusions. An impact was seen in the dysautonomic and hypertonic syndrome on the CEA in cases of absolute and relative Beta2 power both focally and in the nine cortical areas which could suggest the framework of neurological behavior of infants with a history of IHE in future stages of life.
P01.32 A focus on neurophysiology in psychiatric patients A. Lapinet Suárez del Villar 1 , L. Valdés Urrutia Lourdes 2 of Medicine and Complexity, Medical University of Camaguey, Cuba; 2 Department Clínical Neuroimage Cuban Neurociencies Center, Cuba
1 Department
One of the purposes in clinical neurophysiology is the way it can contribute in a good manner to diagnosis in psychiatry diseases, one of the ways, is the potentiation of the disease in the field of neuroimages, that could bring the spatial resolution, that is the truth to proof the checking of temporalspatial methods, such as the electrical tomography of the brain (ETC). Three patients with diagnosis in psychiatry pathologies were examined (one with headache an suicidal ideas, another with symptoms of obsession and one with schizophrenia). We found in the electroencephalogram (EEG) slow electrical activity theta type, from anterolateral regions to back region to the left side. The calculation of the inverse solution (IS) shows a significant increase of energy on these regions for bands delta-theta and topographic localization of these. It is evident asymmetry of the lateral ventricles. The neuropsychological and neurophysiological evaluation, as tools for mixing the cortico-subcorticals irritability with the imagenological founding, on psychiatry pathologies and localization of possible cortical generator for these irritabilities, is valid for the prognosis of the evolution and diagnosis of some psychiatric diseases. Keywords: EEG; TAC; ETC; Schizophrenia
P01.33 Volumetry and EEG in patient with refractory mesial temporal lobe epilepsy O. Trápaga, L.M. Morales, R. Rodríguez, A. Sánchez, M. Zaldivar Departamento de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica de Cuba, La Habana, Cuba, Cuba The aim of this study was to evaluate the contribution of MRI volumetric analysis and EEG for the evaluation of patients with refractory MTLE candidates to surgery. Twelve volumetric studies were carried out using MRI and EEG from 6 patients with MTLE. For the study of the epileptogenic lesion and volume dried up a MRI quantitative analysis was implemented. Frequency of presurgery epileptic interictal discharges (FED/min) in the EEG was calculated in the irritative region. Clinical evaluations were carried out 1, 6 and 12 months after surgery. Presurgical volumetric analysis showed that inferior temporal lobes and parahippocampal cortex volumes were significant diminished ipsilateral to the epileptogenic area. However we didn’t find any reduction in hippocampus area as has been previously reported. FED in the irritative area diminished 6 months after temporal lobectomy. One year after surgery there was a negative correlation between FED and dried up volume percentage of parahippocampal cortex and inferior temporal lobe. We concluded that in patients with MTLE, besides the referred hippocampus reductions, other structures in the mesial temporal lobe are also affected.
P01.29 Quantitative EEG in subjects with mild cognitive impairment carriers and no carriers of allele ε4 of apolipoprotein E R. Rodríguez-Valdés, V. Manrique, A. Amador, L.G. García, Y. Fernández, L. López Canovas, A.M. Riverón, B. León Cuban Neurosciences Center, Cubanacán, Playa, Havana, Cuba Purpose: The mild cognitive impairment (MCI) is considered as a prodromic stage of Alzheimer’s disease. In the preset study we evaluate the sensitive of quantitative EEG to detect functional changes in subjects with MCI. Methods: We evaluate 41 subjects with diagnosed of MCI. The results of quantitative analysis broad band spectral parameter and narrow band were comparing with normative base of data. The group of subjects was divided in carriers and not carriers of allele ε4 of Apolipoprotein E (ApoE). For compare the groups we used a student’s t test and analysis of variance. Results: The subject’s carriers of ApoE ε4 have a significant increase of energy in left temporal region in theta-alpha frequencies. The analysis of variance showed that subjects with a few years of education and carriers of ε4 showed a significant increase of energy in theta-alpha frequencies in left temporal region. Conclusions: The subjects with MCI and carriers of allele ε4 and a few years of education have early alteration in the spectral. Could be interesting investigate if different subtypes of MCI have a same spectral alteration. Relevance: The results of spectral EEG analysis in MCI can be affected by different biological and not biological variables.
P01.30 Postsurgical cognitive changes in temporal lobe epilepsy and their relationship with EEG changes D. Cibils, J.C. Alcántara, A. Silveira, J. Ardanaz, A. Barros, L. Cristino Epilepsy Surgery Program, Neurological Institute, Hospital de Clinicas, Montevideo, Uruguay Objective: To study post-surgical cognitive changes related to pre-surgical cognitive evaluation and it relationships with new EEG findings. Methods: We studied 15 patients with intractable temporal lobe epilepsy that were admitted for study into the Epilepsy Surgery Program of the Hospital de Clinicas. 4/15 were operated of their right temporal lobes and 11/15 on their left one. Neuropsychological evaluation included verbal and visual memory and executive function tests. The EEGs were obtained during awake plus activation with hyperpnea and sleep. We performed two EEG by patient with a twelve months interval, the first one 8 months after surgery. Results: 5 of 15 patients showed a post-surgery cognitive evaluation equal or better than previously. 10 presented low performance only in memory tests. Unchanged cognitive tests or mild improvement were observed in 2/4 patients with right temporal lobe surgery and 3/11 with left temporal surgery EEG evaluation in 5 patients without cognitive deficit showed that 3 presented only interictal epileptogenic activity. Of 10 patients with cognitive deficits, 9 presented focal EEG slowing and 6 interictal epileptogenic activity also. In the follow up only 1/5 patient without cognitive deficit and 5/10 patients with cognitive deficit had seizures. Conclusions: Two thirds, (10/15) of surgical treated temporal lobe epilepsy patients showed new memory deficits. Additional memory impairment was only found associated with new focal EEG slowing. Post-surgical seizures were most common in patients with new cognitive deficits.
P01.31 Quantitative cerebral activity of infants with a history of neonatal ischemic-hypoxic encephalopathy L.M. Cordero-Guzmán, G. Romero-Esquiliano Neurophysiology Department, Instituto Nacional de Pediatría, Mexico City, Mexico Quantitative analysis of cerebral electric activity (CEA) renders valuable information on the organization of cerebral rhythms in the early stages of life. The purpose of this paper is to describe the CEA with respect to frequency as well as of absolute and relative power of nine cortical areas of infants with a history of ischemic hypoxic encephalopathy (IHE) during their first
S165
year of life and its influence on neurologic development at two years of age. Methods. Two-minute simples of sleeping CEA were analyzed in 17 infants, one to twelve months of age who had a history of IHE. Absolute and relative power average values were obtained from nine areas: right and left frontal (RF, LF), anterior, central and posterior sagital (AS, CS, PS), right and left temporal (RT, LT), right and left occipital (RO, LO). This information was also analyzed with respect to gender, encephalopathy, neurological syndrome and with the presence of sequelae at two years of age. Results. There was an association with: A) Disautonomic and hypertonic syndrome which included 1. Delta relative power in the temporal, central and occipital areas. 2. Alfa relative power in the temporal areas. 3. Beta2 absolute power in the frontal and central areas. 4. Beta2 relative power in the frontal, central, left temporal and occipital areas. B) Neuroconduct and development sequelae with Beta2 absolute power in the left temporal and the occipital areas. C) Severe and moderate degree sequelae with Beta2 frequency in the right frontal area (p<0.01). Conclusions. An impact was seen in the dysautonomic and hypertonic syndrome on the CEA in cases of absolute and relative Beta2 power both focally and in the nine cortical areas which could suggest the framework of neurological behavior of infants with a history of IHE in future stages of life.
P01.32 A focus on neurophysiology in psychiatric patients A. Lapinet Suárez del Villar 1 , L. Valdés Urrutia Lourdes 2 of Medicine and Complexity, Medical University of Camaguey, Cuba; 2 Department Clínical Neuroimage Cuban Neurociencies Center, Cuba
1 Department
One of the purposes in clinical neurophysiology is the way it can contribute in a good manner to diagnosis in psychiatry diseases, one of the ways, is the potentiation of the disease in the field of neuroimages, that could bring the spatial resolution, that is the truth to proof the checking of temporalspatial methods, such as the electrical tomography of the brain (ETC). Three patients with diagnosis in psychiatry pathologies were examined (one with headache an suicidal ideas, another with symptoms of obsession and one with schizophrenia). We found in the electroencephalogram (EEG) slow electrical activity theta type, from anterolateral regions to back region to the left side. The calculation of the inverse solution (IS) shows a significant increase of energy on these regions for bands delta-theta and topographic localization of these. It is evident asymmetry of the lateral ventricles. The neuropsychological and neurophysiological evaluation, as tools for mixing the cortico-subcorticals irritability with the imagenological founding, on psychiatry pathologies and localization of possible cortical generator for these irritabilities, is valid for the prognosis of the evolution and diagnosis of some psychiatric diseases. Keywords: EEG; TAC; ETC; Schizophrenia
P01.33 Volumetry and EEG in patient with refractory mesial temporal lobe epilepsy O. Trápaga, L.M. Morales, R. Rodríguez, A. Sánchez, M. Zaldivar Departamento de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica de Cuba, La Habana, Cuba, Cuba The aim of this study was to evaluate the contribution of MRI volumetric analysis and EEG for the evaluation of patients with refractory MTLE candidates to surgery. Twelve volumetric studies were carried out using MRI and EEG from 6 patients with MTLE. For the study of the epileptogenic lesion and volume dried up a MRI quantitative analysis was implemented. Frequency of presurgery epileptic interictal discharges (FED/min) in the EEG was calculated in the irritative region. Clinical evaluations were carried out 1, 6 and 12 months after surgery. Presurgical volumetric analysis showed that inferior temporal lobes and parahippocampal cortex volumes were significant diminished ipsilateral to the epileptogenic area. However we didn’t find any reduction in hippocampus area as has been previously reported. FED in the irritative area diminished 6 months after temporal lobectomy. One year after surgery there was a negative correlation between FED and dried up volume percentage of parahippocampal cortex and inferior temporal lobe. We concluded that in patients with MTLE, besides the referred hippocampus reductions, other structures in the mesial temporal lobe are also affected.