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Re: Obesity, Male Infertility, and the Sperm Epigenome
MALE INFERTILITY
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Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28373640 Editorial Comment: Obesity likely impairs spermatogenesis through pathways that are related to and independent of endocrine mechanisms, although exactly which and how are not yet clear. These investigators demonstrated that a high fat diet affecting spermatogenesis alters interleukin-1beta and testosterone in mice, and interestingly that the direction of the effects is different depending on whether the diet is given to immature or mature mice. While mice are not men, these results suggest a role of interleukin-1beta in the relationship between obesity and male reproductive dysfunction, and that the relationship depends on the timing of the onset of obesity. Craig Niederberger, MD
Re: Obesity, Male Infertility, and the Sperm Epigenome J. R. Craig, T. G. Jenkins, D. T. Carrell and J. M. Hotaling Division of Urology, Department of Surgery, Center for Men’s Health and Reconstructive Surgery, and Department of Obstetrics and Gynecology, University of Utah and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah Fertil Steril 2017; 107: 848e859. doi: 10.1016/j.fertnstert.2017.02.115
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28366411 Editorial Comment: Obesity is reaching epidemic proportions and clearly affects male reproduction. But how? One way that does not involve directly changing DNA and yet can be passed from generation to generation includes mechanisms for how genes are turned on and off, what is referred to as epigenetics. This excellent review details the various means by which epigenetics can serve as the bridge between obesity and male fertility and is well worth reading. We can expect much more from the complex science of epigentics in the future, and understanding how obesity harms male reproduction is a start. Craig Niederberger, MD
Re: Predictive Value of Different Covariates Influencing Pregnancy Rate following Intrauterine Insemination with Homologous Semen: A Prospective Cohort Study A. Thijssen, A. Creemers, W. Van der Elst, E. Creemers, E. Vandormael, N. Dhont and W. Ombelet Department of Obstetrics and Gynecology, Genk Institute for Fertility Technology, Ziekenhuis Oost-Limburg, Genk, Department of Physiology, Hasselt University, Hasselt and Center for Statistics, Hasselt University, Diepenbeek, Belgium Reprod Biomed Online 2017; 34: 463e472. doi: 10.1016/j.rbmo.2017.01.016
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28285953 Editorial Comment: Intrauterine insemination outcomes are an excellent way to understand what clinical features are truly important in fertility as the pathway for reproduction is controlled up to the uterus. These investigators built univariate and multivariate models correlating various male and female clinical features to intrauterine insemination outcomes, and in the multivariate model 3 features stood out: female age, male smoking and whether the infertility was primary or secondary. That male smoking was such a strongly correlated variant to intrauterine insemination outcomes gives much ammunition to the urologist in counseling men to stop smoking to improve fertility. Craig Niederberger, MD
Dochead: Urological Survey
LIT 5.5.0 DTD JURO14979_proof 9 September 2017 8:42 am EO:
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115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28373640 Editorial Comment: Obesity likely impairs spermatogenesis through pathways that are related to and independent of endocrine mechanisms, although exactly which and how are not yet clear. These investigators demonstrated that a high fat diet affecting spermatogenesis alters interleukin-1beta and testosterone in mice, and interestingly that the direction of the effects is different depending on whether the diet is given to immature or mature mice. While mice are not men, these results suggest a role of interleukin-1beta in the relationship between obesity and male reproductive dysfunction, and that the relationship depends on the timing of the onset of obesity. Craig Niederberger, MD
Re: Obesity, Male Infertility, and the Sperm Epigenome J. R. Craig, T. G. Jenkins, D. T. Carrell and J. M. Hotaling Division of Urology, Department of Surgery, Center for Men’s Health and Reconstructive Surgery, and Department of Obstetrics and Gynecology, University of Utah and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah Fertil Steril 2017; 107: 848e859. doi: 10.1016/j.fertnstert.2017.02.115
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28366411 Editorial Comment: Obesity is reaching epidemic proportions and clearly affects male reproduction. But how? One way that does not involve directly changing DNA and yet can be passed from generation to generation includes mechanisms for how genes are turned on and off, what is referred to as epigenetics. This excellent review details the various means by which epigenetics can serve as the bridge between obesity and male fertility and is well worth reading. We can expect much more from the complex science of epigentics in the future, and understanding how obesity harms male reproduction is a start. Craig Niederberger, MD
Re: Predictive Value of Different Covariates Influencing Pregnancy Rate following Intrauterine Insemination with Homologous Semen: A Prospective Cohort Study A. Thijssen, A. Creemers, W. Van der Elst, E. Creemers, E. Vandormael, N. Dhont and W. Ombelet Department of Obstetrics and Gynecology, Genk Institute for Fertility Technology, Ziekenhuis Oost-Limburg, Genk, Department of Physiology, Hasselt University, Hasselt and Center for Statistics, Hasselt University, Diepenbeek, Belgium Reprod Biomed Online 2017; 34: 463e472. doi: 10.1016/j.rbmo.2017.01.016
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28285953 Editorial Comment: Intrauterine insemination outcomes are an excellent way to understand what clinical features are truly important in fertility as the pathway for reproduction is controlled up to the uterus. These investigators built univariate and multivariate models correlating various male and female clinical features to intrauterine insemination outcomes, and in the multivariate model 3 features stood out: female age, male smoking and whether the infertility was primary or secondary. That male smoking was such a strongly correlated variant to intrauterine insemination outcomes gives much ammunition to the urologist in counseling men to stop smoking to improve fertility. Craig Niederberger, MD
Dochead: Urological Survey
LIT 5.5.0 DTD JURO14979_proof 9 September 2017 8:42 am EO:
177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238