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291 metastatic disease; one received pre-irradiation vincristine, 17 were treated with concomitant radiotherapy and cyclophosphamide. From 1981 to the...

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291 metastatic disease; one received pre-irradiation vincristine, 17 were treated with concomitant radiotherapy and cyclophosphamide. From 1981 to the present, four patients received pre-irradiation and one received post-irradiation cisplatin-bleomycin, vinblastine (CDDP-BLEO-VLB) regimens. Four patients received radiotherapy alone. All patients completed chemotherapy and radiation therapy. Twenty-five patients had complete tumor clearance and four had a partial response. Overall, 14 patients are alive continuously without relapse with a median follow-up of 11 years (range 4 to 20). All patients who relapsed did so within 2 years postirradiation. Four patients failed locally - all had advanced (T,-T,) local disease at presentation and three of the failures were at the margin of treatment portals. Thirteen patients failed with distant metastasis. The major prognostic factor in these patients was the local extent of disease. Among the 27 M, patients, all ten patients with T,_, tumors are disease-free, whereas four of nine patients with Ts and two of eight patients with T4 tumors are alive and well. In the 16 patients who are long term survivors, eight have mild neck atrophy, two have shortening of the clavicles; except for one patient who required a neck brace for shoulder drop, all had normal function. Among the seven pre-pubertal patients who are long term survivors, three have decreased growth, including one with documented decreased growth hormone. Two patients developed irregular menstrual periods. One patient developed hypothyroidism, and another had a thyroid adenoma. One patient developed bleomycin pneumonitis and one patient who received pre- and post-irradiation chemotherapy died of laryngeal edema and fibrosis, in remission. Radiotherapy is the major modality in the therapy of childhood nasopharyngeal carcinoma. The long term toxicity of radiotherapy plus or minus chemotherapy is acceptable. In early stage tumors (T,_2, N,_,), radiotherapy alone (55-60 Gy) appears to be sufficient for disease control. The more advanced stage tumors require aggressive chemotherapy. since distant failure is the major problem. How accurate is chest radiography in the diagnosis of tracheobronchial foreign bodies in children? Svedstrom, E., Pubakka, H. and Kero, P. Pediatr. Radial. (1989) 19/8 (521-522) The radiographic and endoscopic findings of 83 consecutive patients with suspected foreign body inhalation into the tracheobronchial tree were compared and the accuracy of chest radiography estimated. Typical radiologic signs of FB aspiration, such as localized air trapping, atelectasis infection occurred on radiographs of patients with and without FB. Twenty-four percent of patients endoscopically verified FB had no abnormalities on chest radiography. In an analysis of radiographs 83 consecutive patients, in which the prevalence of FB aspiration was 41%, the diagnostic accuracy 67’%, sensitivity 68% and specificity 67%. Plain film radiology alone is not a sufficiently sensitive specific method for the diagnosis of FB aspiration.

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Hearing loss in tympanosclerosis caused by grommets Tos, M. and Stangerup, S.-E. Arch. Otolatyngol. Head Neck Surg. (1989) 115/8 (931-935) The aim of the present study was to determine the degree of hearing impairment caused by tympanosclerosis of the eardrum as a result of grommet insertion. During the period 1977 to 1978 we treated 146 children who had bilateral secretory otitis with adenoidectomy, insertion of a ventilation tube on the right side, and myringotomy on the left. The children were reexamined 2 to 3 years and again 6 to 7 years postoperatively, and hearing was evaluated at 250, 1000, and 4000 Hz. Tympanosclerosis was demonstrated in 59% of the children on the side with grommet insertion compared with 13% in the contralateral ear. Hearing was slightly inferior in ears with tympanosclerosis compared with ears without tympanosclerosis, but the difference was small and nonsignificant. The hearing impairment caused by tympanosclerosis was less than 0.5 dB, which is inconsequential and cannot serve as an argument against the use of ventilation tubes. However, further studies with longer observation periods are warranted.

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291 Wallesch B.; Johannsen H.S.; On the aetiology of sulcus glottidis; LARYNGORHINO- OTOL.; 68/9 (506-509)/1989/ Warren D.W.; Dalston R.M.; Morr K.E.; Hairfield W.M.; Smith L.R.; The speech regulating system: Temporal and aerodynamic responses to velopharyngeal inadequacy; J. SPEECH HEAR. RES.: 32;3 (566-575)/1989/ Warren SF.; Bambara L.M.; An experimental analysis of milieu language intervention: Teaching the action-object form; J. SPEECH HEAR. DISORD.; 54/3 (448-461)/1989/ Watanabe A.; Koshinami M.; Clinical studies on cefpodoxime proxetil in the pediatric fields: JPN. J. ANTIBIOT.; 42/7 (1471-1476)/1989/ Watkin P.M.; Otological disease in Turner’s syndrome; J. LARYNGOL. OTOL.; 103/8 (731-738)/1989/ Wild N.J.; Sheppard S.; Smithells R.W.; Holzel H.; Jones G.; Onset and severity of hearing loss due to congenital rubella infection; ARCH. DIS. CHILD.; 64/9 (1280-1283)/1989/ Wouters B.; Van Overbeek J.J.M.; Buiter C.T.; Hoeksema P.E.; Laser surgery in lingual tonsil hyperplasia: CLIN. OTOLARYNGOL. ALLIEDSCI.; 14/4 (291-296)/1989/ Yellin M.W.: Jerger J.; Fifer R.C.; Norms for disproportionate loss in speech intelligibility: EAR HEAR.: 10/4 (231-234)/1989/ Yoder P.J.; Maternal question use predicts later language development in specific-language-disordered children; J. SPEECH HEAR. DISORD.; 54/3 (347-355)/1989/ Zargar S.A.; Kochhar R.; Nagi B.; Mehta S.; Mehta SK.; Ingestion of corrosive acids: Spectrum of injury to upper gastrointestinal tract and natural history: GASTROENTEROLOGY: 97/3 (702-707)/1989/ Zebrowski P.M.; Conture E.G.; Judgments of disfluency by mothers of stuttering and normally fluent children; J. SPEECH HEAR. RES.; 32/3 (625-634)/1989/ Zonneveld F.W.; Lobregt S.; Van der Meulen J.C.H.; Vaandrager J.M.; Three-dimensional imaging in craniofacial surgery: WORLD J. SURG.; 13/4 (328-342)/1989/