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Reorganization of cholinergic-dopaminergic interactions in the striatum induced by Pavlovian drug-conditioning following denervation
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References Abercrombie, E.D., Bona& A.E., and Zigmond, M.J., 1990, Brain Res., in press. Bemheimer, H., Birkmayer, W., Homykiewicz, 0.. Jellinger, K., Seitelberger, F.. 1973, J Neurol. Sci. 20,415. Keefe, K.A., Stricker, E.M., Zigmond, M.J., and Abercrombie, E.D., 1989, Sot. Neurosci. Abstr. 15. 558. MacKenzie, R.G., Srachowiak, M. and Zigmond, M.J., 1989, Eur. J. Pharmacol., 168.43. Orr, W.B., Gardiner, T.W., Stricker, E.M., Zigmond, M.J., and Berger, T.W., 1986, Brain Res. 376, 20. Schwab, R.S. and Zieper, I., 1965, Psychiat. Neurol., Base] 150, 345. Snyder, A.M., Snicker, E.M., and Zigmond, M.J., 1985, AM. Neurol. 18,544. Stachowiak, M.K., Keller, R.W. Jr., Stricker, E.M., and Zigmond, M.J., 1987, J. Neurosci. 7, 1648. Stricker, E.M. and Zigmond, M.J., 1974, J. Comp. Physiol. Psychol. 86, 973. Zigmond, M.J., Acheson, AL., Stachowiak, M.K, and Stricker, E.M., 1984, Arch. Neurol. 41, 856.
eorganization of choline
gic interactions in t Carey, R.J.
VA Medical Cenier and SUNY
_Health Science Center, Syracuse, NY,
U.S.A.
Procedures designed to facilitate recovery from brain injury primarily involve relearning and pharmacological treatment. The relearning aspect of recovery is generally considered to involve neuroplasticity processes whereas drug treatments are simply seen as involving a modulatory effect on response mechanisms. Basically, relearning involves the development of new stimulus-response connections which can emerge through spontaneous behavior interactions with the environment or through explicit experimenter intervention with Pavlovian or operant conditioning methodologies. Stimulus-response connections developed between drug treatments have rarely been considered. Many recent studies, however, have demonstrated that centrally active drugs have interoceptive stimulus properties as well as response effects. Furthermore, these stimulus and response aspects do not always co-vary in magnitude so that some drugs can have strong stimulus effects and weak response effects and vice versa. This feature of co-administered drugs creates the possibility for stimulus properties of one drug to become associated with the response properties of another drug. Such stimulus-response associations between drugs can lead to neuronal plasticity changes that may be presumed to underlie postlesion relearning. The present report will outline evidence in support of this possibility.
pziq anipulation of survival and function of cholinergic ne neurotrophic factors. ehavioral cons Hefti, F., Junard,
E.O., Montero,
C.N. and Will, B.
Andrus Gerontology Center, Uniuersity of Southern California,
Los Angeles, Calijornia,
U.S.A.
and DPpartement de Neurophysiologie et Biology des Comportements, Centre de Neurochimie du CNRS.
Strasbourg
France
The finding that adult choline@ neurons express NGF receptors and that this population of cells is involved in memory function and degenerates in human Alzheimer’s disease prompted us to study the effects of NGF in animals with experimental lesions of forebrain cholinergic neurons. NGF was given intraventricularly to adult rats with partial transections of the fimbria which result in a partial lesion of the septo-hippocampal pathway. Partial rather than complete lesions of the fimbria were chosen to be able to study effects of NGF or other neurotrophic factors on neuronal cell bodies in the septum as well as responses of axons in the hippocampus. Partial lesions leave a natural
References Abercrombie, E.D., Bona& A.E., and Zigmond, M.J., 1990, Brain Res., in press. Bemheimer, H., Birkmayer, W., Homykiewicz, 0.. Jellinger, K., Seitelberger, F.. 1973, J Neurol. Sci. 20,415. Keefe, K.A., Stricker, E.M., Zigmond, M.J., and Abercrombie, E.D., 1989, Sot. Neurosci. Abstr. 15. 558. MacKenzie, R.G., Srachowiak, M. and Zigmond, M.J., 1989, Eur. J. Pharmacol., 168.43. Orr, W.B., Gardiner, T.W., Stricker, E.M., Zigmond, M.J., and Berger, T.W., 1986, Brain Res. 376, 20. Schwab, R.S. and Zieper, I., 1965, Psychiat. Neurol., Base] 150, 345. Snyder, A.M., Snicker, E.M., and Zigmond, M.J., 1985, AM. Neurol. 18,544. Stachowiak, M.K., Keller, R.W. Jr., Stricker, E.M., and Zigmond, M.J., 1987, J. Neurosci. 7, 1648. Stricker, E.M. and Zigmond, M.J., 1974, J. Comp. Physiol. Psychol. 86, 973. Zigmond, M.J., Acheson, AL., Stachowiak, M.K, and Stricker, E.M., 1984, Arch. Neurol. 41, 856.
eorganization of choline
gic interactions in t Carey, R.J.
VA Medical Cenier and SUNY
_Health Science Center, Syracuse, NY,
U.S.A.
Procedures designed to facilitate recovery from brain injury primarily involve relearning and pharmacological treatment. The relearning aspect of recovery is generally considered to involve neuroplasticity processes whereas drug treatments are simply seen as involving a modulatory effect on response mechanisms. Basically, relearning involves the development of new stimulus-response connections which can emerge through spontaneous behavior interactions with the environment or through explicit experimenter intervention with Pavlovian or operant conditioning methodologies. Stimulus-response connections developed between drug treatments have rarely been considered. Many recent studies, however, have demonstrated that centrally active drugs have interoceptive stimulus properties as well as response effects. Furthermore, these stimulus and response aspects do not always co-vary in magnitude so that some drugs can have strong stimulus effects and weak response effects and vice versa. This feature of co-administered drugs creates the possibility for stimulus properties of one drug to become associated with the response properties of another drug. Such stimulus-response associations between drugs can lead to neuronal plasticity changes that may be presumed to underlie postlesion relearning. The present report will outline evidence in support of this possibility.
pziq anipulation of survival and function of cholinergic ne neurotrophic factors. ehavioral cons Hefti, F., Junard,
E.O., Montero,
C.N. and Will, B.
Andrus Gerontology Center, Uniuersity of Southern California,
Los Angeles, Calijornia,
U.S.A.
and DPpartement de Neurophysiologie et Biology des Comportements, Centre de Neurochimie du CNRS.
Strasbourg
France
The finding that adult choline@ neurons express NGF receptors and that this population of cells is involved in memory function and degenerates in human Alzheimer’s disease prompted us to study the effects of NGF in animals with experimental lesions of forebrain cholinergic neurons. NGF was given intraventricularly to adult rats with partial transections of the fimbria which result in a partial lesion of the septo-hippocampal pathway. Partial rather than complete lesions of the fimbria were chosen to be able to study effects of NGF or other neurotrophic factors on neuronal cell bodies in the septum as well as responses of axons in the hippocampus. Partial lesions leave a natural