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Robert E. Scully, MD: A pathologist's perspective
Robert E. Scully, MD: A Pathologist’s A.
TALERMAN,
MD,
Perspective FRCPATH sciiption of I tie most recently J.cc-0gJCzed suhlype, the t-etifortn Sertoti-Leydig cell tuttiot~. It is possible in a short tribute onlv to recouttt but a few of I)r Scutty’s tttany ac~hieveiii~iits and c-otttt-ibutions. I will tnetition some, which undoubt cdly Itave had a persona1 impact His early pdpeJ-s 011 tt?Xi(.tiktJ. tumors, written while still a resident, derttotist rattvl his tmtentiat and were an indication of‘ his futurt. productivity attd interests. A frw years later. iJt 19.53, l‘)r Smutty described the gonadohtastoJtt;t, ati entirely new histopathotogi( entity and 0Jie that f%tnous pathologists iii the past had failed to recognize. ‘I‘his was a harbittget- of rhittgs IO coJne and JtJan~ other entitit>s followed. lttdeed, there can be few pathologists of this or an\’ other generation who have ideittified and categorizrd as ttiatt~ lesions ttow recognized as distinc.r entities. Thr JiutttbeJ ofcandidates for the cpoti~ttious term of “S~utt~‘s JutJtor” is large. and it would be impossible to choose brtweeti gortadohtastotna. sex cord tumor with anttulat~ tubules. juvenile granulosa cell tutmor of the ovary and testis, SCLet-osing stromal t uJnor, sittall cell carcinoni;t of. the ovary. struntal carcinoid. borderline tnucinous tutrlot- ofJttii11erian type, ntiitteriatt 3denosaJ‘(.ottla, and large cell calcifying Sertoli cell tumor. 1)r Sc~~lly’s woJ-k OII the ~onadot)tastottJ~t has beeu followed t+ a lotigstatiditig interest in the patholq? of intersex. an area in whiclt hr has few peers. It is a great tribute to Dt- SCUIIY’S skill as chairman and cootdir~ator, as well as .ic~~oJnl~tisttc~~1pathologist, that few of the WHO classifications of’hutttan tteoplasttts have been J.eceived with as ~nuctt atxlaitJt and full ;I(‘ceptanre throughout the wotld as that OII ovat-ian tteoplasnts fortnutat ed by a cotnmit tee c-ttairtd and guided hy him. 1)r Scully’s tnotiograph, 7’irmorc o/ Ihr Oucl? cl& has becotitc a cl;i:ssic in its own 12lnldrzdoprd (~onclds, right and is used estensively throughout tllc war-Id. Mot-e recently, Dr Scutly has been chairinati of‘1 tie c.oJiitnittee that has produced tlte ;ust-c.ompleted second WHO c.l:issificatioti of o\~ariati tuniors , anti the chairman of the classificxtioii coiJitttittee of the Intet~Jtational Socirty of‘ (;vnfxological I’alhotogists. which has been overseeing the t-r\isioti of the c~lassificatiot15 of dtt ti~optastm of the fetttate geiiital t i-act. When the tntet~Jtatiottat Soviet\ of‘ C~yJiec~ologicnl Pathologists was fouttded itr I !jiti,1)r Scutly was the unanitnous c1toic.e fat- its fit-sr prtxsidmt, atJd hc guided the Societ\. it1 that capacity during its earl\: years. Hr was the iongcst-serving pJ‘esident of the &ciel). and subsequctttly has always provided valuahlr advice and help to his suc~cessoi-s. Dr Scutly has also lx*eii vet-)/ active in the affairs of the ,4nieric;iti Socirt\ ‘of Clinical I’athologists (,4X:1’). For many !‘eal-s. Dr &ully, with three good friends who werr also distitiguisht-cl gynecologic pathologists (Dr WilliaJti (:hI.istoptiet-sotI, the late 1)t.
It is a great honot- to be invited to pay a tribute to Dr Robert E. Scully on the occasion of his 70th birthday. I)r Scully has for many years been one of the leadirtg pathotogtsrs in the world, and the impact of his contributions to patltology in general and to gymecologic and gonadal pathology in particular has been profound ancl uJtequa11ec-1 by any living pathologist. He has carried on the distinguistied tradition of faJnous ~~tiecotogic pathologists like DJ- Robert Meyer, Dr (;umtar~ Teiluttt, and Dr Arthur Hrrtig. Indeed, there are tttan\ threads that link I)J. ScmI!y, 01‘ his contl-ibutiotis, With’ thoSe of’ the aforetric~iitionPd illustrious gymecologic patltologists. The tnost obvious is with l>r Her-t@, since I)I- Scully’s fiJ.st Jtia.ior exposure to &~Jieco1ogic pathology came while worl\ing untlel. Dr Hertig iJt the late I !NOs. 1)r Scully’s ccmnec‘tion with I)J- Teilutn dates back to the l!)GOs. when thcv both worked oJt the FIG0 and World Health Otganil.ation (WHO) classifications of ovarian tuttrors. As I ant fortunate enough to have known DJ Tt~iluttt quite well, I can attest to the fact that he was a gJ-ear adtniJ-er of‘ Dr Scully and his contributions. The work that links these two distitguished pathologists relates to the roles they played in establishing that the 01 ariatt tumor described by Schitler as “tttesonepht-otrla 01 arii” comptised, itt fact, two entities: the yolk sac tumor of get.JJt cell origin and the clear cell c;t’rcittotna of tniitteriatt origitt. In a series of papers in the 1940s and I!).%, Dr Teilutn clarified the histogenesis of‘ the yolk sac (eJtdoderttta1 sinus) tutttor and described Jttost of its Jnam patttrJms. white Dr Scully and others have recently add&d vet ~ttow. In a paper &-authored with Dt- .John Rartcm in IS6 I . DI. Scutty showed that the clear cell ~xtxinotna of the ovary was related to the ettdoJnetrioid c;ircinortia xid. like it, a ttttrior of tniillerian derivation. l)r Sc~~lly’s cottnection with l)r Meyer pertains to their JttuttJat interest in androgettic tumors of the ovary. Dr MeyCt- tnadr the seminal observations on the most chara( teristicaltv andt-ogeitic ovarian tutnor. thta Sertolil,t@g cell t1111101‘, or at~rhenoblastont~t, as I)r Meyet called it in his publications in the late 1920s and 1930s. In a seJ?es of papers JnaitJ1y basecl on his extensive cotlectiori of (0nsiJltatioJi cases. I)r Sculty and his colleagues provided detailed infortnation regarding the clinical and p;ittiologic featirres of thesr tutiioJ3. including the dr-
747
HUMAN PATHOLOGY
Volume 22, No. 8 (August 1991)
James Reagan, and Dr Frank Vellios), participated in an annual course in gynecologic pathology organized by the ASCP. Dr Scully has also participated in the activities of the International Academy of Pathology and its various divisions and gave a short course on ovarian tumors for the US-Canadian division for a number of years. He has also been active as a member of the Editorial Advisory Board of the Atlas of Tumor Pathology Fascicle series, as well as of editorial boards of many scientific journals.
748
Finally, the admiration of his friends and trainees, the achievements of the latter, and the large volume of consultations from all over the world bear witness to Dr Scully’s achievements and impact on pathology today. I am certain that in wishing Dr Scully many happy returns and continued success, I express the sentiments of the entire pathology community throughout the world. I feel very privileged to count this outstanding pathologist. and humble and kind human being, as a close personal friend and trusted advisor.
TALERMAN,
MD,
Perspective FRCPATH sciiption of I tie most recently J.cc-0gJCzed suhlype, the t-etifortn Sertoti-Leydig cell tuttiot~. It is possible in a short tribute onlv to recouttt but a few of I)r Scutty’s tttany ac~hieveiii~iits and c-otttt-ibutions. I will tnetition some, which undoubt cdly Itave had a persona1 impact His early pdpeJ-s 011 tt?Xi(.tiktJ. tumors, written while still a resident, derttotist rattvl his tmtentiat and were an indication of‘ his futurt. productivity attd interests. A frw years later. iJt 19.53, l‘)r Smutty described the gonadohtastoJtt;t, ati entirely new histopathotogi( entity and 0Jie that f%tnous pathologists iii the past had failed to recognize. ‘I‘his was a harbittget- of rhittgs IO coJne and JtJan~ other entitit>s followed. lttdeed, there can be few pathologists of this or an\’ other generation who have ideittified and categorizrd as ttiatt~ lesions ttow recognized as distinc.r entities. Thr JiutttbeJ ofcandidates for the cpoti~ttious term of “S~utt~‘s JutJtor” is large. and it would be impossible to choose brtweeti gortadohtastotna. sex cord tumor with anttulat~ tubules. juvenile granulosa cell tutmor of the ovary and testis, SCLet-osing stromal t uJnor, sittall cell carcinoni;t of. the ovary. struntal carcinoid. borderline tnucinous tutrlot- ofJttii11erian type, ntiitteriatt 3denosaJ‘(.ottla, and large cell calcifying Sertoli cell tumor. 1)r Sc~~lly’s woJ-k OII the ~onadot)tastottJ~t has beeu followed t+ a lotigstatiditig interest in the patholq? of intersex. an area in whiclt hr has few peers. It is a great tribute to Dt- SCUIIY’S skill as chairman and cootdir~ator, as well as .ic~~oJnl~tisttc~~1pathologist, that few of the WHO classifications of’hutttan tteoplasttts have been J.eceived with as ~nuctt atxlaitJt and full ;I(‘ceptanre throughout the wotld as that OII ovat-ian tteoplasnts fortnutat ed by a cotnmit tee c-ttairtd and guided hy him. 1)r Scully’s tnotiograph, 7’irmorc o/ Ihr Oucl? cl& has becotitc a cl;i:ssic in its own 12lnldrzdoprd (~onclds, right and is used estensively throughout tllc war-Id. Mot-e recently, Dr Scutly has been chairinati of‘1 tie c.oJiitnittee that has produced tlte ;ust-c.ompleted second WHO c.l:issificatioti of o\~ariati tuniors , anti the chairman of the classificxtioii coiJitttittee of the Intet~Jtational Socirty of‘ (;vnfxological I’alhotogists. which has been overseeing the t-r\isioti of the c~lassificatiot15 of dtt ti~optastm of the fetttate geiiital t i-act. When the tntet~Jtatiottat Soviet\ of‘ C~yJiec~ologicnl Pathologists was fouttded itr I !jiti,1)r Scutly was the unanitnous c1toic.e fat- its fit-sr prtxsidmt, atJd hc guided the Societ\. it1 that capacity during its earl\: years. Hr was the iongcst-serving pJ‘esident of the &ciel). and subsequctttly has always provided valuahlr advice and help to his suc~cessoi-s. Dr Scutly has also lx*eii vet-)/ active in the affairs of the ,4nieric;iti Socirt\ ‘of Clinical I’athologists (,4X:1’). For many !‘eal-s. Dr &ully, with three good friends who werr also distitiguisht-cl gynecologic pathologists (Dr WilliaJti (:hI.istoptiet-sotI, the late 1)t.
It is a great honot- to be invited to pay a tribute to Dr Robert E. Scully on the occasion of his 70th birthday. I)r Scully has for many years been one of the leadirtg pathotogtsrs in the world, and the impact of his contributions to patltology in general and to gymecologic and gonadal pathology in particular has been profound ancl uJtequa11ec-1 by any living pathologist. He has carried on the distinguistied tradition of faJnous ~~tiecotogic pathologists like DJ- Robert Meyer, Dr (;umtar~ Teiluttt, and Dr Arthur Hrrtig. Indeed, there are tttan\ threads that link I)J. ScmI!y, 01‘ his contl-ibutiotis, With’ thoSe of’ the aforetric~iitionPd illustrious gymecologic patltologists. The tnost obvious is with l>r Her-t@, since I)I- Scully’s fiJ.st Jtia.ior exposure to &~Jieco1ogic pathology came while worl\ing untlel. Dr Hertig iJt the late I !NOs. 1)r Scully’s ccmnec‘tion with I)J- Teilutn dates back to the l!)GOs. when thcv both worked oJt the FIG0 and World Health Otganil.ation (WHO) classifications of ovarian tuttrors. As I ant fortunate enough to have known DJ Tt~iluttt quite well, I can attest to the fact that he was a gJ-ear adtniJ-er of‘ Dr Scully and his contributions. The work that links these two distitguished pathologists relates to the roles they played in establishing that the 01 ariatt tumor described by Schitler as “tttesonepht-otrla 01 arii” comptised, itt fact, two entities: the yolk sac tumor of get.JJt cell origin and the clear cell c;t’rcittotna of tniitteriatt origitt. In a series of papers in the 1940s and I!).%, Dr Teilutn clarified the histogenesis of‘ the yolk sac (eJtdoderttta1 sinus) tutttor and described Jttost of its Jnam patttrJms. white Dr Scully and others have recently add&d vet ~ttow. In a paper &-authored with Dt- .John Rartcm in IS6 I . DI. Scutty showed that the clear cell ~xtxinotna of the ovary was related to the ettdoJnetrioid c;ircinortia xid. like it, a ttttrior of tniillerian derivation. l)r Sc~~lly’s cottnection with l)r Meyer pertains to their JttuttJat interest in androgettic tumors of the ovary. Dr MeyCt- tnadr the seminal observations on the most chara( teristicaltv andt-ogeitic ovarian tutnor. thta Sertolil,t@g cell t1111101‘, or at~rhenoblastont~t, as I)r Meyet called it in his publications in the late 1920s and 1930s. In a seJ?es of papers JnaitJ1y basecl on his extensive cotlectiori of (0nsiJltatioJi cases. I)r Sculty and his colleagues provided detailed infortnation regarding the clinical and p;ittiologic featirres of thesr tutiioJ3. including the dr-
747
HUMAN PATHOLOGY
Volume 22, No. 8 (August 1991)
James Reagan, and Dr Frank Vellios), participated in an annual course in gynecologic pathology organized by the ASCP. Dr Scully has also participated in the activities of the International Academy of Pathology and its various divisions and gave a short course on ovarian tumors for the US-Canadian division for a number of years. He has also been active as a member of the Editorial Advisory Board of the Atlas of Tumor Pathology Fascicle series, as well as of editorial boards of many scientific journals.
748
Finally, the admiration of his friends and trainees, the achievements of the latter, and the large volume of consultations from all over the world bear witness to Dr Scully’s achievements and impact on pathology today. I am certain that in wishing Dr Scully many happy returns and continued success, I express the sentiments of the entire pathology community throughout the world. I feel very privileged to count this outstanding pathologist. and humble and kind human being, as a close personal friend and trusted advisor.