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S171 Where is psa position for prostate cancer finding
S171
Where is psa position for prostate cancer finding Eur Urol Suppl 2013;12;e1279
Nouri A.R.1, Nouri P.2 1Islamic
Azad Univrsity Tehran Medical Branch, Dept. of Urology, Tehran, Iran, 2Islamic Azad Univrsity Tehran-Nourth Branch,
Dept. of Microbiology, Tehran, Iran INTRODUCTION & OBJECTIVES: Prostate specific antigen is a dilemma in field of Urology. Nowadays it is used to detect prostate malignancies and determining the prognosis of patients Physicians are now doubtful about its accuracy and applicability for diagnosis of malignancies. Previous studies have shown different results. Current study has performed to evaluate the positive predictive value and applicability of PSA test for detection of prostate malignancies MATERIAL & METHODS: We randomly selected 390 men undergoing transrectal ultrasound-guided biopsies of the prostate our variables included age, total serum PSA, PSA density, prostate volume, and existence of nodule in prostate. The number of cores were 6-20 with a median of 12. RESULTS: Mean age of the patients were 67.4±8.1 years. PSA was ranging from 4 to90. Patients were stratified in 4 groups according to total serum PSA value (, I: PSA 4-9.9, II: PSA 10-19.9, Ш: PSA 20 to 49.9, group IV: PSA > 50) and observed frequencies were, 44.1, 34, 17.9, and 4% respectively. The mean volume of the prostate was 49.8 ml 197 patients (50.5 %) had a nodular prostate. 200out of 390 patients (51.3 %) had a pathologic report showing adenocarcinoma of prostate. Positive predictive value of total serum PSA was calculated as 51.4%. prostate volume of benign lesions was 58.1 ml comparing with 42 ml for malignant lesions (P < 0.0001). There was a statistically significant association between having malignant or benign lesion with total serum PSA level (24.1 vs. 9.5 ng/ml, P <0.0001). same association was found between PSA density and being malignant or benign (0.57 vs. 0.25, P <0.0001). nodular prostate were more probable to have malignant lesion comparing with benign types (66.3% vs. 36.2%, P <0.0001 CONCLUSIONS: both PSA density and total serum PSA were associated with diagnosis of a cancerous lesion. According to our findings, it is recommended to use PSA test for detection of malignant prostate lesions as a applicable method. Also for increasing the positive predictive value we may consider 12 or more core biopsies.
Where is psa position for prostate cancer finding Eur Urol Suppl 2013;12;e1279
Nouri A.R.1, Nouri P.2 1Islamic
Azad Univrsity Tehran Medical Branch, Dept. of Urology, Tehran, Iran, 2Islamic Azad Univrsity Tehran-Nourth Branch,
Dept. of Microbiology, Tehran, Iran INTRODUCTION & OBJECTIVES: Prostate specific antigen is a dilemma in field of Urology. Nowadays it is used to detect prostate malignancies and determining the prognosis of patients Physicians are now doubtful about its accuracy and applicability for diagnosis of malignancies. Previous studies have shown different results. Current study has performed to evaluate the positive predictive value and applicability of PSA test for detection of prostate malignancies MATERIAL & METHODS: We randomly selected 390 men undergoing transrectal ultrasound-guided biopsies of the prostate our variables included age, total serum PSA, PSA density, prostate volume, and existence of nodule in prostate. The number of cores were 6-20 with a median of 12. RESULTS: Mean age of the patients were 67.4±8.1 years. PSA was ranging from 4 to90. Patients were stratified in 4 groups according to total serum PSA value (, I: PSA 4-9.9, II: PSA 10-19.9, Ш: PSA 20 to 49.9, group IV: PSA > 50) and observed frequencies were, 44.1, 34, 17.9, and 4% respectively. The mean volume of the prostate was 49.8 ml 197 patients (50.5 %) had a nodular prostate. 200out of 390 patients (51.3 %) had a pathologic report showing adenocarcinoma of prostate. Positive predictive value of total serum PSA was calculated as 51.4%. prostate volume of benign lesions was 58.1 ml comparing with 42 ml for malignant lesions (P < 0.0001). There was a statistically significant association between having malignant or benign lesion with total serum PSA level (24.1 vs. 9.5 ng/ml, P <0.0001). same association was found between PSA density and being malignant or benign (0.57 vs. 0.25, P <0.0001). nodular prostate were more probable to have malignant lesion comparing with benign types (66.3% vs. 36.2%, P <0.0001 CONCLUSIONS: both PSA density and total serum PSA were associated with diagnosis of a cancerous lesion. According to our findings, it is recommended to use PSA test for detection of malignant prostate lesions as a applicable method. Also for increasing the positive predictive value we may consider 12 or more core biopsies.