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Serum soluble E-selectin in normal pregnancy and preeclampsia
S110
Abstracts
Conclusion: The results of this study showed that giardiasis increases the level of iron and zinc and decreases the level of copper in the sera of patients. These differences were not significant between patients and control individuals. Keywords: Giardia lamblia, Trace elements, Fe, Cu, Zn, Children doi:10.1016/j.clinbiochem.2011.08.262
E Poster – [A-10-1184-1] Serum soluble E-selectin in normal pregnancy and preeclampsia Nayereh Khadem, Hossein Ayatollahi, Homa Kianifar, Pouran Makhdoumi Obstetrics and Gynecologic Department, Mashhad University of medical sciences, Mashhad, Iran E-mail addresses: [email protected] (N. Khadem), [email protected] (H. Ayatollahi), [email protected] (P. Makhdoumi) Introduction: It is now widely accepted that a dysfunction of endothelial cells leading to cellular activation and/or damage is a primary cause in the pathogenesis of preeclampsia being responsible for the complex systemic manifestation of the disease. Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. Objective: The aim is to compare the levels of E-selectin in normal and preeclamptic pregnancies. Methods: This case-control study was done in Ghaem and Emam Reza hospitals in 2007–2008. We studied the serum levels of E-selectin in peripheral blood obtained from normal pregnant women (n=40) were matched with pre-eclamptic women for gestational age, maternal age, gravidity and parity. Preeclamptic women were divided to two groups: first group with proteinuria more than or equal to 2 g/24 hrs and second ones with proteinuria less than 2 g. Concentrations of soluble adhesion molecule were determined with enzyme-linked immunosorbant assay (ELISA). Results: E-selectin was significantly higher in sera of preeclamptic women than normal pregnancy (p=0.0001). E-selectin concentrations were markedly higher in preeclamptic women with proteinuria more than 2 g in 24 hrs (p<0.05). Conclusion: E-selectin is increased in severe preeclampsia, and may be useful in predicting the severity of preeclampsia. Keywords: Pre-eclampsia, Cell adhesion molecules, E-selectin doi:10.1016/j.clinbiochem.2011.08.263
E Poster – [A-10-1218-1] Serum zinc and copper concentrations in thalassemic patients compard with healthy subjects Elham Ghahramanlua, Majid Ghayour Mobarhanb, Naghme Mirhossinib, Shima Tavalaieb, Abdollah Banihashemc a Blood transfusion center, Mashhad, Iran b Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran c Dr sheikh hospital, Mashhad University of Medical Sciences, Mashhad, Iran E-mail addresses: [email protected] (E. Ghahramanlu), [email protected] (M. Ghayour Mobarhan), [email protected] (N. Mirhossini), [email protected] (S. Tavalaie) Introduction: About 190 million people throughout the world have genetic mutations associated with different hemoglobinopathies.
Delayed puberty and short stature is a great problem of thalassemic patients.Trace elements such as zinc and copper, had important effects on the body. Zinc is available in red blood cell membrane and plays an active role in survival of red blood cell. Some part of growth retardation in thalassemia seems to be related to zinc deficiency. Aim: To compare serum zinc level between thalassemia major patients and normal population , the matching age and gender were recruited as controls. Method: In 140 thalassemia major patients in Sarve center, Mashhad, Iran, (8–20 years old ), serum copper and zinc were estimated by Atomic Absorption spectrophotometer (AAS). Result was compared with 140 healthy subjects. Result: Thalassemic patients had significantly lower zinc (60.11 vs. 86.64) and copper (90.19 vs. 105.59)compared with healthy subjects (p< 0.001). The prevalence of low serum levels of zinc and copper in thalassemic patients was almost twice higher than healthy subjects (69.3% vs. 27.3%) for zinc and 31.8% vs. 14.5% for copper. Conclusion: High prevalence of low levels of serum zinc and copper concentrations was observed in thalassemic patients and to improve zinc and copper status of thalassemic patients were strongly recommended. Keywords: Zinc, Copper, Thalassemia doi:10.1016/j.clinbiochem.2011.08.264
E Poster – [A-10-1237-1] Association between Dietary intake of sodium and selenium and metabolic syndrome Eghbali Mahsa, Ghayour Mobarhan Majid, Sheikh Andalibi Mohammad Sobhan, Akhavan Rezayat Amir, Mohaddes Ardabili Hossein, Mohammadi Maryam, Nematy Mohsen, Mouhebati Mohsen, Baghshini Mohammadreza Department of Biochemistry and Nutrition Center-Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran E-mail addresses: [email protected] (E. Mahsa), [email protected] (G.M. Majid), [email protected] (S.A.M. Sobhan), [email protected] (A.R. Amir), [email protected] (M.A. Hossein) Introduction: Nowadays Metabolic syndrome is one of the most important health problems, which can increase the rate of diabetes and cardiovascular diseases. Metabolic syndrome is a cluster of disease including obesity, dyslipidemia and high systolic and diastolic blood pressure. There are more than 10 different definitions for metabolic syndrome. The role of micro nutrient intake is well known in cardiovascular risk factors such as metabolic syndrome. Therefore we wish to investigate the comparison of Dietary intake of sodium and selenium in metabolic syndrome and healthy subjects. Methods: This study was conducted among 742 men aged 35– 69 years old who were employees in Shahid Hasheminejad Gas Processing Company (S.G.P.C). ATPlll criteria were performed in order to diagnose metabolic syndrome patients. The markers of metabolic syndrome were controlled by blood samples, measuring of blood pressure and also body mass index (BMI) with body composition analyzer. Among them 292 employees (39.3%) were metabolic syndrome patients. Twenty-four-hours recall method was used to assess dietary intake in both groups and the data was analyzed with Dietplan6 software. Results: Metabolic syndrome patients had significantly higher intake amount of sodium (1969.5 ± 1155.3 vs. 1731.2 ± 849.8 mg, p < .005) and selenium (64.7 ± 48.6 vs. 57.2 ± 34.0 μg, p < .005) in comparison with non-metabolic syndrome subjects.
Abstracts
Conclusion: The results of this study showed that giardiasis increases the level of iron and zinc and decreases the level of copper in the sera of patients. These differences were not significant between patients and control individuals. Keywords: Giardia lamblia, Trace elements, Fe, Cu, Zn, Children doi:10.1016/j.clinbiochem.2011.08.262
E Poster – [A-10-1184-1] Serum soluble E-selectin in normal pregnancy and preeclampsia Nayereh Khadem, Hossein Ayatollahi, Homa Kianifar, Pouran Makhdoumi Obstetrics and Gynecologic Department, Mashhad University of medical sciences, Mashhad, Iran E-mail addresses: [email protected] (N. Khadem), [email protected] (H. Ayatollahi), [email protected] (P. Makhdoumi) Introduction: It is now widely accepted that a dysfunction of endothelial cells leading to cellular activation and/or damage is a primary cause in the pathogenesis of preeclampsia being responsible for the complex systemic manifestation of the disease. Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. Objective: The aim is to compare the levels of E-selectin in normal and preeclamptic pregnancies. Methods: This case-control study was done in Ghaem and Emam Reza hospitals in 2007–2008. We studied the serum levels of E-selectin in peripheral blood obtained from normal pregnant women (n=40) were matched with pre-eclamptic women for gestational age, maternal age, gravidity and parity. Preeclamptic women were divided to two groups: first group with proteinuria more than or equal to 2 g/24 hrs and second ones with proteinuria less than 2 g. Concentrations of soluble adhesion molecule were determined with enzyme-linked immunosorbant assay (ELISA). Results: E-selectin was significantly higher in sera of preeclamptic women than normal pregnancy (p=0.0001). E-selectin concentrations were markedly higher in preeclamptic women with proteinuria more than 2 g in 24 hrs (p<0.05). Conclusion: E-selectin is increased in severe preeclampsia, and may be useful in predicting the severity of preeclampsia. Keywords: Pre-eclampsia, Cell adhesion molecules, E-selectin doi:10.1016/j.clinbiochem.2011.08.263
E Poster – [A-10-1218-1] Serum zinc and copper concentrations in thalassemic patients compard with healthy subjects Elham Ghahramanlua, Majid Ghayour Mobarhanb, Naghme Mirhossinib, Shima Tavalaieb, Abdollah Banihashemc a Blood transfusion center, Mashhad, Iran b Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran c Dr sheikh hospital, Mashhad University of Medical Sciences, Mashhad, Iran E-mail addresses: [email protected] (E. Ghahramanlu), [email protected] (M. Ghayour Mobarhan), [email protected] (N. Mirhossini), [email protected] (S. Tavalaie) Introduction: About 190 million people throughout the world have genetic mutations associated with different hemoglobinopathies.
Delayed puberty and short stature is a great problem of thalassemic patients.Trace elements such as zinc and copper, had important effects on the body. Zinc is available in red blood cell membrane and plays an active role in survival of red blood cell. Some part of growth retardation in thalassemia seems to be related to zinc deficiency. Aim: To compare serum zinc level between thalassemia major patients and normal population , the matching age and gender were recruited as controls. Method: In 140 thalassemia major patients in Sarve center, Mashhad, Iran, (8–20 years old ), serum copper and zinc were estimated by Atomic Absorption spectrophotometer (AAS). Result was compared with 140 healthy subjects. Result: Thalassemic patients had significantly lower zinc (60.11 vs. 86.64) and copper (90.19 vs. 105.59)compared with healthy subjects (p< 0.001). The prevalence of low serum levels of zinc and copper in thalassemic patients was almost twice higher than healthy subjects (69.3% vs. 27.3%) for zinc and 31.8% vs. 14.5% for copper. Conclusion: High prevalence of low levels of serum zinc and copper concentrations was observed in thalassemic patients and to improve zinc and copper status of thalassemic patients were strongly recommended. Keywords: Zinc, Copper, Thalassemia doi:10.1016/j.clinbiochem.2011.08.264
E Poster – [A-10-1237-1] Association between Dietary intake of sodium and selenium and metabolic syndrome Eghbali Mahsa, Ghayour Mobarhan Majid, Sheikh Andalibi Mohammad Sobhan, Akhavan Rezayat Amir, Mohaddes Ardabili Hossein, Mohammadi Maryam, Nematy Mohsen, Mouhebati Mohsen, Baghshini Mohammadreza Department of Biochemistry and Nutrition Center-Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran E-mail addresses: [email protected] (E. Mahsa), [email protected] (G.M. Majid), [email protected] (S.A.M. Sobhan), [email protected] (A.R. Amir), [email protected] (M.A. Hossein) Introduction: Nowadays Metabolic syndrome is one of the most important health problems, which can increase the rate of diabetes and cardiovascular diseases. Metabolic syndrome is a cluster of disease including obesity, dyslipidemia and high systolic and diastolic blood pressure. There are more than 10 different definitions for metabolic syndrome. The role of micro nutrient intake is well known in cardiovascular risk factors such as metabolic syndrome. Therefore we wish to investigate the comparison of Dietary intake of sodium and selenium in metabolic syndrome and healthy subjects. Methods: This study was conducted among 742 men aged 35– 69 years old who were employees in Shahid Hasheminejad Gas Processing Company (S.G.P.C). ATPlll criteria were performed in order to diagnose metabolic syndrome patients. The markers of metabolic syndrome were controlled by blood samples, measuring of blood pressure and also body mass index (BMI) with body composition analyzer. Among them 292 employees (39.3%) were metabolic syndrome patients. Twenty-four-hours recall method was used to assess dietary intake in both groups and the data was analyzed with Dietplan6 software. Results: Metabolic syndrome patients had significantly higher intake amount of sodium (1969.5 ± 1155.3 vs. 1731.2 ± 849.8 mg, p < .005) and selenium (64.7 ± 48.6 vs. 57.2 ± 34.0 μg, p < .005) in comparison with non-metabolic syndrome subjects.