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Significance of positive antinuclear factor (ANF) in a neurologic population
A case of frontal type dementia: clinical, radiological and PET-scan findings D. Decoo, W. Ceusters, J. de Reuck, J. van Aken, P. Boon, P. Vanderdonckt (Ghent) The clinical, radiological and PET-scan findings in a 55-year-old white woman with a frontal type dementia are presented. The clinical follow-up revealed a progressive evolution from a focal motor-sensory deficit in the left arm to a dementia with apathy, tetraparesis and spasticity, bilateral Babinski signs,
Siicance
snout-, grasp- and suckreflexes. The neuro-imaging (CT-scan and NMR) showed a progressive cerebral atrophy, starting in the right fronto-parietal cortex. A PET with C150, and lsOz revealed a significant hypometabolism in the cerebral regions more pronounced in the fronto-parietal cortex. The diagnostic interpretation of the results is discussed.
of positive antinuclear factor (ANF) in a neurologic jmpdah
B. Michielsens, ton (Leuven)
M. Wairavens,
and H. Car-
During an 8 year period ANF was determined in 327 neurological patients and found to be positive in 28 (8%). An autoimmune disease, most often systemic lupus erythematoides, was diagnosed in 11 pa-
tients and suspected in 8. Drug induced ANF positivity was found in 2 patients. The importance for the interpretation of the ANF results of the intensity of the irmnunofluorescence, the antibody pattern, the presence of DNA and ENA-antibodies as well as laboratory signs of complement consumption is analyzed.
Effect of hfhemza vaccination on serial MEI-hmages of MS patients
B . Michielsens,
G. Wilms,
and H. Carton
(Leuven) In a prospective controlled study of 11 patients with a relapsing remitting form of MS, influenza
vaccination had no effect on the number of new brain lesions nor on the number of gad&i&m enhanced brain lesions (the so called active plaques).
Neuropathology of Aids and the Aids-dermemtiaco-x A.-E.
Baert
(Ghent)
After a statistical overview of reported Aidscases within the EuropeanCommunity and the natural history of the Aids disease, the Neuropathology was overviewed by a set of slides. These demonstrated the demyelinisation of the white matter in the brain, multi-focal leucoencephalopathy with characteristic m&i-nuclear giant cells and perivascular calcification in young infants.
370
As pathogen&s of the Aids neuropathology and neuro-psychological syndromes was speculated: an infected perigkeral monocyte becomes through syncitium formation a multinuclear giant macrophage in the brain, producing neurotoxines, inhibiting oligodendrocytes and producing immtEnodepression which in turn is the origin of other opporttitic brain infections such as toxoplasmosis, cryptococcosis, aspergillosis, mycobacterium atypicum, CMV, papova and Epstein Barr virus with B-lymphoma.
Siicance
snout-, grasp- and suckreflexes. The neuro-imaging (CT-scan and NMR) showed a progressive cerebral atrophy, starting in the right fronto-parietal cortex. A PET with C150, and lsOz revealed a significant hypometabolism in the cerebral regions more pronounced in the fronto-parietal cortex. The diagnostic interpretation of the results is discussed.
of positive antinuclear factor (ANF) in a neurologic jmpdah
B. Michielsens, ton (Leuven)
M. Wairavens,
and H. Car-
During an 8 year period ANF was determined in 327 neurological patients and found to be positive in 28 (8%). An autoimmune disease, most often systemic lupus erythematoides, was diagnosed in 11 pa-
tients and suspected in 8. Drug induced ANF positivity was found in 2 patients. The importance for the interpretation of the ANF results of the intensity of the irmnunofluorescence, the antibody pattern, the presence of DNA and ENA-antibodies as well as laboratory signs of complement consumption is analyzed.
Effect of hfhemza vaccination on serial MEI-hmages of MS patients
B . Michielsens,
G. Wilms,
and H. Carton
(Leuven) In a prospective controlled study of 11 patients with a relapsing remitting form of MS, influenza
vaccination had no effect on the number of new brain lesions nor on the number of gad&i&m enhanced brain lesions (the so called active plaques).
Neuropathology of Aids and the Aids-dermemtiaco-x A.-E.
Baert
(Ghent)
After a statistical overview of reported Aidscases within the EuropeanCommunity and the natural history of the Aids disease, the Neuropathology was overviewed by a set of slides. These demonstrated the demyelinisation of the white matter in the brain, multi-focal leucoencephalopathy with characteristic m&i-nuclear giant cells and perivascular calcification in young infants.
370
As pathogen&s of the Aids neuropathology and neuro-psychological syndromes was speculated: an infected perigkeral monocyte becomes through syncitium formation a multinuclear giant macrophage in the brain, producing neurotoxines, inhibiting oligodendrocytes and producing immtEnodepression which in turn is the origin of other opporttitic brain infections such as toxoplasmosis, cryptococcosis, aspergillosis, mycobacterium atypicum, CMV, papova and Epstein Barr virus with B-lymphoma.