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Some pharmacological properties of rutin
9.32
AMERICAX
Wilson, R. H., Mortarotti, Rutin. J. Pharmacol.
T. G., & Exper.
IIEART
JOURN.41,
and DeEds, F.: Some Pharmacological Therap. 90:120 (June), 1947.
Properties
of
Rutin, placed in the perfusion fluid surrounding excised segments of guinea-pig colon, was capable of prolonging the relaxation produced by epinephrine. The degree of prolongation was proportional to the dose of rutin. If given intraperitoneally in guinea pigs ten to thirty minutes prior to 50 per cent of the lethal dose of histamine, the mortality was reduced. Simultaneous administration of the two drugs showed no protection. In guinea pigs rendered scorbutic, the authors could demonstrate no significant difference in the animals’ tendency to develop petechial hemorrhages in those given rutin and in those not given rutin. Therefore, the capillary permeability protective power of rutin could not be confirmed.
Meyer,
The
0.: bosis
With
Ambulatory Compression
Treatment Bandages.
of Phlebitis, Surgery 21:843
Thrombophlebitis (June), 1947.
and
Throm-
The author advocates the use of compression bandages in the treatment of venous thrombosis and in the prevention of pulmonary embolism. He uses the combination of a medicated contura bandage applied loosely and a 3-inch-wide pressoplast bandage which is applied over it with strong nonconstricting pressure. The foot, leg, and thigh are covered but the knee as a rule remains free. The patient is then advised to walk as much as possible and to avoid standing. According to the author, the application of the bandgages, using the optimal degree of pressure, will cause immediate relief of pain and rapid reduction in edema in the acute stage of deep thrombophlebitis. He presents statistical studies of others to support the view that with the use of compression bandages, pulmonary embolism is practically prevented. He also points out that the treatment must be supplemented by the removal of primary foci in the oral cavity and secondary foci in the jugular veins, to prevent reinfection of the veins of the leg. ABRAMSON. Hinchey, J. J., Hines, E. A., and Potassium Thiocyanate Therapy Clin. 22:275 (July 9), 1947.
Ghormely, R. K.: for Hypertensive
Osteoporosis Oeeurring During Disease. Proc. Staff Meet., Mayo
The authors studied the records of 360 patients with hypertension to whom potassium thiocyanate had been given. Unexplained osteoporosis involving one or more extremities occurred in seven of these patients (2 per cent). A history of trauma or injury at onset was not present. Unexplained osteoporosis was not noted in the group of patients with hypertension who were not receiving potassium thiocyanate. The average age of this group was 57 years. The dosage of the drug varied considerably during the course of treatment, but was usually in the range of 6 to 9 grains (0.4 to 0.6 Gm.) daily. The onset of symptoms associated with the osteoporosis generally occurred in from three to six months after the patient started taking the drug. They consisted of pain on use of the extremity and subsequent mild swelling of the joint or joints involved. Roentgenograms revealed mild to marked diffuse osteoporosis. Active therapeutic measures directed toward the osteoporosis were carried out in seven cases The symptoms continued to progress despite while thiocyanate therapy was being continued. these measures in six cases. Slight improvement over a period of several months was noted in the seventh case and this was accelerated when the use of potassium thiocyanate was stopped. Cessation of treatment with potassium thiocyanate was followed by relief in every one of the seven cases whether or not specific measures of treatment of the osteoporosis were used. Use of the drug was resumed in four instances. In two neither the symptoms nor the osteoporosis reSymptoms did recur in the other two and were again relieved when administration of curred. thiocyanate was once more discontinued. BELLET.
AMERICAX
Wilson, R. H., Mortarotti, Rutin. J. Pharmacol.
T. G., & Exper.
IIEART
JOURN.41,
and DeEds, F.: Some Pharmacological Therap. 90:120 (June), 1947.
Properties
of
Rutin, placed in the perfusion fluid surrounding excised segments of guinea-pig colon, was capable of prolonging the relaxation produced by epinephrine. The degree of prolongation was proportional to the dose of rutin. If given intraperitoneally in guinea pigs ten to thirty minutes prior to 50 per cent of the lethal dose of histamine, the mortality was reduced. Simultaneous administration of the two drugs showed no protection. In guinea pigs rendered scorbutic, the authors could demonstrate no significant difference in the animals’ tendency to develop petechial hemorrhages in those given rutin and in those not given rutin. Therefore, the capillary permeability protective power of rutin could not be confirmed.
Meyer,
The
0.: bosis
With
Ambulatory Compression
Treatment Bandages.
of Phlebitis, Surgery 21:843
Thrombophlebitis (June), 1947.
and
Throm-
The author advocates the use of compression bandages in the treatment of venous thrombosis and in the prevention of pulmonary embolism. He uses the combination of a medicated contura bandage applied loosely and a 3-inch-wide pressoplast bandage which is applied over it with strong nonconstricting pressure. The foot, leg, and thigh are covered but the knee as a rule remains free. The patient is then advised to walk as much as possible and to avoid standing. According to the author, the application of the bandgages, using the optimal degree of pressure, will cause immediate relief of pain and rapid reduction in edema in the acute stage of deep thrombophlebitis. He presents statistical studies of others to support the view that with the use of compression bandages, pulmonary embolism is practically prevented. He also points out that the treatment must be supplemented by the removal of primary foci in the oral cavity and secondary foci in the jugular veins, to prevent reinfection of the veins of the leg. ABRAMSON. Hinchey, J. J., Hines, E. A., and Potassium Thiocyanate Therapy Clin. 22:275 (July 9), 1947.
Ghormely, R. K.: for Hypertensive
Osteoporosis Oeeurring During Disease. Proc. Staff Meet., Mayo
The authors studied the records of 360 patients with hypertension to whom potassium thiocyanate had been given. Unexplained osteoporosis involving one or more extremities occurred in seven of these patients (2 per cent). A history of trauma or injury at onset was not present. Unexplained osteoporosis was not noted in the group of patients with hypertension who were not receiving potassium thiocyanate. The average age of this group was 57 years. The dosage of the drug varied considerably during the course of treatment, but was usually in the range of 6 to 9 grains (0.4 to 0.6 Gm.) daily. The onset of symptoms associated with the osteoporosis generally occurred in from three to six months after the patient started taking the drug. They consisted of pain on use of the extremity and subsequent mild swelling of the joint or joints involved. Roentgenograms revealed mild to marked diffuse osteoporosis. Active therapeutic measures directed toward the osteoporosis were carried out in seven cases The symptoms continued to progress despite while thiocyanate therapy was being continued. these measures in six cases. Slight improvement over a period of several months was noted in the seventh case and this was accelerated when the use of potassium thiocyanate was stopped. Cessation of treatment with potassium thiocyanate was followed by relief in every one of the seven cases whether or not specific measures of treatment of the osteoporosis were used. Use of the drug was resumed in four instances. In two neither the symptoms nor the osteoporosis reSymptoms did recur in the other two and were again relieved when administration of curred. thiocyanate was once more discontinued. BELLET.