INTERNATIONAL ABSTRACTS
are survivors. In three patients, initial chemotherapy-radiotherapy apparently rendered previously "unresectable" tumors resectable; and two of these have remained diseasefree for 28 and 33 mo, respectively. The third relapsed at 24 mo. Among the 27 patients with measurable (residual) disease following surgery, 12/27 responded to chemotherapy with a median duration of response of 18 mo. Hematologic toxicity was significant, including three fatalities. The major usefulness of this regimen is as an adjuvant to surgery. - - D . M. Hays Sonography of Ovarian Involvement in Childhood Acute Lymphocytic Leukemia. G. H. Bickers, J. J. Siebert, J. C.
Anderson, et al. Am J Roentgenol 137:399-401, (August), 1981.
Two girls, ages 10 and 13, developed symptomatic ovarian involvement 24 and 22 mo after diagnosis of acute lymphocytic leukemia (ALL). Both presented with abdomino-pelvic masses. Sonography revealed solid masses with low echogenicity (similar to lymphomatous pelvic and retroperitoneal masses). The authors recommend pelvic sonography in the followup care of girls with ALL to detect ovarian involvement early and to allow appropriate treatment.--Randall W. Powell Sonographic Detection of Fibromatosis: A Rare Tumor in the Retroperitoneum. K. J. Rogers and R. R. Brock. Clin
Pediatr 20:595-598, (September), 1981. A 4-yr-old male presented with recurrent episodes of abdominal pain. Evaluation, including upper and lower GI series, IVP, and chest films, was normal. Continued symptoms prompted reevaluation and repeated studies were normal. At this time epigastric tenderness and a mass were
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noted. Sonographic examination of the abdomen revealed a retroperitoneal mass in the upper abdomen extending behind the liver and inseparable from pancreas. At exploration a firm, lobulated mass adherent to the pancreas was partially resected. Pathologic diagnosis was benign fibromatosis. Eighteen mo later the mass recurred and over half was resected. Radiation and chemotherapy were withheld due to low risk-benefit ratio.--Randall IV. Powell Management of Solid Tumors in Children: Contribution of Computed Tomography. P. n. Arger, C. B. Mu/hern, Jr.,
P. S. Littman, el al. Am J Roentgenol 137:251-255, (August), 1981.
Fifty-four patients (median age 11 yr) with 13 histologic tumor types underwent 92 computed tomographic (CT) examinations from which therapeutic decisions were made. Twelve scans performed as a baseline were excluded. In these 80 examinations CT provided essential information not obtained on other studies in 21 examinations (26%), confirmatory information in 17 (21%), noncontributory in 16 (20%), and unsatisfactory in 4 (5%). When compared with other forms of evaluation the essential confirmatory, and noncontributory findings were as follows: sonography--5, 1, 6 (50%); chest film/tomography--5, 5, 5; abdominal/pelvic films--7, 7, 3; IVP--4, 8, 3. In conclusion the authors feel that CT examinations impacted on therapeutic decisions in 60 of 80 examinations (75%) including decisions involving surgical therapy. Other advantages of CT include followup examinations to determine response to treatment and accurate mapping of tumor extent for radiotherapeutic treatment fields. The authors predict increasing utilization of CT in the management of pediatric oncology patients.--Randall 14I. Powell