- Email: [email protected]
SPANISH VALIDATION OF THE BACS (BRIEF ASSESSMENT IN COGNITION IN SCHIZOPHRENIA); PERFORMANCE IN PATIENTS AND HEALTHY CONTROLS
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Abstracts / Schizophrenia Research 102/1–3, Supplement 2 (2008) 1–279
279 – A NEW TOOL ASSESSING INTENTION READING, THE V-SIR, AS A MEASURE OF SEVERITY IN SCHIZOPHRENIA Catherine Bourdet 1 , Eric Brunet 2 , Nadine Bazin 2 , Christine Passerieux 2 , Marie-Christine Hardy-Bayle 2 1 CH Versailles, Versailles; 2 CH Versailles and INSERM ERI15, Versailles, France [email protected] Introduction: Different etiopathological models have been proposed for schizophrenia. Following Hardy-Baylé’s proposal, setting communication disorders as a central and specific deficit in schizophrenia1, two new tools for the evaluation of (1) communication disorders2-3 and (2) intentional reading4 have been developed in our team. We have previously demonstrated that both instruments separate significantly schizophrenic patients from normal controls and depressed patients34. Aim: The pre sent study aims at demonstrating, on a large number of schizophrenic patients, the validity and utility of these two scales for the clinical quantitative evaluation of schizophrenic patients. Methods: The study was part of a pharmacological trail assessing a large number of patients (n=206; age mean=41.3 SD=10.49) with different clinical scales (PANSS, BPRS) and measurements of social cognition (SCD*, V-SIR*). Results: The mean value and the range previously reported on smaller groups are confirmed (SCD mean=7.49 SD=4.11; V-SIR mean=24.36 SD=8.00). Results from both scales demonstrate a normal distribution. Intrinsic qualities will be described (Alpha Cronbach SCD= 0.88; V-SIR=0.76). The use of these two tools for the as sessment of patients in a large scale multi-centric pharmacological essay indicate that feasibility and transferability of expertise for testing are very good. Scores from these two tests were significantly correlated. V-SIR scores do not correlate with BPRS scores. Interestingly, only few individual items of the BPRS and the PANSS correlate significantly (p>.05) with ToM scores (SCD scores: 6 out of the 18 items of the BPRS and 17 out of 30 PANSS scores correlate with SCD scores; V-SIR scores: only one out of the 18 items of the BPRS and six out of 30 PANSS items correlate with the V-SIR scores). Conclusions: Evaluation of severity in schizophrenia needs quantitative assessments of communication and ToM disorders. We aimed to demonst rate here, for the SCD and for the V-SIR, the feasibility and utility of their use in a comprehensive battery for clinical and cognitive evaluation in Schizophrenia. English versions of these two scales are now being validated within English-speak ing normal and pathological groups. Acknowledgements: Study was supported by Lilly France References [1] Hardy-Bayle, Schiz.Bull. 29, 459 (2003). [2] Olivier, Eur.Psychiatry 12, 356-361 (1997) [3] Bazin et al, Schizophr.Res. 77, 75-84 (2005) [4] Bazin et al, PsychRes. (in press)
280 – SPANISH VALIDATION OF THE BACS (BRIEF ASSESSMENT IN COGNITION IN SCHIZOPHRENIA); PERFORMANCE IN PATIENTS AND HEALTHY CONTROLS
Nuria Segarra, S. Aspiazu, A. Justicia, E. Fernandez-Egea, F. Gutierrez, M. Allas, L. Sanchez, F. Contreras, G. Safont, J. Gascon, J.M. Menchon, M. Bernardo Hospital Clinic Barcelona, Barcelona, Spain [email protected] Introduction: Spanish validation of the BACS (Brief Assessment in Cognition in Schizophrenia); performance in patients and healthy controls.Neurocognitive impairment is considered a core component of schizophrenia and is increasingly under investigation as a potential treatment target (Keefe, 2007). The Brief Assessment in Cognition in Schizophrenia BACS, assess the main cognitive domains which are impaired in patients with schizophrenia: verbal memory, working memory, motor speed, attention, executive functions and verbal fluency. Also, the BACS has the advantage that takes less than 35 minutes
to be completed and it is as sensitive to cognitive impairment as a standard battery of tests that required over 2 hours to be completed (Keefe et al., 2004). A multicentre study (Hospital Clinic of Barcelona, Bellvitge University Hospital, Hospi tal Mutua of Terrassa), in coordination with the University of Duke, USA (Dr. Keefe), completed the Spanish Adaptation of the BACS. The Spanish Adaptation is suitable to use it in patients with schizophrenia with Spanish as mother tongue. Methods: The total number of subjects are 110 to date. They are divided into two groups: 80 DSM-IV-TR criteria schizophrenia patients all clinically stable and 30 healthy controls.To assess the cognitive status we have used the Spanish Adaptation of t he BACS (randomly assigned to a sequence of versions A and B) and a standard cognitive battery. All the subjects were tested in three separate days with no more than two weeks between each assessment. On the first test session, subjects received o ne version of the BACS (A or B); on the second session they received the standard battery andin the third last session the other version of the BACS. Results: We have found significant correlations for all cognitive domains in patients between both versions of the BACS and the standard cognitive battery. In healthy controls we obtained significant correlations for all the domains.Sensitivity between-group impairment on all measures was determined with independent t-tests in all the tests (BACS and standard battery) and have demonstrated significant differences between controls and patients with schizophrenia. Conclusions: These preliminary results on the Spanish validation of the BACS suggest that the BACS is a good neuropsychological instrument for assessing global cognition in patients with schizophrenia. The scheduled he scheduled sample of 100 patients and 35 healthy controls is going to finish in a short period of time. References [1] Kraus MS, Keefe RS: Cognition as an outcome measure in schizophrenia. Br J Psychiatry Suppl. 2007 Aug;50:s46-51. [2] Keefe RS, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophr Bull. 2007 Jul;33(4):912-20.E pub 2007 Jun 13. [3] Keefe RS, Goldberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res. 2004 Jun1; 68(2-3):28397.
Early Detection 281 – EVALUATION OF PRODROMAL SYMPTOMS IN FIRST-EPISODE PSYCHOSIS Giuliano Aiello Department of Oncology and Neurosciences, Institute of Psychiatry, Chieti Univ., Chieti, Italy [email protected] Introduction: Basic Symptoms were shown to be present prior to a first psychotic episode,. Some were shown to indicate a possible transition to psychosis already years before that. Subsequently, attention has been focused on a subgroup of these signs and syndromes, which are particularly predictive for the pathological evolution. Methods: In an ongoing, naturalistic follow-up study, patients are monitored for the development of some of the most predictive signs and symptoms in the early psychotic phase. Beside a close psychopathological observation and a phenomenological interpretation, patients were assessed with the Schizophrenia Proneness Instrument, Adult version (SPI-A) for basic symptoms, with the Structured Interview of Prodromal Syndromes (SOPS/SIPS) for attenuated positive, negative, disorganized and general symptoms and with the Positive And Negative Syndrome Scale (PANSS) for psychotic, negative and general psychopathological symptoms.
Abstracts / Schizophrenia Research 102/1–3, Supplement 2 (2008) 1–279
279 – A NEW TOOL ASSESSING INTENTION READING, THE V-SIR, AS A MEASURE OF SEVERITY IN SCHIZOPHRENIA Catherine Bourdet 1 , Eric Brunet 2 , Nadine Bazin 2 , Christine Passerieux 2 , Marie-Christine Hardy-Bayle 2 1 CH Versailles, Versailles; 2 CH Versailles and INSERM ERI15, Versailles, France [email protected] Introduction: Different etiopathological models have been proposed for schizophrenia. Following Hardy-Baylé’s proposal, setting communication disorders as a central and specific deficit in schizophrenia1, two new tools for the evaluation of (1) communication disorders2-3 and (2) intentional reading4 have been developed in our team. We have previously demonstrated that both instruments separate significantly schizophrenic patients from normal controls and depressed patients34. Aim: The pre sent study aims at demonstrating, on a large number of schizophrenic patients, the validity and utility of these two scales for the clinical quantitative evaluation of schizophrenic patients. Methods: The study was part of a pharmacological trail assessing a large number of patients (n=206; age mean=41.3 SD=10.49) with different clinical scales (PANSS, BPRS) and measurements of social cognition (SCD*, V-SIR*). Results: The mean value and the range previously reported on smaller groups are confirmed (SCD mean=7.49 SD=4.11; V-SIR mean=24.36 SD=8.00). Results from both scales demonstrate a normal distribution. Intrinsic qualities will be described (Alpha Cronbach SCD= 0.88; V-SIR=0.76). The use of these two tools for the as sessment of patients in a large scale multi-centric pharmacological essay indicate that feasibility and transferability of expertise for testing are very good. Scores from these two tests were significantly correlated. V-SIR scores do not correlate with BPRS scores. Interestingly, only few individual items of the BPRS and the PANSS correlate significantly (p>.05) with ToM scores (SCD scores: 6 out of the 18 items of the BPRS and 17 out of 30 PANSS scores correlate with SCD scores; V-SIR scores: only one out of the 18 items of the BPRS and six out of 30 PANSS items correlate with the V-SIR scores). Conclusions: Evaluation of severity in schizophrenia needs quantitative assessments of communication and ToM disorders. We aimed to demonst rate here, for the SCD and for the V-SIR, the feasibility and utility of their use in a comprehensive battery for clinical and cognitive evaluation in Schizophrenia. English versions of these two scales are now being validated within English-speak ing normal and pathological groups. Acknowledgements: Study was supported by Lilly France References [1] Hardy-Bayle, Schiz.Bull. 29, 459 (2003). [2] Olivier, Eur.Psychiatry 12, 356-361 (1997) [3] Bazin et al, Schizophr.Res. 77, 75-84 (2005) [4] Bazin et al, PsychRes. (in press)
280 – SPANISH VALIDATION OF THE BACS (BRIEF ASSESSMENT IN COGNITION IN SCHIZOPHRENIA); PERFORMANCE IN PATIENTS AND HEALTHY CONTROLS
Nuria Segarra, S. Aspiazu, A. Justicia, E. Fernandez-Egea, F. Gutierrez, M. Allas, L. Sanchez, F. Contreras, G. Safont, J. Gascon, J.M. Menchon, M. Bernardo Hospital Clinic Barcelona, Barcelona, Spain [email protected] Introduction: Spanish validation of the BACS (Brief Assessment in Cognition in Schizophrenia); performance in patients and healthy controls.Neurocognitive impairment is considered a core component of schizophrenia and is increasingly under investigation as a potential treatment target (Keefe, 2007). The Brief Assessment in Cognition in Schizophrenia BACS, assess the main cognitive domains which are impaired in patients with schizophrenia: verbal memory, working memory, motor speed, attention, executive functions and verbal fluency. Also, the BACS has the advantage that takes less than 35 minutes
to be completed and it is as sensitive to cognitive impairment as a standard battery of tests that required over 2 hours to be completed (Keefe et al., 2004). A multicentre study (Hospital Clinic of Barcelona, Bellvitge University Hospital, Hospi tal Mutua of Terrassa), in coordination with the University of Duke, USA (Dr. Keefe), completed the Spanish Adaptation of the BACS. The Spanish Adaptation is suitable to use it in patients with schizophrenia with Spanish as mother tongue. Methods: The total number of subjects are 110 to date. They are divided into two groups: 80 DSM-IV-TR criteria schizophrenia patients all clinically stable and 30 healthy controls.To assess the cognitive status we have used the Spanish Adaptation of t he BACS (randomly assigned to a sequence of versions A and B) and a standard cognitive battery. All the subjects were tested in three separate days with no more than two weeks between each assessment. On the first test session, subjects received o ne version of the BACS (A or B); on the second session they received the standard battery andin the third last session the other version of the BACS. Results: We have found significant correlations for all cognitive domains in patients between both versions of the BACS and the standard cognitive battery. In healthy controls we obtained significant correlations for all the domains.Sensitivity between-group impairment on all measures was determined with independent t-tests in all the tests (BACS and standard battery) and have demonstrated significant differences between controls and patients with schizophrenia. Conclusions: These preliminary results on the Spanish validation of the BACS suggest that the BACS is a good neuropsychological instrument for assessing global cognition in patients with schizophrenia. The scheduled he scheduled sample of 100 patients and 35 healthy controls is going to finish in a short period of time. References [1] Kraus MS, Keefe RS: Cognition as an outcome measure in schizophrenia. Br J Psychiatry Suppl. 2007 Aug;50:s46-51. [2] Keefe RS, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophr Bull. 2007 Jul;33(4):912-20.E pub 2007 Jun 13. [3] Keefe RS, Goldberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res. 2004 Jun1; 68(2-3):28397.
Early Detection 281 – EVALUATION OF PRODROMAL SYMPTOMS IN FIRST-EPISODE PSYCHOSIS Giuliano Aiello Department of Oncology and Neurosciences, Institute of Psychiatry, Chieti Univ., Chieti, Italy [email protected] Introduction: Basic Symptoms were shown to be present prior to a first psychotic episode,. Some were shown to indicate a possible transition to psychosis already years before that. Subsequently, attention has been focused on a subgroup of these signs and syndromes, which are particularly predictive for the pathological evolution. Methods: In an ongoing, naturalistic follow-up study, patients are monitored for the development of some of the most predictive signs and symptoms in the early psychotic phase. Beside a close psychopathological observation and a phenomenological interpretation, patients were assessed with the Schizophrenia Proneness Instrument, Adult version (SPI-A) for basic symptoms, with the Structured Interview of Prodromal Syndromes (SOPS/SIPS) for attenuated positive, negative, disorganized and general symptoms and with the Positive And Negative Syndrome Scale (PANSS) for psychotic, negative and general psychopathological symptoms.