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Studies on the migration velocity and the phagocytose-function of leucocytes of rats. (1st Report) The effects of I131
Reports of meetings excited state due to the sudden change in the charge of the nucleus. (3) In the case of the emission of the positively charged particle, the product atom may have an excess number of orbital electrons due to the sudden decrease in the charge of the nucleus and may correspond to a r e d u c e d state, while in the case of the emission of the negatively charged particle the product atom m a y be in an oxidized state because of the shortage of electrons after the sudden increase in nuclear charge. (4) The change of the nuclear charge at the time of the emission of the charged particle corresponds to the change of the element. Because of this sudden change of the element in the molecule, the chemical binding between the transmutated and the neighboring atoms may not remain stable in some cases. Since P may be incorporated into such an important constituent of the cell as the nucleic acid of the genetic material and the recoil energy of Pa~ may be estimated to be the largest among the various fl-emitting isotopes of biological significance, we have attempted to test the effects of the internal irradiation of E. coli communis with p~z. Comparing the lethal effects of the external irradiation by X-ray (W-K c¢0.2A) and the effects by ps~_fl, the author estimated the effective sensitive volume (V,) from the target theory to be ( V , ) x ~ 7 + 10-4#3 and (Ve)a = 17"6 + 10 -4/,3. From these results the effects of internal irradiation may be estimated to be at least about 2.5 times larger than that of the corresponding external irradiation, and the effects on the growth stage were observed to be much larger than that on the resting stage. Studies on the M i g r a t i o n Velocity and the P h a g o c y t o s e - F u n c t i o n o f Leucocytes o f Rats. (lst Report) The Effects o f I TM.
MASATOSHITANAKA, The 2nd Division of the Department of Physiology, Nihon University, School of Medicine. The author studied the effects of radioactive iodine (I TM) upon the function of leucocytes of rats. That is to say, the velocity of amoeboid,
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wandering movements ( = migration velocity) and the ability of ingesting foreign particle ( = phagocytose function) of leucocytes were tested. In the experiments, I TM was given to the rat by subcutaneous injection at the rate of 1.0-0" 1/~c per g of body weight. The tests were made 1, 3, 7, 14, 21 and 28 days after the injection, namely in each case a small amount of blood was taken and the function of leucocytes was tested. Sugiyama's method was used for the measuring of the migration velocity and Mori's method was used to test the ability of the phagocytose function. The results obtained are as follows: (1) The migration velocity of psuedoeosinophile leucocytes. The administration of I TM at the dose of 0.1/~c per g of body weight to a rat did not give any effect. However, when it was given at the dose of 0.5-1.0/~c per g of the body weight, it showed apparent effect; the velocity always decreased. (2) The phagocytose-function of pseudoeosinophile leucocytes. Likewise, the administration of I TM at the dose of 0.5-1.0 #c per g showed a strong effect; the ability seemed to become always weak. E x p e r i m e n t a l Studies o f F i s s i o n P r o d u c t s Mixture o n the D i s t r i b u t i o n o f F o e t u s e s o f Offspring, and o n the Effects u p o n Sexual Cycles. EINOSUKE NAKAYAMA, SHIGEO SASAOAWA, KUNIO YAMAZAKI and YASUSHI OKAMURA, Department of Obstetrics and Gynaecology, Niigata University, School of Medicine. Experiments were performed with regard to the following four respects by administering Fission Products Mixture of the Oak Ridge National Laboratory into mature white rats: (1) Influences of Fission Products Mixture upon sexual cycles of the female animals. (2) Tissue Fission Products Mixture to fetuses in pregnancy. (3) Tissue Fission Products Mixture levels in fetuses at different periods of pregnancy in mother animals after the administration of Fission Products Mixture into offspring at lactation.
MASATOSHITANAKA, The 2nd Division of the Department of Physiology, Nihon University, School of Medicine. The author studied the effects of radioactive iodine (I TM) upon the function of leucocytes of rats. That is to say, the velocity of amoeboid,
119
wandering movements ( = migration velocity) and the ability of ingesting foreign particle ( = phagocytose function) of leucocytes were tested. In the experiments, I TM was given to the rat by subcutaneous injection at the rate of 1.0-0" 1/~c per g of body weight. The tests were made 1, 3, 7, 14, 21 and 28 days after the injection, namely in each case a small amount of blood was taken and the function of leucocytes was tested. Sugiyama's method was used for the measuring of the migration velocity and Mori's method was used to test the ability of the phagocytose function. The results obtained are as follows: (1) The migration velocity of psuedoeosinophile leucocytes. The administration of I TM at the dose of 0.1/~c per g of body weight to a rat did not give any effect. However, when it was given at the dose of 0.5-1.0/~c per g of the body weight, it showed apparent effect; the velocity always decreased. (2) The phagocytose-function of pseudoeosinophile leucocytes. Likewise, the administration of I TM at the dose of 0.5-1.0 #c per g showed a strong effect; the ability seemed to become always weak. E x p e r i m e n t a l Studies o f F i s s i o n P r o d u c t s Mixture o n the D i s t r i b u t i o n o f F o e t u s e s o f Offspring, and o n the Effects u p o n Sexual Cycles. EINOSUKE NAKAYAMA, SHIGEO SASAOAWA, KUNIO YAMAZAKI and YASUSHI OKAMURA, Department of Obstetrics and Gynaecology, Niigata University, School of Medicine. Experiments were performed with regard to the following four respects by administering Fission Products Mixture of the Oak Ridge National Laboratory into mature white rats: (1) Influences of Fission Products Mixture upon sexual cycles of the female animals. (2) Tissue Fission Products Mixture to fetuses in pregnancy. (3) Tissue Fission Products Mixture levels in fetuses at different periods of pregnancy in mother animals after the administration of Fission Products Mixture into offspring at lactation.