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Study of China national survey for hypertensive patients with multiple cardiovascular risk factors
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Abstracts
declined within normal range for four groups (P b 0.001). After 1 year of treatment, mean of CRE was significantly decreased by 13.51 umol/L (t= 9.796, P b 0.001); eGFR was significantly increased by 27.4 mL/min/ 1.73m2 (t= −7.178, P b 0.001). After 2 years of treatment, means of SBP and DBP decreased by 28.16 mmHg and 10.07 mmHg, respectively (t = 24.731, P b 0.001); CRE decreased by 19.17 umol/L (t = 13.69, P b 0.001); eGFR was increased by 43.23 umol/L (t = − 11.048, P b 0.001). Means of CRE and eGFR among the four groups did not have differences (P N 0.05). Conclusions: The effects of the combination of two antihypertensive drugs in hypertensives are significant, it can not only decrease BP and CRE, but also increase GFR. Decreasing BP can protect the kidney and improve the renal function. Different antihypertensive drugs had no significant difference in benefiting the renal function. doi:10.1016/j.ijcard.2011.08.610 0353 Effect of telmisartan and indapamide on the lipid and glucose metabolism in high-normal blood pressure patients SUHUAN ZHAO, XIYI LIU, LIHUA LIU, WEI YU, AIJING WANG China Aerospace Science and Industry Company 731 Hospital, Beijing, China Objective: To investigate the effect of telmisartan and indapamide on lipid and glucose metabolism in high-normal blood pressure patients. Methods: Ninty-nine high-normal blood pressure patients were randomly divided into two groups, Telmisartan and indapamide. Independent t-test was respectively carried out to compare two group biochemical indicators of pre- and post-treatment. Results: Blood pressure was well controlled in the 2 groups, the difference in systolic and diastolic blood pressure was not significant between preand post-treatments (P N 0.05). The mean of lipids, glucose between telmisartan and indapamide group had no significant difference (P N 0.05). After 12 months of treatment, the mean of TC, LDL-C and HDL-C had significant differences between the two groups (P b 0.05). Conclusion: Telmisartan can not only decrease blood pressure but also improve lipid metabolism in people with high-normal blood pressure. doi:10.1016/j.ijcard.2011.08.611 0357 Study of China national survey for hypertensive patients with multiple cardiovascular risk factors JUN LIU, HONGJUAN LI, XIANGYU GUO, JING LIU, WEI WANG, YUE QI, JIAYI SUN, DONG ZHAO Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Methods: All study subjects were obtained from “China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Cardiovascular Risk Factors, CONSIDER” study. Hypertensive patients were recruited from 46 hospitals (12 secondary hospitals and 34 tertiary hospitals) in 2009. A cluster sampling of 100 consecutively hypertensive patients who visited the outpatient departments and met our entry criteria was identified in each hospital. A total of 4985 patients with complete information were analyzed in this study. Results: Of the 4985 hypertensive patients, mean aged 58.4 years (standard deviation or SD: 9.6), 2476 were males (49.7%). In the study patients,
dyslipidemia was the most prevalent abnormality (81.2%). Dysglycemia was observed in 51.4% of the sample, 56.0% was lack of physical activities, and 18.4% was obesity. The prevalence of smoking in men was 35.5%. Moreover, compared to the older age group, patients in the younger age group (35–44 years) had a higher percentage of combined lacking of physical activities, smoking in men and obesity. 96.2% of hypertensive individuals mixed with cardiovascular risk factors. Hypertensive individuals with two risk factors were 77.1%, with more than three risk factors were 39.8%. The prevalence of patients with thirty-three risk factors were higher in men than that in women (47.8% vs 31.8%, P b 0.01), and 61.2% in the 45–54-year age group, which was the most patients. In patients with one risk factor, dyslipidemia (60.1%) was most commonly, mixed with dyslipidemia and lack of physical activities (37.3%), dyslipidemia and hyperglycemia (36.3%) were most commonly in patients with two risk factors. Conclusion: Coexistence of multiple cardiovascular risk factors is common among treated hypertensive patients in China, particularly in men and in younger patients. This analysis supports the urgent need for more effective and comprehensive strategies for the management of global risk for hypertensive patients. doi:10.1016/j.ijcard.2011.08.612 0359 Survey of dysglycemia in outpatients with hypertension across China — A national multicenter observational study JUN LIU, HONGJUAN LI, XIANGYU GUO, JING LIU, WEI WANG, YUE QI, JIAYI SUN, DONG ZHAO Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Methods: All study subjects were obtained from “China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Cardiovascular Risk Factors, CONSIDE” study. Hypertensive patients were recruited from 46 hospitals (12 secondary hospitals and 34 tertiary hospitals) in 2009. A cluster sampling of 100 consecutively hypertensive patients who visited the outpatient departments and met our entry criteria was identified in each hospital. Anthropometric and clinical data were obtained by a questionnaire survey and the laboratory tests (including fasting blood glucose and 2 h postprandial blood glucose) from each patient. A total of 4719 patients with complete information were analyzed in this study. Results: Of the 4719 hypertensive patients aged 58.4 years (standard deviation or SD: 9.5), 2333 were males (49.4%). There were 53.1% patients combined dysglycemia, 23.9% combined diabetes mellitus (DM), and 29.2% combined impaired glucose regulation (IGR). The prevalence of hypertensive patients concomitant dysglycemia, diabetes was increased with aging (P b 0.01). Among hypertensive patients with dysglycemia, 68.5% patients were newly diagnosed, wherein there were 77.6% patients combined IGR, and 22.4% combined DM. Of patients with newly diagnosed DM, 45.0% patients combined isolated postprandial hyperglycemia, and 31.0% combined compound hyperglycemia. Moreover, of patients with newly diagnosed IGR, 72.1% patients combined isolated impaired glucose tolerance. However, 72.1% IGR and 45.0% DM patients were erroneously diagnosed, if only dependent on examining fasting blood glucose. Of those with established DM, 71.3% patients were receiving medical treatment; among them 33.6% patients controlled fasting blood glucose to normal level. Conclusion: The present study demonstrated that there were more than half of the treated hypertensive patients combined dysglycemia in China, however the detection rate was very low. Nevertheless, it is highly
Abstracts
declined within normal range for four groups (P b 0.001). After 1 year of treatment, mean of CRE was significantly decreased by 13.51 umol/L (t= 9.796, P b 0.001); eGFR was significantly increased by 27.4 mL/min/ 1.73m2 (t= −7.178, P b 0.001). After 2 years of treatment, means of SBP and DBP decreased by 28.16 mmHg and 10.07 mmHg, respectively (t = 24.731, P b 0.001); CRE decreased by 19.17 umol/L (t = 13.69, P b 0.001); eGFR was increased by 43.23 umol/L (t = − 11.048, P b 0.001). Means of CRE and eGFR among the four groups did not have differences (P N 0.05). Conclusions: The effects of the combination of two antihypertensive drugs in hypertensives are significant, it can not only decrease BP and CRE, but also increase GFR. Decreasing BP can protect the kidney and improve the renal function. Different antihypertensive drugs had no significant difference in benefiting the renal function. doi:10.1016/j.ijcard.2011.08.610 0353 Effect of telmisartan and indapamide on the lipid and glucose metabolism in high-normal blood pressure patients SUHUAN ZHAO, XIYI LIU, LIHUA LIU, WEI YU, AIJING WANG China Aerospace Science and Industry Company 731 Hospital, Beijing, China Objective: To investigate the effect of telmisartan and indapamide on lipid and glucose metabolism in high-normal blood pressure patients. Methods: Ninty-nine high-normal blood pressure patients were randomly divided into two groups, Telmisartan and indapamide. Independent t-test was respectively carried out to compare two group biochemical indicators of pre- and post-treatment. Results: Blood pressure was well controlled in the 2 groups, the difference in systolic and diastolic blood pressure was not significant between preand post-treatments (P N 0.05). The mean of lipids, glucose between telmisartan and indapamide group had no significant difference (P N 0.05). After 12 months of treatment, the mean of TC, LDL-C and HDL-C had significant differences between the two groups (P b 0.05). Conclusion: Telmisartan can not only decrease blood pressure but also improve lipid metabolism in people with high-normal blood pressure. doi:10.1016/j.ijcard.2011.08.611 0357 Study of China national survey for hypertensive patients with multiple cardiovascular risk factors JUN LIU, HONGJUAN LI, XIANGYU GUO, JING LIU, WEI WANG, YUE QI, JIAYI SUN, DONG ZHAO Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Methods: All study subjects were obtained from “China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Cardiovascular Risk Factors, CONSIDER” study. Hypertensive patients were recruited from 46 hospitals (12 secondary hospitals and 34 tertiary hospitals) in 2009. A cluster sampling of 100 consecutively hypertensive patients who visited the outpatient departments and met our entry criteria was identified in each hospital. A total of 4985 patients with complete information were analyzed in this study. Results: Of the 4985 hypertensive patients, mean aged 58.4 years (standard deviation or SD: 9.6), 2476 were males (49.7%). In the study patients,
dyslipidemia was the most prevalent abnormality (81.2%). Dysglycemia was observed in 51.4% of the sample, 56.0% was lack of physical activities, and 18.4% was obesity. The prevalence of smoking in men was 35.5%. Moreover, compared to the older age group, patients in the younger age group (35–44 years) had a higher percentage of combined lacking of physical activities, smoking in men and obesity. 96.2% of hypertensive individuals mixed with cardiovascular risk factors. Hypertensive individuals with two risk factors were 77.1%, with more than three risk factors were 39.8%. The prevalence of patients with thirty-three risk factors were higher in men than that in women (47.8% vs 31.8%, P b 0.01), and 61.2% in the 45–54-year age group, which was the most patients. In patients with one risk factor, dyslipidemia (60.1%) was most commonly, mixed with dyslipidemia and lack of physical activities (37.3%), dyslipidemia and hyperglycemia (36.3%) were most commonly in patients with two risk factors. Conclusion: Coexistence of multiple cardiovascular risk factors is common among treated hypertensive patients in China, particularly in men and in younger patients. This analysis supports the urgent need for more effective and comprehensive strategies for the management of global risk for hypertensive patients. doi:10.1016/j.ijcard.2011.08.612 0359 Survey of dysglycemia in outpatients with hypertension across China — A national multicenter observational study JUN LIU, HONGJUAN LI, XIANGYU GUO, JING LIU, WEI WANG, YUE QI, JIAYI SUN, DONG ZHAO Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Methods: All study subjects were obtained from “China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Cardiovascular Risk Factors, CONSIDE” study. Hypertensive patients were recruited from 46 hospitals (12 secondary hospitals and 34 tertiary hospitals) in 2009. A cluster sampling of 100 consecutively hypertensive patients who visited the outpatient departments and met our entry criteria was identified in each hospital. Anthropometric and clinical data were obtained by a questionnaire survey and the laboratory tests (including fasting blood glucose and 2 h postprandial blood glucose) from each patient. A total of 4719 patients with complete information were analyzed in this study. Results: Of the 4719 hypertensive patients aged 58.4 years (standard deviation or SD: 9.5), 2333 were males (49.4%). There were 53.1% patients combined dysglycemia, 23.9% combined diabetes mellitus (DM), and 29.2% combined impaired glucose regulation (IGR). The prevalence of hypertensive patients concomitant dysglycemia, diabetes was increased with aging (P b 0.01). Among hypertensive patients with dysglycemia, 68.5% patients were newly diagnosed, wherein there were 77.6% patients combined IGR, and 22.4% combined DM. Of patients with newly diagnosed DM, 45.0% patients combined isolated postprandial hyperglycemia, and 31.0% combined compound hyperglycemia. Moreover, of patients with newly diagnosed IGR, 72.1% patients combined isolated impaired glucose tolerance. However, 72.1% IGR and 45.0% DM patients were erroneously diagnosed, if only dependent on examining fasting blood glucose. Of those with established DM, 71.3% patients were receiving medical treatment; among them 33.6% patients controlled fasting blood glucose to normal level. Conclusion: The present study demonstrated that there were more than half of the treated hypertensive patients combined dysglycemia in China, however the detection rate was very low. Nevertheless, it is highly