SUN-P106: Fat-Soluble Vitamins and Lung Function in Adult Patients with Cystic Fibrosis (CF)

Nutrition and chronic diseases 1 Rationale: Discrete choice experiment (DCE) methodology was applied to assess preferences for home enteral nutrition (HEN) characteristics among patients and their caregivers, and physicians. Methods: A targeted literature review and later focus group discussion lead to the identification of 6 attributes as able to appropriately describe HEN properties. Attributes included were tolerability, adaptation to comorbidities, nutrition and calories, handling, connections and information. Each attribute had 2 levels (whether satisfying or not). A fractional factorial design (orthogonal and balanced) provided 8 choice scenarios, which were included in 2 different questionnaires, one for patients and their caregivers (in case patients needed help) and one for the physicians. Sociodemographic and clinical facts were included to explore explanatory variables. Partial utilities and relative importance (RI) of attributes were estimated. Results: A total of 148 patients (71 needing caregivers to answer on their behalf ) and 114 physicians completed the survey. Overall, the most important attributes were tolerability (33% RI), nutrition and calories (26% RI) and adaptation to comorbidities (26% RI). However, physicians conferred a greater relative importance to tolerability and nutrition and calories ( p < 0.01) than patients. When subgroup analysis were run, younger patients (<75 yo) were found to prioritize tolerability while older patients were more concerned about handling than youngers. Conclusion: DCE results showed that both patients and physicians have a similar perception on the importance of different HEN attributes. However, the relative weight given to each HEN characteristic may vary. Thus, it is important to consider several points of view when selecting a HEN product. Disclosure of Interest: G. Olveira: None declared, M. A. MartinezOlmos: None declared, B. Fernandez de Bobadilla: None declared, M. Ferrer: None declared, N. Virgili: None declared, B. Vega: None declared, M. Blanco Grant/Research Support from: Funding, M. Layola Grant/Research Support from: Funding, L. Lizan Consultant for: consultant, M. Tribaldos Causadias Consultant for: consultant

SUN-P105 EFFECTS OF WALNUT CONSUMPTION ON BLOOD LIPIDS AND LIPOPROTEINS IN HYPERLIPIDEMIC INDIVIDUALS G. Okburan1, S. M. Mercanlıgil1. 1Nutrition and Dietetics, Eastern Mediterranean University, Mağusa, Turkey Rationale: Cardiovascular diseases (CVD) and CVD related deaths are the leading cause of death globally [1]. Consumption of walnuts has been associated with a decreased risk of cardiovascular disease events [2]. Walnuts have a unique profile, they are rich in polyunsaturated fatty acids, which may improve blood lipids [2]. Methods: Study has been carried out for 6 weeks with a total 37 participants. Participants were have mild to moderate hyperlipidemia who were not taking any lipid-lowering medications. The study was designed in two parallel arms and participants were randomly assigned to control group (n = 17) or study group (n = 20). All participants in both group were adopt AHA “low choloesterol diet” advises. The main difference between groups were participant in intervention group were consumed 40 g/day walnut. Chi-square statistical analysis were used for the qualitative data comparison.

S83 Results: Before and after the study, participants in both group were have similar body composition, total energy intake and total energy expenditure ( p > 0.05). At the end of the study, because of the adoption to AHA diet advises, participants in both groups lowered their total and LDL cholesterol levels. Study group participants have been lowered their total cholesterol and LDL cholesterol levels respectively by %5.3 and %8.8 and similar results were obtained from the control group participants who adopted AHA diet only. Conclusion: Walnut consumption may beneficially alter lipid profiles among various lipoprotein subclasses even when HDL and triglycerides levels do not change. References [1] Lopez ADM, CD, Ezzati M, Jamison DT, Murray CJ, ed. Global Burden of Disease and Risk Factors: Disease Control Priorities Project. New York, NY: World Bank and Oxford University Press; 2006. [2] Banel DK, Hu FB. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. Am J Clin Nutr. 2009 Jul;90(1):56–63. Disclosure of Interest: None declared

SUN-P106 FAT-SOLUBLE VITAMINS AND LUNG FUNCTION IN ADULT PATIENTS WITH CYSTIC FIBROSIS (CF) G. Cárdenas1, H. Segurola1, N. Garcia1, R. Lorite1, S. Redecillas1, B. Sarto1, A. Álvarez2, X. De Gracia2, R. Burgos1. 1 Nutritional Support Unit, 2Pneumology Service, Vall d’Hebron Hospital, Barcelona, Spain Rationale: Nutritional support in patients with CF includes adequate monitoring and supplementation with fat-soluble vitamins. We have found evidence linking levels of some fatsoluble vitamins with lung function parameters in CF stable adult patients. Aim: To determine the relationships between levels of fatsoluble vitamins and lung function parameters in patients with stable CF. Methods: Prospective observational study in not transplanted CF stable adult patients. Variables: age; gender; age at diagnosis; BMI; pancreatic insufficiency (PI); bronchial microbial colonization; fat-soluble vitamins levels: A(retinol), D(25OHD), E(alpha-tocopherol), K(time prothrombin); lung function by spirometry: FVC% (Forced vital capacity) and FEV1 (expiratory volume in the 1st second). Analysis, nutritional assessment and spirometry were performed in the same quarterly visit. Results: 96 adults (40 women), 56% diagnosed in childhood. Mean age 29 years ± 8.2 (R: 18–55). BMI: 21.5 ± 3.8 (R: 15–31.7). 84% showed exocrine PI and of these, 32% also endocrine PI. More than 60% were chronically colonized by Pseudomonas areuginosa. We have found a weak but significant positive correlation between levels of vitamin A and lung function: FVC % (r = 0.3, p = 0.008), FVC1 (r = 0.34, p = 0.002), regardless the presence of exocrine PI. Vitamin A levels weakly correlated with BMI (r = 0.22, p = 0.05). Vitamin D only correlated (r = 0.419, p = 0.006) with lung function (FVC%) in patients who had vitamin D deficiency (<25). We found no correlation between levels of vitamin E and lung function. Nutritional status assessed through BMI clearly correlated with lung function: FVC% (r = 0.34, p = 0.002); FEV1 (r = 0.35, p = 0.001). Conclusion: Fat-soluble vitamins in patients with CF appear to have an implication in lung function, which adds more

S84

Poster

arguments to the need for adequate supplementation and monitoring. The nutritional status also impacts on respiratory function. Disclosure of Interest: None declared

SUN-P107 NUTRITIONAL AND MICRONUTRIENT STATUS IN BULBAR AND SPINAL ONSET AMYOTROPHIC LATERAL SCLEROSIS PATIENTS I. Bretón1, G. Gutiérrez1, C. Velasco1, C. Cuerda1, L. Arhip1, M. Maíz1, J. L. Muñoz-Blanco2, P. García-Peris1. 1Nutrition Unit, 2 Neurology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain Rationale: Malnutrition is a common complication in amyotrophic lateral sclerosis (ALS) patients. The aim of this study was to describe and compare nutritional status in bulbar onset (BO) and spinal onset (SO) ALS patients at diagnosis. Methods: Retrospective study in a cohort of ALS patients. Nutritional evaluation was performed at diagnosis and included BMI, albumin, prealbumin, transferrin, ferritin, Cu, Zn, B12, folate, vit A, E and D. Data are expressed as mean ± SD (IQ) or frequencies. Statistical analysis included: Pearson’s correlation, T test, and χ2. Sig p < 0.05. Results: Two hundred and thirteen (121 men) patients were evaluated, aged 61.9 ± 13.3 y (52–74). 68.5% experimented a SO. There was a higher prevalence of BO in women (61.2%) and SO in men (65.1%) p < 0.001. Age at diagnosis was higher in BO than in SO patients 67.4 ± 12 y (60–77) vs 59.4 ± 13.2 y (50–71) p < 0.001. Mean BMI was 25.6 ± 4.2 kg/m2 (22.8–27.8). BMI is <18.2 kg/m2 in 2.9%. There were no differences in BMI between both onset types. Serum albumin and other evaluated micronutrients were normal in most patients. The percentages of deficiencies at diagnosis are expressed in table. No differences were found between SO or BO.

Spinal/bulbar

Vit D Vit E <20 ng/mL <850 μg/dL

Prealbumin. <20 mg/dL

Ferritin <20 μg/L

Zn Cu <70 μg/dL <80 μg/dL

61/37

21.9/14.9

4.8/9

30.7/41.8 13/7.5

8.2/6

In SO patients, it was found a positive correlation between age and BMI ( p 0.049) and a negative correlation between age and albumin ( p 0.003) and prealbumin ( p 0.009). We did not find any difference in BO patients. In BO patients, a positive correlation was found between age and Cu serum levels. Conclusion: BMI and albumin are normal in most ALS patients at diagnosis but prealbumin low serum levels, Vitamin D and Zn deficiency are common, with no differences between SO and BO, in spite a higher age in BO patients. ASL patients need a close nutrition monitoring, including micronutrients. Disclosure of Interest: None declared

SUN-P108 EFFECTS OF A 2-MONTH DIET AND NUTRACEUTICAL INTERVENTION ON QUALITY OF LIFE AND DEPRESSION WITH RESPECT TO INFLAMMAGING: RISTOMED, AN OPEN LABEL INTERVENTION TRIAL S. C. Regueme1, R. Ostan2, A. Pinto3, L. Valentini4, J. Durrieu1, C. Blanc-Bisson1, L. M. Donini3, H. Lochs4, C. Franceschi2, I. Bourdel-Marchasson1, on behalf of RISTOMED consortium. 1 Geriatrics, University Hospital of Bordeaux, Pessac, France;

2

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, 3Exerimental Medicine, Sapienza University of Rome, Roma, Italy; 4 Gastroenterology and Hepatology, CharitéUniversitätsmedizin Berlin, Berlin, Germany Rationale: Depression symptoms and lower quality of life were shown associated with inflammation. The multicentric, openlabel, randomized intervention trial RISTOMED (www.ristomed. eu, CORDIS FP7 [1]) aims to reduce the level of inflammation in older people. Here we describe the effect of the RISTOMED interventions on HRQoL and depressive symptoms. Methods: A cohort of 125 healthy older subjects was recruited in 3 countries (Italy, France and Germany) and randomized into 4 arms (Arm A, RISTOMED diet; Arm B, RISTOMED diet plus VSL#3 probiotic blend; Arm C, RISTOMED diet plus AISA d-Limonene; Arm D, RISTOMED diet plus Argan oil). The diet was weightmaintaining, adapted to each country and rich in antioxidant vitamins, polyphenols and flavonoids, PUFA (n6:n3 ratio = 3:1) and fibres. Inflammatory parameters, HrQoL (SF-36), physical functioning and depressive symptoms (CES-D) were collected before and after 56 days of intervention, and their changes were analyzed within each arm. Results: As previously reported a decrease in ESR was observed in the 4 arms [1]. A weight decrease occurred in arm A, B and C. Improvement of depressive symptoms was seen in the 4 arms (arm A: −40.0%, p = 0.001, arm B: −32.5%, p = 0.023, arm C: −42.8%, p = 0.004, and arm D: −33.3%, p = 0.021). Improvement of mental health component of HrQoL was shown in arm A (+2%, p = 0.020) and C (+2.1%, p = 0.025). There was no change in physical functioning according to interventions. Conclusion: A 2-month healthy diet adapted to each European population was able to decrease the depressive symptomatology and to improve the mental component of the HrQoL of healthy older subjects. References [1] Ostan R, Bene MC, Spazzafumo L et al. Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial. Clin Nutr 2015. Disclosure of Interest: None declared

SUN-P109 MALNUTRITION AMONG DALMATIAN MAINTENANCE HAEMODIALYSIS PATIENTS J. Radic1, M. Radic2, I. Jelicic1, T. Ilic Begovic3. 1Department od Nephrology and Dialysis, 2Department of Reumatology, 3 Department of Intensive care, University Hospital Split, Split, Croatia Rationale: Malnutrition is common in maintenance haemodialysis (HD) pateints. The aim of this study was to investigate the prevalence of malnutrition among Dalmatian HD patients and find out is there correlation between anaemia and other clinical parameters with nutritional status. Methods: To evaluate nutritional status body mass index (BMI), creatinine, albumin, cholesterol, Dialysis Malnutrition Score (DMS) and Malnutrition Inflammation Score (MIS) were used. Also, for each patient C – reactive protein, haemoglobin (Hb), urea reduction rate (URR) were assessed. Data of ultrafiltration (UF rate per HD) were assessed from patients’ records 3 months