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T-CELL LYMPHOMA, NASAL TYPE: CLINICOPATHOLOGIC ANALYSIS OF 3 CASES
OOOO Volume 129, Number 1 HIV was positive. Patient is on antiretroviral therapy and chemotherapy for sarcoma.
MYOFIBROMA IN PEDIATRIC PATIENTS: DIAGNOSIS AND TREATMENT OF A RARE LESION. CAMILA MELO MESQUITA, CARLA WELCH DA SILVA, GEORGE FERREIRA GOMES, JULIANA MARA OLIVEIRA SANTOS, ELIARDO SILVEIRA ^ SANTOS and, ANTONIO MOTALVERNE LOPES FILHO Myofibroma is a rare benign soft tissue neoplasm characterized by a large, growing, destructive mass. It shows predilection for the head and neck regions, the mandible being the most common oral location. Its biological behavior is unpredictable, presenting malignant lesions as differential diagnosis, and it is usually treated by surgical excision, despite reports of spontaneous regression. Patient E.T.S., 4 years old and female, was referred to our service with a chief complaint of showing "a lump in the chin." A swelling in the left mandible angle that was hard to palpation and associated to pain complaint with evolution of 6 months was observed. An incisional biopsy was performed, and the results revealed the diagnosis of myofibroma. The patient was referred to pediatrics for evaluation, the result being negative for others myofibromas. The treatment consisted of submandibular extraoral access for the excision of the tumor. The patient has 4 years of follow-up without signs of recurrence.
POLYOSTOTIC CRANIOMAXILLOFACIAL FIBROUS DYSPLASIA ASSOCIATED WITH ACROMEGALY: A CASE REPORT. CAMILA MELO MESQUITA, CARLA WELCH DA SILVA, GEORGE FERREIRA GOMES, ELIARDO SILVEIRA SANTOS, JEFERSON MARTINS PEREIRA LUCENA FRANCO, JOSE ITALO SOARES MOTA and, ROBERTO DIAS RE ^ GO McCune-Albright syndrome (MAS) is a complex congenital disorder due to mutations at the onset of embryonic activation of postzygotic somatic cells in the GNAS1 gene. The phenotype is heterogeneous and includes polyostotic/monostotic fibrous dysplasia, cafe-au-lait skin spots, and hyperfunctioning endocrinopathies including excess of growth hormone (GH). Similarly, acromegaly as a manifestation of endocrine hyperfunction is uncommon and affects about 20% of patients with MAS. Here, we describe a 31-year-old woman with severe facial involvement of polyostotic fibrous dysplasia, in association with acromegaly and McCune-Albright syndrome, in which it was satisfactorily managed by surgical recontouring, with no clinical signs of relapse at a 12-year follow-up. Patients with craniomaxillofacial fibrous dysplasia associated with acromegaly may present significant facial asymmetries, which can be satisfactorily solved by cosmetic treatment, especially in patients with psychological problems and problems of severe social acceptance.
USE OF THERMOGRAPHY FOR DIAGNOSIS OF ACTINIC CHEILITS AND LOWER LIP SQUAMOUS CELL CARCINOMA. INGRID MORGANA FERNANDES GONCALVES, ¸ ALANNE VANDREIA DA SILVA ALVES, KATIA ELIZABETE GALDINO, ROBSON PEQUENO DE SOUSA, DANIELA PITA DE MELO, CASSIANO FRANCISCO WEEGE NONAKA and, POLLIANNA MUNIZ ALVES
ABSTRACTS
e97
Lower lip squamous cell carcinoma (LLSCC) represents frequent lip malignant neoplasms, and the majority is preceded by actinic cheilitis (AC), a potentially malignant disorder. In this context, we report 3 cases of AC and 1 of LLSCC, emphasizing the importance of thermography as an auxiliary tool in diagnosis. In AC and LLSCC, thermography showed, respectively, whitish areas with higher heat emission and reddish circular area of irregular thermal distribution. After acquisition of thermography images, incisional biopsies were performed to evaluate microscopic alterations according to the criteria described by the World Health Organization (2017). Of the AC cases, 1 was diagnosed as mild epithelial dysplasia and 2 were moderate epithelial dysplasia. LLSCC was confirmed on anatomopathologic examination. As a result, we observed that thermography is not able to distinguish the different degrees of epithelial dysplasia found in AC, but it is a new imaging method useful in distinguishing AC from LLSCC.
EXTRANODAL NATURAL KILLER/T-CELL LYMPHOMA, NASAL TYPE: CLINICOPATHOLOGIC ANALYSIS OF 3 CASES. SARA FERREIRA DOS SANTOS COSTA, LUCAS LACERDA DE SOUZA, OSLEI PAES DE ALMEIDA, ANDERSON MAURICIO PAIVA E COSTA, FLAVIA SIROTHEAU ^ A PONTES, FELIPE PAIVA FONSECA and, CORRE ^ HELDER ANTONIO REBELO PONTES Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant neoplasia, and the nasal cavity is the most commonly involved site. We present the clinicopathologic features of 3 patients including 2 women and 1 man with age varying from 41 to 70 years. The patients exhibited painful, extensive, destructive lesions with large ulceration predominantly affecting the hard palate. They also revealed other complications such as nasal obstruction, facial asymmetry, fever, and weight loss. Microscopically, all cases revealed a diffuse lymphoid infiltrate composed of small-to-medium sized neoplastic cells with large areas of necrosis and the angiocentric and angiodestructive growth pattern. Positivity for LCA, CD3, CD43, CD56, and granzyme B was observed. A low Ki-67 labeling index and positivity for Epstein-Barr virus were also observed. Two patients died, and 1 remains alive under treatment. Extranodal nasal NK/T-cell lymphoma presents a poor prognosis, and its diagnosis can be challenging. Support: FAPEMIG.
MALT LYMPHOMA OF THE SOFT PALATE: A CASE REPORT. CINTHIA VERONICA BARDALEZ LOPEZ DE CACERES, OSLEI PAES DE ALMEIDA, PABLO AGUSTIN VARGAS, HELDER ^ ANTONIO REBELO PONTES, ANDERSON MAURICIO PAIVA E COSTA, LUCAS LACERDA DE SOUZA and, FELIPE PAIVA FONSECA The aim of this report is to describe an original case of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 63-year-old male patient was referred to our department because of a painless swelling in his soft palate observed 2 months ago. The intraoral examination confirmed the presence of a well-defined swelling in the soft palate, extending to the oropharynx, exhibiting a normal colored overlying mucosa. Microscopically, a diffuse proliferation of small-sized neoplastic cells, some of them showing abundant eosinophilic cytoplasm, and reactive plasma cells were observed.
MYOFIBROMA IN PEDIATRIC PATIENTS: DIAGNOSIS AND TREATMENT OF A RARE LESION. CAMILA MELO MESQUITA, CARLA WELCH DA SILVA, GEORGE FERREIRA GOMES, JULIANA MARA OLIVEIRA SANTOS, ELIARDO SILVEIRA ^ SANTOS and, ANTONIO MOTALVERNE LOPES FILHO Myofibroma is a rare benign soft tissue neoplasm characterized by a large, growing, destructive mass. It shows predilection for the head and neck regions, the mandible being the most common oral location. Its biological behavior is unpredictable, presenting malignant lesions as differential diagnosis, and it is usually treated by surgical excision, despite reports of spontaneous regression. Patient E.T.S., 4 years old and female, was referred to our service with a chief complaint of showing "a lump in the chin." A swelling in the left mandible angle that was hard to palpation and associated to pain complaint with evolution of 6 months was observed. An incisional biopsy was performed, and the results revealed the diagnosis of myofibroma. The patient was referred to pediatrics for evaluation, the result being negative for others myofibromas. The treatment consisted of submandibular extraoral access for the excision of the tumor. The patient has 4 years of follow-up without signs of recurrence.
POLYOSTOTIC CRANIOMAXILLOFACIAL FIBROUS DYSPLASIA ASSOCIATED WITH ACROMEGALY: A CASE REPORT. CAMILA MELO MESQUITA, CARLA WELCH DA SILVA, GEORGE FERREIRA GOMES, ELIARDO SILVEIRA SANTOS, JEFERSON MARTINS PEREIRA LUCENA FRANCO, JOSE ITALO SOARES MOTA and, ROBERTO DIAS RE ^ GO McCune-Albright syndrome (MAS) is a complex congenital disorder due to mutations at the onset of embryonic activation of postzygotic somatic cells in the GNAS1 gene. The phenotype is heterogeneous and includes polyostotic/monostotic fibrous dysplasia, cafe-au-lait skin spots, and hyperfunctioning endocrinopathies including excess of growth hormone (GH). Similarly, acromegaly as a manifestation of endocrine hyperfunction is uncommon and affects about 20% of patients with MAS. Here, we describe a 31-year-old woman with severe facial involvement of polyostotic fibrous dysplasia, in association with acromegaly and McCune-Albright syndrome, in which it was satisfactorily managed by surgical recontouring, with no clinical signs of relapse at a 12-year follow-up. Patients with craniomaxillofacial fibrous dysplasia associated with acromegaly may present significant facial asymmetries, which can be satisfactorily solved by cosmetic treatment, especially in patients with psychological problems and problems of severe social acceptance.
USE OF THERMOGRAPHY FOR DIAGNOSIS OF ACTINIC CHEILITS AND LOWER LIP SQUAMOUS CELL CARCINOMA. INGRID MORGANA FERNANDES GONCALVES, ¸ ALANNE VANDREIA DA SILVA ALVES, KATIA ELIZABETE GALDINO, ROBSON PEQUENO DE SOUSA, DANIELA PITA DE MELO, CASSIANO FRANCISCO WEEGE NONAKA and, POLLIANNA MUNIZ ALVES
ABSTRACTS
e97
Lower lip squamous cell carcinoma (LLSCC) represents frequent lip malignant neoplasms, and the majority is preceded by actinic cheilitis (AC), a potentially malignant disorder. In this context, we report 3 cases of AC and 1 of LLSCC, emphasizing the importance of thermography as an auxiliary tool in diagnosis. In AC and LLSCC, thermography showed, respectively, whitish areas with higher heat emission and reddish circular area of irregular thermal distribution. After acquisition of thermography images, incisional biopsies were performed to evaluate microscopic alterations according to the criteria described by the World Health Organization (2017). Of the AC cases, 1 was diagnosed as mild epithelial dysplasia and 2 were moderate epithelial dysplasia. LLSCC was confirmed on anatomopathologic examination. As a result, we observed that thermography is not able to distinguish the different degrees of epithelial dysplasia found in AC, but it is a new imaging method useful in distinguishing AC from LLSCC.
EXTRANODAL NATURAL KILLER/T-CELL LYMPHOMA, NASAL TYPE: CLINICOPATHOLOGIC ANALYSIS OF 3 CASES. SARA FERREIRA DOS SANTOS COSTA, LUCAS LACERDA DE SOUZA, OSLEI PAES DE ALMEIDA, ANDERSON MAURICIO PAIVA E COSTA, FLAVIA SIROTHEAU ^ A PONTES, FELIPE PAIVA FONSECA and, CORRE ^ HELDER ANTONIO REBELO PONTES Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant neoplasia, and the nasal cavity is the most commonly involved site. We present the clinicopathologic features of 3 patients including 2 women and 1 man with age varying from 41 to 70 years. The patients exhibited painful, extensive, destructive lesions with large ulceration predominantly affecting the hard palate. They also revealed other complications such as nasal obstruction, facial asymmetry, fever, and weight loss. Microscopically, all cases revealed a diffuse lymphoid infiltrate composed of small-to-medium sized neoplastic cells with large areas of necrosis and the angiocentric and angiodestructive growth pattern. Positivity for LCA, CD3, CD43, CD56, and granzyme B was observed. A low Ki-67 labeling index and positivity for Epstein-Barr virus were also observed. Two patients died, and 1 remains alive under treatment. Extranodal nasal NK/T-cell lymphoma presents a poor prognosis, and its diagnosis can be challenging. Support: FAPEMIG.
MALT LYMPHOMA OF THE SOFT PALATE: A CASE REPORT. CINTHIA VERONICA BARDALEZ LOPEZ DE CACERES, OSLEI PAES DE ALMEIDA, PABLO AGUSTIN VARGAS, HELDER ^ ANTONIO REBELO PONTES, ANDERSON MAURICIO PAIVA E COSTA, LUCAS LACERDA DE SOUZA and, FELIPE PAIVA FONSECA The aim of this report is to describe an original case of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 63-year-old male patient was referred to our department because of a painless swelling in his soft palate observed 2 months ago. The intraoral examination confirmed the presence of a well-defined swelling in the soft palate, extending to the oropharynx, exhibiting a normal colored overlying mucosa. Microscopically, a diffuse proliferation of small-sized neoplastic cells, some of them showing abundant eosinophilic cytoplasm, and reactive plasma cells were observed.