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Temporal Order Assessment in Patients with Bipolar Disorder
Available online at www.sciencedirect.com
ScienceDirect Procedia - Social and Behavioral Sciences 126 (2014) 216
ICTTP 2014
Temporal order assessment in patients with Bipolar Disorder Francesco Giorlando1,2,*, Shikha Markanday2, Andrew Anderson3, Roger Carpenter4, Michael Berk1,2,5-7 1 Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia Barwon Health and the Geelong Clinic, Swanston Centre, Geelong, Victoria, Australia 3 Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia 4 Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge UK 5 IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia 6 Orygen Youth Health Research Centre, Centre for Youth Mental Health, Parkville, Victoria, Australia 7 The Florey Insitutoe for Neuroscicence and Mental Health, Parkville, Victoria, Australia 2
Abstract Alterations in temporal perception accompany dissociative symptoms. However, the extent and frequency of these temporal symptoms have not been extensively studied in Bipolar Disorder (BD). The study was a prospective, repeated measures design of 21 patients with BD, conducted at Barwon Health in Geelong, Australia. The study combined questionnaires of mood and dissociative symptoms with a novel psychophysical method of assessing altered sub-second temporal performance. Participants observed a series of two flashed visual stimuli (duration 20 ms, inter stimulus interval 60 ms) while making rapid (saccadic) eye movements. The experimental paradigm resulted in a proportion of observations (47%) in which the perceptual ordering of the flashes was inverted in time. Dissociative symptoms, as measured by the Dissociative Experiences Scale, were common in this patient cohort. The proportion of inverted temporal judgments correlated with both dissociative symptom scores (Clinician Administered Dissociative States Scale, unreality subscale) and with the Young Mania Rating Scale score (in linear model). This study shows that measures of temporal perception correlate with mood alterations in BD. This finding is the first to find such associations with a sub-second timing task. The linkage between the symptoms of BD and testable measures of time perception, supports the case for psychophysical measures of dissociation having utility as biomarkers of disease state. © 2014 The Authors. Published by Elsevier Ltd. © 2014 The Authors. Published by Elsevier Ltd. Selection andpeer-review peer-reviewunder underresponsibility responsibility Organizing Committee ofInternational the International Conference on Timing and Time Selection and of of thethe Organizing Committee of the Conference on Timing and Time Perception. Perception. Keywords: Temporal perception; Bipolar disorder; Dissociation; Mania; Temporal disintegration
* Corresponding author. Tel.: +61(0)406990398; fax: +61(0)390359905. E-mail address: [email protected]
1877-0428 © 2014 The Authors. Published by Elsevier Ltd.
Selection and peer-review under responsibility of the Organizing Committee of the International Conference on Timing and Time Perception. doi:10.1016/j.sbspro.2014.02.381
ScienceDirect Procedia - Social and Behavioral Sciences 126 (2014) 216
ICTTP 2014
Temporal order assessment in patients with Bipolar Disorder Francesco Giorlando1,2,*, Shikha Markanday2, Andrew Anderson3, Roger Carpenter4, Michael Berk1,2,5-7 1 Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia Barwon Health and the Geelong Clinic, Swanston Centre, Geelong, Victoria, Australia 3 Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia 4 Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge UK 5 IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia 6 Orygen Youth Health Research Centre, Centre for Youth Mental Health, Parkville, Victoria, Australia 7 The Florey Insitutoe for Neuroscicence and Mental Health, Parkville, Victoria, Australia 2
Abstract Alterations in temporal perception accompany dissociative symptoms. However, the extent and frequency of these temporal symptoms have not been extensively studied in Bipolar Disorder (BD). The study was a prospective, repeated measures design of 21 patients with BD, conducted at Barwon Health in Geelong, Australia. The study combined questionnaires of mood and dissociative symptoms with a novel psychophysical method of assessing altered sub-second temporal performance. Participants observed a series of two flashed visual stimuli (duration 20 ms, inter stimulus interval 60 ms) while making rapid (saccadic) eye movements. The experimental paradigm resulted in a proportion of observations (47%) in which the perceptual ordering of the flashes was inverted in time. Dissociative symptoms, as measured by the Dissociative Experiences Scale, were common in this patient cohort. The proportion of inverted temporal judgments correlated with both dissociative symptom scores (Clinician Administered Dissociative States Scale, unreality subscale) and with the Young Mania Rating Scale score (in linear model). This study shows that measures of temporal perception correlate with mood alterations in BD. This finding is the first to find such associations with a sub-second timing task. The linkage between the symptoms of BD and testable measures of time perception, supports the case for psychophysical measures of dissociation having utility as biomarkers of disease state. © 2014 The Authors. Published by Elsevier Ltd. © 2014 The Authors. Published by Elsevier Ltd. Selection andpeer-review peer-reviewunder underresponsibility responsibility Organizing Committee ofInternational the International Conference on Timing and Time Selection and of of thethe Organizing Committee of the Conference on Timing and Time Perception. Perception. Keywords: Temporal perception; Bipolar disorder; Dissociation; Mania; Temporal disintegration
* Corresponding author. Tel.: +61(0)406990398; fax: +61(0)390359905. E-mail address: [email protected]
1877-0428 © 2014 The Authors. Published by Elsevier Ltd.
Selection and peer-review under responsibility of the Organizing Committee of the International Conference on Timing and Time Perception. doi:10.1016/j.sbspro.2014.02.381