- Email: [email protected]
The creamatocrit, lipid concentration and caloric density in mother's milk
Abstracts
We collected data of paired UNGAL–echocardiogram measurements on the first day of life. We first set infants with PDA either closed or open and then infants with hemodynamically significant PDA (ductus diameter > or = 1.4 mm body weight-left atrium to aortic root ratio > or = 1.4) in two groups: moderate size 1.4–2.9 mm and large size > or =3 mm. Significantly higher levels of UNGAL were detected in VLBW with a larger PDA (p < 0.05). Those with a closed or a small PDA showed decreased levels of UNGAL though this finding was not statistically significant. The present study shows no significant difference of UNGAL levels between a PDA either closed or open suggesting that high levels of UNGAL detected at birth might be related to a large and hemodynamically significant PDA but cannot alone justify the presence of a PDA. Many other factors probably influence that value. Further studies are required to better understand the relationship between UNGAL and PDA and future clinical usefulness. doi:10.1016/j.earlhumdev.2010.12.026
The creamatocrit, lipid concentration and caloric density in mother's milk Bozena Kociszewska-Najman⁎, Beata Borek-Dzieciol, Ewa Sanczyk Medical University of Warsaw, First Department of Obstetrics and Gynecology, Neonatal Ward, Pl., Starynkiewicza 1/3, 02-015 Warszawa, Poland ⁎Corresponding author.
S91
Few data are available on antifungal therapy in pediatric patients, even less in neonates or preterms, despite the frequency of such infections. Micafungin is an echinocandin, approved for invasive candidiasis in adults and pediatric patients, including neonates, and is a fungicide on both C. albicans and non-albicans spp. In addition, it shows a very good activity profile on Candida biofilms. We report our experience with Micafungin use in four preterm neonates, admitted in our tertiary NICU in Siena, Italy during the year 2010. Their gestational age was 24 (two cases), 28 and 33 weeks, respectively. Their birth weight was 810, 830, 1130 and 1500 g, respectively. All infants underwent mechanical ventilation and had a CVC placed for long periods; in addition, they all received antibiotic prophylaxis since birth and antifungal prophylaxis with fluconazole from day 3 of life. All of them developed C. parapsilosis sepsis with positive blood cultures in the second and third week of life, and thus Micafungin treatment at 2 mg/kg/day was instituted. Renal and liver function were constantly monitored and checked with serial laboratory testings twice a week, and once a week, respectively. Blood cultures became negative after 14 mean days of treatment and therapy continued for another 10 days. Renal and liver tests remained within normal range at all times in all 4 patients. In conclusion, Micafungin was safe and effective in the treatment of C. parapsilosis infections when administered at 2 mg/kg/day for about 1 month. Considering the very good tolerability, in order to reach a faster effect, administration of a higher dosage (i.e. 4 mg/kg/day) could be considered. doi:10.1016/j.earlhumdev.2010.12.028
The objective of this study was to estimate creamatocrit, calories, fats in colostrum, transitional milk, mature milk in the morning and at night in women after preterm and term births. 61 mothers were recruited to the study: 22 mothers after preterm (MAP) deliveries: 26–37 weeks gestation and 39 mothers after term (MAT) births: =37 weeks. Estimations of creamatocrit (%), calories (kcal/L), fats (g/L) were made in colostrum (1–5 days), transitional milk (6–14 days), mature milk (over 15 days), in the morning (9:00–11:00 am) and at night (9:00–11:00 pm). In colostrum, the lowest levels was in morning samples MAP: 4.8%, 656 kcal/L, 32 g/L. In night samples from MAP and in morning samples from MAT the content of the above was similar: 5.3–5.4%, 680–670 kcal/L and 36–37 g/L. In transitional milk levels in morning samples from MAP, MAT and in night samples from MAP were the same: 7.9%, 825– 829 kcal/L, 51 g/L. The content of the above was higher in night samples from MAT: 8.9%, 886 kcal/L, 56.6 g/L In mature milk the lowest levels were in morning samples from MAP: 6.8%, 770 kcal/L, 45 g/L. The highest levels were in night samples from MAT: 9.6%, 920 kcal/L, 66 g/L. Test results are very important for optimal nutrition planning. doi:10.1016/j.earlhumdev.2010.12.027
Efficacy of Micafungin in very low birth weight (VLBW) neonates affected by Candida parapsilosis sepsis L. Le Pera, S. Cecchi, C. Coviello, M. Casucci, S. Nappini, A. Rossetti, F. Bagnoli Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Unità di Terapia Intensiva Neonatale, Azienda Ospedaliera Universitaria Senese, Siena, Italy The incidence of invasive fungal infections is in constant growth, also due to the increasing number of neonates at risk in the NICUs. Among all fungi, Candida spp is the main cause of high morbidity and mortality among VLBW neonates due the frequent use of devices (i.e. CVC), antibiotics and steroids.
Lutein and zeaxanthin supplementation in preterm VLBW neonates in NICU: A multicentre RCT ☆ Paolo Manzonia,⁎, Roberta Guardionea, Paolo Bonettib, Claudio Prioloa, Andrea Maestria, Caterina Mansoldob, Michael Mostertc, Giovanni Anselmettid, Massimo Bellettatoe, Paolo Bibanb, Daniele Farinaa a Neonatology and NICU, S. Anna Hospital, Torino, Italy b Paediatrics/Neonatal Intensive Care Unit, Division of Paediatrics, Azienda Ospedaliera, Verona, Italy c Division of Neonatology and Paediatrics, City Hospital, Thiene, Italy d Referral Center for ROP of Piedmont, Torino, Italy e Department of Paediatrics, University of Torino, Italy ⁎Corresponding author. Neonatology and Hospital NICU, S. Anna Hospital., Azienda Ospedaliera Regina Margherita-S. Anna., C. Spezia 60. 10126 Torino, Italy. Tel.: +39 11 3134304/5/8; fax: +39 11 3134888. E-mail: [email protected] (P. Manzoni). Keywords: Nutrition, Lutein, Zeaxanthin, Preterm neonates, ROP, BPD, NEC, Prevention Background: Preterm infants are at high risk of oxidative stress-induced damage, including severe multifactorial diseases such as ROP, NEC and BPD. Human milk feeding of preterms is speculated to protect against these three conditions. The carotenoids are a family of polyene, lipophilic molecules found in human milk but not in formulas. These molecules might account for the protective role of human milk, providing protection against both light-induced and metabolic oxidative damage in the retina and in other developing tissues. Objective: To establish if supplementation of carotenoids in preterm infants protects against ROP, BPD and NEC.
☆ Trial registration: www.controlled-trials.com; ISRCTN number 29971311.
We collected data of paired UNGAL–echocardiogram measurements on the first day of life. We first set infants with PDA either closed or open and then infants with hemodynamically significant PDA (ductus diameter > or = 1.4 mm body weight-left atrium to aortic root ratio > or = 1.4) in two groups: moderate size 1.4–2.9 mm and large size > or =3 mm. Significantly higher levels of UNGAL were detected in VLBW with a larger PDA (p < 0.05). Those with a closed or a small PDA showed decreased levels of UNGAL though this finding was not statistically significant. The present study shows no significant difference of UNGAL levels between a PDA either closed or open suggesting that high levels of UNGAL detected at birth might be related to a large and hemodynamically significant PDA but cannot alone justify the presence of a PDA. Many other factors probably influence that value. Further studies are required to better understand the relationship between UNGAL and PDA and future clinical usefulness. doi:10.1016/j.earlhumdev.2010.12.026
The creamatocrit, lipid concentration and caloric density in mother's milk Bozena Kociszewska-Najman⁎, Beata Borek-Dzieciol, Ewa Sanczyk Medical University of Warsaw, First Department of Obstetrics and Gynecology, Neonatal Ward, Pl., Starynkiewicza 1/3, 02-015 Warszawa, Poland ⁎Corresponding author.
S91
Few data are available on antifungal therapy in pediatric patients, even less in neonates or preterms, despite the frequency of such infections. Micafungin is an echinocandin, approved for invasive candidiasis in adults and pediatric patients, including neonates, and is a fungicide on both C. albicans and non-albicans spp. In addition, it shows a very good activity profile on Candida biofilms. We report our experience with Micafungin use in four preterm neonates, admitted in our tertiary NICU in Siena, Italy during the year 2010. Their gestational age was 24 (two cases), 28 and 33 weeks, respectively. Their birth weight was 810, 830, 1130 and 1500 g, respectively. All infants underwent mechanical ventilation and had a CVC placed for long periods; in addition, they all received antibiotic prophylaxis since birth and antifungal prophylaxis with fluconazole from day 3 of life. All of them developed C. parapsilosis sepsis with positive blood cultures in the second and third week of life, and thus Micafungin treatment at 2 mg/kg/day was instituted. Renal and liver function were constantly monitored and checked with serial laboratory testings twice a week, and once a week, respectively. Blood cultures became negative after 14 mean days of treatment and therapy continued for another 10 days. Renal and liver tests remained within normal range at all times in all 4 patients. In conclusion, Micafungin was safe and effective in the treatment of C. parapsilosis infections when administered at 2 mg/kg/day for about 1 month. Considering the very good tolerability, in order to reach a faster effect, administration of a higher dosage (i.e. 4 mg/kg/day) could be considered. doi:10.1016/j.earlhumdev.2010.12.028
The objective of this study was to estimate creamatocrit, calories, fats in colostrum, transitional milk, mature milk in the morning and at night in women after preterm and term births. 61 mothers were recruited to the study: 22 mothers after preterm (MAP) deliveries: 26–37 weeks gestation and 39 mothers after term (MAT) births: =37 weeks. Estimations of creamatocrit (%), calories (kcal/L), fats (g/L) were made in colostrum (1–5 days), transitional milk (6–14 days), mature milk (over 15 days), in the morning (9:00–11:00 am) and at night (9:00–11:00 pm). In colostrum, the lowest levels was in morning samples MAP: 4.8%, 656 kcal/L, 32 g/L. In night samples from MAP and in morning samples from MAT the content of the above was similar: 5.3–5.4%, 680–670 kcal/L and 36–37 g/L. In transitional milk levels in morning samples from MAP, MAT and in night samples from MAP were the same: 7.9%, 825– 829 kcal/L, 51 g/L. The content of the above was higher in night samples from MAT: 8.9%, 886 kcal/L, 56.6 g/L In mature milk the lowest levels were in morning samples from MAP: 6.8%, 770 kcal/L, 45 g/L. The highest levels were in night samples from MAT: 9.6%, 920 kcal/L, 66 g/L. Test results are very important for optimal nutrition planning. doi:10.1016/j.earlhumdev.2010.12.027
Efficacy of Micafungin in very low birth weight (VLBW) neonates affected by Candida parapsilosis sepsis L. Le Pera, S. Cecchi, C. Coviello, M. Casucci, S. Nappini, A. Rossetti, F. Bagnoli Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Unità di Terapia Intensiva Neonatale, Azienda Ospedaliera Universitaria Senese, Siena, Italy The incidence of invasive fungal infections is in constant growth, also due to the increasing number of neonates at risk in the NICUs. Among all fungi, Candida spp is the main cause of high morbidity and mortality among VLBW neonates due the frequent use of devices (i.e. CVC), antibiotics and steroids.
Lutein and zeaxanthin supplementation in preterm VLBW neonates in NICU: A multicentre RCT ☆ Paolo Manzonia,⁎, Roberta Guardionea, Paolo Bonettib, Claudio Prioloa, Andrea Maestria, Caterina Mansoldob, Michael Mostertc, Giovanni Anselmettid, Massimo Bellettatoe, Paolo Bibanb, Daniele Farinaa a Neonatology and NICU, S. Anna Hospital, Torino, Italy b Paediatrics/Neonatal Intensive Care Unit, Division of Paediatrics, Azienda Ospedaliera, Verona, Italy c Division of Neonatology and Paediatrics, City Hospital, Thiene, Italy d Referral Center for ROP of Piedmont, Torino, Italy e Department of Paediatrics, University of Torino, Italy ⁎Corresponding author. Neonatology and Hospital NICU, S. Anna Hospital., Azienda Ospedaliera Regina Margherita-S. Anna., C. Spezia 60. 10126 Torino, Italy. Tel.: +39 11 3134304/5/8; fax: +39 11 3134888. E-mail: [email protected] (P. Manzoni). Keywords: Nutrition, Lutein, Zeaxanthin, Preterm neonates, ROP, BPD, NEC, Prevention Background: Preterm infants are at high risk of oxidative stress-induced damage, including severe multifactorial diseases such as ROP, NEC and BPD. Human milk feeding of preterms is speculated to protect against these three conditions. The carotenoids are a family of polyene, lipophilic molecules found in human milk but not in formulas. These molecules might account for the protective role of human milk, providing protection against both light-induced and metabolic oxidative damage in the retina and in other developing tissues. Objective: To establish if supplementation of carotenoids in preterm infants protects against ROP, BPD and NEC.
☆ Trial registration: www.controlled-trials.com; ISRCTN number 29971311.