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The effect of endometrial pipelle biopsy on clinical pregnancy rate in women with previous IVF failure undergoing IVF treatment
Abstracts / European Journal of Obstetrics & Gynecology and Reproductive Biology 206 (2016) e1–e127
Infertility No Preference The effect of endometrial pipelle biopsy on clinical pregnancy rate in women with previous IVF failure undergoing IVF treatment Aleksandra Zygula ∗ , Iwona Szymusik, Piotr Marianowski First Department of Obstertics and Gynecology, Warsaw Medical University, Warsaw, Poland E-mail address: [email protected] (A. Zygula). Objectives: Implantation failure is one of the major factors limiting success in in vitro fertilization (IVF) treatment. According to the ESHRE only 32% of fresh embryo transfers resulted in clinical pregnancies. They are many ways to try to improve the treatment outcomes and one of the ways is endometrial biopsy. It has been suggested that local endometrial injury may increase clinical pregnancy rate. The aim of our study was to find out whether
e127
endometrial pipelle biopsy performed in the luteal phase of the cycle preceding IVF treatment improve the clinical pregnancy rate. Methods: In a prospective randomised controlled trial, 120 women under the age of 40 with previous IVF failure were divided into two groups. Group A (59 women) subjects underwent endometrial pipelle biopsy performed 7 days after ovulation of the preceding IVF cycle, while group B (61 women) subjects received casual care. Results: The clinical and embryological characteristics were comparable in the two groups, and no significant difference was observed in the fertilization rate (55.47% in the group A vs 60.72% in the group B), the implantation rate (28% in the group A vs 32% in the group B) and the clinical pregnancy rate (31% in the group A vs 26% in the group B). Conclusion: Currently, there is a lack of strong evidence to support routine endometrial pipelle biopsy in women prior to IVF treatment. http://dx.doi.org/10.1016/j.ejogrb.2016.07.478
Infertility No Preference The effect of endometrial pipelle biopsy on clinical pregnancy rate in women with previous IVF failure undergoing IVF treatment Aleksandra Zygula ∗ , Iwona Szymusik, Piotr Marianowski First Department of Obstertics and Gynecology, Warsaw Medical University, Warsaw, Poland E-mail address: [email protected] (A. Zygula). Objectives: Implantation failure is one of the major factors limiting success in in vitro fertilization (IVF) treatment. According to the ESHRE only 32% of fresh embryo transfers resulted in clinical pregnancies. They are many ways to try to improve the treatment outcomes and one of the ways is endometrial biopsy. It has been suggested that local endometrial injury may increase clinical pregnancy rate. The aim of our study was to find out whether
e127
endometrial pipelle biopsy performed in the luteal phase of the cycle preceding IVF treatment improve the clinical pregnancy rate. Methods: In a prospective randomised controlled trial, 120 women under the age of 40 with previous IVF failure were divided into two groups. Group A (59 women) subjects underwent endometrial pipelle biopsy performed 7 days after ovulation of the preceding IVF cycle, while group B (61 women) subjects received casual care. Results: The clinical and embryological characteristics were comparable in the two groups, and no significant difference was observed in the fertilization rate (55.47% in the group A vs 60.72% in the group B), the implantation rate (28% in the group A vs 32% in the group B) and the clinical pregnancy rate (31% in the group A vs 26% in the group B). Conclusion: Currently, there is a lack of strong evidence to support routine endometrial pipelle biopsy in women prior to IVF treatment. http://dx.doi.org/10.1016/j.ejogrb.2016.07.478