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The effect of estrin on the histologic structure of the human breast
Fana, Camille : Experimental mary Gland, Folin gynaec.
Research on the Endocrine 25:
119,
Function
of the Mam-
10.18,
animals the extract of mammary The author claims t,hat in experimental gland has shown an endocrine activity bringing on est,rus and inducing a decided atrophy in the utero-ovarian region, but only in the presence of ovaries. He feels that the hypophysis is primaril? stimulat,ed and this, in turn, stimulates the ovary. In conclusion, the author states that the extract of the mammary gland gives good therapeutic results ill any condition where an ischemia of the uterosuch :I$. menorrhagin, uterine fihmrrrq subinvolution ovarian region is desired, of the post-partum uterus? etc.
on the Histologic Hoffmann, F. : The Effect of E&in Breast, Zentralbl. f. GynLk. 63: 422, 1939).
Structure
of the Human
E’or the first time, Hoffmann st,udied the ef%‘ect of large doses of estrin on the histologic structure of the human breast. He obtained the tissue while performing plastic operations on the breasts. In a woman past the menopause, 50,000 estradiol benzoate units were given. The breast showed an increase in the milk These changes are identical with those observed ducts and a marked hyperemia. in castrated animals after the administration of estrin. In a second case, a woman in the reproductive age, a total of 250,OOO units were given. The breast tissue was removed or1 the twenty-third day of the cycle and showed an increase in the milk ducts, an increase in the nlreolar tissne, and extreme hpperemia and edema. These results indicate that even with relatively small doses of estrin, morphologic changes may be brought xl>out in the human breasts. They also show that, analogous to animal experiments, estrin affects the milk duct system, whereas the corpus luteum hormone in association with estrin controls the alveolar system. These results support the belief that until puberty the human breasts are only a milk duct organ and that anly with the development of corpora hitea does the nlveolar system begin to function. Therapeutically the author advocates estrin to stop the secretion of milk, especially in cases of milk fistula after incisions for infection. In cases of breast abscess as well as in plastic operations on the breasts, estrin may help WOUJld healing by its power of inducing hgperemia and stimulating growth of tissue. J. P. GREENIIITJ..
Hormonally Induced Asymmetric Preissenker: Puberty, Zentralbl. f. GynLk. 63: 451, 1939.
Swelling
of the Breasts
Before
The author reports the case of a nine-year-old girl who received 35,000 international units of e&in because of gonorrhea1 vulvovaginitis. Shortly after this a painful lump developed in t,he right breast. With this there was escessive vomiting. Because of this combination of ,symptoms, corpus luteum hormone was administered to overcome the effects of the estrin. As a result of this therapy, all the disagreeable symptoms subsided. In three other girls treated with estrin before puberty, the author observed asymmetric breast swellings. Histologic studies were, of course, not made. On the other hand, in a 35-year-old woman, an adenoma was removed. This tumor developed a few weeks after 550,000 units of estrin had been given to overcome amenorrhea. Hence, estrin
Research on the Endocrine 25:
119,
Function
of the Mam-
10.18,
animals the extract of mammary The author claims t,hat in experimental gland has shown an endocrine activity bringing on est,rus and inducing a decided atrophy in the utero-ovarian region, but only in the presence of ovaries. He feels that the hypophysis is primaril? stimulat,ed and this, in turn, stimulates the ovary. In conclusion, the author states that the extract of the mammary gland gives good therapeutic results ill any condition where an ischemia of the uterosuch :I$. menorrhagin, uterine fihmrrrq subinvolution ovarian region is desired, of the post-partum uterus? etc.
on the Histologic Hoffmann, F. : The Effect of E&in Breast, Zentralbl. f. GynLk. 63: 422, 1939).
Structure
of the Human
E’or the first time, Hoffmann st,udied the ef%‘ect of large doses of estrin on the histologic structure of the human breast. He obtained the tissue while performing plastic operations on the breasts. In a woman past the menopause, 50,000 estradiol benzoate units were given. The breast showed an increase in the milk These changes are identical with those observed ducts and a marked hyperemia. in castrated animals after the administration of estrin. In a second case, a woman in the reproductive age, a total of 250,OOO units were given. The breast tissue was removed or1 the twenty-third day of the cycle and showed an increase in the milk ducts, an increase in the nlreolar tissne, and extreme hpperemia and edema. These results indicate that even with relatively small doses of estrin, morphologic changes may be brought xl>out in the human breasts. They also show that, analogous to animal experiments, estrin affects the milk duct system, whereas the corpus luteum hormone in association with estrin controls the alveolar system. These results support the belief that until puberty the human breasts are only a milk duct organ and that anly with the development of corpora hitea does the nlveolar system begin to function. Therapeutically the author advocates estrin to stop the secretion of milk, especially in cases of milk fistula after incisions for infection. In cases of breast abscess as well as in plastic operations on the breasts, estrin may help WOUJld healing by its power of inducing hgperemia and stimulating growth of tissue. J. P. GREENIIITJ..
Hormonally Induced Asymmetric Preissenker: Puberty, Zentralbl. f. GynLk. 63: 451, 1939.
Swelling
of the Breasts
Before
The author reports the case of a nine-year-old girl who received 35,000 international units of e&in because of gonorrhea1 vulvovaginitis. Shortly after this a painful lump developed in t,he right breast. With this there was escessive vomiting. Because of this combination of ,symptoms, corpus luteum hormone was administered to overcome the effects of the estrin. As a result of this therapy, all the disagreeable symptoms subsided. In three other girls treated with estrin before puberty, the author observed asymmetric breast swellings. Histologic studies were, of course, not made. On the other hand, in a 35-year-old woman, an adenoma was removed. This tumor developed a few weeks after 550,000 units of estrin had been given to overcome amenorrhea. Hence, estrin