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The headaches
115
Libri
Drugs Affecting Lipid Metabolism. Medical Science Symposia series 2. AL Catapano. AM Gotto. Jr. LC Smith, R Paoletti. Kluwer Academic Publishers. Dordrecht/Boston/London, 1993. A great deal of experimental, clinical and epidemiological data have been gathered to confirm the strict and causal correlation between plasma lipoproteins and coronary heart disease. However. as usually happens in research, many more interesting issues are being studied, opening new fields of research for the future. These new advances. together with the combined efforts of cell biologists and lipoprotein chemists. have set the pace for an exciting period of research and clinical applications of diets and drugs affecting plasma and cell lipids. This volume, which includes the work of many of the leading world laboratories, represents an authoritative and up-to-date appraisal of the state-of-the-art and a stimulus for future research at the laboratory and clinical level in a fascinating area of clinical and preventive medicine. Immunology and Blood Transfusion. Developments in Hematology and Immunology 28. Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion. C T Smit Sibinga, PC Das, T The. Kluwer Academic Publishers. Dordrecht/Boston/London, 1993. In transfusion medicine, the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer. where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer, MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus, reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibodies could play an important role in platelet theory. However, the potential infection risks in transfusion such as HIV and HCV remain, but application of molecular biological methods such as PCR or RT/PCR has great potential in the detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concen-
trates. such as factor 1X and protein C, could reduce patients’ immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge’ through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell-mediated immune deficiency, as in ADA. Lectins and Glycobiology. HJ Gabius. S Gabius. SpringerVerlag. Berlin/Heidelberg/New York/London/Paris/Tokyo/Hong Kong, 1993. The role of lectins and glycoconjugates in various cellular processes is receiving increasing interest. Since many cellular glycoconjugates are ligands for lectins, they are used as efficacious tools in biochemistry and cell research. Lectins and Glycobiology provide all the relevant techniques to investigate the structure and function of lectins and their various reactions. Included are methods for the preparation of synthetic carbohydrate ligands, the determination ofphysico-chemical properties of lectin-oligosaccharide interactions, the isolation and chemical modification of lectins, and assays to detect and quantitate lectins. Several chapters focus on the study of signal transduction and cellular responses induced by lectins as well as on cellular adhesion and cell recognition involving lectin-glycoprotein interaction. Further major topics are molecular biological techniques such as the use of recombinant or mutant lectin genes. The Cardiomyopatbic Heart. M Nagano, T Takeda, NS Dhalla, Raven Press, New York, 1993. This volume synthesizes recent research on the pathophysiology, biochemistry, and pharmacology of the cardiomyopathic heart. Leading investigators review a variety of experimental studies on the cellular and subcellular basis of contractile dysfunction, the signal transduction mechanisms involved in cardiomyopathies. These studies shed new light on key cellular, metabolic, and molecular mechanisms in various human cardiomyopathies. including cardiomyopathy associated with Keshan disease, trauma-sepsis syndrome, viral and autoimmune myocarditis, diabetes, hypothyroidism, alcoholism, and adriamycin and catecholamine cardiotoxicity. The Headaches. J Olesen, P Tfelt-Hansen, Raven Press. New York, 1993.
KMA
Welch.
This encyclopeadic reference provides definitive coverage of every aspect of every clinically discrete type of headache from the ubiquitous tension headache to the neurologically complicated headache associated with life-threatening cerebrovascular disorders. Under the editorial guidance of three distinguished headache spe-
116 cialists, more than 100 leading international authorities in pertinent basic and clinical areas have joined forces to produce this timely, comprehensive review. The Headaches offers clinicians a systematic approach to rapid diagnosis and optimal management. as well as an enhanced appreciation of the anatomy, physiology. pathophysiology. and biochemistry of the cephalic circulation and pericranial muscles: the psychological dimensions of headache; and the rationale underlying pharmacological and nonpharmacological prophylaxis
and palliation. For each headache type. the book details the etiology: signs and symptoms; physical. neurological, imaging. and laboratory findings: and treatment options. Complete information is provided on the entire current pharmacological armamentarium-including the new serotonin agonist, sumatriptan and on psychological, behavioral. and other nonpharmacological interventions. Management issues in special patient populations such as children. the elderly. and the psychiatrically ill are also addressed.
Libri
Drugs Affecting Lipid Metabolism. Medical Science Symposia series 2. AL Catapano. AM Gotto. Jr. LC Smith, R Paoletti. Kluwer Academic Publishers. Dordrecht/Boston/London, 1993. A great deal of experimental, clinical and epidemiological data have been gathered to confirm the strict and causal correlation between plasma lipoproteins and coronary heart disease. However. as usually happens in research, many more interesting issues are being studied, opening new fields of research for the future. These new advances. together with the combined efforts of cell biologists and lipoprotein chemists. have set the pace for an exciting period of research and clinical applications of diets and drugs affecting plasma and cell lipids. This volume, which includes the work of many of the leading world laboratories, represents an authoritative and up-to-date appraisal of the state-of-the-art and a stimulus for future research at the laboratory and clinical level in a fascinating area of clinical and preventive medicine. Immunology and Blood Transfusion. Developments in Hematology and Immunology 28. Proceedings of the Seventeenth Annual International Symposium on Blood Transfusion. C T Smit Sibinga, PC Das, T The. Kluwer Academic Publishers. Dordrecht/Boston/London, 1993. In transfusion medicine, the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer. where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer, MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus, reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibodies could play an important role in platelet theory. However, the potential infection risks in transfusion such as HIV and HCV remain, but application of molecular biological methods such as PCR or RT/PCR has great potential in the detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concen-
trates. such as factor 1X and protein C, could reduce patients’ immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge’ through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell-mediated immune deficiency, as in ADA. Lectins and Glycobiology. HJ Gabius. S Gabius. SpringerVerlag. Berlin/Heidelberg/New York/London/Paris/Tokyo/Hong Kong, 1993. The role of lectins and glycoconjugates in various cellular processes is receiving increasing interest. Since many cellular glycoconjugates are ligands for lectins, they are used as efficacious tools in biochemistry and cell research. Lectins and Glycobiology provide all the relevant techniques to investigate the structure and function of lectins and their various reactions. Included are methods for the preparation of synthetic carbohydrate ligands, the determination ofphysico-chemical properties of lectin-oligosaccharide interactions, the isolation and chemical modification of lectins, and assays to detect and quantitate lectins. Several chapters focus on the study of signal transduction and cellular responses induced by lectins as well as on cellular adhesion and cell recognition involving lectin-glycoprotein interaction. Further major topics are molecular biological techniques such as the use of recombinant or mutant lectin genes. The Cardiomyopatbic Heart. M Nagano, T Takeda, NS Dhalla, Raven Press, New York, 1993. This volume synthesizes recent research on the pathophysiology, biochemistry, and pharmacology of the cardiomyopathic heart. Leading investigators review a variety of experimental studies on the cellular and subcellular basis of contractile dysfunction, the signal transduction mechanisms involved in cardiomyopathies. These studies shed new light on key cellular, metabolic, and molecular mechanisms in various human cardiomyopathies. including cardiomyopathy associated with Keshan disease, trauma-sepsis syndrome, viral and autoimmune myocarditis, diabetes, hypothyroidism, alcoholism, and adriamycin and catecholamine cardiotoxicity. The Headaches. J Olesen, P Tfelt-Hansen, Raven Press. New York, 1993.
KMA
Welch.
This encyclopeadic reference provides definitive coverage of every aspect of every clinically discrete type of headache from the ubiquitous tension headache to the neurologically complicated headache associated with life-threatening cerebrovascular disorders. Under the editorial guidance of three distinguished headache spe-
116 cialists, more than 100 leading international authorities in pertinent basic and clinical areas have joined forces to produce this timely, comprehensive review. The Headaches offers clinicians a systematic approach to rapid diagnosis and optimal management. as well as an enhanced appreciation of the anatomy, physiology. pathophysiology. and biochemistry of the cephalic circulation and pericranial muscles: the psychological dimensions of headache; and the rationale underlying pharmacological and nonpharmacological prophylaxis
and palliation. For each headache type. the book details the etiology: signs and symptoms; physical. neurological, imaging. and laboratory findings: and treatment options. Complete information is provided on the entire current pharmacological armamentarium-including the new serotonin agonist, sumatriptan and on psychological, behavioral. and other nonpharmacological interventions. Management issues in special patient populations such as children. the elderly. and the psychiatrically ill are also addressed.