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THE HYPOLIPIDEMIC EFFECT OF A NEW DIETARY SUPPLEMENT
140
Poster Sessions PO30 Obesity
treatment of mild hypercholesterolaemia, and an advantageous support to pharmacological therapies. PO29-501
DYSFUNCTIONAL HEMODYNAMIC REGULATION AFTER DAILY MEAL INTAKE IN THE METABOLIC SYNDROME
J. Funada 1 , Y. Takata 2 , Y. Matsumoto 3 , S. Sato 3 , G. Hiasa 4 , K. Inoue 4 , A. Fujii 1 , H. Hashida 1 , H. Okayama 5 , J. Higaki 5 . 1 Department of Cardiology, Ehime National Hospital, Toon, Ehime, Japan; 2 Department of Molecular and Genetics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 3 Department of Cardiology, Saijo Central Hospital, Saijo, Ehime, Japan; 4 Department of Cardiology, Kitaishikai Hospital, Ozu, Ehime, Japan; 5 Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan Backgrounds and aim: It is thought that postprandial hyperlipidemia and insulin resistance play roles in the development of atherosclerosis in the metabolic syndrome (MS). However, the clinical significance of postprandial hemodynamic variables in this condition is still in question. The aim of this study was to investigate hemodynamic and metabolic indicators related to MS after a mixed meal (Calorie-mate 500 kCal). Methods: Of 88 participants undergoing this investigation, 23 fulfilled the ATPIII criteria for MS (Group MS). The remaining 65 subjects were controls (Group C). Both augmentation index (AIx) of radial artery and central systolic pressure (CSP) were monitored using HEM-9000AI (Omron Healthcare, Kyoto, Japan) until 240 min after meal intake. Results: Pulse wave velocity was significantly higher in the MS group (1518±346 cm/sec vs 1325±219 cm/sec, p<0.03). There was no difference in the changes in AIx (postprandial AIx - fasting AIx) between two groups throughout the investigation. The early postprandial CSP reduction (30 and 60 min after meal intake) was comparable between the groups, whereas the late postprandial CSP reduction (120 min after meal) was significantly lower in the MS group (-0.4±9.8mmHg vs 5.5±8.1mmHg, p<0.01). The late postprandial CSP reduction in the MS group showed an inverse correlation with visceral fat area (r=-0.48, p<0.05). Conclusions: Subjects with MS exhibit signs of arterial stiffness and this appear to be associated with a blunted central pressure regulation after food intake. Dysfunctional postprandial hemodynamic regulation is another feature of MS that may contribute to the progression of cardiovascular disease. PO29-502
LUNCH-TIME NAPPING IS ASSOCIATED WITH A MORE ADVERSE VASCULAR DISEASE RISK FACTOR PROFILE IN OLDER CHINESE: GUANGZHOU BIOBANK COHORT STUDY
G.N. Thomas 1 , C.Q. Jiang 3 , X.Q. Lao 2 , W.S. Zhang 3 , P. Adab 1 , T.H. Lam 2 , K.K. Cheng 1 . 1 Dept. of Public Health and Epidemiology, Univ. of Birmingham, Edgbaston, Birmingham, UK; 2 Dept. of Community Medicine and School of Public Health, Univ, of Hong Kong, Pokfulam, Hong Kong; 3 Guangzhou No. 12 Hospital, Guangzhou, China Aim: Millions of people worldwide take a nap or siesta after lunch, but data describing potential health impacts are very limited. Studies have been called for in Chinese populations where napping is the norm. We therefore report on possible associations between napping and vascular risk in a large group of Chinese subjects. Methods: A total of 10375 older subjects (≥50 years) were recruited and vascular risk factors measured. Sociodemographic parameters, including frequency of lunch time napping were collected by nurse-administered questionnaire. Following categorisation by napping frequency, the relationship between napping and vascular risk factors was investigated using analysis of variance and logistic regression analyses. Results: A total of 70.9% of this population napped at least 1-3 times per week. The prevalence of most vascular risk factors, including metabolic syndrome, and self-reported, physician-diagnosed vascular disease increased with napping frequency (p<0.05 for all). After adjustment for age, sex, education, job, exercise, self-reported health, alcohol, BMI, smoking, and, as appropriate, waist circumference, glucose, LDL-cholesterol, HDLcholesterol, and mean arterial pressure, napping remained independently associated with the risk factors. Risk of having these conditions increased by 15-37% in daily nappers compared to those who never nap (p≤0.0010.006). Removal of those with existing vascular disease did not affect the observed associations.
Conclusion: After adjustment for a wide range of potential confounding factors, our data suggests that napping is harmful with regards to vascular disease in these older Chinese subjects, and thus has important public health implications should these results be confirmed in other or younger populations. PO29-503
TEN YEARS’ TRENDS OF NUTRITION AND RISK FACTORS NON-COMMUNICABLE DISEASES IN THE WESTERN SIBERIA
O.M. Bragina, G.I. Simonova, S.K. Maljutina, L.V. Scherbakova. Institute of Internal Medicine SB RAMN, Novosibirsk, Russia Purpose: To study 10-years trends of nutrition of Novosibirsk’s population and dynamics of risk factors NCD within of two population screenings HWO MONICA and HAPIEE. Materials and methods: 1470 persons were investigated in 45-64 agegroup. The nutrition was studied by 24-hour dietary recall and FFQ. For an estimation of risk factors NCD were used the standardized methods. Results: Daily caloric consumption was increased to 2005 from 2240 kcal to 2356 kcal, consumption of the total fiber from 13,2% and 14,6%, as total fat was increased from 39% up to 46% as SFA, MUFA, PUFA. Consumption of the total carbohydrates was decreased from 46% up to 38%, but consumption of simple sugars has increased from 14,2% and 15,6%. Similar results have been received in analyze separately for men and women. Increased of level TC from 216 mg/dl to 226 mg/dl and HDL from 55,8 mg/dl to 58,1 mg/dl. Has decreased the SBP from 144 mm Hg to 141 mm Hg, BMI has remained at the same level 28 kg/m2 . Similar results have been received in analyze Daily caloric consumption for men. Conclusions: The increase of daily caloric consumption and unbalanced structure of nutrition on fats and carbohydrates was characterized by growth of levels TC and preservation of stably high levels as the SBP and BMI. PO29-504
THE HYPOLIPIDEMIC EFFECT OF A NEW DIETARY SUPPLEMENT
E. Farinaro, E. Della Valle, R. Grimaldi. Department of Preventive Medical Sciences University The aim was to test a new dietary supplement (Armolipid) containing natural agents (Policosanolis, Red Yeast, Coenzyme Q10, Astaxantine, Folic Acid). A multicenter study was carried out to evaluate the efficacy of the supplement with diet (A-D) versus the diet alone (D).2400 patients were enrolled in 266 units, for this study 1008 were treated with supplement and diet (A-D) and 894 with diet alone (D). The remaining 498 were treated with supplement and diet. Criteria for the entry-study were: serum chol>200 or LDL >150 mg/dl; all patients were on a diet whilst at the AD group was prescribed to take one tablet of supplement per day for sixteen weeks. Mean age 58 yrs (A-D) and 57.5 yrs (D) almost equally distributed between males and females; BMI 27 kg/m2 for both. Total Cholesterol 257 mg/dl in A-D, 247 in D; LDL Chol 159 in A-D, 166 in D; HDL Chol 48 mg/dl in A/D, 41 mg/dl in D. The reduction of total cholesterol during the treatment in the AD group was on the average for 14%. In the D group the reduction of cholesterol was in the average 9%. As for LDL Chol the reduction was similar to cholesterol. A moderate increase in the HDL levels was found. A more effective reduction of lipid was found in the group treated with supplement and diet suggesting that this natural products could be used for the improvement of lipid profile with a positive impact on the prevention of CHD.
PO30 OBESITY PO30-505
LEVELS OF LEPTIN AND SOLUBLE LEPTIN RECEPTORS AT PATIENTS WITH A METABOLIC SYNDROME DEPENDING ON CARBOHYDRATE DISODERS
O. Kulyk, O. Mitchenko, V. Romanov, T. Belyaeva, L. Yakuschko. Dyslipidemia Department, Institute of Cardiology, Kyiv, Ukraine Background and aims: To study leptin levels and levels of soluble leptin receptors(sOB-R) at patients with the metabolic syndrome (MS) diagnosed, according to criteria IDF, depending on carbohydrate disorders (CD). Methods: 43 women(51,5±1,9 years) and 27men(48,7±2,7 years). 4
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
Poster Sessions PO30 Obesity
treatment of mild hypercholesterolaemia, and an advantageous support to pharmacological therapies. PO29-501
DYSFUNCTIONAL HEMODYNAMIC REGULATION AFTER DAILY MEAL INTAKE IN THE METABOLIC SYNDROME
J. Funada 1 , Y. Takata 2 , Y. Matsumoto 3 , S. Sato 3 , G. Hiasa 4 , K. Inoue 4 , A. Fujii 1 , H. Hashida 1 , H. Okayama 5 , J. Higaki 5 . 1 Department of Cardiology, Ehime National Hospital, Toon, Ehime, Japan; 2 Department of Molecular and Genetics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 3 Department of Cardiology, Saijo Central Hospital, Saijo, Ehime, Japan; 4 Department of Cardiology, Kitaishikai Hospital, Ozu, Ehime, Japan; 5 Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan Backgrounds and aim: It is thought that postprandial hyperlipidemia and insulin resistance play roles in the development of atherosclerosis in the metabolic syndrome (MS). However, the clinical significance of postprandial hemodynamic variables in this condition is still in question. The aim of this study was to investigate hemodynamic and metabolic indicators related to MS after a mixed meal (Calorie-mate 500 kCal). Methods: Of 88 participants undergoing this investigation, 23 fulfilled the ATPIII criteria for MS (Group MS). The remaining 65 subjects were controls (Group C). Both augmentation index (AIx) of radial artery and central systolic pressure (CSP) were monitored using HEM-9000AI (Omron Healthcare, Kyoto, Japan) until 240 min after meal intake. Results: Pulse wave velocity was significantly higher in the MS group (1518±346 cm/sec vs 1325±219 cm/sec, p<0.03). There was no difference in the changes in AIx (postprandial AIx - fasting AIx) between two groups throughout the investigation. The early postprandial CSP reduction (30 and 60 min after meal intake) was comparable between the groups, whereas the late postprandial CSP reduction (120 min after meal) was significantly lower in the MS group (-0.4±9.8mmHg vs 5.5±8.1mmHg, p<0.01). The late postprandial CSP reduction in the MS group showed an inverse correlation with visceral fat area (r=-0.48, p<0.05). Conclusions: Subjects with MS exhibit signs of arterial stiffness and this appear to be associated with a blunted central pressure regulation after food intake. Dysfunctional postprandial hemodynamic regulation is another feature of MS that may contribute to the progression of cardiovascular disease. PO29-502
LUNCH-TIME NAPPING IS ASSOCIATED WITH A MORE ADVERSE VASCULAR DISEASE RISK FACTOR PROFILE IN OLDER CHINESE: GUANGZHOU BIOBANK COHORT STUDY
G.N. Thomas 1 , C.Q. Jiang 3 , X.Q. Lao 2 , W.S. Zhang 3 , P. Adab 1 , T.H. Lam 2 , K.K. Cheng 1 . 1 Dept. of Public Health and Epidemiology, Univ. of Birmingham, Edgbaston, Birmingham, UK; 2 Dept. of Community Medicine and School of Public Health, Univ, of Hong Kong, Pokfulam, Hong Kong; 3 Guangzhou No. 12 Hospital, Guangzhou, China Aim: Millions of people worldwide take a nap or siesta after lunch, but data describing potential health impacts are very limited. Studies have been called for in Chinese populations where napping is the norm. We therefore report on possible associations between napping and vascular risk in a large group of Chinese subjects. Methods: A total of 10375 older subjects (≥50 years) were recruited and vascular risk factors measured. Sociodemographic parameters, including frequency of lunch time napping were collected by nurse-administered questionnaire. Following categorisation by napping frequency, the relationship between napping and vascular risk factors was investigated using analysis of variance and logistic regression analyses. Results: A total of 70.9% of this population napped at least 1-3 times per week. The prevalence of most vascular risk factors, including metabolic syndrome, and self-reported, physician-diagnosed vascular disease increased with napping frequency (p<0.05 for all). After adjustment for age, sex, education, job, exercise, self-reported health, alcohol, BMI, smoking, and, as appropriate, waist circumference, glucose, LDL-cholesterol, HDLcholesterol, and mean arterial pressure, napping remained independently associated with the risk factors. Risk of having these conditions increased by 15-37% in daily nappers compared to those who never nap (p≤0.0010.006). Removal of those with existing vascular disease did not affect the observed associations.
Conclusion: After adjustment for a wide range of potential confounding factors, our data suggests that napping is harmful with regards to vascular disease in these older Chinese subjects, and thus has important public health implications should these results be confirmed in other or younger populations. PO29-503
TEN YEARS’ TRENDS OF NUTRITION AND RISK FACTORS NON-COMMUNICABLE DISEASES IN THE WESTERN SIBERIA
O.M. Bragina, G.I. Simonova, S.K. Maljutina, L.V. Scherbakova. Institute of Internal Medicine SB RAMN, Novosibirsk, Russia Purpose: To study 10-years trends of nutrition of Novosibirsk’s population and dynamics of risk factors NCD within of two population screenings HWO MONICA and HAPIEE. Materials and methods: 1470 persons were investigated in 45-64 agegroup. The nutrition was studied by 24-hour dietary recall and FFQ. For an estimation of risk factors NCD were used the standardized methods. Results: Daily caloric consumption was increased to 2005 from 2240 kcal to 2356 kcal, consumption of the total fiber from 13,2% and 14,6%, as total fat was increased from 39% up to 46% as SFA, MUFA, PUFA. Consumption of the total carbohydrates was decreased from 46% up to 38%, but consumption of simple sugars has increased from 14,2% and 15,6%. Similar results have been received in analyze separately for men and women. Increased of level TC from 216 mg/dl to 226 mg/dl and HDL from 55,8 mg/dl to 58,1 mg/dl. Has decreased the SBP from 144 mm Hg to 141 mm Hg, BMI has remained at the same level 28 kg/m2 . Similar results have been received in analyze Daily caloric consumption for men. Conclusions: The increase of daily caloric consumption and unbalanced structure of nutrition on fats and carbohydrates was characterized by growth of levels TC and preservation of stably high levels as the SBP and BMI. PO29-504
THE HYPOLIPIDEMIC EFFECT OF A NEW DIETARY SUPPLEMENT
E. Farinaro, E. Della Valle, R. Grimaldi. Department of Preventive Medical Sciences University The aim was to test a new dietary supplement (Armolipid) containing natural agents (Policosanolis, Red Yeast, Coenzyme Q10, Astaxantine, Folic Acid). A multicenter study was carried out to evaluate the efficacy of the supplement with diet (A-D) versus the diet alone (D).2400 patients were enrolled in 266 units, for this study 1008 were treated with supplement and diet (A-D) and 894 with diet alone (D). The remaining 498 were treated with supplement and diet. Criteria for the entry-study were: serum chol>200 or LDL >150 mg/dl; all patients were on a diet whilst at the AD group was prescribed to take one tablet of supplement per day for sixteen weeks. Mean age 58 yrs (A-D) and 57.5 yrs (D) almost equally distributed between males and females; BMI 27 kg/m2 for both. Total Cholesterol 257 mg/dl in A-D, 247 in D; LDL Chol 159 in A-D, 166 in D; HDL Chol 48 mg/dl in A/D, 41 mg/dl in D. The reduction of total cholesterol during the treatment in the AD group was on the average for 14%. In the D group the reduction of cholesterol was in the average 9%. As for LDL Chol the reduction was similar to cholesterol. A moderate increase in the HDL levels was found. A more effective reduction of lipid was found in the group treated with supplement and diet suggesting that this natural products could be used for the improvement of lipid profile with a positive impact on the prevention of CHD.
PO30 OBESITY PO30-505
LEVELS OF LEPTIN AND SOLUBLE LEPTIN RECEPTORS AT PATIENTS WITH A METABOLIC SYNDROME DEPENDING ON CARBOHYDRATE DISODERS
O. Kulyk, O. Mitchenko, V. Romanov, T. Belyaeva, L. Yakuschko. Dyslipidemia Department, Institute of Cardiology, Kyiv, Ukraine Background and aims: To study leptin levels and levels of soluble leptin receptors(sOB-R) at patients with the metabolic syndrome (MS) diagnosed, according to criteria IDF, depending on carbohydrate disorders (CD). Methods: 43 women(51,5±1,9 years) and 27men(48,7±2,7 years). 4
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey