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Time segmented EEG potential mapping in medication free schizophrenic patients
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ISward L. Merrin, M.D., Patricia MeeJc,Ph.D., Thcmas C. Floyd, M.A., Enc& Callaway III, M.D. sanFrancisco,
CA
traditionaln&ha% of aquteranalysispmcesscmpomuof prior to tqqra@ical analysis, m theEFGsignalovermanysecorx% intorapidly hasdemm&ratedthatEEXSactivitycanbetimesegmnkd chaqixqspatial configurations(map6) cha.racterizedbylocatimof dipole-. Weenployedtime~tiontedmiquestostudyEEG recordedfmnmedicatian-free~z~cpatierrtsand~ls, hypothesizingthat functionaldeficits associatslwithscbizcp-jlrenic illnesswouldmsultinmxefrequentswitchingbetweenmaps.
hlheras
NinechannelEM;wasreoordedfran11urrmedicatedschiz~cpatients and10 normal amtmlsduringactivetaskandresting (witheyesopen) conditions. Eightpatimtswere retestedafter l%?umleptictreatraerrt. Afterel iminationofartifactcontaminateddataand~fo~ti~to averagereference, thefirst seco&sofdatafraneachcoi&ticmwas filtered intotheta, alpha, andbetaldataseti. Global fieldpmer WP) wascmputedateachsamplingpointbyrectifyiqandsmning poixntialvalues foreachelectruk. F&entialmap6fnxneachpeakin GFPwereclassifiedamm-dingtotheelectmde locationswiththetm highestrectifiedpotentials. Map transitionswere classifiedby the tm maps involved. Comparisons~mdebyrepeatedANovAsonthe number of transitionsbetween maps, the mmbex of different transitions thatoczurr&,thernrmberoftransitions occumingwithakahemi@er' crossing, andthemnnkerofmaptypes (outofapossible 36) left2. Schiz~~didnotswitch~nrorefrequerrtly,~left significantly (p < .003) less theta maps mused acmss ax-ditions. Moreover, medication significantly (p < .02) increasedthe mm&m- of urrusedthetamaps, particularly~~activetask~~ons. We interpretedthese findingsas evidenceof incmxedspatialvariability ofbrainelectrical activityinschizophrenicsthatmybedirectly relatedtoanomaliesof selectiveattention.
ISward L. Merrin, M.D., Patricia MeeJc,Ph.D., Thcmas C. Floyd, M.A., Enc& Callaway III, M.D. sanFrancisco,
CA
traditionaln&ha% of aquteranalysispmcesscmpomuof prior to tqqra@ical analysis, m theEFGsignalovermanysecorx% intorapidly hasdemm&ratedthatEEXSactivitycanbetimesegmnkd chaqixqspatial configurations(map6) cha.racterizedbylocatimof dipole-. Weenployedtime~tiontedmiquestostudyEEG recordedfmnmedicatian-free~z~cpatierrtsand~ls, hypothesizingthat functionaldeficits associatslwithscbizcp-jlrenic illnesswouldmsultinmxefrequentswitchingbetweenmaps.
hlheras
NinechannelEM;wasreoordedfran11urrmedicatedschiz~cpatients and10 normal amtmlsduringactivetaskandresting (witheyesopen) conditions. Eightpatimtswere retestedafter l%?umleptictreatraerrt. Afterel iminationofartifactcontaminateddataand~fo~ti~to averagereference, thefirst seco&sofdatafraneachcoi&ticmwas filtered intotheta, alpha, andbetaldataseti. Global fieldpmer WP) wascmputedateachsamplingpointbyrectifyiqandsmning poixntialvalues foreachelectruk. F&entialmap6fnxneachpeakin GFPwereclassifiedamm-dingtotheelectmde locationswiththetm highestrectifiedpotentials. Map transitionswere classifiedby the tm maps involved. Comparisons~mdebyrepeatedANovAsonthe number of transitionsbetween maps, the mmbex of different transitions thatoczurr&,thernrmberoftransitions occumingwithakahemi@er' crossing, andthemnnkerofmaptypes (outofapossible 36) left2. Schiz~~didnotswitch~nrorefrequerrtly,~left significantly (p < .003) less theta maps mused acmss ax-ditions. Moreover, medication significantly (p < .02) increasedthe mm&m- of urrusedthetamaps, particularly~~activetask~~ons. We interpretedthese findingsas evidenceof incmxedspatialvariability ofbrainelectrical activityinschizophrenicsthatmybedirectly relatedtoanomaliesof selectiveattention.