tPA stimulation of local prostacyclin production in thrombosed coronary arteries

ACC

Vol.

February

e have

17, No. 2 199 1: 195A

showr;

prewisusly

that

activation

of

leukocytes

Steven F. Boiling,

virtually adventitia.

leukocyies regression, source of

absent

in

the

intima,

but

present

in

P. Gallagher. University

cof

the

egression of oes not eliminate t lar response ctiwetion of leukoc peculate that abnormal adherence of to endothelium may persist despite or that adventitial leukocytes may be the vaseconstrictor factor(s).

These results demonstrate that ~yocardial adenosine levels 81 end &hernia are important determinants of functional recovery. Consequently, maintaining or augmenting myoc&ial adenosine during isckmia should be of clmical benefit

tPA STIMULATION OF LOCAL "ROSTACYCLIN THROMBOSED CORONARY ARTERIES John F. Czaja, MD 6 Washington

, Gale Fellowes, Robere E. Goldstein, iiospital Center,

PRODUCTION

IN

Diane C. Eliades, WSWHS, Bethesda, Washington, DC

Thus, tPA raises local PGI2 metabolite levels in thrombosed coronary vessels, an action magnified by PreferOKY and not reflected in samples from SV. ential enhancement of PGI2 synthesis near Th may be important for tPA-induced thrombolysis. Further increase in local PGI2 by TxA2 synthetic blockade may add to thrombolytic efficacy while avoiding adverse effects of systenuc increases in PGI2. different experimental

cortditlcvls.