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Use of septoplasty prior to tympanopiasty
P 176
Otolaryngology Head and Neck Surgery
Scientific Posters
presence of basic fibroblast growth factor (bFGF) in human saliva, bFGF is stimulating the proliferation of cells of mesodermal and neuroectodermal origin and is highly angiogenetic. Materials and methods: From 20 human volunteers of both sexes ages 20 to 50 years, saliva was collected and analyzed. For the analyses a commercially available kit for bFGF was used. Results: bFGF was detected in all samples. The mean concentration was 0.6 pg/ml (SD 0.16). Discussion and conclusions: bFGF is present in human saliva. It may even constitute a constant component. The physiological importance of this finding and the clinical aspects are discussed. 48 Study of Elastic Fibers in the Lamina Proprin of Vocal Folds Using Autofluorescent and Confacal Microscopy JOHN E. BUTLER, MD, STEVEN D, GRAY, MD, and ELIZABETH H. HAMMOND, MD, Salt Lake City, Utah
Objective: This study evaluates the morphologic characteristics of elastin fibers in the lamina propria using fluorescent microscopy and confocal reflected light microscopy. The confocal microscope produces three-dimensional imaging of the fibrous elastic architecture using computer-assisted "reconstruction" of successive noninvasive x-y sections. Methods: Normal human adult larynges were obtained postmortem with no history of instrumentation or laryngeal trauma. Vocal folds were excised, autoclaved to destroy the collagen, then processed and embedded in paraffin. Coronal 5 micron sections were examined under autofluorescence with cosin staining. Thicker sections were stained with cosin and examined under the confocal reflected light microscope for three-dimensional imaging of the elastic fibers. Results and conclusions: Both methods revealed a distribution of elastic fibers throughout the lamina propria, with more concentration in the intermediate layer. A fine reticular layer of elastic fibers were noted immediately below the basement membrane of the epithelium. Elastic fibers appeared thin, cylindrical, tortuous, and formed a loose network. The confocal microscopic studies revealed the threedimensional architecture of the elastic fibers within the lamina propria (photomicrographs to be included). 49 Use of Septoplasty Prior to Tympanoplasty ANNE1TE KREBS,MD, and WOLFGANG MAIER, MD, Freiburg, Germany
Objective: In case of chronic otitis media, the interactions between eustachian tube function and pathology of nose and nasopharynx have to be taken in account. To increase the success rate, septoplasty is recommended prior to tympanoplasty by several authors. Methods: To investigate the influence of nasal septal deviation On eustachian tube function, we examined 40 patients with airway obstruction caused by septal deviation
August 1997
before and after septoplasty. Eustachian tube function was examined in a pressure chamber using the dual impedance method. This method describes opening parameters of active and passive tubal function during the pressure change in the chamber. Results: Preoperatively more than 50% of our patients presented with pathologic active parameters and more than two thirds with pathologic passive parameters of eustachian tube function. One week postoperatively these parameters were even worth. The results if at all were better after 3 months. Conclusions: We conclude from our data that (1) impaired eustachian tube function occurs more often in patients with nasal septal deviation, (2) septoplasty may be useful in special cases but cannot be recommended generally, and (3) tympanoplasty should only be performed several months after septoplasty. 5O Primary Ciliary Dyskinesia in Patients With Repeated Upper Airway Infections SILVIO A. MONTEIRO, MD, PhD, ARACY PEREIRA SILVEIRA BALBANI, MD, and PAULO HILARIO NASCIMENTO SALDIVA, MD, PhD, Sao Paulo/SP, Brazil
Thirteen cases of repeated upper airway infections were evaluated to identify primary ciliary dyskinesia (PCD). There were nine men and four women between 3 and 30 years of age (mean, 17.2 years), and 38.4% of the patients had presented family history of relation by blood, lmmunodeficiencies (both congenital and acquired) and cystic fibrosis were ruled out. Perennial purulent nasal discharge was seen in 61.5% and secretory otitis media was diagnosed in 61.6% of those patients; paranasal sinus disease was diagnosed in all patients by plain RX. Five patients (38.4%) presented situs inversus totalis. Nasal mucosa biopsies studied by means of phase contrast optic microscopy revealed absence of ciliary beat in three cases, and electronic transmission microscopy showed ultrastructural ciliary defects in eight patients (whose findings were absence of dynein arms, microtubule alterations, and absence of cilia). The authors conclude that primary ciliary dyskinesia is an important differential diagnosis in the routine evaluation of recurrent upper airway infections. Tests of ciliary motility and ultrastructural pathology are very useful tools in this investigation. 51 Nasal Polypi and Allergic Fungal Sinusitis MOHAMMED YOUSEF-MIAN, MD, SENTHILKUMAREN, MD, FRCS, ABDULLA ABDULQADIR, MD, FRCP, and MOHAMMED PIRANI, MD, FRCPC, Riyadh, Saudi Arabia
Allergic fungal sinusitis (AFS) is increasingly being recognized as a separate entity characterized by a hypersensitivity reaction to fungi mediated by IgE and resembles al-
Otolaryngology Head and Neck Surgery
Scientific Posters
presence of basic fibroblast growth factor (bFGF) in human saliva, bFGF is stimulating the proliferation of cells of mesodermal and neuroectodermal origin and is highly angiogenetic. Materials and methods: From 20 human volunteers of both sexes ages 20 to 50 years, saliva was collected and analyzed. For the analyses a commercially available kit for bFGF was used. Results: bFGF was detected in all samples. The mean concentration was 0.6 pg/ml (SD 0.16). Discussion and conclusions: bFGF is present in human saliva. It may even constitute a constant component. The physiological importance of this finding and the clinical aspects are discussed. 48 Study of Elastic Fibers in the Lamina Proprin of Vocal Folds Using Autofluorescent and Confacal Microscopy JOHN E. BUTLER, MD, STEVEN D, GRAY, MD, and ELIZABETH H. HAMMOND, MD, Salt Lake City, Utah
Objective: This study evaluates the morphologic characteristics of elastin fibers in the lamina propria using fluorescent microscopy and confocal reflected light microscopy. The confocal microscope produces three-dimensional imaging of the fibrous elastic architecture using computer-assisted "reconstruction" of successive noninvasive x-y sections. Methods: Normal human adult larynges were obtained postmortem with no history of instrumentation or laryngeal trauma. Vocal folds were excised, autoclaved to destroy the collagen, then processed and embedded in paraffin. Coronal 5 micron sections were examined under autofluorescence with cosin staining. Thicker sections were stained with cosin and examined under the confocal reflected light microscope for three-dimensional imaging of the elastic fibers. Results and conclusions: Both methods revealed a distribution of elastic fibers throughout the lamina propria, with more concentration in the intermediate layer. A fine reticular layer of elastic fibers were noted immediately below the basement membrane of the epithelium. Elastic fibers appeared thin, cylindrical, tortuous, and formed a loose network. The confocal microscopic studies revealed the threedimensional architecture of the elastic fibers within the lamina propria (photomicrographs to be included). 49 Use of Septoplasty Prior to Tympanoplasty ANNE1TE KREBS,MD, and WOLFGANG MAIER, MD, Freiburg, Germany
Objective: In case of chronic otitis media, the interactions between eustachian tube function and pathology of nose and nasopharynx have to be taken in account. To increase the success rate, septoplasty is recommended prior to tympanoplasty by several authors. Methods: To investigate the influence of nasal septal deviation On eustachian tube function, we examined 40 patients with airway obstruction caused by septal deviation
August 1997
before and after septoplasty. Eustachian tube function was examined in a pressure chamber using the dual impedance method. This method describes opening parameters of active and passive tubal function during the pressure change in the chamber. Results: Preoperatively more than 50% of our patients presented with pathologic active parameters and more than two thirds with pathologic passive parameters of eustachian tube function. One week postoperatively these parameters were even worth. The results if at all were better after 3 months. Conclusions: We conclude from our data that (1) impaired eustachian tube function occurs more often in patients with nasal septal deviation, (2) septoplasty may be useful in special cases but cannot be recommended generally, and (3) tympanoplasty should only be performed several months after septoplasty. 5O Primary Ciliary Dyskinesia in Patients With Repeated Upper Airway Infections SILVIO A. MONTEIRO, MD, PhD, ARACY PEREIRA SILVEIRA BALBANI, MD, and PAULO HILARIO NASCIMENTO SALDIVA, MD, PhD, Sao Paulo/SP, Brazil
Thirteen cases of repeated upper airway infections were evaluated to identify primary ciliary dyskinesia (PCD). There were nine men and four women between 3 and 30 years of age (mean, 17.2 years), and 38.4% of the patients had presented family history of relation by blood, lmmunodeficiencies (both congenital and acquired) and cystic fibrosis were ruled out. Perennial purulent nasal discharge was seen in 61.5% and secretory otitis media was diagnosed in 61.6% of those patients; paranasal sinus disease was diagnosed in all patients by plain RX. Five patients (38.4%) presented situs inversus totalis. Nasal mucosa biopsies studied by means of phase contrast optic microscopy revealed absence of ciliary beat in three cases, and electronic transmission microscopy showed ultrastructural ciliary defects in eight patients (whose findings were absence of dynein arms, microtubule alterations, and absence of cilia). The authors conclude that primary ciliary dyskinesia is an important differential diagnosis in the routine evaluation of recurrent upper airway infections. Tests of ciliary motility and ultrastructural pathology are very useful tools in this investigation. 51 Nasal Polypi and Allergic Fungal Sinusitis MOHAMMED YOUSEF-MIAN, MD, SENTHILKUMAREN, MD, FRCS, ABDULLA ABDULQADIR, MD, FRCP, and MOHAMMED PIRANI, MD, FRCPC, Riyadh, Saudi Arabia
Allergic fungal sinusitis (AFS) is increasingly being recognized as a separate entity characterized by a hypersensitivity reaction to fungi mediated by IgE and resembles al-