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USEFULNESS OF ADMIRE-HF RISK SCORE FOR THE PREDICTION OF SUDDEN CARDIAC DEATH IN PATIENTS WITH CHRONIC HEART FAILURE
1814 JACC April 5, 2016 Volume 67, Issue 13
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) USEFULNESS OF ADMIRE-HF RISK SCORE FOR THE PREDICTION OF SUDDEN CARDIAC DEATH IN PATIENTS WITH CHRONIC HEART FAILURE Poster Contributions Poster Area, South Hall A1 Monday, April 04, 2016, 9:45 a.m.-10:30 a.m. Session Title: Nuclear Cardiology: Beyond Perfusion Imaging Abstract Category: 31. Non Invasive Imaging: Nuclear Presentation Number: 1262-240 Authors: Iyo Ikeda, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Eiji Fukuhara, Masatake Fukunami, Osaka General Medical Center, Osaka, Japan
Background: AdreView Myocardial Imaging for Risk Evaluation in Heart Failure (ADMIRE-HF) risk score is a novel risk score that combines clinical characteristics and imaging variables to provide individualized estimates of serious arrhythmic risk in patients (pts) with chronic heart failure (CHF). However, there is no information available on the external validation of the ADMIRE-HF score for the prediction of sudden cardiac death (SCD) in CHF pts.
Methods: We studied 113 CHF outpatients (NYHA class: 2.1±0.6) with radionuclide left ventricular ejection fraction (LVEF) < 40%, who did not have an implantable cardioverter defibrillator at the time of enrollment. At entry, cardiac I-123 MIBG imaging was performed, where heart-to-mediastinum ratio (HMR) was measured at the chest anterior view images obtained at 200 min after isotope injection. ADMIRE-HF score was derived from the sum of the point values of the following parameters: LVEF (<25%: 5 points), HMR (<1.6: 12 points) and systolic blood pressure (140: -3 points), as previously reported. Results: During a follow-up period of 6.9±3.2 years, 23 pts had SCD. At multivariate Cox analysis, out of variables including clinical, hemodynamic, biochemical, echocardiographic and MIBG parameters, ADMIRE-HF score was significantly independently associated with SCD. Kaplan-Meier analysis revealed that the higher ADMIRE-HF score was, the higher SCD risk was (Figure). Conclusions: ADMIRE-HF score would be useful for the prediction of SCD in pts with CHF.
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) USEFULNESS OF ADMIRE-HF RISK SCORE FOR THE PREDICTION OF SUDDEN CARDIAC DEATH IN PATIENTS WITH CHRONIC HEART FAILURE Poster Contributions Poster Area, South Hall A1 Monday, April 04, 2016, 9:45 a.m.-10:30 a.m. Session Title: Nuclear Cardiology: Beyond Perfusion Imaging Abstract Category: 31. Non Invasive Imaging: Nuclear Presentation Number: 1262-240 Authors: Iyo Ikeda, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Eiji Fukuhara, Masatake Fukunami, Osaka General Medical Center, Osaka, Japan
Background: AdreView Myocardial Imaging for Risk Evaluation in Heart Failure (ADMIRE-HF) risk score is a novel risk score that combines clinical characteristics and imaging variables to provide individualized estimates of serious arrhythmic risk in patients (pts) with chronic heart failure (CHF). However, there is no information available on the external validation of the ADMIRE-HF score for the prediction of sudden cardiac death (SCD) in CHF pts.
Methods: We studied 113 CHF outpatients (NYHA class: 2.1±0.6) with radionuclide left ventricular ejection fraction (LVEF) < 40%, who did not have an implantable cardioverter defibrillator at the time of enrollment. At entry, cardiac I-123 MIBG imaging was performed, where heart-to-mediastinum ratio (HMR) was measured at the chest anterior view images obtained at 200 min after isotope injection. ADMIRE-HF score was derived from the sum of the point values of the following parameters: LVEF (<25%: 5 points), HMR (<1.6: 12 points) and systolic blood pressure (140: -3 points), as previously reported. Results: During a follow-up period of 6.9±3.2 years, 23 pts had SCD. At multivariate Cox analysis, out of variables including clinical, hemodynamic, biochemical, echocardiographic and MIBG parameters, ADMIRE-HF score was significantly independently associated with SCD. Kaplan-Meier analysis revealed that the higher ADMIRE-HF score was, the higher SCD risk was (Figure). Conclusions: ADMIRE-HF score would be useful for the prediction of SCD in pts with CHF.