β-ADRENOCEPTOR-MEDIATED RELAXATION INHIBITED BY TETRAPENTYLAMMONIUM IONS IN RAT MESENTERIC ARTERY

β-ADRENOCEPTOR-MEDIATED RELAXATION INHIBITED BY TETRAPENTYLAMMONIUM IONS IN RAT MESENTERIC ARTERY

L S V C P @1 U r 1 I r 0 PII SOO24-32O5(97)O1O65-5 E 1 S E $ + PH4%UACOLOGYLETTERS AcceleratedCommunication t R I T D P C a O r ...

975KB Sizes 0 Downloads 21 Views

L

S

V C P

@1 U

r

1 I r

0

PII SOO24-32O5(97)O1O65-5

E

1 S

E

$

+

PH4%UACOLOGYLETTERS AcceleratedCommunication

t

R

I

T

D

P

C

a O

r

A a c

e m r

a

p + s

r a

a i

e i

de i e

e

r

p

r

a a &

s m

e

g

i

e

E

r

f

p t

r

i

a T

a a

e C

B

h

r

a w

f a

+

g r

a d

I oe

c B

K

c

r

A T

E

U

(

r p r @

3

M

c m

s

n

a

S

Wordr: t

i

p

r

m

a

channels -

e

I v

m

i a

l

B

r

i

i c

A

r

m

v c

c

a c B

i

c

t

S

i

: r

d a

c a c

i

C

r I

i 1

i c

a

c

d

i

r r

i (

I

f

h

a l

v

c

r s

i c a i i v a p r

r

r a

m

aG

t

a

c an D 8

( 1

i

a P E

f U

y

a

PL20

p

f

R

~ 1998

e g

a

c

r

g p M

preparations

Tissue

F

S

-

g

d

was dissectedand connectivetissueswere Carefilh

m r

- 3 K

s

c

c

a

t

e

e

5

i

f

e

e S p

r

t

m e a

e

e

p

d

Experimentalprotocol p c

a

p

c

i

g c

i

1

e

p

a

c e

r

c

n

e

c

f

a v

o a

K

i

c

e

-

a

Chemicals P

h

i

f

G d

f i

a

i

G c

r

c

Statisticalanalysis v

s e

r P<

( S

0.05 o

a c

v

(

c

ne

+ t

s

E#ect of TPA+on isoprenaline-andfenoterol-inducedrelaxations P i

1 e c

a

m +

+

e p

c

o

~ 1998

Vol. 63

TPA+ andp-adrenoeeptor inRelaxation

0.26 ~ 0.03

PL-21

e

P r

c i e

s

s P<

i

r

0.05

a

+

e

i

r

F

i

p

P< 0.05

e

i

s

c &

f

+ e

r

r

ac

B

A. -

,.

Control

8

60 4 2

0 I

1

c.1 -

.

+

3

+

5

0

D“ 80

~

6

(s

.+ 1PMTPA + 3/ 5

40

& *

20 0u 0

1 1

F

.

c C

o

& G

2 0@ 0

1 1 1

I

G

6 4

1

0

1 1 (

8

&

+ u e

e

(

.

1 1

0.

(

e

F

0

1 C

i

r 1

e

●,

5

e

C

f 1 e

p e

5

a

■, 3

1 a

o ●,

3

■, 3

1

+, 5 c

a +

■, 3

ne

o 5 n

TPA+ and@-adrenoeeptor inRelaxation

PIA?2

~ 1998

Vol.62

1 &

R

e

e E.m (%)

n

EC,O

E

n

I o 1 3 5

0.26 & 0.03

102.4 + 1.8 13

4.86 + 0.83

91.7 * 3.3

9

* + *

97.9 + 6.2 t +

6 6 6

+ * t

+ + +

6 6 6

o 1 3 5

~ & * ~

97.3 i- 2.3 93.3 * 5.0 &

14 7 7 7

+ + * ~

85.5 + 6.2 t + 57.4 + 11*

8 9 8 6

r

i

f f

e

s +

d ne

Effect of TPA+in thepresenceof iberiotoxinor glibenclamia’e G

3

r

a

e

+

i

f

~ f

i

g

s

i

r

a

i

+ a

A

i i

i

i

P

i

S

i

+

i

g

r

3

+

A

B.

C

oC

!’i!Eu!E 0.010.1 1

0.010.1

10 100

I

1

I

(

10 100

s(

2 C c C c

●, ●,

3

T



i

■,

g +

i

■,

i

ne

o 5

i g

o 5

s

Vol. 63

~A+ andP.adrenoceptor in Relution

No.2, 1998

PL23

Effect of raisingextracellularK+onJ-adrenoceptor-mediated relaxation A e e

e

&

~

e

a

r I

r

i

n

c

(<

3

f

i

a

c

a

a

e

K

a

r

n

f

r

p

c a

i

c

A G o ! % l N

B

6

G o

4

2

G Z t

k

B

+ I + F

40

~

2

8

-

L 0

1 1 1

f

(

.

(

-

Fig. 3

i

K

a

f

e

Effect of TPA+onforskolin-inducedrelaxation F p

c

e

o

1 +

f

D i r f a 1

e c

i s p

a m

i s r

d

c

a

1 as e

3

e

a r 1 c p i

m

a

c

o (

c

g

a r

1

F

p

PL24

i

i

No.2, 1998

R

r

g

c an c

s

a c

a

r

1

c

1 m

A

i

c

i

s

c

p e

i

r

i I T r a a

a

a

c

i

r f

s

c

c

e

c

i

r

r

t

a

c

a

m

r f

d

a f

c

a

S

g g

v

d c

T

B

r

m

t

-

a

a

r c g

c

m

B

r

i i

a

a s

r

d

e

d

A s 4

s

P

S

R N

2 S

T N

P V M

P P C

1

P

P P

d i

S

3 4 P P C

Vol.63

No.~ 1998

TPA+and/3-adrenoceptor inRelaxation

PL25

S 2 V

C

P P

P

1 H

G P L

2