0032 Brazilian elementary school children achievement and attention deficit hyperactivity disorder

Poster Abstracts Comparison characteristic of E E G showed irritation o f diencephalon and frontal cortex more frequently in nonepileptic attacks. Local and generalized epileptifomt activity were in 72"/0 patients with epilepsy, also irritation of parietal cortex a n d medial stem structures were oftener in E E G of patient with epileptic paroxysms. Computerized tomography and Magnetic Resonance Imaging of brain showed up brain organic, pathology 0aydrocranium, cyst and tumor of brain) in 56% of children with epilepsy and in 4% 0aydrocranium) of children with nonepilepric disorders. The clinical picture o f the different paroxysmal disorders either epileptic or nonepileptic genesis often is similar. However stereotypy of seizure, unconsciousness, convulsion a n d post seizure sleep characterize epileptic attack. Epileptiform activity a n d brain organic pathology are the most important to difference epileptic and nonepileptic paroxysm. Also the genetic predisposition to epilepsy n m s t be take into consideration. 0031 Analysis of IL-4, MxA, and IRF-1 Genes in Filipino Patients with Subaeute Sclerosing Panencephalitis Pipo-Deveza, J~, Kusuhara, K 2, Silao, C a, Salonga, A a, Lukban, M ~, Sanchez, B a, Abaya, E 3, Asprer,J 3, Cutiongco, E 3, Padilla, C 3, Torisu, H 2, Kira, R 2, Hara, T 2. 1Section of Pediatric Neurology,

University of the Philippines-Philippine General Hospital, Manila, Philippines; 2Department of Pediatrics, Kyushu University, Fukuoka, Japan; 3Institute of Human Genetics, NIH, Manila, Philippines Background: Subacute Sclerosing Panencephalitis (SSPE) is a chronic and debilitating disease of the central nervous system caused by a latent measles infection. Although reported to be rare globally, this m a y not be so in a country like the Philippines were the prevalence of measles remains high.Three candidate genes, IL-4, 1VLxA, and IRF-I were shown to be associated a m o n g Japanese patients with SSPE. These genes have been suggested to play a role in the establishment of persistent viral infection of neural cells. Method: Total of 180 samples (160 Filipino SSPE patients and 120 healthy controls) were included in the study. - 5 9 0 C / T IL4 and -88G/T M x A promoter regions were screened using P C R - R F L P method. Genotyping was done for IRF-1 gene. Association studies were performed between genotypes and SSPE. Results: Our data showed that there is a male predominance a m o n g the SSPE patients, m e a n age at the time of diagnosis was 11 years old. The T T genotype of MxA, as well as the CT genotype o f IL-4, were seen a little more frequent a m o n g the SSPE patients as compared to the control subjects. The values though, did not reach statistical significance. IRF- 1 gene analysis did n o t differ a m o n g the two groups. Conclusion: Our study has demonstrated that there is no significant association o f IL-4, M x A a n d IRF-1 genes among Filipino SSPE patients. Our study group is presently screening other candidate genes which m a y confer host genetic susceptibility to SSPE. 0032 Brazilian Elementary School Children Achievement and Attention Deficit Hyperactivity Disorder Prufer De Queiroz Campos Araujo ~, Pastura, G M C a, Mattos, PEL a.

1The Federal University of Rio de Janeiro, Rio de Janeiro, Brasil Backgrouml: Attention Deficit Hyperactivity Disorder ( A D H D ) h a s a prevalence of 5% in school children and could be associated with scholastic underachievement. The objective o f tiffs study was to calculate the risk of underachievement in the presence of A D H D , in Brazilian elementary school children. Method: We performed an analytic study comparing the mathematic and portuguese grades of 26 students with A D H D and 31 students without tiffs condition. Children were selected according to SNAP-IV, P-ChIPS and clinical evaluation. They h a d their grades on mathematics a n d portuguese recorded. The Institutional Review Board

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approved this study, and informed consent was obtained from all patients. Results: Of the 381 elementary school children, 304 agreed to participate. The screening questionnaire (SNAP-IV) indicated that 19.7% h a d A D H D . After clinical evaluation with P-ChiPS, the final prevalence fell to 8.6%. Grades bellow the tenth percentile were found in 10 of the 26 students with A D H D , and in 4 out of 31 without this disorder (risk of 2.98, CI 95%, 1.06-8.40). This was most frequently seen in the inattentive subtype. Conclusion: A D H D is associated with underachievement in mathematics and portuguese in Brazilian elementary school children. 0033 GiBes de la Tourette Syndrome, a malurafional disorder? Rotteveel, J. St Radboud University Hospital Background: Gilles de la Tourette (GdlT) Syndrome m a y be considered as a genetically determined neurodevelopmental disorder. Since the first description of the syndrome by Itard (1825), various theories have been presented regarding the pathophysiology: perinatal, infectious and neuroimmunological factors, neurotransmitter a n d neuromodulalion defects a m o n g others. M a n y cortical and subcortical structures are involved in the symptomatology of the syadrome and the comorbidity. In this report attention has been drawn to the potential role of maturational factors. Methods: For that reason the growth characteristics (length, weight/ BMI, HC) were analysed retrospectively in a group of 49 children meeting the criteria for the GdlT syndrome. Results: At birth a significant number of infants were too small for date (length p - 0.13, weight p < 0.00, H C normal). In the course of 2-3 years length and weight were normal compared to the Dutch population. Intrauterine maternal factors were not related. Parental weight and length were normal. Severity of GdiT symptoms was associated with initial SGA. Lower birth weight was associated with more need for medical symptomatic treatment for GdlT signs and syrup toms. Conchision: A maturational factor expressing itself in intrauterine growth and maturation of the cerebral network involved in GdlT syndrome might be the c o m m o n denominator in the pathophysiology of the Gilles de la Tourette Syndrome. 0034 Relationship between Febrile convulsion and serum level of Magnesium (Nlg) in children Morteza Sadinejad, A m i r khashayar Varkoohi. Lorestan University

Of Medical Sciences, Iran Introduction: Febrile convulsion is the most c o m m o n type of seizure in childhood. (19m o n t h to 5 years old). Its pathogenesis is unknown, so study about its causes is valuable. The purpose of this study was determining serum level of M a g n e s i u m in children with FC (19 m o n t h to 5 years old) in compare with febrile children with no seizure. Materials & Methods: In tiffs analytical study, serum level of Magnesium in 102 adnfftted children with F C in shahid Madani hospital of K h o r r a n m b a d was determined in compare with 102 febrile children with no seizure, the studied children in case and control groups were 9 m o n t h to 5 years old . serum level of Magnesium was determined through biochemical methods in a reference lab. Finally the data were analysed with SPSS program. Results: a m o n g 102 children with FC, 57"/0 were male and 43"/0 were female. In control group, 38% were male and 62% were female. The mean serum level of m a g n e s i u m was lower in children with F C and there was relation between serum level of M a g n e s i u m and presence of F C in children (p < 0.0001). There was no relation between sex and serum level of m a g n e s i u m in children all groups. Conclusion: As a result, there is relation between serum level of Magnesium and presence of Febrile convulsion in children and