- Email: [email protected]
0298 : Hyperkalaemia in patients with chronic heart failure
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Archives of Cardiovascular Diseases Supplements (2016) 8, 238-239
Conclusion Our data is consistent with the literature and prove that even in our population, the combination of significant FTR and right ventricular dysfunction, is independently associated with renal dysfunction. The presence of significant FTR is related to an excess event rate of heart failure and has significant impact on outcome.
Topic 20 Clinical heart failure – C April 07th, Thursday 2016
The author hereby declares no conflict of interest
0243
0350
Prevalence, clinical features and effect of severity of mitral regurgitation on outcomes of patients with left ventricular systolic dysfunction
Factors related to hospitalization and mortality in patients with chronic heart failure with systolic dysfunction
Fatima Arhlade *, Ichrak Nassiri, Zineb Benchaouia, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Fatima Arhlade)
Chaymaa Houari (1), Amina Bami (1), Nelly Kemayou (1), Diane Kapche (1), Leila Azzouzi (1), Rachida Habbal (1) CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected]
Background Functional mitral regurgitation (FMR) is a common finding in patients with heart failure but its effect on outcome is still uncertain. The aim of this study is to evaluate the prognostic value of FMR in patients with heart failure. Methods From 1613 patients, we enrolled 893 (67 years, 530 were male) patients admitted to the therapeutic unit of chronic heart failure from as follow: group 1: no/mild FMR (n=403, 45%), group 2: moderate FMR (n=466, 52%) and group 3: severe FMR (n=24, 3%) and compared the results from their demographic, clinical data and echocardiography. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm(2) or RV >30 ml or VC >0.4 cm. Results We found FMR in 55% patients with HF. those with severe FMR had more hospitalization for cardiac decompensation (p=0.0002), more Ischemic heart disease (p=0.001), were more likely to have atrial fibrillation (p=0.04), to be treated with high doses of diuretics (p=0.00001); had higher pulmonary pressures (p=0.00004) and right ventricular systolic dysfunction (p=0.00001).There was a good correlation with NYHA functional class (p=0.009), and diastolic dysfunction (p=0.0001). However male sex, diabetes, hypertension, did not differ among the groups. Conclusion Mitral regurgitation has a negative effect on prognosis of patients with heart failure. The author hereby declares no conflict of interest
Introduction With increasing life expectancy, monitoring of chronic heart failure patients is more heterogeneous, because of the etiologies of the CHF, the severity of symptoms, and comorbidities. Many prognostic factors are described to help clinicians better determine the medium- and long-term prognosis. The aim of our study is to determine the main factors related to mortality and hospitalization for heart failure in the first year in a population followed in chronic heart failure. Method and results It is a case-control study conducted between January 2014 and July 201, having compiled 237 patients (GT) followed in chronic heart failure with systolic dysfunction in the unit of treatment of heart failure. Among these patients, the death rate is 11.4% and hospitalization for heart failure is 52.1%, making a total event during the first year of 63.3% (GC). The average age is 63.3 years and 72.9 years respectively in the GT and GC. The two groups did not differ as to gender, cardiovasclar risk factors, except for diabetes, which is more present in the GC (p = 0.04). Clinically, a NYHA class III or IV is found in 12% and 45.8% respectively in the GT and GC (p<0.05). The ischemic etiology is predominant in the GC. In the electrocardioram, atrial fibrillation was found in 5.34% and 44.1% respectively in the GT and GC (p<0.05). The median of the LVEF was 41% and 31.3% respectively in the GT and GC (p<0.05). Biologically, anemia is found in 5% and 10.3% respectively in the GT and GC (p<0.05). Creatinine clearance less than 60 ml / min is observed in 17.5% and 37.6% respectively in the GT and GC (p<0.05). Conclusions In our population, the mortality rate and rehospitalization are high. This risk is particularly increased in older patients with more comorbidities, which have an arrhythmia, and having a more impaired LVEF. The author hereby declares no conflict of interest
0273 Functional tricuspid regurgitation and renal function and there prognosis value in patients with heart failure: Moroccan experience
0298
Fatimazahra Sabri *, Mariam Abelhad, Fatima Arhlade, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Fatimazahra Sabri)
Hyperkalaemia in patients with chronic heart failure
Purpose Many recent studies suggests the important role for systemic venous congestion and functional tricuspid regurgitation (FTR) in the pathophysiology of renal dysfunction which is common in heart failure. We thought to investigate the role of FTR as a determinant of renal dysfunction and a predictor of poor prognosis in chronic systolic heart failure Moroccan patients. Methods and results Over 1422 patients only 132 how had moderate or severe FTR were enrolled (mean age 64 ± 5 years) with chronic heart failure and left ventricular ejection fraction less than 45%. The period of study was 6 years. The FTR severity was quantified by transthoracic echocardiography. Renal function was evaluated with the estimated glomerular filtration rate measured by the simplified Modification of Diet in Renal Disease formula (MDRD). The association between moderate/severe FTR and renal dysfunction, and its impact on heart failure episodes (acute heart failure decompensation) were also assessed. The interaction between moderate/severe FTR with tricuspid annular plane systolic excursion less than 16?mm was found to be an independent determinant of renal dysfunction [40,8%]. Moderate/severe FTR and tricuspid annular plane systolic excursion below 16?mm were related to the heart failure episodes (20%). Moreover, we find that worse outcome (acute heart failure decompensation and readmissions) was associated with moderate/severe FTR.
© Elsevier Masson SAS. All rights reserved.
Kaoutar Kharbouche * (1), Fairouz Haloui (2), Rachida Habbal (1) (1) CHU Ibn Rochd, Casablanca, Maroc – (2) CHU Ibn Rochd, Cardiologie, Casablanca, Maroc * Corresponding author: [email protected] (Kaoutar Kharbouche) Background Heart failure (HF) patients are particularly susceptible to electrolyte abnormalities and especially to hyperkalemia. Potassium (K) balance may be lost botht hrough the neurohormonal mechanisms and through the drugs used in the treatment of this illness. Both hypokalaemia and hyperkalaemia are associated with increased mortality, mainly due to a higher risk of potentially fatal arrhythmia. The aim of this study was to explore the incidence and predictors of hyperkalemia in a broad population of heart failure patients. Methods This was a retrospective study of 1614 consecutive patients admitted to the therapeutic unit for HF between May 2006 and September 2014. Patients on dialysis and those with an estimated glomular filtration rate (GFR) <10ml/min/ 1,73m2 were excluded. Complete history on admission, age, sex, body weight, physical findings, comorbidities, and laboratory information were collected. Results The mean age of our population was 68.3 years, with a male predominance (62.6%). In 20 patients (1.2%) K was<3.0 mmol/L, and in 392patients (24.2%) K was>5.0 mmol/L. Independent of treatment assignment, patients at
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Archives of Cardiovascular Diseases Supplements (2016) 8, 238-239
highest risk for hyperkalemia were those with age ≥75 years (58%), diabetes (51.9%), male gender (66.5%), high potassium at baseline (70.5%), renal dysfunction (49.9%), and those receiving therapy with angiotensin-converting enzyme (ACE) inhibitors (55.3%) or spironolactone (57.2%). Conclusion Changes in potassium ion may cause life-threatening arrhythmias. The risk of hyperkalemia is increased in symptomatic HF patients with comorbidities or combined renin-angiotensin-aldosterone system (RAAS) blockade. The author hereby declares no conflict of interest
0289 Correlation of higher serum uric acid and severity of congestive heart failure in myocardial infarction: prospective study Najoua Fikal *, Imad Nouamou, Amina Bami, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Najoua Fikal) Introduction Serum uric acid (SUA) reflects xanthine oxidase activity’s level and oxidative stress’ production. Hyperuricemia has been identified as a marker of poor prognosis in patients with congestive heart failure (CHF) after acute myocardial infarction (AMI). Aim To assess SUA levels determined on admission as a potential predictor of severity of the CHF in AMI patients. Methods Data for this prospective observational study were collected from the ACS database register created on January 2015. We included consecutive patients with verified AMI admitted within 48 hours since the symptom onset during the period between January and November 2015. Clinical, biological and echocardiographic data were collected through direct contacts with patients during their hospitalization. The study was conducted on two groups: Fifty four patients (42.1%) with high level of SUA on admission were allocated to the group I and were compared to patients of group II (n=74, 57.9%) with normal SUA. Results Group I patients had less previous history of hypertension, dyslipidemia and smoking (37.8% vs 45.3%; 10.8% vs 17.6% and 51.3% vs 58.8% respectively ) but more history of stroke 5.4% vs 1.96%. On admission, mean HR was higher in group 1 than in group 2 (83,73 +/– 17,19 vs 78,37+/–14,64 bpm). Mean SBP was lower in group 1 than in group 2. The mean LVEF was significantly lower in group 1 (40%+/–9,675 vs 45,67 %+/–7,528 ; p= 0.03). This observational cohort identified a close relationship between SUA and Killip classification. Patients who developed short-term CHF had higher concentrations of SUA; the severity of the congestion was proportional to the value of SUA (Killip III-IV: 27.02% vs 7.8%; p=0.04). Conclusion Our results suggest that hyperuricemia after myocardial infarction is associated with the severity of CHF. The serum level of uric acid is a suitable marker to predict adverse events related to myocardial infarction. The author hereby declares no conflict of interest
0364 Anemia and chronic heart failure (CHF): prevalence and prognosis: about 3000 cases Abdelaziz Hadadi *, Chafia Chehbouni, Amina Bami, Anass Inchaouh, Karim Hafdi, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Abdelaziz Hadadi) Introduction Anemia is common in patients with heart failure (HF) and it is one of many factors whose presence allows us to draw a gloomy prognosis.
The aim of the study was to determine the prevalence of anemia, its potential prognostic impact and its physio-pathological mechanism in patients suffering of heart failure. Methods Retrospective study of all CHF patients registered in the therapeutic Unit of Chronic Heart failure over a period of 8 years, between June 2006 and March 2015. Anemia is defined as a hemoglobin level less than 11 g/dl. During this period 3000 patients were studied and divided into two groups: group1 with anemia (58.5 %) and group 2 without anemia (41.5%). Results The mean age is 66 years in the group 1 and 65 in the group 2. A male predominance in both groups was notified. Ischemic heart disease was the most common etiology in both groups. The average heart rate of group 1 was higher than the group 2. It was found that the group 1 was more symptomatic than the group 2 and these patients had more cardiac decompensation. The atrial fibrillation in group 1 and group 2 was respectively 6.9% and 10.9%. Renal failure was significantly more frequent in group 1 (34.3 %) than the group 2 (10.3%). There was not much difference concerning therapeutic classes used in both groups. The presence of anemia increases the risk of rehospitalization and mortality rate at 4 years. Conclusion In the context of heart failure, anemia is a common complication as shown in our study. It is an important and common factor for predicting unfortunate evolution in patients with HF. An early and appropriate management of anemia would improve the symptoms of these patients and reduce the frequency of re-hospitalization. The author hereby declares no conflict of interest
0088 Depression and medication adherence in elderly patients with chronic heart failure Imad Nouamou *, Yassine Ragbaoui, Ayoub Hammiri, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Imad Nouamou) Introduction Depression leads to adverse outcomes in elderly patients with chronic heart failure (CHF). Medication non adherence is a potential mechanism for the increased risk of CHF events. Aim To examine relationships between depression measures in explaining medication adherence in elderly patients with chronic heart failure (HF) patients. Methods We examined the association between current depression (assessed using the Patient Health Questionnaire (PHQ-9)) and medication adherence assessed by Morisky Medication Adherence Scale (MMAS 4 – item version) in a cross-sectional study of 147 patients with CHF followed in heart failure Unit of Cardiology department of IBN ROCHD University Hospital of Casablanca. Results Of 147 patients enrolled in our study, 55 was elderly, 47,3% were diabetic, and 47% were hypertensive, a total of 22 participants (40%) had depression. 16,4% patients reported not taking their medications as prescribed. 11% of depressed patients and 7,3 % of non depressed patients don’t respect the time taken medication. The relationship between depression and non adherence persisted after adjustment for potential confounding variables, including age, education and social support (CI=95%, p=0.008). Conclusion Our findings should direct attention toward depression as independent predictor of medication adherence in elderly patients with CHF. The author hereby declares no conflict of interest
© Elsevier Masson SAS. All rights reserved.
Archives of Cardiovascular Diseases Supplements (2016) 8, 238-239
Conclusion Our data is consistent with the literature and prove that even in our population, the combination of significant FTR and right ventricular dysfunction, is independently associated with renal dysfunction. The presence of significant FTR is related to an excess event rate of heart failure and has significant impact on outcome.
Topic 20 Clinical heart failure – C April 07th, Thursday 2016
The author hereby declares no conflict of interest
0243
0350
Prevalence, clinical features and effect of severity of mitral regurgitation on outcomes of patients with left ventricular systolic dysfunction
Factors related to hospitalization and mortality in patients with chronic heart failure with systolic dysfunction
Fatima Arhlade *, Ichrak Nassiri, Zineb Benchaouia, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Fatima Arhlade)
Chaymaa Houari (1), Amina Bami (1), Nelly Kemayou (1), Diane Kapche (1), Leila Azzouzi (1), Rachida Habbal (1) CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected]
Background Functional mitral regurgitation (FMR) is a common finding in patients with heart failure but its effect on outcome is still uncertain. The aim of this study is to evaluate the prognostic value of FMR in patients with heart failure. Methods From 1613 patients, we enrolled 893 (67 years, 530 were male) patients admitted to the therapeutic unit of chronic heart failure from as follow: group 1: no/mild FMR (n=403, 45%), group 2: moderate FMR (n=466, 52%) and group 3: severe FMR (n=24, 3%) and compared the results from their demographic, clinical data and echocardiography. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm(2) or RV >30 ml or VC >0.4 cm. Results We found FMR in 55% patients with HF. those with severe FMR had more hospitalization for cardiac decompensation (p=0.0002), more Ischemic heart disease (p=0.001), were more likely to have atrial fibrillation (p=0.04), to be treated with high doses of diuretics (p=0.00001); had higher pulmonary pressures (p=0.00004) and right ventricular systolic dysfunction (p=0.00001).There was a good correlation with NYHA functional class (p=0.009), and diastolic dysfunction (p=0.0001). However male sex, diabetes, hypertension, did not differ among the groups. Conclusion Mitral regurgitation has a negative effect on prognosis of patients with heart failure. The author hereby declares no conflict of interest
Introduction With increasing life expectancy, monitoring of chronic heart failure patients is more heterogeneous, because of the etiologies of the CHF, the severity of symptoms, and comorbidities. Many prognostic factors are described to help clinicians better determine the medium- and long-term prognosis. The aim of our study is to determine the main factors related to mortality and hospitalization for heart failure in the first year in a population followed in chronic heart failure. Method and results It is a case-control study conducted between January 2014 and July 201, having compiled 237 patients (GT) followed in chronic heart failure with systolic dysfunction in the unit of treatment of heart failure. Among these patients, the death rate is 11.4% and hospitalization for heart failure is 52.1%, making a total event during the first year of 63.3% (GC). The average age is 63.3 years and 72.9 years respectively in the GT and GC. The two groups did not differ as to gender, cardiovasclar risk factors, except for diabetes, which is more present in the GC (p = 0.04). Clinically, a NYHA class III or IV is found in 12% and 45.8% respectively in the GT and GC (p<0.05). The ischemic etiology is predominant in the GC. In the electrocardioram, atrial fibrillation was found in 5.34% and 44.1% respectively in the GT and GC (p<0.05). The median of the LVEF was 41% and 31.3% respectively in the GT and GC (p<0.05). Biologically, anemia is found in 5% and 10.3% respectively in the GT and GC (p<0.05). Creatinine clearance less than 60 ml / min is observed in 17.5% and 37.6% respectively in the GT and GC (p<0.05). Conclusions In our population, the mortality rate and rehospitalization are high. This risk is particularly increased in older patients with more comorbidities, which have an arrhythmia, and having a more impaired LVEF. The author hereby declares no conflict of interest
0273 Functional tricuspid regurgitation and renal function and there prognosis value in patients with heart failure: Moroccan experience
0298
Fatimazahra Sabri *, Mariam Abelhad, Fatima Arhlade, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Fatimazahra Sabri)
Hyperkalaemia in patients with chronic heart failure
Purpose Many recent studies suggests the important role for systemic venous congestion and functional tricuspid regurgitation (FTR) in the pathophysiology of renal dysfunction which is common in heart failure. We thought to investigate the role of FTR as a determinant of renal dysfunction and a predictor of poor prognosis in chronic systolic heart failure Moroccan patients. Methods and results Over 1422 patients only 132 how had moderate or severe FTR were enrolled (mean age 64 ± 5 years) with chronic heart failure and left ventricular ejection fraction less than 45%. The period of study was 6 years. The FTR severity was quantified by transthoracic echocardiography. Renal function was evaluated with the estimated glomerular filtration rate measured by the simplified Modification of Diet in Renal Disease formula (MDRD). The association between moderate/severe FTR and renal dysfunction, and its impact on heart failure episodes (acute heart failure decompensation) were also assessed. The interaction between moderate/severe FTR with tricuspid annular plane systolic excursion less than 16?mm was found to be an independent determinant of renal dysfunction [40,8%]. Moderate/severe FTR and tricuspid annular plane systolic excursion below 16?mm were related to the heart failure episodes (20%). Moreover, we find that worse outcome (acute heart failure decompensation and readmissions) was associated with moderate/severe FTR.
© Elsevier Masson SAS. All rights reserved.
Kaoutar Kharbouche * (1), Fairouz Haloui (2), Rachida Habbal (1) (1) CHU Ibn Rochd, Casablanca, Maroc – (2) CHU Ibn Rochd, Cardiologie, Casablanca, Maroc * Corresponding author: [email protected] (Kaoutar Kharbouche) Background Heart failure (HF) patients are particularly susceptible to electrolyte abnormalities and especially to hyperkalemia. Potassium (K) balance may be lost botht hrough the neurohormonal mechanisms and through the drugs used in the treatment of this illness. Both hypokalaemia and hyperkalaemia are associated with increased mortality, mainly due to a higher risk of potentially fatal arrhythmia. The aim of this study was to explore the incidence and predictors of hyperkalemia in a broad population of heart failure patients. Methods This was a retrospective study of 1614 consecutive patients admitted to the therapeutic unit for HF between May 2006 and September 2014. Patients on dialysis and those with an estimated glomular filtration rate (GFR) <10ml/min/ 1,73m2 were excluded. Complete history on admission, age, sex, body weight, physical findings, comorbidities, and laboratory information were collected. Results The mean age of our population was 68.3 years, with a male predominance (62.6%). In 20 patients (1.2%) K was<3.0 mmol/L, and in 392patients (24.2%) K was>5.0 mmol/L. Independent of treatment assignment, patients at
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Archives of Cardiovascular Diseases Supplements (2016) 8, 238-239
highest risk for hyperkalemia were those with age ≥75 years (58%), diabetes (51.9%), male gender (66.5%), high potassium at baseline (70.5%), renal dysfunction (49.9%), and those receiving therapy with angiotensin-converting enzyme (ACE) inhibitors (55.3%) or spironolactone (57.2%). Conclusion Changes in potassium ion may cause life-threatening arrhythmias. The risk of hyperkalemia is increased in symptomatic HF patients with comorbidities or combined renin-angiotensin-aldosterone system (RAAS) blockade. The author hereby declares no conflict of interest
0289 Correlation of higher serum uric acid and severity of congestive heart failure in myocardial infarction: prospective study Najoua Fikal *, Imad Nouamou, Amina Bami, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Najoua Fikal) Introduction Serum uric acid (SUA) reflects xanthine oxidase activity’s level and oxidative stress’ production. Hyperuricemia has been identified as a marker of poor prognosis in patients with congestive heart failure (CHF) after acute myocardial infarction (AMI). Aim To assess SUA levels determined on admission as a potential predictor of severity of the CHF in AMI patients. Methods Data for this prospective observational study were collected from the ACS database register created on January 2015. We included consecutive patients with verified AMI admitted within 48 hours since the symptom onset during the period between January and November 2015. Clinical, biological and echocardiographic data were collected through direct contacts with patients during their hospitalization. The study was conducted on two groups: Fifty four patients (42.1%) with high level of SUA on admission were allocated to the group I and were compared to patients of group II (n=74, 57.9%) with normal SUA. Results Group I patients had less previous history of hypertension, dyslipidemia and smoking (37.8% vs 45.3%; 10.8% vs 17.6% and 51.3% vs 58.8% respectively ) but more history of stroke 5.4% vs 1.96%. On admission, mean HR was higher in group 1 than in group 2 (83,73 +/– 17,19 vs 78,37+/–14,64 bpm). Mean SBP was lower in group 1 than in group 2. The mean LVEF was significantly lower in group 1 (40%+/–9,675 vs 45,67 %+/–7,528 ; p= 0.03). This observational cohort identified a close relationship between SUA and Killip classification. Patients who developed short-term CHF had higher concentrations of SUA; the severity of the congestion was proportional to the value of SUA (Killip III-IV: 27.02% vs 7.8%; p=0.04). Conclusion Our results suggest that hyperuricemia after myocardial infarction is associated with the severity of CHF. The serum level of uric acid is a suitable marker to predict adverse events related to myocardial infarction. The author hereby declares no conflict of interest
0364 Anemia and chronic heart failure (CHF): prevalence and prognosis: about 3000 cases Abdelaziz Hadadi *, Chafia Chehbouni, Amina Bami, Anass Inchaouh, Karim Hafdi, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Abdelaziz Hadadi) Introduction Anemia is common in patients with heart failure (HF) and it is one of many factors whose presence allows us to draw a gloomy prognosis.
The aim of the study was to determine the prevalence of anemia, its potential prognostic impact and its physio-pathological mechanism in patients suffering of heart failure. Methods Retrospective study of all CHF patients registered in the therapeutic Unit of Chronic Heart failure over a period of 8 years, between June 2006 and March 2015. Anemia is defined as a hemoglobin level less than 11 g/dl. During this period 3000 patients were studied and divided into two groups: group1 with anemia (58.5 %) and group 2 without anemia (41.5%). Results The mean age is 66 years in the group 1 and 65 in the group 2. A male predominance in both groups was notified. Ischemic heart disease was the most common etiology in both groups. The average heart rate of group 1 was higher than the group 2. It was found that the group 1 was more symptomatic than the group 2 and these patients had more cardiac decompensation. The atrial fibrillation in group 1 and group 2 was respectively 6.9% and 10.9%. Renal failure was significantly more frequent in group 1 (34.3 %) than the group 2 (10.3%). There was not much difference concerning therapeutic classes used in both groups. The presence of anemia increases the risk of rehospitalization and mortality rate at 4 years. Conclusion In the context of heart failure, anemia is a common complication as shown in our study. It is an important and common factor for predicting unfortunate evolution in patients with HF. An early and appropriate management of anemia would improve the symptoms of these patients and reduce the frequency of re-hospitalization. The author hereby declares no conflict of interest
0088 Depression and medication adherence in elderly patients with chronic heart failure Imad Nouamou *, Yassine Ragbaoui, Ayoub Hammiri, Rachida Habbal CHU Ibn Rochd, Casablanca, Maroc * Corresponding author: [email protected] (Imad Nouamou) Introduction Depression leads to adverse outcomes in elderly patients with chronic heart failure (CHF). Medication non adherence is a potential mechanism for the increased risk of CHF events. Aim To examine relationships between depression measures in explaining medication adherence in elderly patients with chronic heart failure (HF) patients. Methods We examined the association between current depression (assessed using the Patient Health Questionnaire (PHQ-9)) and medication adherence assessed by Morisky Medication Adherence Scale (MMAS 4 – item version) in a cross-sectional study of 147 patients with CHF followed in heart failure Unit of Cardiology department of IBN ROCHD University Hospital of Casablanca. Results Of 147 patients enrolled in our study, 55 was elderly, 47,3% were diabetic, and 47% were hypertensive, a total of 22 participants (40%) had depression. 16,4% patients reported not taking their medications as prescribed. 11% of depressed patients and 7,3 % of non depressed patients don’t respect the time taken medication. The relationship between depression and non adherence persisted after adjustment for potential confounding variables, including age, education and social support (CI=95%, p=0.008). Conclusion Our findings should direct attention toward depression as independent predictor of medication adherence in elderly patients with CHF. The author hereby declares no conflict of interest
© Elsevier Masson SAS. All rights reserved.