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0481 PERSONALITY PATHOLOGY TRAITS AND HIGH RISK FOR PSYCHOSIS
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Schizophrenia Research 86 (2006)
increased to see lasting therapeutic change. Some case study material and treatment interventions employed by the Birmingham ED:IT Service are described 0474 DEPRESSIVE SYMPTOMS AND CLINICAL DEPRESSION IN PATIENTS AT RISK OF PSYCHOSIS T.P. Svirskis *, M. Heinimaa, J. Korkeila, L. Vaskelainen, J. Huttunen, T. Ristkari, J. Rekola, A.M. Heinisuo, T. Laine, T. Ilonen, R.K.R. Salokangas. University of Turku, Department of Psychiatry, Turku, Finland Presenting author contact: tapasu@utu.fi Aim: To study Axis-I disorders, especially depression and depressive symptoms in patients participating in the European Prediction of Psychosis Study in Turku, Finland. Method: Study subjects comprised patients at risk of psychosis, aged 16−35 years (n = 55), who were compared with three different control groups: patients who reported no psychotic-like or basic symptoms (n = 13), patients who had subthreshold psychotic-like or basic symptoms (n = 12) and randomly selected control subjects from the population. Results: Major depressive disorder was the most common Axis-I diagnosis among patients at risk of psychosis. Subthreshold psychoticlike or basic symptoms were also associated with clinical depression. The Beck Depression Inventory mean score was higher in the at risk group compared with the control groups. Panic disorder and social phobia were common diagnoses in both the at risk group and the subthreshold symptom group. Conclusion: Vulnerability to psychosis is associated with high prevalence of clinical depression and anxiety disorders. Patients who fulfill the criteria for these disorders should be assessed carefully keeping in mind that possible psychotic-like symptoms may occur at the same time. 0480 PERSONALITY PATHOLOGY TRAITS AND RISK FOR PSYCHOSIS P.M.A.J. Dingemans1 *, H.E. Becker1 , J.R. Fliert van de1 , M.A. Niessen1 , D.H. Nieman1 , D.H. Linszen1 , S. Ruhrmann2 , M. Heinimaa3 , P. Patterson4 , H. Graf von Reventlow2 , G. Juckel5 , A. Morrison6 , R.K.R. Salokangas3 , M. Birchwood4 , J. Klosterk¨otter2 , EPOS Group1 . 1 AMC/De Meren, Amsterdam, Netherlands, 2 Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany, 3 Department of Psychiatry, University of Turku, Turku, Finland, 4 Early Intervention Service, University of Birmingham, Birmingham, United Kingdom, 5 Department of Psychiatry and Psychotherapy, Charite, Humboldt University Berlin, Berlin, Germany, 6 Department of Psychology, University of Manchester, Manchester, United Kingdom Presenting author contact: [email protected] Introduction: There is growing evidence from longitudinal research that comorbidity of clinical and personality characteristics influences the outcome in persons at risk for psychosis. In particular, schizotypy has been associated with an enhanced risk of transition. Furthermore, it is likely that personality pathology traits play a role for both, differential diagnosis in early recognition and adequate treatment. Method: Clinical pathology and personality were assessed in the ultra high risk sample of the European Prediction of Psychosis Study (EPOS, n = 240) with the Personality Diagnostic Questionnaire (PDQ), Schizotypal Personality Questionnaire (SPQ), the Positive
Abstracts and Negative Syndrome Scale (PANSS), Structured Interview for Prodromal Syndromes (SIPS 3.0), and Revised Bonn Scale for the Assessment of Basic Symptoms (BSABS-P), among others. Subscales were derived on the various measures and cluster analysed and compared. Results: In a first analysis, meaningful comorbidity profiles were found in this high-risk group that may have relevance for psychosis transition. Discussion: Final results of the then completed study will be presented and discussed, emphasising especially the relationship between schizotypal features and basic symptoms. 0481 PERSONALITY PATHOLOGY TRAITS AND HIGH RISK FOR PSYCHOSIS P.M.A.J. Dingemans *, H.E. Becker, J.R. van de Fliert, M.A.J. Niessen, D.H. Nieman, D.H. Linszen. AMC/de Meren, Amsterdam, Netherlands Presenting author contact: [email protected] Introduction: There is growing evididence from longitudinal research that comorbidity of clinical and personality characteristics influences outcome. We examined personality and clinical pathology in an ultra high risk group (EPOS) with the Personality Diagnostic Questionnaire, Schizotypal Personality Questionnair, and the Positive and Negative Syndrome Scale. Method: Subscales were derived on the various measures and cluster analysed and compared Results: We were able to find meaningful comorbidity profiles in this high risk group that may have relevance for psychosis transition. Discussion: This project is one of the first in high risk research to combine 1 and axis 2 pathology in outcome assessment. 0496 EMOTION RECOGNITION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS M. Schloegelhofer *, M. Schaefer, K. Papageorgiou, S. WerneckRohrer, G.P. Amminger. 1 Department of Child and Adolescent Psychiatry, Vienna, Austria, 2 Department of General Psychiatry, Vienna, Austria, 3 ORYGEN Research Centre, Melbourne, France Presenting author contact: [email protected]
Introduction: Patients with first-episode schizophrenia have problems in the perception of emotional material, in particular deficits in the recognition of fear and sadness (Edwards et al, 2001). Whether affect perception deficits predate illness onset is still unclear. Methods: We assessed emotion recognition in three different groups: 35 individuals at ultra-high risk (UHR) for psychosis (according to criteria of Yung et al., 1998) (mean age 16.1, SD = 1.9 years), 30 individuals with first-episode schizophrenia (mean age 16.8, SD = 1.4 years) and 30 normal controls (mean age 15.6, SD = 2.0 years). Facial tasks were computerised modifications of the Feinberg et al. (1986) procedure, prosody task were developed by Edwards et al. Fundamental emotions such as fear, sadness, surprise, anger, and neutral were included. Summary scores comprising facial affect and affective prosody recognition for each emotion, and a combined fear–sadness score were analysed. Results: There were significant group differences for sadness, anger, and the combined fear–sadness score (One-way ANOVAs). UHR individuals and individuals with first-episode schizophrenia demonstrated a significant deficit in the recognition of sadness and on the
Schizophrenia Research 86 (2006)
increased to see lasting therapeutic change. Some case study material and treatment interventions employed by the Birmingham ED:IT Service are described 0474 DEPRESSIVE SYMPTOMS AND CLINICAL DEPRESSION IN PATIENTS AT RISK OF PSYCHOSIS T.P. Svirskis *, M. Heinimaa, J. Korkeila, L. Vaskelainen, J. Huttunen, T. Ristkari, J. Rekola, A.M. Heinisuo, T. Laine, T. Ilonen, R.K.R. Salokangas. University of Turku, Department of Psychiatry, Turku, Finland Presenting author contact: tapasu@utu.fi Aim: To study Axis-I disorders, especially depression and depressive symptoms in patients participating in the European Prediction of Psychosis Study in Turku, Finland. Method: Study subjects comprised patients at risk of psychosis, aged 16−35 years (n = 55), who were compared with three different control groups: patients who reported no psychotic-like or basic symptoms (n = 13), patients who had subthreshold psychotic-like or basic symptoms (n = 12) and randomly selected control subjects from the population. Results: Major depressive disorder was the most common Axis-I diagnosis among patients at risk of psychosis. Subthreshold psychoticlike or basic symptoms were also associated with clinical depression. The Beck Depression Inventory mean score was higher in the at risk group compared with the control groups. Panic disorder and social phobia were common diagnoses in both the at risk group and the subthreshold symptom group. Conclusion: Vulnerability to psychosis is associated with high prevalence of clinical depression and anxiety disorders. Patients who fulfill the criteria for these disorders should be assessed carefully keeping in mind that possible psychotic-like symptoms may occur at the same time. 0480 PERSONALITY PATHOLOGY TRAITS AND RISK FOR PSYCHOSIS P.M.A.J. Dingemans1 *, H.E. Becker1 , J.R. Fliert van de1 , M.A. Niessen1 , D.H. Nieman1 , D.H. Linszen1 , S. Ruhrmann2 , M. Heinimaa3 , P. Patterson4 , H. Graf von Reventlow2 , G. Juckel5 , A. Morrison6 , R.K.R. Salokangas3 , M. Birchwood4 , J. Klosterk¨otter2 , EPOS Group1 . 1 AMC/De Meren, Amsterdam, Netherlands, 2 Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany, 3 Department of Psychiatry, University of Turku, Turku, Finland, 4 Early Intervention Service, University of Birmingham, Birmingham, United Kingdom, 5 Department of Psychiatry and Psychotherapy, Charite, Humboldt University Berlin, Berlin, Germany, 6 Department of Psychology, University of Manchester, Manchester, United Kingdom Presenting author contact: [email protected] Introduction: There is growing evidence from longitudinal research that comorbidity of clinical and personality characteristics influences the outcome in persons at risk for psychosis. In particular, schizotypy has been associated with an enhanced risk of transition. Furthermore, it is likely that personality pathology traits play a role for both, differential diagnosis in early recognition and adequate treatment. Method: Clinical pathology and personality were assessed in the ultra high risk sample of the European Prediction of Psychosis Study (EPOS, n = 240) with the Personality Diagnostic Questionnaire (PDQ), Schizotypal Personality Questionnaire (SPQ), the Positive
Abstracts and Negative Syndrome Scale (PANSS), Structured Interview for Prodromal Syndromes (SIPS 3.0), and Revised Bonn Scale for the Assessment of Basic Symptoms (BSABS-P), among others. Subscales were derived on the various measures and cluster analysed and compared. Results: In a first analysis, meaningful comorbidity profiles were found in this high-risk group that may have relevance for psychosis transition. Discussion: Final results of the then completed study will be presented and discussed, emphasising especially the relationship between schizotypal features and basic symptoms. 0481 PERSONALITY PATHOLOGY TRAITS AND HIGH RISK FOR PSYCHOSIS P.M.A.J. Dingemans *, H.E. Becker, J.R. van de Fliert, M.A.J. Niessen, D.H. Nieman, D.H. Linszen. AMC/de Meren, Amsterdam, Netherlands Presenting author contact: [email protected] Introduction: There is growing evididence from longitudinal research that comorbidity of clinical and personality characteristics influences outcome. We examined personality and clinical pathology in an ultra high risk group (EPOS) with the Personality Diagnostic Questionnaire, Schizotypal Personality Questionnair, and the Positive and Negative Syndrome Scale. Method: Subscales were derived on the various measures and cluster analysed and compared Results: We were able to find meaningful comorbidity profiles in this high risk group that may have relevance for psychosis transition. Discussion: This project is one of the first in high risk research to combine 1 and axis 2 pathology in outcome assessment. 0496 EMOTION RECOGNITION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS M. Schloegelhofer *, M. Schaefer, K. Papageorgiou, S. WerneckRohrer, G.P. Amminger. 1 Department of Child and Adolescent Psychiatry, Vienna, Austria, 2 Department of General Psychiatry, Vienna, Austria, 3 ORYGEN Research Centre, Melbourne, France Presenting author contact: [email protected]
Introduction: Patients with first-episode schizophrenia have problems in the perception of emotional material, in particular deficits in the recognition of fear and sadness (Edwards et al, 2001). Whether affect perception deficits predate illness onset is still unclear. Methods: We assessed emotion recognition in three different groups: 35 individuals at ultra-high risk (UHR) for psychosis (according to criteria of Yung et al., 1998) (mean age 16.1, SD = 1.9 years), 30 individuals with first-episode schizophrenia (mean age 16.8, SD = 1.4 years) and 30 normal controls (mean age 15.6, SD = 2.0 years). Facial tasks were computerised modifications of the Feinberg et al. (1986) procedure, prosody task were developed by Edwards et al. Fundamental emotions such as fear, sadness, surprise, anger, and neutral were included. Summary scores comprising facial affect and affective prosody recognition for each emotion, and a combined fear–sadness score were analysed. Results: There were significant group differences for sadness, anger, and the combined fear–sadness score (One-way ANOVAs). UHR individuals and individuals with first-episode schizophrenia demonstrated a significant deficit in the recognition of sadness and on the