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0770 Dementia in Ismailia Governorate (Egypt): An epidemiological study
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Poster Abstracts
Wednesday, November 9, 2005
(p - 0.02). Duration of caregiving was highly correlated especfially with financial and social restrictions (p - 0,002). Contusion: Data obtained using the QCBD show that one of the most significant factors causing feeling of burden a m o n g carers of patients with advanced A D is duration of caregiving. It causes mainly financial and social restrictions.
explain some of the site differences in rates of A D between African Americans and Yoruba.
0768 Dysexecutive syndrome in Binswanger's disease and frontal variant of t~ontoteinporal dementia
Osama, A / El-Tamawy, M 2, Fahmy, M ~, Hier, D ~, A b d AI-Aty, Y~.
Ode, G 1, Dackovic, j 1 Savic, A 1, Zugic, S 1, Ilic, V ~, Pantelic, Z 2.
2Institute of Neurology, Clinical Centre of Serbia, Belgrade, Serbia and Montenegro; 2Medical Centre, Negotin, Serbia and Montenegro Background: The cognitive syndrome of Binswanger's disease (BD) is characterized by impairment of executive functions, m e m o r y deficit and slowed information processing. Beside alterations of behavior, dysexecutive syndrome is the main cognitive feature of the frontal variant of frontotemporal dementia. The aim of this study was to investigate the characteristics of executive functions in Binswanger disease and frontal variant of frontotemporal dementia (fFTD). Method: We examined 22 patients with BD, 18 patients with fFTD and 20 healthy subjects. In all of the groups Mini Mental State Exanfination, Wisconsin Card Sorting Test, Verbal Fluency Test, and Trail-Making Test - F o r m A and B were applied. Results: N o differences were found between BD and the fFI'D patients in M M S E score (BD 24.94; f F I ' F D 23.94) and Trail Making Test scores (BD 263.00, fFTD 255.50). However, f F T D patients had lower performances on W C S T measures (Categories completed p < 0.05, percentage of Conceptual responses P < 0.05 and Verbal fluency Category p < 0.05). There were no differences between two pathological groups in perseverative responses. Conclusion: We concluded that executive functions and verbal fluency were more affected in f F T D than in BD group. Such cognitive profile is not specific enough neither for BD, n o r for fFI'D, so the diagnostic importance of behavioral changes in fFTD is stressed. 0769 A P O E Genotype, Lipids and risk for Alzheimar's disease in the Yoruba Ogunniyi, A x, Hall, KS 2, Murrell, j 2 Baiyewu, O 1, Deeg, M 2, Gureje, O 1, Gao, S2, Unverzagt, F W 2, Shen, j2, Smfith-Gamble, V 2, Dickson, j2, Hendrie, HC 2. 1College of Medicine, University of
Ibadan, Ibadan, Nigeria; 2Indiana University School of Medicine, Indianapolis, USA Background: Significant interaction between APOE4 and cholesterol in detemfining risk for Alzheimer's disease (AD) has been reported in some studies. In African Americans, increasing levels of cholesterol increased the risk of A D in individuals who did not posses an Ed allele. In this study, we investigated the possible relationship between APOE4, cholesterol, and risk of A D in a sample of Yoruba. Method: Blood samples and clinical data were collected from 1390 Yoruba study participants age >70 years. Biomarkers for cholesterol metabolism (cholesterol, LDL, HDL, and triglycerides) were measured in fasting blood samples. D N A was extracted and APOE genotyped. Diagnoses of A D were m a d e using N I N D S - N I N D S criteria. A logistic. regression model was run for each biomarker with A D as the dependent variable, adjusting for age, gender, education, and BML Results: Significant interactions on the risk of A D were found between APOE4 and cholesterol (p - 0.0033), L D L (p - 0.0035), and triglycerides (p - 0.0321). Rising levels of cholesterol increased the risk of A D for individuals with no APOE4. For individuals with APOE4, anincrease in risk for A D was found in only those individuals with low cholesterol levels, as were with L D L and triglycerides. Conclusion: Our results suggest an interaction between E4, cholesterol and risk for A D in a population where previous reports h a d s h o m t no such association. It is possible that tiffs reported interaction m a y
0770 Denlentia in Ismailia Govemorate (Egypt): An Epidemiological Study
1Department of Neuropsyehiatry Suez Canal University,2Department of neurology Cairo University ("Egypt); 3Department of neurology University of Illinois (Chicago) Objective: This cross sectional study was done to determine prevalence rate a n d demographics of dementia in the Ismailia Governorate. Subjects and Methods: The study included 1000 persons over the age of sixty years (1500 in a rural area and 500 in an u r b a n area). Mini Mental State Examination test was used as initial screening tool to pick up demented subjects who scored less than 24 points out of 30 (for literates) or scored less than 22 points out of 28 (for illiterates). All demented subjects were subjected to full physical and neurological examination and computed tomographic brain scan. Results: Prevalence of dementia a m o n g elderly over 60 years of age was 3.8% (2.5"/0 Vascular dementia and 0.8"/0 Alzheimer's disease). The mean age of demented subjects was 68.8 3_ 6.7 years. Dementia was significantly associated with age. Prevalence of dementia a m o n g age group of 60-64 years was 2.1%, while it was 30% a m o n g age group > 80 years. Vascular dementia was the most c o m m o n type of dementia (165.8% of demented subjects) a n d its highest incidence was among the age group of 60-64 years old. Alzheimer's disease was the second most c o m m o n type (21.1% of demented subjects) and its highest incidence was a m o n g the age group of 75-79 years old. Hypertension, diabetes mellitus and smoking were significantly associated with vascular dementia. N o significant differences were found among demented subjects according to areas, gender and literacy. 0771 Assessment of memory impairments in patients with dementia with Lewy bodies, Alzheimar's disease and Parkinson's disease Pelrovie, M 1, Zlatic, G 1, Ode, G 2, Savic, A 2, TomJc, G 2, Knezevic, Z 1, Toncev, G 1. 1Centerfor Neurology, Clinical Center Kragujevac,
Kragujevac, Serbia & Montenegro; 2Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia & Montenegro Introduction: Some preliminary evidences exists that the pattern of m e m o r y impairments are different in dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and Parkinson's disease (PD). The A i m of this study was to identify the m e m o r y characteristics predictive of dementia in DLB, A D and PD. Methods: Twenty-three demented patients (8 D L B patients and 15 A D patients), 10 patients with Parkinson's disease (PD) and 10 healthy subjects were analysed. All groups matched with age, educated level and time of the beginning of the disorders. The baseline neuropsychological profiles were exanfined by the global score in Mini Mental State Exanfination. Subscores for m e m o r y were compared by Mattis Dementia Rating Scale. Results: D L B patients were found to have significantly greater impairment of m e m o r y in subscore of menlory visual recall than PD (p - 0.011) and A D (p -- 0.003). PD and A D patients were found to have significantly greater impairment of m e m o r y in subscore of m e m o r y verbal recall than D L B (PD vs. D L B p -- 0.041; A D vs. D L B p -- 0.040). PD patients were found to have greater impairment of m e m o r y in subscore of m e m o r y sentences recall than A D (p -- 0.201) and DLB (iJ -- 0.220) but there was no significance. A D patients were found to have greater impairment of m e m o r y in subscore of m e m o r y of making sentences than D L B (p -- 0.079) and PD (p -- 0.201) but there was no significance.
Poster Abstracts
Wednesday, November 9, 2005
(p - 0.02). Duration of caregiving was highly correlated especfially with financial and social restrictions (p - 0,002). Contusion: Data obtained using the QCBD show that one of the most significant factors causing feeling of burden a m o n g carers of patients with advanced A D is duration of caregiving. It causes mainly financial and social restrictions.
explain some of the site differences in rates of A D between African Americans and Yoruba.
0768 Dysexecutive syndrome in Binswanger's disease and frontal variant of t~ontoteinporal dementia
Osama, A / El-Tamawy, M 2, Fahmy, M ~, Hier, D ~, A b d AI-Aty, Y~.
Ode, G 1, Dackovic, j 1 Savic, A 1, Zugic, S 1, Ilic, V ~, Pantelic, Z 2.
2Institute of Neurology, Clinical Centre of Serbia, Belgrade, Serbia and Montenegro; 2Medical Centre, Negotin, Serbia and Montenegro Background: The cognitive syndrome of Binswanger's disease (BD) is characterized by impairment of executive functions, m e m o r y deficit and slowed information processing. Beside alterations of behavior, dysexecutive syndrome is the main cognitive feature of the frontal variant of frontotemporal dementia. The aim of this study was to investigate the characteristics of executive functions in Binswanger disease and frontal variant of frontotemporal dementia (fFTD). Method: We examined 22 patients with BD, 18 patients with fFTD and 20 healthy subjects. In all of the groups Mini Mental State Exanfination, Wisconsin Card Sorting Test, Verbal Fluency Test, and Trail-Making Test - F o r m A and B were applied. Results: N o differences were found between BD and the fFI'D patients in M M S E score (BD 24.94; f F I ' F D 23.94) and Trail Making Test scores (BD 263.00, fFTD 255.50). However, f F T D patients had lower performances on W C S T measures (Categories completed p < 0.05, percentage of Conceptual responses P < 0.05 and Verbal fluency Category p < 0.05). There were no differences between two pathological groups in perseverative responses. Conclusion: We concluded that executive functions and verbal fluency were more affected in f F T D than in BD group. Such cognitive profile is not specific enough neither for BD, n o r for fFI'D, so the diagnostic importance of behavioral changes in fFTD is stressed. 0769 A P O E Genotype, Lipids and risk for Alzheimar's disease in the Yoruba Ogunniyi, A x, Hall, KS 2, Murrell, j 2 Baiyewu, O 1, Deeg, M 2, Gureje, O 1, Gao, S2, Unverzagt, F W 2, Shen, j2, Smfith-Gamble, V 2, Dickson, j2, Hendrie, HC 2. 1College of Medicine, University of
Ibadan, Ibadan, Nigeria; 2Indiana University School of Medicine, Indianapolis, USA Background: Significant interaction between APOE4 and cholesterol in detemfining risk for Alzheimer's disease (AD) has been reported in some studies. In African Americans, increasing levels of cholesterol increased the risk of A D in individuals who did not posses an Ed allele. In this study, we investigated the possible relationship between APOE4, cholesterol, and risk of A D in a sample of Yoruba. Method: Blood samples and clinical data were collected from 1390 Yoruba study participants age >70 years. Biomarkers for cholesterol metabolism (cholesterol, LDL, HDL, and triglycerides) were measured in fasting blood samples. D N A was extracted and APOE genotyped. Diagnoses of A D were m a d e using N I N D S - N I N D S criteria. A logistic. regression model was run for each biomarker with A D as the dependent variable, adjusting for age, gender, education, and BML Results: Significant interactions on the risk of A D were found between APOE4 and cholesterol (p - 0.0033), L D L (p - 0.0035), and triglycerides (p - 0.0321). Rising levels of cholesterol increased the risk of A D for individuals with no APOE4. For individuals with APOE4, anincrease in risk for A D was found in only those individuals with low cholesterol levels, as were with L D L and triglycerides. Conclusion: Our results suggest an interaction between E4, cholesterol and risk for A D in a population where previous reports h a d s h o m t no such association. It is possible that tiffs reported interaction m a y
0770 Denlentia in Ismailia Govemorate (Egypt): An Epidemiological Study
1Department of Neuropsyehiatry Suez Canal University,2Department of neurology Cairo University ("Egypt); 3Department of neurology University of Illinois (Chicago) Objective: This cross sectional study was done to determine prevalence rate a n d demographics of dementia in the Ismailia Governorate. Subjects and Methods: The study included 1000 persons over the age of sixty years (1500 in a rural area and 500 in an u r b a n area). Mini Mental State Examination test was used as initial screening tool to pick up demented subjects who scored less than 24 points out of 30 (for literates) or scored less than 22 points out of 28 (for illiterates). All demented subjects were subjected to full physical and neurological examination and computed tomographic brain scan. Results: Prevalence of dementia a m o n g elderly over 60 years of age was 3.8% (2.5"/0 Vascular dementia and 0.8"/0 Alzheimer's disease). The mean age of demented subjects was 68.8 3_ 6.7 years. Dementia was significantly associated with age. Prevalence of dementia a m o n g age group of 60-64 years was 2.1%, while it was 30% a m o n g age group > 80 years. Vascular dementia was the most c o m m o n type of dementia (165.8% of demented subjects) a n d its highest incidence was among the age group of 60-64 years old. Alzheimer's disease was the second most c o m m o n type (21.1% of demented subjects) and its highest incidence was a m o n g the age group of 75-79 years old. Hypertension, diabetes mellitus and smoking were significantly associated with vascular dementia. N o significant differences were found among demented subjects according to areas, gender and literacy. 0771 Assessment of memory impairments in patients with dementia with Lewy bodies, Alzheimar's disease and Parkinson's disease Pelrovie, M 1, Zlatic, G 1, Ode, G 2, Savic, A 2, TomJc, G 2, Knezevic, Z 1, Toncev, G 1. 1Centerfor Neurology, Clinical Center Kragujevac,
Kragujevac, Serbia & Montenegro; 2Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia & Montenegro Introduction: Some preliminary evidences exists that the pattern of m e m o r y impairments are different in dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and Parkinson's disease (PD). The A i m of this study was to identify the m e m o r y characteristics predictive of dementia in DLB, A D and PD. Methods: Twenty-three demented patients (8 D L B patients and 15 A D patients), 10 patients with Parkinson's disease (PD) and 10 healthy subjects were analysed. All groups matched with age, educated level and time of the beginning of the disorders. The baseline neuropsychological profiles were exanfined by the global score in Mini Mental State Exanfination. Subscores for m e m o r y were compared by Mattis Dementia Rating Scale. Results: D L B patients were found to have significantly greater impairment of m e m o r y in subscore of menlory visual recall than PD (p - 0.011) and A D (p -- 0.003). PD and A D patients were found to have significantly greater impairment of m e m o r y in subscore of m e m o r y verbal recall than D L B (PD vs. D L B p -- 0.041; A D vs. D L B p -- 0.040). PD patients were found to have greater impairment of m e m o r y in subscore of m e m o r y sentences recall than A D (p -- 0.201) and DLB (iJ -- 0.220) but there was no significance. A D patients were found to have greater impairment of m e m o r y in subscore of m e m o r y of making sentences than D L B (p -- 0.079) and PD (p -- 0.201) but there was no significance.