- Email: [email protected]
1034 CLINICAL OUTCOMES OF PRIMARY BLADDER CARCINOMA IN SITU IN A CONTEMPORARY SERIES
WLPHLQWHUYDOIURPᚏUVW%&*WR5&3DWLHQWVUHFHLYLQJQHRDGMXYDQWFKHPRWKHUDS\ ZHUHH[FOXGHG7KHSURSRUWLRQRISDWLHQWVZLWK S7%&KDVUHPDLQHGWKHVDPH S RI JURXS DQG RI JURXS KDG ุS7 %& ZLWK DQG KDYLQJH[WUDYHVLFDO%& S7S7 RIJURXSDQGLQJURXSZHUH1 Conclusions: 7KHWLPLQJRI5&KDVQRWLPSURYHGLQUHFHQW\HDUV$KLJKSURSRUWLRQ RISDWLHQWVXQGHUJRLQJ5&DIWHUUHFHLYLQJ%&*KDYHS7RUKLJKHU%&$EODGGHU SUHVHUYDWLRQDSSURDFKVKRXOGEHGLVFRQWLQXHGDWWKHᚏUVWLQGLFDWLRQRISHUVLVWHQWRU UHFXUUHQWKLJKJUDGH%&
1034
CLINICAL OUTCOMES OF PRIMARY BLADDER CARCINOMA IN SITU IN A CONTEMPORARY SERIES
&KDGH'6KDULDW6)*RGR\*6DYDJH&&URQLQ$%RFKQHU% 'RQDW60'+HUU+'DOEDJQL* 1 Memorial Sloan-Kettering Cancer Center, Dept. of Urology, New York, United States of America, 2Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology and Biostatistics, New York, United States of America Introduction & Objectives: 7KHQDWXUDOKLVWRU\RISULPDU\EODGGHUFDUFLQRPDLQ VLWX &,6 KDVQRWEHHQZHOOGHVFULEHG SUHYLRXVVWXGLHVIDLOHGWRDQDO\]HLWDVD GLVWLQFWHQWLW\RURFFXUUHGSULRUWREDFLOOXV&DOPHWWH*XHULQ %&* WKHUDS\EHLQJ LQWURGXFHGLQWRFOLQLFDOSUDFWLFH7KHREMHFWLYHRIWKHVWXG\LVWRGHVFULEHSDWWHUQV RIGLVHDVHUHFXUUHQFHDQGSURJUHVVLRQDQGLGHQWLI\FOLQLFDORXWFRPHSUHGLFWRUVIRU SULPDU\&,6DIWHU%&*WKHUDS\ Material & Methods: 7KLVLVDUHWURVSHFWLYHDQDO\VLVRIFRQVHFXWLYHSDWLHQWV GLDJQRVHG ZLWK LVRODWHG SULPDU\ KLJKJUDGH &,6 LQ D WHUWLDU\ UHIHUUDO FHQWHU IURP WR DQG WUHDWHG ZLWK %&* ZLWKLQ PRQWK RI GLDJQRVLV (QGSRLQWV LQFOXGHG UHVSRQVH WR %&* GLVHDVH UHFXUUHQFH SURJUHVVLRQ WR LQYDVLYH GLVHDVH ุF7 DQG WR PXVFOHLQYDVLYH GLVHDVH ุF7 DQG HDUO\ UDGLFDO F\VWHFWRP\ 3UHGLFWRUVLQFOXGHGJHQGHUDJHUDFHVPRNLQJKLVWRU\SUHVHQWLQJV\PSWRPVDQG &,6SDWWHUQ&RPSHWLQJULVNDQDO\VHVZHUHSHUIRUPHG Results: SDWLHQWV UHFHLYHG %&* WKHUDS\ ZLWKLQ PR DQG ZHUH IROORZHG PRUH WKDQ PR 5HVSRQVH UDWH WR %&* WKHUDS\ ZDV 0HGLDQ IROORZXS ZDV \U )LYH\U FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQ WR ุF7 ZDV &, ದ WR ุF7 ZDV ZKLOH XQGHUZHQW UDGLFDO F\VWHFWRP\ 5& ZLWKRXWSURJUHVVLRQWRุF75HVSRQVHWR%&*ZLWKLQPRZDVVLJQLᚏFDQWO\ DVVRFLDWHGZLWKSURJUHVVLRQWRุF7 S DQGWRุF7 S DGMXVWLQJ IRUWKHFRPSHWLQJULVNRI5&2ISDWLHQWVGHYHORSLQJPXVFOHLQYDVLYHGLVHDVH SURJUHVVHGGLUHFWO\IURP&,6WRุF71RRWKHUYDULDEOHVZHUHVLJQLᚏFDQWO\ DVVRFLDWHGZLWKUHFXUUHQFHRUSURJUHVVLRQ/LPLWDWLRQVRIWKHFXUUHQWVWXG\DUHWKH UHWURVSHFWLYHGHVLJQDQGWKHFRKRUWRIDUHIHUUDOFHQWHU Conclusions: 'HVSLWH%&*WKHUDS\DQGHDUO\5&SDWLHQWVZLWKSULPDU\&,6KDG DKLJKUDWHRIGLVHDVHSURJUHVVLRQ5HVSRQVHWR%&*WKHUDS\ZLWKLQPRZDVWKH VROHSUHGLFWRURIRXWFRPHIRUERWKLQYDVLYHDQGPXVFOHLQYDVLYHEODGGHUFDQFHU
1035
VARIABILITY OF TREATMENT SELECTION AMONG SURGEONS IN PATIENTS WITH CT1 UROTHELIAL CARCINOMA
'DOEDJQL*.DDJ0&URQLQ$9RUD.%RFKQHU%'RQDW60+HUU+ 1 Memorial Sloan-Kettering Cancer Center, Dept. of Urology, New York, United States of America, 2Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology and Biostatistics, New York, United States of America Introduction & Objectives: 7RUHSRUWWKHKHWHURJHQHLW\LQWKHWUHDWPHQWRISDWLHQWV ZLWKF7E\VXUJHRQDQGWRUHSRUWUHFXUUHQFHSURJUHVVLRQDQGVXUYLYDOLQSDWLHQWV ZLWKDQGZLWKRXW%&* Material & Methods: :H LGHQWLᚏHG SDWLHQWV ZLWK D UHVWDJLQJ 785 :H LQYHVWLJDWHGWKHGLᚎHUHQFHVLQWKHWUHDWPHQWRISDWLHQWVZLWKF7EODGGHUFDQFHUE\ VXUJHRQ:HDOVRLQYHVWLJDWHGWKHDVVRFLDWLRQEHWZHHQHDUO\WUHDWPHQWZLWK%&* DQGUHFXUUHQFHSURJUHVVLRQDQGEODGGHUFDQFHUVSHFLᚏFGHDWK Results: 2QPXOWLYDULDEOHDQDO\VLVWKHUHZDVVLJQLᚏFDQWKHWHURJHQHLW\LQXWLOL]DWLRQ RIHDUO\F\VWHFWRP\DQG%&*DPRQJVXUJHRQV2YHUDOOWKH\HDUSUREDELOLW\RI IUHHGRPIURPUHFXUUHQFHZDV &, ,QDPXOWLYDULDEOHPRGHO WKHUH ZDV VLJQLᚏFDQW KHWHURJHQHLW\ LQ UHFXUUHQFH EHWZHHQ VXUJHRQV S 6XUJHRQV ZLWK OHVV WKDQ 785 SHUIRUPHG FDSWXUHG PXVFOH LQ WKH UHVWDJH 785VSHFLPHQOHVVIUHTXHQWO\ YHUVXVWR 7KHUHZDVVLJQLᚏFDQW KHWHURJHQHLW\LQWKHXWLOL]DWLRQRIGHIHUUHGF\VWHFWRP\ S +RZHYHU7KHUH ZDV QR HYLGHQFH RI KHWHURJHQHLW\ EHWZHHQ VXUJHRQV IRURYHUDOO VXUYLYDO S! SDWLHQWVZHUHSODFHGRQVXUYHLOODQFH7KH\HDUSUREDELOLW\RIIUHHGRPIURP UHFXUUHQFH ZDV &, IRU WKRVH UHFHLYLQJ DQG &, IRU WKRVH QRW UHFHLYLQJ HDUO\ %&* 2Q PXOWLYDULDEOH DQDO\VLV WKHUH ZDVQRVLJQLᚏFDQWDVVRFLDWLRQEHWZHHQHDUO\WUHDWPHQWZLWK%&*DQGUHFXUUHQFH KD]DUG UDWLR &, S 7KH FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQDQGEODGGHUFDQFHUVSHFLᚏFGHDWKZHUHYHU\VLPLODULQWKHWZRJURXSV 7KH FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQ ZDV IRU ERWK WKRVH UHFHLYLQJ DQG QRW UHFHLYLQJ HDUO\ %&* ZKLOH WKH FXPXODWLYH LQFLGHQFH RI GHIHUUHG F\VWHFWRP\ EHIRUHSURJUHVVLRQZDVIRUWKRVHUHFHLYLQJDQGIRUWKRVHQRWUHFHLYLQJ HDUO\%&* Conclusions: 7KHUHLVDVLJQLᚏFDQWYDULDELOLW\DPRQJVXUJHRQVLQWKHPDQDJHPHQW RISDWLHQWVZLWK7GLVHDVH7KHVLPLODURXWFRPHIRUWKH%&*DQGQRQ%&*WUHDWHG SDWLHQWVLVPRVWOLNHO\UHODWHGWRSDWLHQWVHOHFWLRQ
Eur Urol Suppl 2010;9(2):324
1036
VALIDATION OF SYLVESTER PREDICTIVE MODEL IN CASES OF PROGRESSION ON TOP OF NON-MUSCLE INVASIVE BLADDER TCC
$OL(O'HLQ%%DUDNDW761DEHHK$,EUDKLHP(, Urology and Nephrology Center, Dept. of Urology, Mansoura, Egypt Introduction & Objectives: :HHYDOXDWHWKHDFFXUDF\RIULVNWDEOHVRI6\OYHVWHU (257& PRGHO LQ D UHWURVSHFWLYH FRKRUW RI QRQPXVFOH LQYDVLYH EODGGHU 7&& 10,%& ZKRGHYHORSHGPXVFOHLQYDVLYHSURJUHVVLRQGXULQJIROORZXS Material & Methods: 7KHVWXG\ZDVFRQGXFWHGEHWZHHQ2FWREHU DQG2FWREHU DQGLQFOXGHGSDWLHQWV2XWRIWKHVH VWXG\FRKRUW SUHVHQWHGLQLWLDOO\ ZLWK KLVWRORJLFDOO\ SURYHQ EODGGHU 7&& VWDJHV S7D DQG S7 DQG GHYHORSHG ODWHU PXVFOHLQYDVLYHSURJUHVVLRQ7KHPRGHRIWUHDWPHQWLQWKLVFRKRUWFDXVHRIFKRLFH RIWKLVPRGHW\SHRIGLYHUVLRQDQGO\PSKQRGHVWDWXVZHUHDVVHVVHG3DWLHQWVZHUH FODVVLᚏHGDFFRUGLQJWRULVNWDEOHVIRUSURJUHVVLRQRI6\OYHVWHU(257&PRGHO Results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onclusions: $OWKRXJK 6\OYHVWHU (257& SUHGLFWLYH PRGHO LV VLPSOH \HW LW FDQ DOORFDWH RQO\ RQH WKLUG RI WKHVH FDVHV LQ WKH KLJK ULVN FDWHJRU\ ,I WKLV ᚏQGLQJ LV UHSURGXFHG LQ RWKHU WULDOV WKHQ WKH (257& SUHGLFWLYH PRGHO ZLOO EH LQ QHHG IRU UHYLVLRQRUPRGLᚏFDWLRQIRUWKHSXUSRVHRISUHGLFWLQJSURJUHVVLRQ
1037
EXTERNAL VALIDATION AND APPLICABILITY OF THE EORTC RISK TABLES FOR NON MUSCLE-INVASIVE BLADDER CANCER
+HUQ£QGH]9'H/D3H³D(0DUW¯Q0'$PDUXFK1%O£]TXH]& *DUF¯D'&DSLW£Q&'H/D0RUHQD-0/ORUHQWH& 1 Hospital Universitario Fundación De Alcorcón, Dept. of Urology, Madrid, Spain, 2 Hospital Universitario Fundación De Alcorcón, Dept. of Preventive Medicine, Madrid, Spain Introduction & Objectives: 6LQFH WKHUH DUH WRROV DYDLODEOH WR GHWHUPLQH D SDWLHQWಬV ULVN RI UHFXUUHQFH DQG SURJUHVVLRQ ZLWK QRQ PXVFOHLQYDVLYH EODGGHU WXPRU KWWS ZZZHRUWFEHWRROVEODGGHUFDOFXODWRUGHIDXOWKWP 7KH REMHFWLYH RI WKH VWXG\ LV WR SHUIRUP DQ H[WHUQDO YDOLGDWLRQ RI WKH WDEOHV DQG HYDOXDWH WKHLU DSSOLFDELOLW\ LQ WKH SDWLHQWV RI RXU LQVWLWXWLRQ E\ FRPSDULQJ WKHULVN RI UHFXUUHQFH DQG SURJUHVVLRQ LQ RXU VHULHV WR WKRVH REWDLQHG WKURXJK WKH DSSOLFDWLRQ RI WKH (257&WDEOHV Material & Methods: $SURVSHFWLYHFRKRUWRISDWLHQWVLQIROORZXSZLWK7D7 EODGGHUWXPRUVLQWHUYHQHGLQRXUFHQWUHEHWZHHQ DQGZDVVWXGLHG5LVN VFRUHVZHUHDVVLJQHGGHSHQGLQJRQWKHWXPRUFKDUDFWHULVWLFVWRGLYLGHGRXUVHULHV LQWRIRXUULVNJURXSVDFFRUGLQJWRWKHVHUDWLQJV7KHYDULDEOHVXVHGWRVHWVFRUHV ZHUH VL]HQXPEHURIWXPRUVVWDJHJUDGH&,6DQGUHFXUUHQFHUDWH$QDQDO\VLV RIVXUYLYDOZDVFDUULHGRXWWRNQRZWKHSUREDELOLW\RIUHFXUUHQFHE\WKHPHWKRGRI .DSSOHU0HLHU Results: SDWLHQWVZLWKDPHGLDQIROORZXSRI PRQWKVDQGDYHUDJHDJHRI \HDUV ZHUHVWXGLHGZHUHPDOH'LVWULEXWLRQRIWKHVHULHVZDV 1XPEHU RI WXPRUV 6LQJOH WXPRUV ! WXPRUV 7XPRXU VL]H FP uFP 5HFXUUHQFH UDWH 3ULPDU\ WXPRU UHFXUUHQFH \HDU ! UHFXUUHQFH \HDU 7FDWHJRU\ 7D 7 &,6
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1034
CLINICAL OUTCOMES OF PRIMARY BLADDER CARCINOMA IN SITU IN A CONTEMPORARY SERIES
&KDGH'6KDULDW6)*RGR\*6DYDJH&&URQLQ$%RFKQHU% 'RQDW60'+HUU+'DOEDJQL* 1 Memorial Sloan-Kettering Cancer Center, Dept. of Urology, New York, United States of America, 2Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology and Biostatistics, New York, United States of America Introduction & Objectives: 7KHQDWXUDOKLVWRU\RISULPDU\EODGGHUFDUFLQRPDLQ VLWX &,6 KDVQRWEHHQZHOOGHVFULEHG SUHYLRXVVWXGLHVIDLOHGWRDQDO\]HLWDVD GLVWLQFWHQWLW\RURFFXUUHGSULRUWREDFLOOXV&DOPHWWH*XHULQ %&* WKHUDS\EHLQJ LQWURGXFHGLQWRFOLQLFDOSUDFWLFH7KHREMHFWLYHRIWKHVWXG\LVWRGHVFULEHSDWWHUQV RIGLVHDVHUHFXUUHQFHDQGSURJUHVVLRQDQGLGHQWLI\FOLQLFDORXWFRPHSUHGLFWRUVIRU SULPDU\&,6DIWHU%&*WKHUDS\ Material & Methods: 7KLVLVDUHWURVSHFWLYHDQDO\VLVRIFRQVHFXWLYHSDWLHQWV GLDJQRVHG ZLWK LVRODWHG SULPDU\ KLJKJUDGH &,6 LQ D WHUWLDU\ UHIHUUDO FHQWHU IURP WR DQG WUHDWHG ZLWK %&* ZLWKLQ PRQWK RI GLDJQRVLV (QGSRLQWV LQFOXGHG UHVSRQVH WR %&* GLVHDVH UHFXUUHQFH SURJUHVVLRQ WR LQYDVLYH GLVHDVH ุF7 DQG WR PXVFOHLQYDVLYH GLVHDVH ุF7 DQG HDUO\ UDGLFDO F\VWHFWRP\ 3UHGLFWRUVLQFOXGHGJHQGHUDJHUDFHVPRNLQJKLVWRU\SUHVHQWLQJV\PSWRPVDQG &,6SDWWHUQ&RPSHWLQJULVNDQDO\VHVZHUHSHUIRUPHG Results: SDWLHQWV UHFHLYHG %&* WKHUDS\ ZLWKLQ PR DQG ZHUH IROORZHG PRUH WKDQ PR 5HVSRQVH UDWH WR %&* WKHUDS\ ZDV 0HGLDQ IROORZXS ZDV \U )LYH\U FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQ WR ุF7 ZDV &, ದ WR ุF7 ZDV ZKLOH XQGHUZHQW UDGLFDO F\VWHFWRP\ 5& ZLWKRXWSURJUHVVLRQWRุF75HVSRQVHWR%&*ZLWKLQPRZDVVLJQLᚏFDQWO\ DVVRFLDWHGZLWKSURJUHVVLRQWRุF7 S DQGWRุF7 S DGMXVWLQJ IRUWKHFRPSHWLQJULVNRI5&2ISDWLHQWVGHYHORSLQJPXVFOHLQYDVLYHGLVHDVH SURJUHVVHGGLUHFWO\IURP&,6WRุF71RRWKHUYDULDEOHVZHUHVLJQLᚏFDQWO\ DVVRFLDWHGZLWKUHFXUUHQFHRUSURJUHVVLRQ/LPLWDWLRQVRIWKHFXUUHQWVWXG\DUHWKH UHWURVSHFWLYHGHVLJQDQGWKHFRKRUWRIDUHIHUUDOFHQWHU Conclusions: 'HVSLWH%&*WKHUDS\DQGHDUO\5&SDWLHQWVZLWKSULPDU\&,6KDG DKLJKUDWHRIGLVHDVHSURJUHVVLRQ5HVSRQVHWR%&*WKHUDS\ZLWKLQPRZDVWKH VROHSUHGLFWRURIRXWFRPHIRUERWKLQYDVLYHDQGPXVFOHLQYDVLYHEODGGHUFDQFHU
1035
VARIABILITY OF TREATMENT SELECTION AMONG SURGEONS IN PATIENTS WITH CT1 UROTHELIAL CARCINOMA
'DOEDJQL*.DDJ0&URQLQ$9RUD.%RFKQHU%'RQDW60+HUU+ 1 Memorial Sloan-Kettering Cancer Center, Dept. of Urology, New York, United States of America, 2Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology and Biostatistics, New York, United States of America Introduction & Objectives: 7RUHSRUWWKHKHWHURJHQHLW\LQWKHWUHDWPHQWRISDWLHQWV ZLWKF7E\VXUJHRQDQGWRUHSRUWUHFXUUHQFHSURJUHVVLRQDQGVXUYLYDOLQSDWLHQWV ZLWKDQGZLWKRXW%&* Material & Methods: :H LGHQWLᚏHG SDWLHQWV ZLWK D UHVWDJLQJ 785 :H LQYHVWLJDWHGWKHGLᚎHUHQFHVLQWKHWUHDWPHQWRISDWLHQWVZLWKF7EODGGHUFDQFHUE\ VXUJHRQ:HDOVRLQYHVWLJDWHGWKHDVVRFLDWLRQEHWZHHQHDUO\WUHDWPHQWZLWK%&* DQGUHFXUUHQFHSURJUHVVLRQDQGEODGGHUFDQFHUVSHFLᚏFGHDWK Results: 2QPXOWLYDULDEOHDQDO\VLVWKHUHZDVVLJQLᚏFDQWKHWHURJHQHLW\LQXWLOL]DWLRQ RIHDUO\F\VWHFWRP\DQG%&*DPRQJVXUJHRQV2YHUDOOWKH\HDUSUREDELOLW\RI IUHHGRPIURPUHFXUUHQFHZDV &, ,QDPXOWLYDULDEOHPRGHO WKHUH ZDV VLJQLᚏFDQW KHWHURJHQHLW\ LQ UHFXUUHQFH EHWZHHQ VXUJHRQV S 6XUJHRQV ZLWK OHVV WKDQ 785 SHUIRUPHG FDSWXUHG PXVFOH LQ WKH UHVWDJH 785VSHFLPHQOHVVIUHTXHQWO\ YHUVXVWR 7KHUHZDVVLJQLᚏFDQW KHWHURJHQHLW\LQWKHXWLOL]DWLRQRIGHIHUUHGF\VWHFWRP\ S +RZHYHU7KHUH ZDV QR HYLGHQFH RI KHWHURJHQHLW\ EHWZHHQ VXUJHRQV IRURYHUDOO VXUYLYDO S! SDWLHQWVZHUHSODFHGRQVXUYHLOODQFH7KH\HDUSUREDELOLW\RIIUHHGRPIURP UHFXUUHQFH ZDV &, IRU WKRVH UHFHLYLQJ DQG &, IRU WKRVH QRW UHFHLYLQJ HDUO\ %&* 2Q PXOWLYDULDEOH DQDO\VLV WKHUH ZDVQRVLJQLᚏFDQWDVVRFLDWLRQEHWZHHQHDUO\WUHDWPHQWZLWK%&*DQGUHFXUUHQFH KD]DUG UDWLR &, S 7KH FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQDQGEODGGHUFDQFHUVSHFLᚏFGHDWKZHUHYHU\VLPLODULQWKHWZRJURXSV 7KH FXPXODWLYH LQFLGHQFH RI SURJUHVVLRQ ZDV IRU ERWK WKRVH UHFHLYLQJ DQG QRW UHFHLYLQJ HDUO\ %&* ZKLOH WKH FXPXODWLYH LQFLGHQFH RI GHIHUUHG F\VWHFWRP\ EHIRUHSURJUHVVLRQZDVIRUWKRVHUHFHLYLQJDQGIRUWKRVHQRWUHFHLYLQJ HDUO\%&* Conclusions: 7KHUHLVDVLJQLᚏFDQWYDULDELOLW\DPRQJVXUJHRQVLQWKHPDQDJHPHQW RISDWLHQWVZLWK7GLVHDVH7KHVLPLODURXWFRPHIRUWKH%&*DQGQRQ%&*WUHDWHG SDWLHQWVLVPRVWOLNHO\UHODWHGWRSDWLHQWVHOHFWLRQ
Eur Urol Suppl 2010;9(2):324
1036
VALIDATION OF SYLVESTER PREDICTIVE MODEL IN CASES OF PROGRESSION ON TOP OF NON-MUSCLE INVASIVE BLADDER TCC
$OL(O'HLQ%%DUDNDW761DEHHK$,EUDKLHP(, Urology and Nephrology Center, Dept. of Urology, Mansoura, Egypt Introduction & Objectives: :HHYDOXDWHWKHDFFXUDF\RIULVNWDEOHVRI6\OYHVWHU (257& PRGHO LQ D UHWURVSHFWLYH FRKRUW RI QRQPXVFOH LQYDVLYH EODGGHU 7&& 10,%& ZKRGHYHORSHGPXVFOHLQYDVLYHSURJUHVVLRQGXULQJIROORZXS Material & Methods: 7KHVWXG\ZDVFRQGXFWHGEHWZHHQ2FWREHU DQG2FWREHU DQGLQFOXGHGSDWLHQWV2XWRIWKHVH VWXG\FRKRUW SUHVHQWHGLQLWLDOO\ ZLWK KLVWRORJLFDOO\ SURYHQ EODGGHU 7&& VWDJHV S7D DQG S7 DQG GHYHORSHG ODWHU PXVFOHLQYDVLYHSURJUHVVLRQ7KHPRGHRIWUHDWPHQWLQWKLVFRKRUWFDXVHRIFKRLFH RIWKLVPRGHW\SHRIGLYHUVLRQDQGO\PSKQRGHVWDWXVZHUHDVVHVVHG3DWLHQWVZHUH FODVVLᚏHGDFFRUGLQJWRULVNWDEOHVIRUSURJUHVVLRQRI6\OYHVWHU(257&PRGHO Results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onclusions: $OWKRXJK 6\OYHVWHU (257& SUHGLFWLYH PRGHO LV VLPSOH \HW LW FDQ DOORFDWH RQO\ RQH WKLUG RI WKHVH FDVHV LQ WKH KLJK ULVN FDWHJRU\ ,I WKLV ᚏQGLQJ LV UHSURGXFHG LQ RWKHU WULDOV WKHQ WKH (257& SUHGLFWLYH PRGHO ZLOO EH LQ QHHG IRU UHYLVLRQRUPRGLᚏFDWLRQIRUWKHSXUSRVHRISUHGLFWLQJSURJUHVVLRQ
1037
EXTERNAL VALIDATION AND APPLICABILITY OF THE EORTC RISK TABLES FOR NON MUSCLE-INVASIVE BLADDER CANCER
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