1038 HEXAMINOLEVULINATE FLUORESCENCE CYSTOSCOPY IMPROVES DETECTION AND RESECTION OF BLADDER CANCER: EXPERIENCE OF THE SPANISH B.L.U.E. GROUP

Conclusions: 5LVNVRIUHFXUUHQFHDQGSURJUHVVLRQRIRXUSDWLHQWVDUHVLPLODUWR WKRVH LQ WKH VWXG\ RI 6\OYHVWHU VR ZH FDQ FRQFOXGH WKDW WKH (257& ULVN WDEOHV DSSO\UHOLDEO\LQRXUFOLQLFDOVHWWLQJ

1038

HEXAMINOLEVULINATE FLUORESCENCE CYSTOSCOPY IMPROVES DETECTION AND RESECTION OF BLADDER CANCER: EXPERIENCE OF THE SPANISH B.L.U.E. GROUP

%XUJXHV-3&RQGH*,ERUUD,3XHUWDV02UGR³R)*UXSR%/8( EOXHOLJKWXURORJLFHQGRVFRS\ 1 Hospital Universitario Son Dureta, Dept. of Urology, Palma De Mallorca, Spain, 2 Hospital Son Llatzer, Dept. of Urology, Palma De Mallorca, Spain, 3Instituto Valenciano De Oncología, Dept. of Urology, Valencia, Spain, 4Hospital Marina Baixa, Dept. of Urology, Villajoyosa, Spain, 5Hospital Arnau De Vilanova, Dept. of Urology, Valencia, Spain Introduction & Objectives: 7KHSKRWRDFWLYHSRUSK\ULQKH[DPLQROHYXOLQDWH+$/  ᚏ[HVVHOHFWLYHO\RQXURWKHOLDOQHRSODVWLFFHOOVDIWHULWVLQWUDYHVLFDOGHOLYHU\$EOXH OLJKWF\VWRVFRS\FDQWKHQLGHQWLI\WKHUHGᚐXRUHVFHQFHHPLWWHGE\WXPRUDOOHVLRQV PDNLQJYLVLEOHᚐDWWXPRXUVRUWLQ\SDSLOODU\OHVLRQVQRWYLVLEOHXQGHUFRQYHQWLRQDO ZKLWHOLJKW2XUSXUSRVHZDVWRTXDQWLI\WKHEHQHᚏWRISKRWRG\QDPLFGLDJQRVLVDW WKHWLPHRI785DQGWRDQDO\]HVHQVLELOLW\DQGVSHFLᚏFLW\RIWKHWHFKQLTXH Material & Methods: %HWZHHQ$SULODQG2FWREHUᚐXRUHVFHQFHJXLGHG F\VWRVFRS\XVLQJKH[DPLQROHYXOLQDWH+H[YL[p ZDVSHUIRUPHGDWWKHWLPHRI785 LQSDWLHQWVZLWKVXVSHFWHGEODGGHUFDQFHUIURPGLᚎHUHQWKRVSLWDOV$OOOHVLRQV IRXQG ZLWK ZKLWH OLJKW DQG EOXH OLJKW ZHUH QXPEHUHG DQG UHFRUGHG LQ DQ RQOLQH GDWDEDVH 5HVHFWLRQELRSV\ ZDV PDGH DQG D VDPSOH RI HDFK OHVLRQ ZDV VHQW VHSDUDWHO\IRUKLVWRORJ\ Results: $WRWDORIYDOLGELRSVLHVZHUHREWDLQHGYLVLEOHXQGHUZKLWHOLJKW HQGRVFRS\RQO\VHHQXQGHUEOXHOLJKWHQGRVFRS\DQGUDQGRPELRSVLHV  2YHUOHVLRQVLGHQWLᚏHGRQO\ZLWKEOXHOLJKW ZHUHWXPRUDOWKHPRVW IUHTXHQW ZDV  &,6 IROORZHG E\  7D7* DQG  381/03  7KH RWKHU  OHVLRQV   ZHUH IDOVH SRVLWLYHV WKH PRVW IUHTXHQW ZDV  LQᚐDPPDWRU\ OHVLRQVIROORZHGE\QRUPDOPXFRVDK\SHUSODVLDDQGSDSLOORPD 6HQVLWLYLW\ RI+$/F\VWRVFRS\ZDVDQGVSHFLᚏFLW\ZDV,QSDWLHQWV DW OHDVWRQHDGGLWLRQDO7LV7D7WXPRXUZDVGHWHFWHGZLWKEOXHOLJKW5HPDUNDEO\ SDWLHQWVZHUHQHZO\GLDJQRVHGRI&,6RQO\GHWHFWHGXQGHUEOXHOLJKW Conclusions: +H[DPLQROHYXOLQDWH ᚐXRUHVFHQFH F\VWRVFRS\ LPSURYHV GHWHFWLRQ DQG UHVHFWLRQ RI QRQPXVFOH LQYDVLYH EODGGHU FDQFHU 7ZHQW\ ᚏYH SHUFHQW RI SDWLHQWVKDYHDGGLWLRQDOWXPRUDOOHVLRQVRQO\GHPRQVWUDWHGE\EOXHOLJKW&,6LVWKH DGGLWLRQDOOHVLRQPRVWIUHTXHQWO\IRXQG)DOVHSRVLWLYHVDUHIUHTXHQWEHLQJPRVWO\ LQᚐDPPDWRU\OHVLRQV)DOVHQHJDWLYHVDUHUDUH

1039

PHOTODYNAMIC DIAGNOSIS IN PATIENTS WITH T1G3 BLADDER CANCER: INFLUENCE ON RECURRENCE AND RATE OF DEFERRED CYSTECTOMIES

.DUO$6WDQLVODXV36WDGOHU77ULWVFKOHU6.QXHFKHO5=DDN' 6WLHI& 1 Ludwig-Maximilians-Universtiy, Campus Grosshadern, Dept. of Urology, Munich, Germany, 2Ludwig-Maximilians-University, Campus Grosshadern, Dept. of Urology, Munich, Germany, 3Rwth Aachen University, Dept. of Pathology, Aachen, Germany Introduction & Objectives: 7KHUDSHXWLFVWUDWHJLHVRQWUHDWPHQWRI7*XURWKHOLDO FDQFHURIWKHXULQDU\EODGGHUDUHGHSHQGHQWRQPXOWLSOHIDFWRUV7KLVUHWURVSHFWLYH VWXG\ZDVSHUIRUPHGWRLQYHVWLJDWHWKHLPSDFWRI3KRWRG\QDPLF'LDJQRVLV3''  RQUHFXUUHQFHUDWHVDQGWKHSHUIRUPDQFHRIGHIHUUHGF\VWHFWRPLHVLQSDWLHQWVZLWK 7*EODGGHUFDQFHU Material & Methods: %HWZHHQDQGSDWLHQWVZHUHGLDJQRVHGZLWK 7*EODGGHUFDQFHUDWRXULQVWLWXWLRQ,QSDWLHQWVLQLWLDO785%7ZDVSHUIRUPHG XQGHU3''FRQGLWLRQDQGSDWLHQWVXQGHUZHQW785%7LQDVWDQGDUGZKLWHOLJKW VHWWLQJ3''ZDVSHUIRUPHGHLWKHUXVLQJDPLQROHYXOLQDWHRUKH[DPLQROHYXOLQDWH IRUEODGGHULQVWLOODWLRQ$YHUDJHIROORZXSZDVPRQWKV)LVKHUಬVH[DFWWHVWDQG .DSODQ0HLHUPHWKRGZHUHXVHGWRWHVWGDWDIRUVLJQLᚏFDQFH Results: 2ISDWLHQWVZKRZHUHWUHDWHGXVLQJ3''DWLQLWLDO785%7UHFXUUHQFH RFFXUUHGLQ FDVHVZKHUHDVRI SDWLHQWVWUHDWHGZLWKRXW 3''VKRZHGDUHFXUUHQFHS ,QWKH3''JURXSDGHIHUUHGF\VWHFWRP\GXH WRWXPRUUHFXUUHQFHSURJUHVVLRQZDVSHUIRUPHGLQ,QWKHZKLWHOLJKWJURXS XQGHUZHQWDGHIHUUHGF\VWHFWRP\S  0HGLDQWLPHWRF\VWHFWRP\LQ WKH3''JURXSZDVWZRPRQWKVFRPSDUHGWRPRQWKVLQWKHZKLWHOLJKWJURXS S $OLPLWDWLRQRIWKHSUHVHQWVWXG\LVWKHUHWURVSHFWLYHPRQRFHQWHUVHWWLQJ ZKLFKLVPRUHOLNHO\WREHELDVHG Conclusions: 3'' GXULQJ LQLWLDO 785%7 LQ 7* EODGGHU FDQFHU VLJQLᚏFDQWO\ UHGXFHG WKH UDWH RI UHFXUUHQFH LQ RXU VWXG\SRSXODWLRQ 7KH XVH RI 3'' ZDV DVVRFLDWHGZLWKDORZHUQXPEHURIGHIHUUHGF\VWHFWRPLHVFRPSDUHGWRWKHZKLWHOLJKW JURXS7KHUHIRUHWKHVHOHFWLRQRISDWLHQWVZKRDUHVXLWDEOHIRUDEODGGHUSUHVHUYLQJ DSSURDFKZDVPRUHIHDVLEOHLQSDWLHQWVZKRXQGHUZHQWLQLWLDO785%7XQGHU3'' FRQGLWLRQV 3'' VHHPV WR EH DVVRFLDWHG ZLWK VXSHULRU LQLWLDO WXPRXU FRQWURO DQG PRUHHᚎHFWLYHWXPRXUWUHDWPHQWDOVRLQSDWLHQWVZLWK7*EODGGHUFDQFHU

1040

ADJUVANT PHOTODYNAMIC THERAPY (PDT) IN COMBINATION TREATMENT OF BLADDER CANCER

$SROLNKLQ2,&KHUQ\VKHY,9$OWXQLQ'9%HGUHWGLQRYD'$ Research Institute of Urology, Dept. of Oncourology, Moscow, Russia Introduction & Objectives: 3KRWRG\QDPLFWKHUDS\3'7 LVSURPLVLQJWUHDWPHQW RSWLRQRIPDOLJQDQWDQGEHQLJQQHRSODVPV,WLVEDVHGRQDELOLW\RISKRWRVHQVLWL]LQJ SURGXFWV ZKLFK VHOHFWLYHO\ DFFXPXODWH LQ WXPRXU DQG G\VSODVWLF WLVVXHV 7KH LUUDGLDWLRQRIWKHVHWLVVXHVZLWKDZDYHOHQJWKLQYLVLEOHVSHFWUXPODPEGD QP  SURGXFHV F\WRWR[LF HᚎHFWV OHDGLQJ WR QHFURVLV ZLWK IXUWKHU VXEVWLWXWLRQ ZLWK FRQQHFWLYHWLVVXH Material & Methods: 7KHDLPRIFRQGXFWHGVWXG\ZDVDVVHVVPHQWRIHᚑFDF\RI )'7ZLWKSKRWRVHQVLWL]HU3KRWRVHQVDVDGMXYDQWWKHUDS\RIQRQPXVFOHLQYDVLYH EODGGHUFDQFHU$GMXYDQWWUHDWPHQWZLWK3'7ZDVSHUIRUPHGRQSDWLHQWVZLWK WUDQVLWLRQDOFHOO EODGGHU FDQFHU LQ VWDJH 710* DIWHU WUDQVXUHWKUDO EODGGHU UHVHFWLRQ  KRXUV SULRU WR 3'7VHVVLRQ LQWUDYHQRXV LQIXVLRQ ZDV GRQH ZLWK SKRWRVHQVLWL]HU3KRWRVHQVPJNJ 3'7ZDVSHUIRUPHGZLWKGLRGHODVHU HTXLSPHQW VHW ಯ%LRVSHFರ /)7   QP  ZLWK F\OLQGULFDO ᚏEHU RSWLF 3RZHUGHQVLW\ZDV-FPLQRQHVHVVLRQ0HDQVHVVLRQWLPHZDVPLQXWHV )XUWKHU DOO SDWLHQWV XQGHUZHQW XOWUDVRXQG UHJXODU DQG ᚐXRUHVFHQW F\VWRVFRS\ ELRSV\ IURP SRVWRSHUDWLYH VFDU DQG IURP VXVSLFLRXV IRU FDQFHU UHFXUUHQFH SDUWV RIEODGGHUPXFRVD Results: )ROORZXS SHULRG LV QR PRUH WKDQ  PRQWKV WR WKH UHFHQW PRPHQW   SDWLHQWVKDYHKDGUHFXUUHQFH5HJLVWHUHGGXULQJ3'7VHVVLRQVLGHHᚎHFWV DQG FRPSOLFDWLRQV ZHUH QRW OLIHWKUHDWHQLQJ    SDWLHQWV KDG VXQEXUQ RHGHPDDQGK\SHUHPLDRIVNLQ GXHWRPLVFRQGXFWRISUHVFULEHGUHJLPH'XULQJ 3'7 VHVVLRQ    SDWLHQWV KDG DQQR\LQJ RU SDLQIXO VHQVDWLRQ LQ WKH SHOYLF DUHD ZKLFK SDVVHG E\ LWVHOI RU UHTXLUHG DQDOJHVLFV 7KHUH ZDV QR V\VWHPLF RU DOOHUJLFUHDFWLRQGXULQJLQWUDYHQRXVLQIXVLRQRI)RWRVHQV Conclusions: $GMXYDQW3'7RIEODGGHUFDQFHUFDQEHXVHGLQRXWSDWLHQWEDVLVRU GD\KRVSLWDO7KHUHLVQHHGRIIXUWKHUVWXG\LQJDQGGHYHORSPHQWRI3'7UHJLPHV )LUVW UHVXOWV VKRZ VLJQLᚏFDQW GHFUHDVH RI EODGGHU FDQFHU UHFXUUHQFH UDWH DIWHU 3'7 )XUWKHU IROORZXS ZLOO KHOS LQ GHᚏQLQJ HᚑFDF\ RI WKLV PHWKRG DQG SURGXFH SUDFWLFDOUHFRPPHQGDWLRQVIRULWVXVDJH

1041

MONTHLY MAINTENANCE AFTER EARLY INTRAVESICAL CHEMOTHERAPY

6HUUHWWD9$OWLHUL90RUJLD*0HOORQL'5XJJLUHOOR$&DUULHUL* $QQHVH35XJJLHUR*'L/DOOR$6HOYDJJL)3,DGHYDLD0 )DOVDSHUOD0'DULFHOOR'9DFLUFD)$OOHJUR5*678)RXQGDWLRQ 1 University of Palermo, Section of Urology, Dept. of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, Palermo, Italy, 2University of Napoli, Dept. of Urology, Naples, Italy, 3University of Messina, Dept. of Urology, Messina, Italy, 4University of Foggia, Dept. of Urology, Foggia, Italy, 5Civic Hospital, Dept. of Urology, Matera, Italy, 6Civic Hospital, Dept. of Urology, Telese Terme (bn), Italy, 7Civic Hospital, Dept. of Urology, Campobasso, Italy, 8University of Bari, Dept. of Urology, Bari, Italy, 9Civic Hospital, Dept. of Urology, Maddaloni (ce), Italy, 10University of Catania, Dept. of Urology, Catania, Italy, 11University of Palermo, Dept. of Human Pathology, Palermo, Italy, 12Civic Hospital, Dept. of Urology, Caltanissetta, Italy, 13GSTU Foundation, Dept. of Statistics, Palermo, Italy Introduction & Objectives: 7KH FOLQLFDO YDOXH RI HDUO\ LQWUDYHVLFDO DGMXYDQW FKHPRWKHUDS\DIWHU785RI10,%&LVZHOOHVWDEOLVKHG7KHUROHRIPDLQWHQDQFHLV VWLOOGHEDWHG7KHDLPRIWKLVUDQGRPL]HGWULDOZDVWRDQDO\]HWKHUROHRIRQH\HDU PDLQWHQDQFHDIWHUDZHHNF\FOHRIHDUO\LQWUDYHVLFDOFKHPRWKHUDS\3DUWLFXODUO\ WKHPDLQHQGSRLQWVZHUHWRGHWHUPLQHWKHGXUDWLRQRIWKHSURSK\ODFWLFDFWLRQRI PDLQWHQDQFH DQG WR LGHQWLI\ WKH FOLQLFDO FKDUDFWHULVWLFV RI WKH EODGGHU WXPRXUV REWDLQLQJWKHKLJKHUEHQHᚏWIURPLW Material & Methods:  SDWLHQWV DᚎHFWHG E\ LQWHUPHGLDWH ULVN 10,%& DQG UHFHLYLQJ HSLUXELFLQ PJPO  ZLWKLQ  KRXUV DIWHU 785 ZHUH UDQGRPL]HG EHWZHHQZHHNಬVLQGXFWLRQF\FOHDQGLQGXFWLRQSOXVPDLQWHQDQFHZLWKPRQWKO\ LQVWLOODWLRQV $ ZULWWHQ LQIRUPHG FRQVHQW ZDV REWDLQHG &\WRORJ\ DQG F\VWRVFRS\ ZHUHSHUIRUPHGPRQWKO\IRU\HDUVDQGPRQWKO\WKHUHDIWHU Results: $W D PHGLDQ IROORZXS ZDV  PRQWKV    SDWLHQWV   UHFXUUHGDQGSDWLHQWV SURJUHVVHG7UHDWPHQWLQWHUUXSWLRQIRUWR[LFLW\ZDV UHTXLUHGLQSDWLHQWV2QHGHDWKGXHWRWR[LFLW\RIHDUO\LQVWLOODWLRQRFFXUUHG1R VWDWLVWLFDOO\ VLJQLᚏFDQW GLᚎHUHQFH LQ UHFXUUHQFH IUHH VXUYLYDO 5)6  ZDV GHWHFWHG EHWZHHQ WKH WZR DUPV S   $Q DGYDQWDJH LQ WHUPV RI UHFXUUHQFH IUHH UDWH 5)5 LQIDYRXURIWKHPDLQWHQDQFHDUPZDVHYLGHQWRQO\XQWLOPRQWKVS   7DE   $ KLJKHU EHQHᚏW IURP PDLQWHQDQFH LQ SDWLHQWV ZLWK SULPDU\ PXOWLSOH WXPRXUVS  DQG*JUDGHWXPRXUVS  ZDVGHWHFWHG7DEOH5HVXOWV 0HGLDQ)ROORZXSUDQJH

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