- Email: [email protected]
104 – Never-treated patients with schizophrenia in rural China
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ABSTRACTS / Schizophrenia Research 98 (2008) 3–199
103 – PRETERM BIRTH AND PSYCHIATRIC OUTCOME IN ADOLESCENCE AND EARLY ADULTHOOD: A STUDY USING THE SWEDISH NATIONAL REGISTERS C. Nosarti 1, C.M. Hultman 2, S. Cnattingius 2, M. Lambe 2, L. Rifkin 1, R.M. Murray 1. 1 Department of Psychiatry, Institute of Psychiatry and King's College London, UK 2 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Presenting Author details: [email protected] PO Box 63, De Crespigny Park, SE5 8AF London, United Kingdom, Tel.: +44 207 8480133. Background: Several studies have reported an association between obstetric complications and psychiatric disorders, particularly schizophrenia. The current investigation prospectively studied whether individuals exposed to obstetric hazards grow up to have an increased risk of psychiatric illness. Methods: Data from the National Board of Health and Welfare, Stockholm, Sweden, were used, which include two population based registers, the Swedish National Birth Register and the Swedish National Inpatient Register. We used an historical population based cohort design and selected all individuals born between 1973 and 2001 (n = 2,686,364), 34,853 of whom were born ‘very preterm’ (before 32 weeks) and 155,634 ‘moderately preterm’ (between 32 and 36 weeks). We then identified all individuals who were subsequently listed in the Inpatient Register as having been first admitted to hospital from 1987 through 2002 with a main psychiatric diagnosis (n = 2608). Adjusted associations between exposure and risk of psychiatric outcome (diagnosis age 16+) were assessed by Cox proportional hazard models. The models included the following risk factors: gestational age, birth weight for gestational age, Apgar score at 5 min, mother's age at delivery, mother's educational level, gender, parity and maternal family history of at least one psychiatric diagnosis (any). Results: Very preterm individuals are more likely to be hospitalized with a diagnosis of psychosis (OR = 3.0), bipolar affective disorder (OR = 10.4), depression (OR = 2.7) and eating disorder (OR = 2.9) than individuals born between 37 and 41 weeks of gestation. Results further indicate that being born ‘moderately preterm’ increases the risk for psychosis (OR = 1.7), bipolar affective disorder (OR = 2.7), depression (OR = 1.4) and eating disorder (OR = 1.6). Conclusions: This study suggests that those individuals exposed to obstetric hazards grow up to have an increased risk of psychiatric illness in general, which include but is not confined to psychosis. doi:10.1016/j.schres.2007.12.170
4 HKJC Centre for Suicide Research and Prevention, The University of Hong Kong, Hong Kong 5 Department of Psychiatry, University of Rochester Medical Center, NY, USA
Presenting Author details: [email protected] UOG Station, 96923 Mangilao, Guam, Tel.: +671 735 2655; fax: +671 734 1203. Background: It is very important to understand the characteristics of never-treated patients with schizophrenia, especially in the community. This study is to explore the characteristics of never-treated patients with schizophrenia in a Chinese rural area. Methods: A 10-year follow-up investigation (1994–2004) among a 1994 cohort (n = 510) of patients with schizophrenia was conducted in Xinjin County, Chengdu, China. Results: One hundred and fifty-six patients (30.6%) had never been treated with antipsychotic medications in 1994. Among these nevertreated patients, 58 patients (37.2%) took antipsychotic medications and 98 patients (62.8%) still did not receive any antipsychotic medications during the 10-year follow-up period. Among the 58 treated patients, 31 patients (53.5%) were hospitalized, and 5 patients (8.6%) also took traditional herbal medicine. Compared with the treated patients, the never-treated patients in 2004 were more likely to be older and unmarried (p b 0.001). These patients either were less likely to be cared by their parents and spouse or have caregivers. These patients had significantly lower family economic status (70.4% of patients bmean level), longer duration of illness {24.0 years (13.1 years)}, older age of onset {34.5 years (13.9 years)} and a higher mortality. Conclusions In rural China, many patients with schizophrenia do not receive any antipsychotic medications after they suffer from the illness. These patients may have a poor outcome than those with medication. Basic antipsychotic medication for these never-treated patients should be helpful for the prognosis of the illness. Acknowledgement: This work was supported in part by HKU and NIH (1 R01 TW007260-01) (Dr. M.S. Ran, PI). Reference: Ran MS, Xiang MZ, Huang MS, Shan YH. Natural course of schizophrenia: two-year follow-up study in a rural Chinese community. British Journal of Psychiatry 2001; 178, 154–158. doi:10.1016/j.schres.2007.12.171
105 – COURSE AND PATTERNS OF SUBSTANCE DEPENDENCE IN PSYCHOSIS S. Saddichha 1, B.N.P. Sinha 1, C.R.J. Khess 1. 1
104 – NEVER-TREATED PATIENTS WITH SCHIZOPHRENIA IN RURAL CHINA M.S. Ran 1, W.J. Mao 2, S.H. Hu 2, C.P. Tang 3, F.R. Lin 3, L. Li 3, S.G. Li 3, E.Y.H. Chen 4, C.L.W. Chan 4, Y. Conwell 5. 1
School of Nursing and Health Sciences, University of Guam 2 Chengdu Mental Health Center, Chengdu, China 3 Xinjin Mental Hospital, Chengdu, China
Crisis Resolution and Home Treatment, University Hospital of North Tees, Cleveland, UK Presenting Author details: [email protected] Kanke, 834009 Ranchi, India, Tel.: +91 9919962608. Background: Substance use in mentally ill patients is now a major problem that influences the course and outcome of psychosis. With prevalence ranging up to 60%, several theories were postulated to explain the link. It would be interesting to know if substances behave
ABSTRACTS / Schizophrenia Research 98 (2008) 3–199
103 – PRETERM BIRTH AND PSYCHIATRIC OUTCOME IN ADOLESCENCE AND EARLY ADULTHOOD: A STUDY USING THE SWEDISH NATIONAL REGISTERS C. Nosarti 1, C.M. Hultman 2, S. Cnattingius 2, M. Lambe 2, L. Rifkin 1, R.M. Murray 1. 1 Department of Psychiatry, Institute of Psychiatry and King's College London, UK 2 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Presenting Author details: [email protected] PO Box 63, De Crespigny Park, SE5 8AF London, United Kingdom, Tel.: +44 207 8480133. Background: Several studies have reported an association between obstetric complications and psychiatric disorders, particularly schizophrenia. The current investigation prospectively studied whether individuals exposed to obstetric hazards grow up to have an increased risk of psychiatric illness. Methods: Data from the National Board of Health and Welfare, Stockholm, Sweden, were used, which include two population based registers, the Swedish National Birth Register and the Swedish National Inpatient Register. We used an historical population based cohort design and selected all individuals born between 1973 and 2001 (n = 2,686,364), 34,853 of whom were born ‘very preterm’ (before 32 weeks) and 155,634 ‘moderately preterm’ (between 32 and 36 weeks). We then identified all individuals who were subsequently listed in the Inpatient Register as having been first admitted to hospital from 1987 through 2002 with a main psychiatric diagnosis (n = 2608). Adjusted associations between exposure and risk of psychiatric outcome (diagnosis age 16+) were assessed by Cox proportional hazard models. The models included the following risk factors: gestational age, birth weight for gestational age, Apgar score at 5 min, mother's age at delivery, mother's educational level, gender, parity and maternal family history of at least one psychiatric diagnosis (any). Results: Very preterm individuals are more likely to be hospitalized with a diagnosis of psychosis (OR = 3.0), bipolar affective disorder (OR = 10.4), depression (OR = 2.7) and eating disorder (OR = 2.9) than individuals born between 37 and 41 weeks of gestation. Results further indicate that being born ‘moderately preterm’ increases the risk for psychosis (OR = 1.7), bipolar affective disorder (OR = 2.7), depression (OR = 1.4) and eating disorder (OR = 1.6). Conclusions: This study suggests that those individuals exposed to obstetric hazards grow up to have an increased risk of psychiatric illness in general, which include but is not confined to psychosis. doi:10.1016/j.schres.2007.12.170
4 HKJC Centre for Suicide Research and Prevention, The University of Hong Kong, Hong Kong 5 Department of Psychiatry, University of Rochester Medical Center, NY, USA
Presenting Author details: [email protected] UOG Station, 96923 Mangilao, Guam, Tel.: +671 735 2655; fax: +671 734 1203. Background: It is very important to understand the characteristics of never-treated patients with schizophrenia, especially in the community. This study is to explore the characteristics of never-treated patients with schizophrenia in a Chinese rural area. Methods: A 10-year follow-up investigation (1994–2004) among a 1994 cohort (n = 510) of patients with schizophrenia was conducted in Xinjin County, Chengdu, China. Results: One hundred and fifty-six patients (30.6%) had never been treated with antipsychotic medications in 1994. Among these nevertreated patients, 58 patients (37.2%) took antipsychotic medications and 98 patients (62.8%) still did not receive any antipsychotic medications during the 10-year follow-up period. Among the 58 treated patients, 31 patients (53.5%) were hospitalized, and 5 patients (8.6%) also took traditional herbal medicine. Compared with the treated patients, the never-treated patients in 2004 were more likely to be older and unmarried (p b 0.001). These patients either were less likely to be cared by their parents and spouse or have caregivers. These patients had significantly lower family economic status (70.4% of patients bmean level), longer duration of illness {24.0 years (13.1 years)}, older age of onset {34.5 years (13.9 years)} and a higher mortality. Conclusions In rural China, many patients with schizophrenia do not receive any antipsychotic medications after they suffer from the illness. These patients may have a poor outcome than those with medication. Basic antipsychotic medication for these never-treated patients should be helpful for the prognosis of the illness. Acknowledgement: This work was supported in part by HKU and NIH (1 R01 TW007260-01) (Dr. M.S. Ran, PI). Reference: Ran MS, Xiang MZ, Huang MS, Shan YH. Natural course of schizophrenia: two-year follow-up study in a rural Chinese community. British Journal of Psychiatry 2001; 178, 154–158. doi:10.1016/j.schres.2007.12.171
105 – COURSE AND PATTERNS OF SUBSTANCE DEPENDENCE IN PSYCHOSIS S. Saddichha 1, B.N.P. Sinha 1, C.R.J. Khess 1. 1
104 – NEVER-TREATED PATIENTS WITH SCHIZOPHRENIA IN RURAL CHINA M.S. Ran 1, W.J. Mao 2, S.H. Hu 2, C.P. Tang 3, F.R. Lin 3, L. Li 3, S.G. Li 3, E.Y.H. Chen 4, C.L.W. Chan 4, Y. Conwell 5. 1
School of Nursing and Health Sciences, University of Guam 2 Chengdu Mental Health Center, Chengdu, China 3 Xinjin Mental Hospital, Chengdu, China
Crisis Resolution and Home Treatment, University Hospital of North Tees, Cleveland, UK Presenting Author details: [email protected] Kanke, 834009 Ranchi, India, Tel.: +91 9919962608. Background: Substance use in mentally ill patients is now a major problem that influences the course and outcome of psychosis. With prevalence ranging up to 60%, several theories were postulated to explain the link. It would be interesting to know if substances behave